H L Pan

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Role of spinal NO in antiallodynic effect of intrathecal clonidine in neuropathic rats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 89:1518-23. 1998
  2. ncbi request reprint Intrathecal clonidine alleviates allodynia in neuropathic rats: interaction with spinal muscarinic and nicotinic receptors
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 90:509-14. 1999
  3. ncbi request reprint Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats
    H L Pan
    Department of Anesthesiology, Physiology, and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    J Pharmacol Exp Ther 288:1026-30. 1999
  4. pmc Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Physiol 518:857-66. 1999
  5. ncbi request reprint Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain
    J K Cheng
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 92:1126-31. 2000
  6. ncbi request reprint Spinal endogenous acetylcholine contributes to the analgesic effect of systemic morphine in rats
    S R Chen
    Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey 17033-0850, USA
    Anesthesiology 95:525-30. 2001
  7. ncbi request reprint Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors
    S R Chen
    Department of Anesthesiology, H187, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033 0850, USA
    Neuroscience 125:141-8. 2004
  8. ncbi request reprint Antiallodynic effect of intrathecal neostigmine is mediated by spinal nitric oxide in a rat model of diabetic neuropathic pain
    S R Chen
    Department of Anesthesiology, The Pennsylvania State University College of Medicine, Hershey 17033-0850, USA
    Anesthesiology 95:1007-12. 2001
  9. ncbi request reprint Differential responses of regional sympathetic activity and blood flow to visceral afferent stimulation
    H L Pan
    Department of Anesthesiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1781-9. 2001
  10. ncbi request reprint Potentiation of glutamatergic synaptic input to supraoptic neurons by presynaptic nicotinic receptors
    D P Li
    Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033-0850, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1105-13. 2001

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Role of spinal NO in antiallodynic effect of intrathecal clonidine in neuropathic rats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 89:1518-23. 1998
    ..The objectives of this study were to assess the role of spinal NO in maintenance of allodynia and to determine the role of spinal NO in the antiallodynic effect of intrathecal clonidine...
  2. ncbi request reprint Intrathecal clonidine alleviates allodynia in neuropathic rats: interaction with spinal muscarinic and nicotinic receptors
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 90:509-14. 1999
    ..The current study determined the role of spinal muscarinic and nicotinic receptors in the antiallodynic effect of intrathecally administered clonidine in spinal nerve-ligated rats...
  3. ncbi request reprint Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats
    H L Pan
    Department of Anesthesiology, Physiology, and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    J Pharmacol Exp Ther 288:1026-30. 1999
    ..This action may contribute, at least in part, to the antiallodynic effect of gabapentin on neuropathic pain...
  4. pmc Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Physiol 518:857-66. 1999
    ..4. Collectively, this study provides important in vivo evidence that protons contribute to activation/sensitization of cardiac sympathetic C-fibre afferents during myocardial ischaemia...
  5. ncbi request reprint Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain
    J K Cheng
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 92:1126-31. 2000
    ....
  6. ncbi request reprint Spinal endogenous acetylcholine contributes to the analgesic effect of systemic morphine in rats
    S R Chen
    Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey 17033-0850, USA
    Anesthesiology 95:525-30. 2001
    ..CONCLUSIONS: The data in the current study indicate that spinal endogenous acetylcholine plays an important role in mediating the analgesic effect of systemic morphine through both muscarinic and nicotinic receptors...
  7. ncbi request reprint Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors
    S R Chen
    Department of Anesthesiology, H187, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033 0850, USA
    Neuroscience 125:141-8. 2004
    ..The inhibitory action of muscarinic agonists on these dorsal horn neurons is mediated in part by spinal GABAB receptors...
  8. ncbi request reprint Antiallodynic effect of intrathecal neostigmine is mediated by spinal nitric oxide in a rat model of diabetic neuropathic pain
    S R Chen
    Department of Anesthesiology, The Pennsylvania State University College of Medicine, Hershey 17033-0850, USA
    Anesthesiology 95:1007-12. 2001
    ..Spinal endogenous nitric oxide contributes to the analgesic action of intrathecal neostigmine in this rat model of diabetic neuropathic pain...
  9. ncbi request reprint Differential responses of regional sympathetic activity and blood flow to visceral afferent stimulation
    H L Pan
    Department of Anesthesiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1781-9. 2001
    ..Therefore, this study provides substantial new evidence that stimulation of abdominal visceral afferents differentially induces sympathetic outflow to the splanchnic vascular bed...
  10. ncbi request reprint Potentiation of glutamatergic synaptic input to supraoptic neurons by presynaptic nicotinic receptors
    D P Li
    Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033-0850, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1105-13. 2001
    ..Activation of presynaptic nicotinic, but not muscarinic, receptors located in the glutamatergic terminals increases the excitatory synaptic input to the SON neurons of the hypothalamus...
  11. ncbi request reprint Effects of intrathecal neostigmine, bupivacaine, and their combination on sympathetic nerve activity in rats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 88:481-6. 1998
    ..The current study examined directly the interaction of intrathecal injection of bupivacaine and neostigmine on splanchnic sympathetic efferent nerve activity...
  12. ncbi request reprint Regulation of synaptic input to hypothalamic presympathetic neurons by GABA(B) receptors
    Q Chen
    Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Neuroscience 142:595-606. 2006
    ..This presynaptic action of GABA(B) receptors is mediated by the N-ethylmaleimide-sensitive G(i/o) proteins, but independent of voltage-gated Ca2+ and K+ channels...
  13. ncbi request reprint Chronic intrathecal morphine administration produces homologous mu receptor/G-protein desensitization specifically in spinal cord
    C E Maher
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
    Brain Res 895:1-8. 2001
    ..t. morphine treatment were observed in brain sections. These data show that homologous desensitization of mu receptor/G-protein coupling occurs specifically in spinal cord following chronic morphine administration...
  14. ncbi request reprint Stereospecific effect of pregabalin on ectopic afferent discharges and neuropathic pain induced by sciatic nerve ligation in rats
    S R Chen
    Department of Anesthesiology, The Pennsylvania State University College of Medicine, Hershey 17033-0850, USA
    Anesthesiology 95:1473-9. 2001
    ....
  15. ncbi request reprint Antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, MPV-2426, in sheep
    J C Eisenach
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 91:1425-36. 1999
    ..This study determined the antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, MPV-2426, in sheep...
  16. ncbi request reprint Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats
    A P Gokin
    Molecular Neurobiology of Pain, and Sensory Neurophysiology Laboratories of the Pain Research Center, Department of Anesthesiology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 21:5358-66. 2001
    ..These data demonstrate that subcutaneous administration of ET-1 to the rat plantar hindpaw produces pain-like behavior and selective excitation of nociceptive fibers through activation of ET(A) receptors...
  17. ncbi request reprint Allosteric adenosine modulation to reduce allodynia
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA
    Anesthesiology 95:416-20. 2001
    ..Although obvious adverse effects were not observed in this investigation, further study is required to determine the feasibility of the use of such modulators in the treatment of chronic pain associated with hyperalgesia and allodynia...
  18. ncbi request reprint Acetylcholine attenuates synaptic GABA release to supraoptic neurons through presynaptic nicotinic receptors
    D P Li
    Department of Anesthesiology, H187, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USA
    Brain Res 920:151-8. 2001
    ..Activation of presynaptic nicotinic receptors located in the GABAergic terminals plays a major role in the cholinergic regulation of the inhibitory GABAergic input to SON neurons...
  19. ncbi request reprint Differential roles for glutamate receptor subtypes within commissural NTS in cardiac-sympathetic reflex
    D P Li
    Department of Anesthesiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 281:R935-43. 2001
    ....