M Pahor

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi Therapeutic benefits of ACE inhibitors and other antihypertensive drugs in patients with type 2 diabetes
    M Pahor
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    Diabetes Care 23:888-92. 2000
  2. ncbi Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials
    M Pahor
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    Lancet 356:1949-54. 2000
  3. ncbi Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1
    Marco Pahor
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circulation 105:457-61. 2002
  4. ncbi Inflammatory markers and physical function among older adults with knee osteoarthritis
    Brenda W J H Penninx
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157, USA
    J Rheumatol 31:2027-31. 2004
  5. ncbi Anemia is associated with disability and decreased physical performance and muscle strength in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:719-24. 2004
  6. ncbi Isradipine in prediabetic hypertensive subjects
    R P Byington
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Diabetes Care 21:2103-10. 1998
  7. ncbi Inflammatory markers and onset of cardiovascular events: results from the Health ABC study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circulation 108:2317-22. 2003
  8. ncbi Inflammatory markers and incident mobility limitation in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:1105-13. 2004
  9. ncbi Antihypertensive medications and differences in muscle mass in older persons: the Health, Aging and Body Composition Study
    Mauro Di Bari
    Department of Internal Medicine, Sticht Center on Aging, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:961-6. 2004
  10. ncbi The lifestyle interventions and independence for elders (LIFE) pilot study: design and methods
    W Jack Rejeski
    Department of HES, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
    Contemp Clin Trials 26:141-54. 2005

Detail Information

Publications90

  1. ncbi Therapeutic benefits of ACE inhibitors and other antihypertensive drugs in patients with type 2 diabetes
    M Pahor
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    Diabetes Care 23:888-92. 2000
    ..To assess whether ACE inhibitors are superior to alternative agents for the prevention of cardiovascular events in patients with hypertension and type 2 diabetes...
  2. ncbi Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials
    M Pahor
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    Lancet 356:1949-54. 2000
    ..The aim of this meta-analysis was to compare the effects of calcium antagonists and other antihypertensive drugs on major cardiovascular events...
  3. ncbi Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1
    Marco Pahor
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circulation 105:457-61. 2002
    ..ACE inhibitors and calcium antagonists may modulate fibrinolysis. We conducted a randomized controlled trial to assess the effects of these drugs on plasminogen activator inhibitor-1 (PAI-1) antigen, an inhibitor of fibrinolysis...
  4. ncbi Inflammatory markers and physical function among older adults with knee osteoarthritis
    Brenda W J H Penninx
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157, USA
    J Rheumatol 31:2027-31. 2004
    ..CONCLUSION: Especially high levels of the soluble receptors of TNF-alpha were found to be associated with lower physical function, increased OA symptoms, and worse knee radiographic scores in older obese adults with knee OA...
  5. ncbi Anemia is associated with disability and decreased physical performance and muscle strength in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:719-24. 2004
    ..To examine the association between anemia and disability, physical performance, and muscle strength in older persons...
  6. ncbi Isradipine in prediabetic hypertensive subjects
    R P Byington
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Diabetes Care 21:2103-10. 1998
    ....
  7. ncbi Inflammatory markers and onset of cardiovascular events: results from the Health ABC study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circulation 108:2317-22. 2003
    ..CONCLUSIONS: Findings suggest that inflammatory markers are independent predictors of cardiovascular events in older persons...
  8. ncbi Inflammatory markers and incident mobility limitation in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:1105-13. 2004
    ..To examine the relationship between indicators of inflammation and the incidence of mobility limitation in older persons...
  9. ncbi Antihypertensive medications and differences in muscle mass in older persons: the Health, Aging and Body Composition Study
    Mauro Di Bari
    Department of Internal Medicine, Sticht Center on Aging, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:961-6. 2004
    ..To evaluate whether older persons using angiotensin-converting enzyme (ACE) inhibitors have a larger lower extremity muscle mass (LEMM) than users of other antihypertensive drugs...
  10. ncbi The lifestyle interventions and independence for elders (LIFE) pilot study: design and methods
    W Jack Rejeski
    Department of HES, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
    Contemp Clin Trials 26:141-54. 2005
    ..Other goals of this pilot phase include assessments of health-related quality of life and cost-effectiveness...
  11. ncbi Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study
    Brenda W J H Penninx
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Biol Psychiatry 54:566-72. 2003
    ..In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation...
  12. ncbi Clinical Implications of Recent Findings from the Antihypertensive and Lipid-Lowering Treatment To Prevent Heart Attack Trial (ALLHAT) and Other Studies of Hypertension
    C D Furberg
    Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1063, USA
    Ann Intern Med 135:1074-8. 2001
    ....
  13. ncbi Physical activity in prefrail older adults: confidence and satisfaction related to physical function
    W Jack Rejeski
    Department of Health and Exercise Science, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
    J Gerontol B Psychol Sci Soc Sci 63:P19-26. 2008
    ..This is an important finding in light of the importance of these process variables in behavior change and quality of life...
  14. ncbi Change in physical performance over time in older women: the Women's Health and Aging Study
    Graziano Onder
    Sticht Center on Aging, Section on Gerontology and Geriatrics, Department of Internal Medicine, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 57:M289-93. 2002
    ....
  15. ncbi Obese, older adults with knee osteoarthritis: weight loss, exercise, and quality of life
    W Jack Rejeski
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Health Psychol 21:419-26. 2002
    ....
  16. ncbi Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial
    Stephen P Messier
    Claude D Pepper Older Americans Independence Center, Wake Forest University, Winston Salem, NC 27109, USA
    Arthritis Rheum 50:1501-10. 2004
    ....
  17. ncbi Treatment of minor depression in older adults: a pilot study comparing sertraline and exercise
    G A Brenes
    Department of Social Sciences and Health Policy, Winston Salem, NC 25157, USA
    Aging Ment Health 11:61-8. 2007
    ..Both sertraline and exercise show promise as treatments for late-life minor depression. However, exercise has the added benefit of improving physical functioning as well...
  18. ncbi Evaluation and correction for a 'training effect' in the cognitive assessment of older adults
    M Di Bari
    Sticht Center on Aging, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    Neuroepidemiology 21:87-92. 2002
    ..Yet, a training effect has been poorly considered in longitudinal studies of cognitive changes in older persons...
  19. ncbi Lower extremity performance in nondisabled older persons as a predictor of subsequent hospitalization
    B W Penninx
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Gerontol A Biol Sci Med Sci 55:M691-7. 2000
    ..This study examines, in initially nondisabled older persons, the impact of reduced lower extremity performance on subsequent hospitalizations...
  20. ncbi Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial
    Barbara J Nicklas
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 79:544-51. 2004
    ..Persistent, low-grade inflammation is an independent predictor of several chronic diseases and all-cause mortality...
  21. ncbi Inflammatory markers and cardiovascular health in older adults
    Stephen B Kritchevsky
    Sticht Center on Aging, Section of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cardiovasc Res 66:265-75. 2005
    ..Thus it is possible that, in older age-groups, interventions designed to prevent cardiovascular disease through the modulation of inflammation would also be helpful in reducing disability and mortality...
  22. ncbi Bone density and hemoglobin levels in older persons: results from the InCHIANTI study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina, NC 27157, USA
    Osteoporos Int 16:691-9. 2005
    ..The bone loss associated with hemoglobin levels mainly occurs in the cortical bone. Women with lower hemoglobin levels demonstrate a higher bone loss than male counterparts...
  23. ncbi Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Epidemiol 160:741-9. 2004
    ..79, 95% confidence interval: 1.24, 2.58 per standard-deviation increase; p < 0.01). The amount of adipose tissue stored in the intraabdominal cavity is an important, independent risk factor for MI in well-functioning, elderly women...
  24. ncbi Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Clin Nutr 79:289-94. 2004
    ..Muscle strength and physical performance in old age might be related to the oxidative damage caused by free radicals...
  25. ncbi Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke
    Jingzhong Ding
    Department of Internal Medicine Geriatrics, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    Am Heart J 152:1109-15. 2006
    ..We investigated the association of polymorphisms and common haplotypes of the PAI-1 gene with plasma PAI-1 levels, as well as the risk of myocardial infarction and stroke...
  26. ncbi Chronic inflammation is associated with low physical function in older adults across multiple comorbidities
    Tina E Brinkley
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 64:455-61. 2009
    ....
  27. ncbi Impact of hospitalization on blood pressure control in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA)
    Graziano Onder
    Section of Gerontology and Geriatrics, Stricht Center on Aging, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
    Pharmacotherapy 23:240-7. 2003
    ..To evaluate whether hospitalization affects blood pressure control in hypertensive patients, and to identify factors associated with attainment of adequate blood pressure control and with aggressive pharmacologic treatment...
  28. ncbi Designing clinical trials of interventions for mobility disability: results from the lifestyle interventions and independence for elders pilot (LIFE-P) trial
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 62:1237-43. 2007
    ..Clinical trials to assess interventions for mobility disability are critically needed; however, data for efficiently designing such trials are lacking...
  29. ncbi Long-term physical activity and inflammatory biomarkers in older adults
    Kristen M Beavers
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Med Sci Sports Exerc 42:2189-96. 2010
    ..The purpose of this study was to determine the effects of a 12-month physical activity (PA) intervention on inflammatory biomarkers in elderly men and women...
  30. ncbi Effects of birth cohort and age on body composition in a sample of community-based elderly
    Jingzhong Ding
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Clin Nutr 85:405-10. 2007
    ..The effect of the recent obesity epidemic on body composition remains unknown. Furthermore, age-related changes in body composition are still unclear...
  31. ncbi Exercise training and plasma C-reactive protein and interleukin-6 in elderly people
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 56:2045-52. 2008
    ..To determine the effects of a long-term exercise intervention on two prominent biomarkers of inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)) in elderly men and women...
  32. ncbi Changes in cognitive function in a randomized trial of physical activity: results of the lifestyle interventions and independence for elders pilot study
    Jeff D Williamson
    Roena Kulynych Center for Memory and Cognition Research, Department of Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27151, USA
    J Gerontol A Biol Sci Med Sci 64:688-94. 2009
    ....
  33. ncbi Physical function and its response to exercise: associations with cytokine gene variation in older adults with knee osteoarthritis
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 60:1292-8. 2005
    ....
  34. ncbi Intraindividual variability and the effect of acute illness on immune senescence markers
    Kevin P High
    Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 53:1761-6. 2005
    ..To determine the intraindividual variability and effect of acute illness on two markers of immune senescence...
  35. ncbi Long-term exercise therapy resolves ethnic differences in baseline health status in older adults with knee osteoarthritis
    Capri Gabrielle Foy
    Department of Public Health Sciences, Wake Forest University, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 53:1469-75. 2005
    ....
  36. ncbi Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    CMAJ 172:1199-209. 2005
    ....
  37. ncbi Abdominal obesity is an independent risk factor for chronic heart failure in older people
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 54:413-20. 2006
    ..To examine whether total and abdominal adiposity are risk factors for the development of chronic heart failure (CHF) in older men and women...
  38. ncbi Angiotensin-converting enzyme insertion/deletion genotype, exercise, and physical decline
    Stephen B Kritchevsky
    The Sticht Center on Aging and Center for Human Genomics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    JAMA 294:691-8. 2005
    ....
  39. ncbi Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study)
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Cardiol 92:522-8. 2003
    ..Thus, our findings suggest an important role for IL-6 and TNF-alpha in clinical as well as subclinical cardiovascular disease. In this study, CRP had a weaker association with cardiovascular disease than the cytokines...
  40. ncbi Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study
    Graziano Onder
    Sticht Center on Aging, Section on Gerontology and Geriatrics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Lancet 359:926-30. 2002
    ..We aimed to see whether ACE inhibitors also prevent reduction in physical performance and in muscle strength in older women who do not have CHF...
  41. ncbi Physical performance and longevity in aged rats
    Christy S Carter
    Department of Internal Medicine, Section on Gerontology and Geriatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 57:B193-7. 2002
    ....
  42. ncbi Exercise and depressive symptoms: a comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology
    Brenda W J H Penninx
    Sticht Center on Aging, Department of Internal Medicine Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol B Psychol Sci Soc Sci 57:P124-32. 2002
    ..Aerobic and resistance exercise significantly reduced disability and pain and increased walking speed both, and to an equal extent, in persons with high depressive symptomatology and persons with low depressive symptomatology...
  43. ncbi Anemia and decline in physical performance among older persons
    Brenda W J H Penninx
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Med 115:104-10. 2003
    ..We examined whether anemia in older persons increases the risk of subsequent decline in physical function, as measured by objective performance-based tests...
  44. ncbi Inflammatory markers and physical performance in older persons: the InCHIANTI study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 59:242-8. 2004
    ..The aim of this study is to evaluate the relationship between several inflammatory markers and physical performance in an older population...
  45. ncbi Hemoglobin levels and skeletal muscle: results from the InCHIANTI study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 59:249-54. 2004
    ..Anemia is associated with reduced physical performance and muscle strength. The aim of the study was to explore whether anemia and hemoglobin levels are associated with differences in quantitative and qualitative measures of muscle and fat...
  46. ncbi Reliability of the 400-m usual-pace walk test as an assessment of mobility limitation in older adults
    Yves M Rolland
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:972-6. 2004
    ..To assess the test-retest reliability of the 400-m usual-pace walk test (400-MWT), and to determine whether the 4-m walk test predicts inability to walk 400 m...
  47. ncbi Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats
    Christy S Carter
    Sticht Center on Aging, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 59:416-23. 2004
    ..These results suggest that ACE inhibition may prevent age-related declines in physical performance, which may be mediated by a reduction in body fat mass...
  48. ncbi Assessment of physical function in aging rodents: a strategy for improving preclinical testing
    C S Carter
    Department of Internal Medicine, Section on Gerontology and Geriatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Exp Aging Res 27:271-82. 2001
    ....
  49. ncbi Physical exercise and the prevention of disability in activities of daily living in older persons with osteoarthritis
    B W Penninx
    Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Arch Intern Med 161:2309-16. 2001
    ..However, proved preventive strategies for ADL disability are lacking. A sedentary lifestyle is an important cause of disability. This study examines whether an exercise program can prevent ADL disability...
  50. ncbi Lifestyle Interventions and Independence for Elders pilot study: recruitment and baseline characteristics
    Jeffrey A Katula
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, North Carolina 27109, USA
    J Am Geriatr Soc 55:674-83. 2007
    ..To describe several recruitment parameters derived from the Lifestyle Interventions and Independence for Elders pilot (LIFE-P) study for use in a full-scale trial of mobility disability prevention...
  51. ncbi Sexual satisfaction and risk of disability in older women
    Graziano Onder
    Sticht Center on Aging, Section on Gerontology and Geriatrics, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, N C, USA
    J Clin Psychiatry 64:1177-82. 2003
    ....
  52. ncbi Beta-blockers after acute myocardial infarction in elderly patients with diabetes mellitus: time to reassess
    Mauro Di Bari
    Department of Internal Medicine, Sticht Center on Aging, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina, USA
    Drugs Aging 20:13-22. 2003
    ..The use of these agents in clinical practice should therefore be encouraged, in order to reduce the burden of cardiovascular mortality and morbidity in older diabetic patients post-infarction...
  53. ncbi Gender differences in morbidity and mortality related to depression: a review of the literature
    M A Sevick
    Department of Public Health Sciences, Wake Forest University, North Carolina 27157 1063, USA
    Aging (Milano) 12:407-16. 2000
    ..Future researchers may wish to concentrate their efforts in the identification of possible biophysiologic mechanisms underlying the association between depression and a variety of health outcomes...
  54. ncbi Interaction between angiotensin converting enzyme insertion/deletion genotype and exercise training on knee extensor strength in older individuals
    V Giaccaglia
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, United States
    Int J Sports Med 29:40-4. 2008
    ..13), but changes in 6-minute walk distance were not different between genotype groups. Thus, changes in muscle strength with exercise training in older individuals may be dependent on ACE I/D genotype...
  55. ncbi Comorbidity and physical function: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study)
    Matteo Cesari
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Rome, Italy
    Gerontology 52:24-32. 2006
    ..Physical function measures have gained increased importance in the evaluation of older persons. The presence of comorbidity is a major and growing issue in geriatrics...
  56. ncbi Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study
    Jane A Cauley
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 22:1088-95. 2007
    ..We tested this hypothesis in relationship to fractures in 2985 men and women enrolled in the Health ABC study. Results showed that subjects with the greatest number of inflammatory markers have the highest risk of fracture...
  57. ncbi Research partnership with underserved African-American communities to improve the health of older persons with disability: a pilot qualitative study
    Mauro Di Bari
    Unit of Gerontology and Geriatrics, Department of Critical Care Medicine and Surgery, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Aging Clin Exp Res 19:110-8. 2007
    ..The aim of this study was to investigate an African-American community's perceptions about the barriers that hinder participation in research studies and, more broadly, on the status of institution/community relationships...
  58. ncbi Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study
    Lisa H Colbert
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    J Am Geriatr Soc 52:1098-104. 2004
    ..To examine the association between physical activity and inflammatory markers, with consideration for body fatness and antioxidant use...
  59. ncbi Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the Health, Aging and Body Composition study
    Nicole Vogelzangs
    Department of Psychiatry and Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:563-9. 2007
    ..This study investigated the cross-sectional relationship between psychosocial risk factors and the metabolic syndrome in a community-based sample of older persons...
  60. ncbi Prognostic value of usual gait speed in well-functioning older people--results from the Health, Aging and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida 32608, USA
    J Am Geriatr Soc 53:1675-80. 2005
    ..To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons...
  61. ncbi African-American ethnicity in epidemiological studies of calcium antagonists in relation to cancer
    Kangmin Zhu
    Department of Health Evaluation Sciences, College of Medicine, Pennsylvania State University, Hershey 17033-0855, USA
    Ethn Dis 12:144-8. 2002
  62. ncbi Depression and physical function: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE Study)
    Andrea Russo
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Roma, Italy
    J Geriatr Psychiatry Neurol 20:131-7. 2007
    ..In conclusion, physical performance and functional status measures are significantly and negatively influenced by the presence of depression in community-dwelling older persons aged 80 years and older...
  63. ncbi Health-related quality of life in older adults at risk for disability
    Erik J Groessl
    Health Services Research and Development Unit, VA San Diego Healthcare System, San Diego, California 92161, USA
    Am J Prev Med 33:214-8. 2007
    ..The objective of this study is to describe and examine correlates of health-related quality of life in this population subgroup using baseline data from a larger intervention study...
  64. ncbi Correlation between two markers of inflammation, serum C-reactive protein and interleukin 6, and indices of oxidative stress in patients with high risk of cardiovascular disease
    Dora Il'yasova
    Duke Comprehensive Cancer Center, 2424 Erwin Rd, Hock Bldg, Ste 602, Box 2949, Durham, NC 27710, USA
    Biomarkers 13:41-51. 2008
    ..Urinary levels of F2-IsoP and serum levels of CRP represent appropriate biomarkers for future studies of inflammation and oxidative status in humans...
  65. ncbi HDL-cholesterol and physical performance: results from the ageing and longevity study in the sirente geographic area (ilSIRENTE Study)
    Francesco Landi
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Roma, Italy
    Age Ageing 36:514-20. 2007
    ..We evaluate the relationship of HDL-cholesterol with measures of physical performance, muscle strength, and functional status in older persons aged 80years or older...
  66. ncbi Anemia and cognitive performance in hospitalized older patients: results from the GIFA study
    Valentina Zamboni
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Rome, Italy
    Int J Geriatr Psychiatry 21:529-34. 2006
    ..Anemia represents a major risk factor for adverse health-related events in older persons. The aim of this study was to evaluate the association between hemoglobin levels/anemia and cognitive function in hospitalized older persons...
  67. ncbi Functional outcomes for clinical trials in frail older persons: time to be moving
    Shalender Bhasin
    J Gerontol A Biol Sci Med Sci 63:160-4. 2008
  68. ncbi Evaluation of continuous summary physical performance scores (CSPPS) in an elderly cohort
    Jeri W Nieves
    Clinical Research Center, Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993, USA
    Aging Clin Exp Res 17:193-200. 2005
    ..The aim of this study was to examine the validity and reliability of the Continuous Summary Physical Performance Score (CSPPS) and its relationship to the Quartile Summary Physical Performance Score (QSPPS)...
  69. ncbi Relationship of alcohol intake with inflammatory markers and plasminogen activator inhibitor-1 in well-functioning older adults: the Health, Aging, and Body Composition study
    Stefano Volpato
    Department of Clinical and Experimental Medicine, University of Ferrara, Via Savonarola, 9, I 44100 Ferrara, Italy
    Circulation 109:607-12. 2004
    ..We investigated the relationship between weekly alcohol intake and interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and plasminogen activator inhibitor-1 (PAI-1)...
  70. ncbi Muscle strength in obese elderly women: effect of recreational physical activity in a cross-sectional study
    Yves Rolland
    Service de Medecine Interne et de Gerontologie Clinique, Hopital La Grave Casselardit, Toulouse, France
    Am J Clin Nutr 79:552-7. 2004
    ..Muscle strength (MS) may be impaired in obese persons, and this impairment may be a consequence of both obesity and low physical fitness...
  71. ncbi Effects of exercise adherence on physical function among overweight older adults with knee osteoarthritis
    Coen H van Gool
    Universiteit Maastricht, Maastricht, The Netherlands
    Arthritis Rheum 53:24-32. 2005
    ..To determine whether high exercise adherence improved physical function among older adults with knee osteoarthritis (OA) who were overweight or obese...
  72. ncbi Anemia is associated with depression in older adults: results from the InCHIANTI study
    Graziano Onder
    Geriatric Department, Catholic University of the Sacred Heart, Rome, Italy
    J Gerontol A Biol Sci Med Sci 60:1168-72. 2005
    ..The objective of this study was to examine whether depressive symptoms and anemia are associated among older adults living in the community...
  73. ncbi Walking while talking: effect of task prioritization in the elderly
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA
    Arch Phys Med Rehabil 88:50-3. 2007
    ..To examine the effect of 2 instructions on the same walking while talking (WWT) task on task prioritization by nondisabled subjects...
  74. ncbi The ilSIRENTE study: a prospective cohort study on persons aged 80 years and older living in a mountain community of Central Italy
    Francesco Landi
    Department of Gerontology, Geriatric and Physiatric, Catholic University of Sacred Heart, Rome, Italy
    Aging Clin Exp Res 17:486-93. 2005
    ....
  75. ncbi Sarcopenia, obesity, and inflammation--results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL, USA
    Am J Clin Nutr 82:428-34. 2005
    ..Age-related body-composition changes are associated with health-related outcomes in elders. This relation may be explained by inflammation and hemostatic abnormalities...
  76. ncbi Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6
    Rizwan Kalani
    Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32608, USA
    J Gerontol A Biol Sci Med Sci 61:211-7. 2006
    ..These studies highlight the anti-inflammatory effects of CR and exercise...
  77. ncbi Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability
    Anne B Newman
    Department of Epidemiology, Physical Therapy, University of Pittsburgh, Pittsburgh, PA 15213, USA
    JAMA 295:2018-26. 2006
    ..Extended walking tests have been examined as outcome predictors in medically ill populations but not in community-dwelling older adults...
  78. ncbi Relation of angiotensin-converting enzyme inhibitor treatment to insulin-like growth factor-1 serum levels in subjects >65 years of age (the InCHIANTI study)
    Marcello Maggio
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 97:1525-9. 2006
    ..This may be 1 of the mechanisms by which ACE inhibitors might slow the decreases in muscle strength and physical function that are often observed in older subjects...
  79. ncbi Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32608, USA
    Am J Clin Nutr 83:1142-8. 2006
    ..Frailty is a common condition in elders and identifies a state of vulnerability for adverse health outcomes...
  80. ncbi Anemia and recovery from disability in activities of daily living in hospitalized older persons
    Cinzia Maraldi
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32608, USA
    J Am Geriatr Soc 54:632-6. 2006
    ..To evaluate the predictive value of hemoglobin levels upon hospital admission on recovery from activity of daily living (ADL) disability during hospital stay in older patients...
  81. ncbi Randomized controlled trials involving multidisciplinary interventions in the community
    Marco Pahor
    Department of Aging and Geriatric Research, Institute on Aging, University of Florida College of Medicine, 1329 SW 16th St, Rm. 5263, P.O. Box 100107, Gainesville, FL 32610-0107, USA
    J Gerontol A Biol Sci Med Sci 61:472-3. 2006
  82. ncbi Anemia in old age is associated with increased mortality and hospitalization
    Brenda W J H Penninx
    EMGO Institute Department of Psychiatry, VU University School of Medicine, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:474-9. 2006
    ..To more fully understand the detrimental health effects of anemia, we examined the relationship of anemia with death and hospitalization outcomes in a large community-based sample of older persons...
  83. ncbi Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville 32608, USA
    Arch Intern Med 165:2148-54. 2005
    ..The aim of this study was to assess the predictive value of a lipoprotein peroxidation marker, oxidized low-density lipoprotein (oxLDL) for incident mobility limitation (ML)...
  84. ncbi Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study
    Cinzia Maraldi
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, 1329 SW 16th St, Gainesville, FL 32608, USA
    Arch Intern Med 166:1490-7. 2006
    ..We investigated the relationship of alcohol intake with all-cause mortality and cardiac events and evaluated whether this relationship is mediated or modified by inflammatory markers...
  85. ncbi Anemia, physical disability, and survival in older patients with heart failure
    Cinzia Maraldi
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida 32608, USA
    J Card Fail 12:533-9. 2006
    ..33; CI = 1.02-5.30). CONCLUSION: Anemia is a predictor of physical disability in older heart failure patients, and in women anemia is associated with increased mortality...
  86. ncbi The effects of cognitive impairment on mortality among hospitalized patients with heart failure
    Giuseppe Zuccala
    Department of Gerontology, Catholic University of the Sacred Heart, Rome, Italy
    Am J Med 115:97-103. 2003
    ..Because cerebral metabolic abnormalities have been associated with reduced survival in younger patients with advanced heart failure, we assessed the effect of cognitive impairment on the survival of older patients with heart failure...
  87. ncbi Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis
    Bruce M Psaty
    Department of Medicine, University of Washington, Seattle, USA
    JAMA 289:2534-44. 2003
    ..Establishing relative benefit or harm from specific antihypertensive agents is limited by the complex array of studies that compare treatments. Network meta-analysis combines direct and indirect evidence to better define risk or benefit...
  88. ncbi Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study
    Marco Pahor
    Department of Aging and Geriatric Research, College of Medicine, University of Florida, 1329 SW 16th St, Rm 5161, Gainesville, FL 32608, USA
    J Gerontol A Biol Sci Med Sci 61:1157-65. 2006
    ..Our objective was to assess the effect of a comprehensive physical activity (PA) intervention on the SPPB and other physical performance measures...
  89. ncbi Physical exercise and comorbidity. Results from the Fitness and Arthritis in Seniors Trial (FAST)
    Irene Mangani
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL, USA
    Aging Clin Exp Res 18:374-80. 2006
    ..The impact of comorbidity on the benefits from physical exercise has not been clearly investigated. Elders with comorbidity may benefit from physical exercise to preserve physical function...
  90. ncbi Impact of inappropriate drug use on physical performance among a frail elderly population living in the community
    Francesco Landi
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Rome, Italy
    Eur J Clin Pharmacol 63:791-9. 2007
    ..The aim of the present study was to evaluate the relationship between the use of inappropriate drugs and measures of physical performance, muscle strength and functional status in an elderly population (80+ years)...