Barbara Nicklas

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA
    BMC Musculoskelet Disord 10:93. 2009
  2. ncbi Abdominal obesity is an independent risk factor for chronic heart failure in older people
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 54:413-20. 2006
  3. pmc Exercise training as a treatment for chronic inflammation in the elderly
    Barbara J Nicklas
    J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Exerc Sport Sci Rev 37:165-70. 2009
  4. ncbi Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial
    Barbara J Nicklas
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 79:544-51. 2004
  5. ncbi Physical function and its response to exercise: associations with cytokine gene variation in older adults with knee osteoarthritis
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 60:1292-8. 2005
  6. pmc Exercise training and plasma C-reactive protein and interleukin-6 in elderly people
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 56:2045-52. 2008
  7. ncbi Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 26:1413-20. 2003
  8. ncbi Lifestyle intervention of hypocaloric dieting and walking reduces abdominal obesity and improves coronary heart disease risk factors in obese, postmenopausal, African-American and Caucasian women
    Barbara J Nicklas
    Department of Medicine, Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 58:181-9. 2003
  9. pmc Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Clin Nutr 89:1043-52. 2009
  10. ncbi Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Epidemiol 160:741-9. 2004

Collaborators

Detail Information

Publications69

  1. pmc The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA
    BMC Musculoskelet Disord 10:93. 2009
    ..This article describes the intervention, the empirical evidence to support it, and test-retest reliability data...
  2. ncbi Abdominal obesity is an independent risk factor for chronic heart failure in older people
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 54:413-20. 2006
    ..To examine whether total and abdominal adiposity are risk factors for the development of chronic heart failure (CHF) in older men and women...
  3. pmc Exercise training as a treatment for chronic inflammation in the elderly
    Barbara J Nicklas
    J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Exerc Sport Sci Rev 37:165-70. 2009
    ..This article highlights emerging data suggesting that increasing physical activity could be effective for reducing chronic inflammation in the elderly...
  4. ncbi Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial
    Barbara J Nicklas
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 79:544-51. 2004
    ..Persistent, low-grade inflammation is an independent predictor of several chronic diseases and all-cause mortality...
  5. ncbi Physical function and its response to exercise: associations with cytokine gene variation in older adults with knee osteoarthritis
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 60:1292-8. 2005
    ....
  6. pmc Exercise training and plasma C-reactive protein and interleukin-6 in elderly people
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 56:2045-52. 2008
    ..To determine the effects of a long-term exercise intervention on two prominent biomarkers of inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)) in elderly men and women...
  7. ncbi Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 26:1413-20. 2003
    ..This study determined whether there is a critical level of visceral adipose tissue (VAT) associated with elevated coronary heart disease (CHD) risk factors in a cohort of women >45 years of age...
  8. ncbi Lifestyle intervention of hypocaloric dieting and walking reduces abdominal obesity and improves coronary heart disease risk factors in obese, postmenopausal, African-American and Caucasian women
    Barbara J Nicklas
    Department of Medicine, Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 58:181-9. 2003
    ..This study determined the efficacy of a lifestyle weight loss intervention in reducing total and abdominal obesity and improving CHD risk factors in obese Caucasian and African-American postmenopausal women...
  9. pmc Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Clin Nutr 89:1043-52. 2009
    ..Exercise intensity may affect the selective loss of abdominal adipose tissue...
  10. ncbi Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Epidemiol 160:741-9. 2004
    ..79, 95% confidence interval: 1.24, 2.58 per standard-deviation increase; p < 0.01). The amount of adipose tissue stored in the intraabdominal cavity is an important, independent risk factor for MI in well-functioning, elderly women...
  11. pmc Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Aging Clin Exp Res 20:302-9. 2008
    ..The purpose of this study was to determine whether physical function is independently associated with histologic and metabolic properties of skeletal muscle in elderly adults...
  12. pmc Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    CMAJ 172:1199-209. 2005
    ....
  13. ncbi Racial differences in insulin resistance and mid-thigh fat deposition in postmenopausal women
    Alice S Ryan
    Department of Medicine, Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Obes Res 10:336-44. 2002
    ..To determine whether racial differences in insulin resistance between African American (AA) and white women exist in postmenopausal women and whether they are related to physical fitness and/or obesity...
  14. ncbi Inflammatory markers and physical function among older adults with knee osteoarthritis
    Brenda W J H Penninx
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Rheumatol 31:2027-31. 2004
    ..To investigate whether serum concentrations of various inflammatory markers are associated with physical function and disease severity among older obese adults with knee osteoarthritis (OA)...
  15. pmc Lean mass loss is associated with low protein intake during dietary-induced weight loss in postmenopausal women
    Melanie J Bopp
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, General Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Am Diet Assoc 108:1216-20. 2008
    ..Therefore, inadequate protein intake during caloric restriction may be associated with adverse body-composition changes in postmenopausal women...
  16. ncbi Comparison of VO2max and disease risk factors between perimenopausal and postmenopausal women
    Nicole A Lynch
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Menopause 9:456-62. 2002
    ....
  17. doi Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy
    Gary D Miller
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109 7868, USA
    J Am Geriatr Soc 56:644-51. 2008
    ..To describe the relationships between proinflammatory biomarkers and self-reported and performance-based physical function and to examine the effect of weight loss on these markers of inflammation...
  18. ncbi Effects of apolipoprotein E genotype on dietary-induced changes in high-density lipoprotein cholesterol in obese postmenopausal women
    Barbara J Nicklas
    Department of Medicine, Division of Gerontology, University of Maryland School of Medicine, and the Geriatric Research, Education and Clinical Center GRECC, Baltimore VA Medical Center, Baltimore, MD, USA
    Metabolism 51:853-8. 2002
    ..01 between groups). It may be prudent to genotype older women before initiating low-fat diet therapy, as those with the APOE4 allele benefit the most, while the lipid profile could worsen in women without the APOE4 allele...
  19. ncbi Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity
    Alice S Ryan
    Department of Medicine, Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 26:2383-8. 2003
    ..The purpose of this study was to determine the relationships between plasma adiponectin and leptin levels, total and central obesity, and glucose utilization across the adult age span...
  20. pmc Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction
    Dalane W Kitzman
    Cardiology Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina
    Am J Physiol Heart Circ Physiol 306:H1364-70. 2014
    ..This suggests potential new therapeutic targets in this difficult to treat disorder. ..
  21. ncbi Regulation of lipolysis and lipoprotein lipase after weight loss in obese, postmenopausal women
    Dora M Berman
    Division of Gerontology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Obes Res 12:32-9. 2004
    ....
  22. ncbi Reductions in plasma cytokine levels with weight loss improve insulin sensitivity in overweight and obese postmenopausal women
    Alice S Ryan
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Diabetes Care 27:1699-705. 2004
    ..The purpose of this study was to determine whether improvements in insulin sensitivity with weight loss are mediated by changes in inflammation in obese, postmenopausal women...
  23. pmc Sex differences in insulin action and body fat distribution in overweight and obese middle-aged and older men and women
    Cynthia M Ferrara
    Division of Gerontology, University of Maryland, Baltimore, and Baltimore VA Medical Center, Geriatric Research, Education and Clinical Center, Baltimore, MD 21201, USA
    Appl Physiol Nutr Metab 33:784-90. 2008
    ..This difference in insulin sensitivity is not explained by abdominal fat distribution, therefore other metabolic factors contribute to the sex differences in insulin sensitivity...
  24. pmc Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications
    Rong Ze Yang
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    PLoS Med 3:e287. 2006
    ..However, the molecular and cellular mechanisms that link obesity to chronic inflammation and CVD are poorly understood...
  25. pmc Resting energy expenditure changes with weight loss: racial differences
    Xuewen Wang
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 18:86-91. 2010
    ..254 for total, limb, and trunk, respectively; P < 0.05) independent of baseline REE in white women. Therefore, with weight loss, REE decreased in proportion to the amount of fat and lean mass lost in white, but not black, women...
  26. ncbi Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal women
    Alice S Ryan
    Department of Medicine, Division of Gerontology at the University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Diabetes Care 25:127-33. 2002
    ....
  27. ncbi Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis
    Gary D Miller
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Obesity (Silver Spring) 14:1219-30. 2006
    ..Physical function and body composition in older obese adults with knee osteoarthritis (OA) were examined after intensive weight loss...
  28. ncbi Inflammatory markers and onset of cardiovascular events: results from the Health ABC study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circulation 108:2317-22. 2003
    ..Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older persons...
  29. ncbi Inflammatory markers and incident mobility limitation in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:1105-13. 2004
    ..To examine the relationship between indicators of inflammation and the incidence of mobility limitation in older persons...
  30. ncbi Physical activity and physical function in older adults with knee osteoarthritis
    Elizabeth Chmelo
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Dept of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC
    J Phys Act Health 10:777-83. 2013
    ..5 ± 3.8 kg/m2), sedentary (less than 30 mins of activity, 3 days a week) individuals with knee osteoarthritis...
  31. pmc Renal sinus fat and poor blood pressure control in middle-aged and elderly individuals at risk for cardiovascular events
    Haroon L Chughtai
    Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hypertension 56:901-6. 2010
    ..These results indicate that further studies are warranted to determine whether fat accumulation in the RS promotes hypertension...
  32. ncbi Dietary intake and changes in lipoprotein lipids in obese, postmenopausal women placed on an American Heart Association Step 1 diet
    Linda B Bunyard
    Department of Medicine, University of Maryland at Baltimore, USA
    J Am Diet Assoc 102:52-7. 2002
    ..Dietary intake and changes in lipoprotein lipids in obese, postmenopausal women placed on an American Heart Association Step 1 diet...
  33. ncbi Differences in adipose tissue metabolism between postmenopausal and perimenopausal women
    Cynthia M Ferrara
    Department of Medicine, University of Maryland School of Medicine, and the Geriatric Research, Education and Clinical Center, Baltimore VA Medical Center, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 87:4166-70. 2002
    ..The lower lipolysis and higher AT-LPL activity in postmenopausal women may predispose them to gain body fat after menopause...
  34. ncbi Physical activity and physical function in older adults with knee osteoarthritis
    Elizabeth Chmelo
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Dept of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC
    J Phys Act Health 10:777-83. 2012
    ..Conclusions: This study demonstrates that a population who has higher levels of spontaneous activity have better overall physical function than those who engage in less activity. ..
  35. ncbi Aerobic exercise is necessary to improve glucose utilization with moderate weight loss in women
    Alice S Ryan
    Department of Medicine, Division of Gerontology at the University of Maryland School of Medicine, VA Maryland Health Care System, Baltimore, MD 21201, USA
    Obesity (Silver Spring) 14:1064-72. 2006
    ....
  36. pmc Addition of aerobic exercise to a weight loss program increases BMD, with an associated reduction in inflammation in overweight postmenopausal women
    Natalie E Silverman
    University of Maryland School of Medicine, Geriatric Research, Education and Clinical Center of the Baltimore Veterans Affairs Medical Center, GRECC BT 18 GR, 10 North Greene Street, Baltimore, MD 21201 1524, USA
    Calcif Tissue Int 84:257-65. 2009
    ..Our findings suggest that the addition of aerobic exercise is recommended to decrease inflammation and increase BMD during weight loss in overweight postmenopausal women...
  37. pmc Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failure
    Chirapa Puntawangkoon
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Cardiovasc Magn Reson 11:48. 2009
    ..We hypothesized that reduced lower extremity blood flow (LBF) due to reduced forward cardiac output would contribute to submaximal exercise intolerance in older HF patients...
  38. pmc Chronic inflammation is associated with low physical function in older adults across multiple comorbidities
    Tina E Brinkley
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 64:455-61. 2009
    ....
  39. pmc Association between inflammatory components and physical function in the health, aging, and body composition study: a principal component analysis approach
    Fang Chi Hsu
    Department of Biostatistical Sciences, Wake Forest University School of Medicine, 100 North Main Street, Suite 2323, Winston Salem, NC 27101, USA
    J Gerontol A Biol Sci Med Sci 64:581-9. 2009
    ..This study uses principal component analysis to identify inflammatory "component(s)" and evaluates associations between the identified component(s) and measures of physical function...
  40. pmc Overweight and obesity over the adult life course and incident mobility limitation in older adults: the health, aging and body composition study
    Denise K Houston
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1207, USA
    Am J Epidemiol 169:927-36. 2009
    ..0001) on risk of mobility limitation for the cumulative effect of obesity in men and overweight and/or obesity in women. Onset of overweight and obesity in earlier life contributes to an increased risk of mobility limitation in old age...
  41. doi Weighty concerns: the growing prevalence of obesity among older adults
    Denise K Houston
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Am Diet Assoc 109:1886-95. 2009
    ....
  42. pmc Change in 25-hydroxyvitamin D and physical performance in older adults
    Denise K Houston
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1207, USA
    J Gerontol A Biol Sci Med Sci 66:430-6. 2011
    ....
  43. pmc The effect of randomization to weight loss on total mortality in older overweight and obese adults: the ADAPT Study
    M Kyla Shea
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 65:519-25. 2010
    ..Data from the Arthritis, Diet, and Activity Promotion Trial (ADAPT) were used to determine whether randomization to a weight reduction program was associated with total mortality in overweight/obese older adults...
  44. pmc Long-term physical activity and inflammatory biomarkers in older adults
    Kristen M Beavers
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Med Sci Sports Exerc 42:2189-96. 2010
    ..The purpose of this study was to determine the effects of a 12-month physical activity (PA) intervention on inflammatory biomarkers in elderly men and women...
  45. pmc Effects of lifestyle interventions on inflammatory markers in the metabolic syndrome
    Kristen M Beavers
    J Paul Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest, University School of Medicine, Winston Salem, North Carolina 27157, USA
    Front Biosci (Schol Ed) 3:168-77. 2011
    ..Data currently suggest that alterations in dietary composition may be the most effective lifestyle change, although there is a need for more research in this area...
  46. doi Physical function improvements after laparoscopic Roux-en-Y gastric bypass surgery
    Gary D Miller
    Department of Health and Exercise Science, Wake Forest University, Box 7868 Reynolda Station, Winston Salem, NC 27109 7868, USA
    Surg Obes Relat Dis 5:530-7. 2009
    ..Mild-to-moderate weight loss has been shown to improve function in older adults. The impact of laparoscopic Roux-en-Y gastric bypass surgery on weight loss and physical function in morbidly obese individuals was assessed...
  47. pmc Weight regain is related to decreases in physical activity during weight loss
    Xuewen Wang
    Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Med Sci Sports Exerc 40:1781-8. 2008
    ..To examine whether adaptations in physical activity energy expenditure (PAEE) and resting metabolic rate (RMR) during weight loss were associated with future weight regain in overweight/obese, older women...
  48. ncbi Heritability of body composition measured by DXA in the diabetes heart study
    Fang Chi Hsu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Obes Res 13:312-9. 2005
    ..The purpose of this study was to investigate the heritability of body composition measured by DXA in the Diabetes Heart Study (DHS)...
  49. ncbi Angiotensin-converting enzyme insertion/deletion genotype, exercise, and physical decline
    Stephen B Kritchevsky
    The Sticht Center on Aging and Center for Human Genomics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    JAMA 294:691-8. 2005
    ....
  50. ncbi Variability of serum soluble intercellular adhesion molecule-1 measurements attributable to a common polymorphism
    Thomas C Register
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Clin Chem 50:2185-7. 2004
  51. ncbi Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke
    Jingzhong Ding
    Department of Internal Medicine Geriatrics, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    Am Heart J 152:1109-15. 2006
    ..We investigated the association of polymorphisms and common haplotypes of the PAI-1 gene with plasma PAI-1 levels, as well as the risk of myocardial infarction and stroke...
  52. ncbi Effects of birth cohort and age on body composition in a sample of community-based elderly
    Jingzhong Ding
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Clin Nutr 85:405-10. 2007
    ..The effect of the recent obesity epidemic on body composition remains unknown. Furthermore, age-related changes in body composition are still unclear...
  53. pmc Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study
    Tina E Brinkley
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Hypertension 53:846-52. 2009
    ..These data suggest that ox-LDL may be related to the pathogenesis of arterial stiffness...
  54. ncbi Knee strength maintained despite loss of lean body mass during weight loss in older obese adults with knee osteoarthritis
    Xuewen Wang
    Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 62:866-71. 2007
    ..The effects of weight loss on muscle function in older adults have not been well studied. This study determined the effects of a 6-month weight-loss intervention on muscle strength and quality in older obese adults with knee osteoarthritis...
  55. ncbi Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study
    Denise K Houston
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157 1207, USA
    Am J Clin Nutr 87:150-5. 2008
    ..Dietary surveys suggest that many older, community-dwelling adults consume insufficient dietary protein, which may contribute to the age-related loss of lean mass (LM)...
  56. ncbi Chronic inflammation: role of adipose tissue and modulation by weight loss
    Tongjian You
    J Paul Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Diabetes Rev 2:29-37. 2006
    ..e. interleukin 10, interleukin 1 receptor antagonist). More studies are needed to investigate the role of regional adipose tissue cytokine production in regulation of inflammation and the modulating effects of weight loss...
  57. ncbi The metabolic syndrome in obese postmenopausal women: relationship to body composition, visceral fat, and inflammation
    Tongjian You
    Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 89:5517-22. 2004
    ..We conclude that obese older women with the MS are characterized by high lean mass, high visceral fat, and elevated sTNFR1, and the severity of the MS is associated with body composition, visceral adiposity, and inflammation...
  58. ncbi Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women
    Tongjian You
    Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 89:1739-46. 2004
    ..In addition, modification of chronic inflammation is associated with changes in local adipose tissue metabolism in response to diet and exercise...
  59. ncbi Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study)
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Cardiol 92:522-8. 2003
    ..Thus, our findings suggest an important role for IL-6 and TNF-alpha in clinical as well as subclinical cardiovascular disease. In this study, CRP had a weaker association with cardiovascular disease than the cytokines...
  60. ncbi Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors
    Tongjian You
    Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Endocrinol Metab 288:E741-7. 2005
    ..26 +/- 0.46 vs. 3.31 +/- 0.33, P < 0.05). We conclude that abdominal subcutaneous adipose tissue expression of inflammatory cytokines is a potential mechanism linking obesity with its metabolic comorbidities...
  61. pmc Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys
    Seung Jun Choi
    Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 68:258-67. 2013
    ..Our results support a detrimental effect of aging on the intrinsic force and power generation of myofilament lattice and physical performance in vervet monkeys...
  62. pmc Effect of exercise training on chronic inflammation
    Kristen M Beavers
    J Paul Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Clin Chim Acta 411:785-93. 2010
    ....
  63. ncbi Physical activity in prefrail older adults: confidence and satisfaction related to physical function
    W Jack Rejeski
    Department of Health and Exercise Science, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
    J Gerontol B Psychol Sci Soc Sci 63:P19-26. 2008
    ..This is an important finding in light of the importance of these process variables in behavior change and quality of life...
  64. ncbi Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville 32608, USA
    Arch Intern Med 165:2148-54. 2005
    ..The aim of this study was to assess the predictive value of a lipoprotein peroxidation marker, oxidized low-density lipoprotein (oxLDL) for incident mobility limitation (ML)...
  65. ncbi Racial differences in adipocyte size and relationship to the metabolic syndrome in obese women
    Thomas J Tittelbach
    Baltimore VA Medical Center, Geriatric Research, Education, and Clinical Center BT GR 18, 10 N Greene Street, MD 21201, USA
    Obes Res 12:990-8. 2004
    ..To determine whether racial differences exist in the relationship of the abnormalities defining the metabolic syndrome (MS) to regional adiposity and fat cell size (FCS) in obese postmenopausal women...
  66. ncbi Effects of exercise on adipokines and the metabolic syndrome
    Tongjian You
    Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Curr Diab Rep 8:7-11. 2008
    ....
  67. ncbi The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity
    Tongjian You
    Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY 14214, USA
    J Gerontol A Biol Sci Med Sci 63:414-9. 2008
    ..The purpose of this study was to examine the relationship of metabolic syndrome to several adipokines and the role of total and visceral adiposity in influencing this relationship in older adults...
  68. ncbi Prognostic value of usual gait speed in well-functioning older people--results from the Health, Aging and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida 32608, USA
    J Am Geriatr Soc 53:1675-80. 2005
    ..To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons...
  69. ncbi Associations between sex steroid hormone levels and depressive symptoms in elderly men and women: results from the Health ABC study
    Lisette F J Morsink
    EMGO Institute Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Psychoneuroendocrinology 32:874-83. 2007
    ..This study investigates the association between total testosterone, free testosterone, and DHEAS levels with depressive symptoms in a well-functioning elderly population...

Research Grants16

  1. Excercise and Regional Fat Metabolism after Menopause
    Barbara Nicklas; Fiscal Year: 2002
    ....
  2. Effect of fat loss on functional and cardiovascular benefits of aerobic exercise
    Barbara J Nicklas; Fiscal Year: 2010
    ..The results will also provide information on whether the location of fat loss is important for improving fitness and cardiovascular disease risk. ..
  3. Loss of fat tissue and functional responses to exercise in older, obese adults
    Barbara Nicklas; Fiscal Year: 2009
    ....
  4. Exercise training and inflammatory risk factors for disability
    Barbara Nicklas; Fiscal Year: 2009
    ....
  5. Effect of fat loss on functional and cardiovascular benefits of aerobic exercise
    Barbara Nicklas; Fiscal Year: 2009
    ..The results will also provide information on whether the location of fat loss is important for improving fitness and cardiovascular disease risk. ..
  6. Exercise Training Inflammatory Risk Factors Disability
    Barbara Nicklas; Fiscal Year: 2007
    ..abstract_text> ..
  7. Exercise training and inflammatory risk factors for disability
    Barbara Nicklas; Fiscal Year: 2007
    ....
  8. Exercise Training Inflammatory Risk Factors Disability
    Barbara Nicklas; Fiscal Year: 2006
    ....
  9. Excercise and Regional Fat Metabolism after Menopause
    Barbara Nicklas; Fiscal Year: 2006
    ....
  10. Excercise and Regional Fat Metabolism after Menopause
    Barbara Nicklas; Fiscal Year: 2004
    ....
  11. Excercise and Regional Fat Metabolism after Menopause
    Barbara Nicklas; Fiscal Year: 2005
    ....
  12. Excercise and Regional Fat Metabolism after Menopause
    Barbara Nicklas; Fiscal Year: 2004
    ....
  13. Excercise and Regional Fat Metabolism after Menopause
    Barbara Nicklas; Fiscal Year: 2003
    ....
  14. Excercise and Regional Fat Metabolism after Menopause
    Barbara Nicklas; Fiscal Year: 2003
    ....
  15. Loss of fat tissue and functional responses to exercise in older, obese adults
    Barbara J Nicklas; Fiscal Year: 2010
    ....