Research Topics
Genomes and GenesSpecies | Michael NaderSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Publications
The effects of benzamide analogues on cocaine self-administration in rhesus monkeysM A Nader
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
Psychopharmacology (Berl) 147:143-52. 1999..e., higher affinity at D(3)- than D(2)-receptors) would be more potent than D(2)-selective antagonists at decreasing total cocaine intake relative to disrupting rates of responding...- Brain imaging in nonhuman primates: insights into drug addictionMichael A Nader
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
ILAR J 49:89-102. 2008..These techniques will provide the foundation for future studies aimed at developing behavioral and pharmacological treatments for many human diseases... - Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonistMichael A Nader
Department of Physiology and Pharmacology, The Center for Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, 5th Floor NRC, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
Psychopharmacology (Berl) 163:292-301. 2002..The hypothesis was that changes in the magnitude of food reinforcement would affect cocaine-maintained response rates and influence the behavioral potency of a dopamine antagonist to decrease cocaine self-administration... - PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulationMichael A Nader
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Psychiatry 162:1473-82. 2005.... - Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposureMichael A Nader
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Neuropsychopharmacology 27:35-46. 2002..These findings demonstrate that chronic cocaine self-administration produces neuroadaptations in dopamine systems, but that these changes do not occur in a parallel fashion... - PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeysMichael A Nader
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
Nat Neurosci 9:1050-6. 2006..Individual differences in the rate of recovery of D2 receptor function during abstinence were noted... - Effects of negative punishment contingencies on cocaine self-administration by rhesus monkeysM A Nader
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
Behav Pharmacol 12:91-9. 2001..These results demonstrate that cocaine-maintained behavior can be decreased by environmental manipulations involving negative punishment contingencies... 
Review. Positron emission tomography imaging studies of dopamine receptors in primate models of addictionMichael A Nader
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 546 NRC, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
Philos Trans R Soc Lond B Biol Sci 363:3223-32. 2008..These findings highlight a pervasive influence of the environment in modifying the reinforcing effects of cocaine and strongly implicate brain D2 receptors...- Chronic cocaine self-administration is associated with altered functional activity in the temporal lobes of non human primatesThomas J R Beveridge
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA
Eur J Neurosci 23:3109-18. 2006.... - Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocainePaul W Czoty
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA
Psychopharmacology (Berl) 174:381-8. 2004..These findings suggest that cocaine exposure attenuated the impact of social housing on DA receptor function... 
Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeysThomas J R Beveridge
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
Neuropsychopharmacology 34:1162-71. 2009....- Effects of chronic cocaine self-administration on norepinephrine transporters in the nonhuman primate brainThomas J R Beveridge
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
Psychopharmacology (Berl) 180:781-8. 2005.... - The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeysRenee Claytor
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083, USA
Pharmacol Biochem Behav 83:456-64. 2006..Future studies with more selective D3 antagonists are needed to better address the role of this receptor subtype in cocaine addiction... - Long-term cocaine self-administration under fixed-ratio and second-order schedules in monkeysPaul W Czoty
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, 546 NRC, Winston Salem, NC 27157 1083, USA
Psychopharmacology (Berl) 191:287-95. 2007..Studies in rodents have demonstrated that increased access to cocaine can result in increases in drug intake per unit time... - Social dominance in monkeys: dopamine D2 receptors and cocaine self-administrationDrake Morgan
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
Nat Neurosci 5:169-74. 2002..These data demonstrate that alterations in an organism's environment can produce profound biological changes that have important behavioral associations, including vulnerability to cocaine addiction... - Characterization of the dopamine receptor system in adult rhesus monkeys exposed to cocaine throughout gestationLindsey R Hamilton
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 546 NRC, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
Psychopharmacology (Berl) 210:481-8. 2010..Cocaine use during pregnancy is associated with alterations in the dopamine (DA) system in the fetal brain. However, little is known about the effects of prenatal cocaine exposure on the postnatal dopaminergic system... - Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeysMatthew L Banks
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
Neuropsychopharmacology 33:219-25. 2008..The higher level of SERT availability in cocaine-experienced monkeys may lead to a reduced inhibitory tone of 5-HT on the DA system, which may explain, in part, differences in the abuse liability between cocaine and MDMA... - Influence of abstinence and conditions of cocaine access on the reinforcing strength of cocaine in nonhuman primatesPaul W Czoty
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083, USA
Drug Alcohol Depend 85:213-20. 2006..These results fail to support the views that increasing access to cocaine or abstinence enhances the reinforcing strength of cocaine... - Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeysPaul W Czoty
Department of Physiology and Pharmacology, Center for the Neurobiology of Addiction Treatments CNAT, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1083, USA
Psychopharmacology (Berl) 209:375-82. 2010..In preclinical studies, chronic d-amphetamine treatment decreased ongoing cocaine self-administration... - Effect of menstrual cycle phase on dopamine D2 receptor availability in female cynomolgus monkeysPaul W Czoty
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
Neuropsychopharmacology 34:548-54. 2009.... - Effect of time-out duration on the reinforcing strength of cocaine assessed under a progressive-ratio schedule in rhesus monkeysJennifer L Martelle
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Behav Pharmacol 19:743-6. 2008..However, the reinforcing strength of higher cocaine doses was unaffected by manipulating TO, suggesting that the BP value is a useful measure of reinforcing strength... - Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primatesPaul W Czoty
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Pharmacol Biochem Behav 96:274-8. 2010..In addition, the present findings suggest that changes in PR session length can influence potency comparisons between drugs, but not measures of reinforcing strength... - The effects of cocaine: a shifting target over the course of addictionLinda J Porrino
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:1593-600. 2007.... - The influence of reinforcing effects of cocaine on cocaine-induced increases in extinguished responding in cynomolgus monkeysMatthew L Banks
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Psychopharmacology (Berl) 192:449-56. 2007..e., unconditioned, discriminative or reinforcing) mediate the increases in responding after extinction... - The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administrationLinda J Porrino
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Neurosci Biobehav Rev 27:813-20. 2004.... - Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domainsLinda J Porrino
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
J Neurosci 24:3554-62. 2004.... - The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamicsJoshua A Lile
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Center for the Neurobiological Investigation of Drug Abuse, Winston-Salem, NC 27157-1083, USA
J Pharmacol Exp Ther 307:356-66. 2003..These data question the dogma regarding the role of pharmacokinetic factors and the relative influence of DAT and 5-HTT in stimulant reinforcement... - Functional effects of cocaine self-administration in primate brain regions regulating cardiovascular functionThomas J R Beveridge
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Neurosci Lett 370:201-5. 2004..These alterations progress with prolonged cocaine exposure, and therefore may be involved in mediating changes in central autonomic control and the neuroadaptations reported to result from chronic drug abuse... - Chronic cocaine self-administration upregulates the norepinephrine transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus monkeyDarrel J Macey
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, USA
J Neurosci 23:12-6. 2003..Furthermore, given the role of the BNST in cocaine withdrawal and stress-related reinstatement of self-administration, the changes reported here may provide a substrate for these phenomena... - Metabolic mapping of the effects of cocaine during the initial phases of self-administration in the nonhuman primateLinda J Porrino
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Neurosci 22:7687-94. 2002..The assessment of the effects of cocaine at a time not readily evaluated in humans provides a baseline from which the effects of chronic cocaine exposure can be investigated... - PET imaging of striatal dopamine D2 receptors in nonhuman primates: increases in availability produced by chronic raclopride treatmentPaul W Czoty
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Synapse 58:215-9. 2005..Individual differences in rates of recovery were observed, such that the increases in DVR persisted in two of three subjects... - A within-subject assessment of the discriminative stimulus and reinforcing effects of self-administered cocaine in rhesus monkeysJennifer L Martelle
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 546 NRC, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
Psychopharmacology (Berl) 203:343-53. 2009..All preclinical studies with cocaine have examined the discriminative stimulus (S(D)) and reinforcing (S(R)) effects in separate groups of subjects... - The reinforcing efficacy of the dopamine reuptake inhibitor 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) as measured by a progressive-ratio schedule and a choice procedure in rhesus monkeysJoshua A Lile
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA
J Pharmacol Exp Ther 303:640-8. 2002.... - Effects of the dopamine reuptake inhibitor PTT on reinstatement and on food- and cocaine-maintained responding in rhesus monkeysJoshua A Lile
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
Psychopharmacology (Berl) 174:246-53. 2004..It appears that the potency of this class of drugs to reinstate cocaine-seeking is substantially greater than their potency at decreasing cocaine self-administration... - Relationship between response rates and measures of reinforcing strength using a choice procedure in monkeysMatthew L Banks
Department of Physiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
Behav Pharmacol 19:365-9. 2008.... - Assessment of the relative reinforcing strength of cocaine in socially housed monkeys using a choice procedurePaul W Czoty
Center for the Neurobiogical Investigation of Drug Abuse, Department of Physiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
J Pharmacol Exp Ther 312:96-102. 2005..053). These data indicate that despite an extensive history of cocaine self-administration, most subordinate monkeys were more sensitive to the relative reinforcing strength of cocaine than dominant monkeys... - A comparison of the reinforcing efficacy of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") with cocaine in rhesus monkeysJoshua A Lile
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Drug Alcohol Depend 78:135-40. 2005..These data demonstrate that MDMA functions as a reinforcer, although its reinforcing efficacy appears to be less than that of cocaine... - Effects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the reinforcing and discriminJennifer L Martelle
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, NRC 546, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
J Pharmacol Exp Ther 321:573-82. 2007..The present findings support the continued examination of D3 compounds as pharmacological tools for better understanding the role of this receptor subtype in cocaine addiction and as potential lead compounds for novel therapeutic agents... - Effects of ambient temperature on the relative reinforcing strength of MDMA using a choice procedure in monkeysMatthew L Banks
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Psychopharmacology (Berl) 196:63-70. 2008..3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is frequently used in hot environments, such as rave parties. Studies in laboratory animals have shown that ambient temperature can alter the behavioral and neurochemical effects of MDMA... - Influence of thyroid hormones on 3,4-methylenedioxymethamphetamine-induced thermogenesis and reinforcing strength in monkeysMatthew L Banks
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
Behav Pharmacol 19:167-70. 2008..These results suggest that changes in thyroxine levels do not parallel the changes in ambient temperature in altering the reinforcing strength of MDMA... - A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticloprideJennifer L Martelle
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
CNS Neurosci Ther 14:248-62. 2008..While eticlopride is not used clinically, it remains a viable research tool for understanding DA receptor function and behavior... - A MEG investigation of somatosensory processing in the rhesus monkeyTony W Wilson
Department of Neurology, Wake Forest University School of Medicine, USA
Neuroimage 46:998-1003. 2009.... - Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agentsAmy Hauck Newman
National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
J Med Chem 48:3663-79. 2005
Research Grants
- Transition to Cocaine Abuse in Monkey:Role of DopamineMichael Nader; Fiscal Year: 2005....
- Chronic Stress and Cocaine Abuse in Female MonkeysMichael Nader; Fiscal Year: 2007....
- Social Stress: Vulnerability to Cocaine Abuse in MonkeysMichael Nader; Fiscal Year: 2007..Such information will lead to better treatment and prevention strategies. ..
- Impact of In Utero Cocaine Exposure on Vulnerability to Drug Abuse in Monkeys.Michael Nader; Fiscal Year: 2009..These studies will further explore factors related to etiology and maintenance of drug abuse, which should aid in the development of novel treatment strategies. ..
- Impact of In Utero Cocaine Exposure on Vulnerability to Drug Abuse in Monkeys.Michael A Nader; Fiscal Year: 2010..These studies will further explore factors related to etiology and maintenance of drug abuse, which should aid in the development of novel treatment strategies. ..
- DOPAMINE D2 RECEPTORS IN PRIMATE MODELS OF COCAINE ABUSEMichael Nader; Fiscal Year: 2004..Such knowledge will be vital for understanding the neuropharmacology of cocaine and to the development of effective pharmacotherapies for cocaine abuse. ..
- SOCIAL STRESS--VULNERABILITY TO COCAINE ABUSEMichael Nader; Fiscal Year: 1999..A better understanding of the variables that contribute to enhanced sensitivity to the reinforcing effects of cocaine may lead to better behavioral and/or pharmacological strategies for the treatment and prevention of cocaine abuse. ..
- DOPAMINE D2 RECEPTORS IN PRIMATE MODELS OF COCAINE ABUSEMichael A Nader; Fiscal Year: 2010....