Wendy C Moore

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 181:315-23. 2010
  2. doi Update in asthma 2007
    Wendy C Moore
    Center for Human Genomics and Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 177:1068-73. 2008
  3. ncbi Update in asthma 2006
    Wendy C Moore
    Center for Human Genomics and Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 175:649-54. 2007
  4. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
  5. pmc Safety of investigative bronchoscopy in the Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 128:328-336.e3. 2011
  6. ncbi Severe asthma: an overview
    Wendy C Moore
    Center for Human Genomics, and Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 117:487-94; quiz 495. 2006
  7. pmc The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    Gregory A Hawkins
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:510-5.e1. 2012
  8. pmc Importance of hedgehog interacting protein and other lung function genes in asthma
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 127:1457-65. 2011
  9. pmc Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 132:313-20.e15. 2013
  10. ncbi A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects
    Monica J Basehore
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 114:80-7. 2004

Detail Information

Publications20

  1. pmc Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 181:315-23. 2010
    ..The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma...
  2. doi Update in asthma 2007
    Wendy C Moore
    Center for Human Genomics and Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 177:1068-73. 2008
  3. ncbi Update in asthma 2006
    Wendy C Moore
    Center for Human Genomics and Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 175:649-54. 2007
  4. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
    ..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...
  5. pmc Safety of investigative bronchoscopy in the Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 128:328-336.e3. 2011
    ..We evaluated the safety aspects of this procedure in this cohort with specific focus on patients with severe asthma...
  6. ncbi Severe asthma: an overview
    Wendy C Moore
    Center for Human Genomics, and Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 117:487-94; quiz 495. 2006
    ..Treatment algorithms based on markers of airway inflammation may decrease measures of health care utilization in severe asthma...
  7. pmc The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    Gregory A Hawkins
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:510-5.e1. 2012
    ..The SNP rs4129267 is in linkage disequilibrium (r(2) = 1) with the IL6R coding SNP rs2228145 (Asp(358)Ala). This IL6R coding change increases IL-6 receptor (IL-6R) shedding and promotes IL-6 transsignaling...
  8. pmc Importance of hedgehog interacting protein and other lung function genes in asthma
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 127:1457-65. 2011
    ..The importance of these genes in lung function in white and African American subjects with asthma is unknown...
  9. pmc Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 132:313-20.e15. 2013
    ..Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function...
  10. ncbi A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects
    Monica J Basehore
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 114:80-7. 2004
    ..This cytokine is important in IgE isotype switching and the regulation of allergic inflammation; however, published studies have not delineated the specific role of variation in this gene in allergic disorders...
  11. pmc Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 174:1101-9. 2006
    ....
  12. pmc Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
    Annette T Hastie
    Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 132:72-80. 2013
    ..Availability and ease of measurement are useful characteristics, but accuracy in predicting airway eosinophil and neutrophil percentages either individually or combined is not established...
  13. pmc Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:861-8.e7. 2012
    ....
  14. pmc Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes
    Annette T Hastie
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 125:1028-1036.e13. 2010
    ..Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma...
  15. pmc Tiotropium bromide step-up therapy for adults with uncontrolled asthma
    Stephen P Peters
    Wake Forest University Health Sciences, Center for Genomics and Personalized Medicine Research, Medical Center Blvd, Winston Salem, NC 27157, USA
    N Engl J Med 363:1715-26. 2010
    ..Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for adults with uncontrolled asthma are needed...
  16. doi Clinical heterogeneity in the severe asthma research program
    Wendy C Moore
    1 Wake Forest University School of Medicine, Center for Human Genomics, Winston Salem, North Carolina and
    Ann Am Thorac Soc 10:S118-24. 2013
    ..This is extremely important for subjects with severe asthma who may be on the "edge" of two phenotypes that may be driven by different pathobiologic mechanisms that warrant different therapeutic approaches. ..
  17. ncbi Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population
    Richard S Smith
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    DNA Seq 18:47-53. 2007
    ..Two-thirds of the polymorphisms reported in dbSNP were not identified in our screening panel. Although similar in sequence, HSPAIA and HSPAIB do not share common patterns of polymorphisms...
  18. ncbi Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 112:717-22. 2003
    ..Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33 (ADAM33), was implicated in asthma susceptibility...
  19. ncbi Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol (1985) 104:394-403. 2008
    ..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
  20. ncbi Control of airway inflammation maintained at a lower steroid dose with 100/50 microg of fluticasone propionate/salmeterol
    Nizar N Jarjour
    Pulmonary and Critical Care Medicine Section, University of Wisconsin School of Medicine, Madison, WI, USA
    J Allergy Clin Immunol 118:44-52. 2006
    ..Inhaled corticosteroids (ICSs) have been shown to reverse epithelial damage and decrease lamina reticularis thickness in patients with asthma...