Allison Miller

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Enhanced endothelin activity prevents vasodilation to insulin in insulin resistance
    Allison W Miller
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hypertension 40:78-82. 2002
  2. ncbi request reprint Arachidonic acid-induced vasodilation of rat small mesenteric arteries is lipoxygenase-dependent
    Allison W Miller
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Pharmacol Exp Ther 304:139-44. 2003
  3. ncbi request reprint Potassium (BK(Ca)) currents are reduced in microvascular smooth muscle cells from insulin-resistant rats
    Christiana Dimitropoulou
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912 2300, USA
    Am J Physiol Heart Circ Physiol 282:H908-17. 2002
  4. ncbi request reprint Vasoconstrictor mechanisms in the cerebral circulation are unaffected by insulin resistance
    Benedek Erdos
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1456-61. 2004
  5. ncbi request reprint Mechanisms of vascular dysfunctionin insulin resistance
    David W Busija
    Wake Forest University Health Sciences, Department of Physiology and Pharmacology, Winston Salem, NC 27157 1023, USA
    Curr Opin Investig Drugs 5:929-35. 2004
  6. ncbi request reprint Impaired insulin-induced vasodilation in small coronary arteries of Zucker obese rats is mediated by reactive oxygen species
    Prasad V G Katakam
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Physiol Heart Circ Physiol 288:H854-60. 2005
  7. ncbi request reprint Insulin resistance does not impair contractile responses of cerebral arteries
    Steve A Simandle
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, United States
    Life Sci 77:2262-72. 2005
  8. ncbi request reprint Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production
    Benedek Erdos
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, North Carolina 27157 1083, USA
    Am J Physiol Heart Circ Physiol 290:H1264-70. 2006
  9. ncbi request reprint Impaired endothelin-induced vasoconstriction in coronary arteries of Zucker obese rats is associated with uncoupling of [Ca2+]i signaling
    Prasad V G Katakam
    Deptartment of Physiology and Pharmacology, Wake Forest University Health Sciences, Hanes 1050, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Regul Integr Comp Physiol 290:R145-53. 2006
  10. ncbi request reprint Adverse effects of reactive oxygen species on vascular reactivity in insulin resistance
    David W Busija
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Antioxid Redox Signal 8:1131-40. 2006

Research Grants

Detail Information

Publications21

  1. ncbi request reprint Enhanced endothelin activity prevents vasodilation to insulin in insulin resistance
    Allison W Miller
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hypertension 40:78-82. 2002
    ..Thus, impaired relaxation to insulin in insulin-resistant rats is due to enhanced vasoconstriction by endothelin, which offsets a normal vasodilatory response to insulin...
  2. ncbi request reprint Arachidonic acid-induced vasodilation of rat small mesenteric arteries is lipoxygenase-dependent
    Allison W Miller
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Pharmacol Exp Ther 304:139-44. 2003
    ..These findings provide functional and biochemical evidence that the lipoxygenase pathway mediates arachidonic acid-induced vasodilation in rat small mesenteric arteries through a K+ channel-dependent mechanism...
  3. ncbi request reprint Potassium (BK(Ca)) currents are reduced in microvascular smooth muscle cells from insulin-resistant rats
    Christiana Dimitropoulou
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912 2300, USA
    Am J Physiol Heart Circ Physiol 282:H908-17. 2002
    ..These data provide the first direct evidence that microvascular potassium currents are reduced in IR and suggest a molecular mechanism that could account for impaired vascular relaxation in IR...
  4. ncbi request reprint Vasoconstrictor mechanisms in the cerebral circulation are unaffected by insulin resistance
    Benedek Erdos
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1456-61. 2004
    ..01). These findings indicate that vasoconstrictor responses of the BA mediated by ET-1, TxA(2), PKC, and Rho-kinase are not affected by IR...
  5. ncbi request reprint Mechanisms of vascular dysfunctionin insulin resistance
    David W Busija
    Wake Forest University Health Sciences, Department of Physiology and Pharmacology, Winston Salem, NC 27157 1023, USA
    Curr Opin Investig Drugs 5:929-35. 2004
    ....
  6. ncbi request reprint Impaired insulin-induced vasodilation in small coronary arteries of Zucker obese rats is mediated by reactive oxygen species
    Prasad V G Katakam
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Physiol Heart Circ Physiol 288:H854-60. 2005
    ....
  7. ncbi request reprint Insulin resistance does not impair contractile responses of cerebral arteries
    Steve A Simandle
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, United States
    Life Sci 77:2262-72. 2005
    ....
  8. ncbi request reprint Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production
    Benedek Erdos
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, North Carolina 27157 1083, USA
    Am J Physiol Heart Circ Physiol 290:H1264-70. 2006
    ..These findings demonstrate that RSV improves cerebrovascular function in insulin-resistance independently from its lipid-lowering effect by the inhibition of NAD(P)H oxidase...
  9. ncbi request reprint Impaired endothelin-induced vasoconstriction in coronary arteries of Zucker obese rats is associated with uncoupling of [Ca2+]i signaling
    Prasad V G Katakam
    Deptartment of Physiology and Pharmacology, Wake Forest University Health Sciences, Hanes 1050, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Regul Integr Comp Physiol 290:R145-53. 2006
    ..Thus coronary arteries from ZO rats exhibit reduced ET-1-induced vasoconstriction resulting from increased ET(B)-mediated generation of NO and diminished elevation of myoplasmic [Ca2+]i...
  10. ncbi request reprint Adverse effects of reactive oxygen species on vascular reactivity in insulin resistance
    David W Busija
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Antioxid Redox Signal 8:1131-40. 2006
    ..Nonetheless, the most effective approach appears to involve prevention of IR via adoption of a healthy lifestyle by young people...
  11. ncbi request reprint Cerebrovascular dysfunction in Zucker obese rats is mediated by oxidative stress and protein kinase C
    Benedek Erdos
    Department of Physiology and Pharmacology, Wake Forest University Health Science, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Diabetes 53:1352-9. 2004
    ..The revealed impairment of NO and K+ channel-dependent dilator responses may be responsible for the increased risk of cerebrovascular events and neurodegenerative disorders in IR...
  12. ncbi request reprint Rosuvastatin treatment reverses impaired coronary artery vasodilation in fructose-fed, insulin-resistant rats
    Allison W Miller
    Dept of Physiology and Pharmacology, Wake Forest Univ School of Medicine, Hanes 1050, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Regul Integr Comp Physiol 287:R157-60. 2004
    ..Moreover, this recovery in function was due to an improvement in vasodilation via K(Ca). Thus rosuvastatin treatment of IR rats normalizes coronary vascular dilator responses by improving the K(Ca) function...
  13. ncbi request reprint Potassium channel dysfunction in cerebral arteries of insulin-resistant rats is mediated by reactive oxygen species
    Benedek Erdos
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    Stroke 35:964-9. 2004
    ..One possible underlying factor is cerebrovascular dysfunction resulting from altered K(+) channel function. Thus, the goal of this study was to examine K+ channel-mediated relaxation in IR cerebral arteries...
  14. ncbi request reprint Heart mitochondria contain functional ATP-dependent K+ channels
    Zsombor Lacza
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Mol Cell Cardiol 35:1339-47. 2003
    ..We conclude that a functional K(ATP) channel is present in heart mitochondria, which can be opened by diazoxide or BMS-191095. The channel can be composed of Kir6.1 and Kir6.2 subunits and does not contain either SUR1 or SUR2...
  15. ncbi request reprint Fructose-fed rats are protected against ischemia/reperfusion injury
    James E Jordan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Hanes 1050, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Pharmacol Exp Ther 307:1007-11. 2003
    ..This study suggests that fructose feeding affords protection against MI/R that is related to or mimics preconditioning. This protection is not consistent with other models of IR and is likely related to the fructose diet itself...
  16. ncbi request reprint Alterations in KATP and KCa channel function in cerebral arteries of insulin-resistant rats
    Benedek Erdos
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Am J Physiol Heart Circ Physiol 283:H2472-7. 2002
    ..01). These findings demonstrate that insulin resistance alters the function of K(ATP) and K(Ca) channels in isolated MCAs and affects the control of resting vascular tone and the mediation of dilator stimuli...
  17. ncbi request reprint Hydrogen peroxide acts as an EDHF in the piglet pial vasculature in response to bradykinin
    Zsombor Lacza
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Physiol Heart Circ Physiol 283:H406-11. 2002
    ..We conclude that H(2)O(2) mediates the non-nitric oxide-, non-prostanoid-dependent vasorelaxation to BK in the piglet pial vasculature. The response is mediated via BK(2) receptors and the opening of K(ATP) channels...
  18. ncbi request reprint Impaired endothelium-mediated relaxation in isolated cerebral arteries from insulin-resistant rats
    Benedek Erdos
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Am J Physiol Heart Circ Physiol 282:H2060-5. 2002
    ..These findings demonstrate that endothelium-dependent dilation in cerebral arteries is impaired in IR primarily because of a defect of the COX-mediated pathways. In contrast, nitric oxide-mediated dilation remains intact in IR arteries...
  19. ncbi request reprint Role of endothelium in hyperemia during cortical spreading depression (CSD) in the rat
    Katsuyoshi Shimizu
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Brain Res 928:40-9. 2002
    ..Thus, our results provide strong evidence that endothelium-mediated mechanisms have minimal effects on the CSD-associated hyperemia...
  20. ncbi request reprint Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance
    Prasad V G Katakam
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Hanes 1050, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Regul Integr Comp Physiol 292:R920-6. 2007
    ..Thus obesity accompanied by IR is associated with the inability to precondition against ischemic cardiac injury, which is mediated by enhanced mitochondrial oxidative stress and impaired activation of mitochondrial K(ATP)...
  21. ncbi request reprint Electrical heterogeneity and arrhythmogenesis: importance of conduction velocity dispersion
    J Jason Sims
    University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, USA
    J Cardiovasc Pharmacol 41:795-803. 2003
    ..Regional lidocaine had profibrillatory effects when stimuli were delivered in non-drug perfused areas, whereas regional d-sotalol did not. Hence, CV dispersion is a more likely determinant of myocardial vulnerability than refractoriness...

Research Grants3

  1. Endothelial Dysfunction in Insulin Resistance
    Allison Miller; Fiscal Year: 2002
    ..Findings from this project may provide important information that can be used to design treatments to prevent the cardiovascular complications of IR. ..
  2. IMPAIRED CORONARY ARTERY FUNCTION IN INSULIN RESISTANCE
    Allison Miller; Fiscal Year: 2002
    ..Findings from this project may provide important information that can be used in future studies to design treatments to prevent or abort the cardiovascular complications of insulin resistance. ..