STEPHEN MESSIER

Summary

Affiliation: Wake Forest University
Country: USA

Publications

  1. ncbi request reprint Declines in strength and balance in older adults with chronic knee pain: a 30-month longitudinal, observational study
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Arthritis Rheum 47:141-8. 2002
  2. ncbi request reprint Influences of alignment and obesity on knee joint loading in osteoarthritic gait
    S P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA Section on Gerontology and Geriatric Medicine, Wake Forest University, School of Medicine, USA Electronic address
    Osteoarthritis Cartilage 22:912-7. 2014
  3. ncbi request reprint Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, North Carolina 27109, USA
    JAMA 310:1263-73. 2013
  4. ncbi request reprint Physical activity and weight loss interventions in older adults with knee osteoarthritis
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Sport Science, Wake Forest University, Winston Salem, NC 27109, USA
    N C Med J 68:436-8. 2007
  5. pmc Obesity and osteoarthritis: disease genesis and nonpharmacologic weight management
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Rheum Dis Clin North Am 34:713-29. 2008
  6. doi request reprint Risk factors and mechanisms of knee injury in runners
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Med Sci Sports Exerc 40:1873-9. 2008
  7. doi request reprint Obesity and osteoarthritis: disease genesis and nonpharmacologic weight management
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Med Clin North Am 93:145-59, xi-xii. 2009
  8. pmc The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA
    BMC Musculoskelet Disord 10:93. 2009
  9. pmc Diet and exercise for obese adults with knee osteoarthritis
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Clin Geriatr Med 26:461-77. 2010
  10. pmc Does high weight loss in older adults with knee osteoarthritis affect bone-on-bone joint loads and muscle forces during walking?
    S P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Osteoarthritis Cartilage 19:272-80. 2011

Research Grants

Detail Information

Publications29

  1. ncbi request reprint Declines in strength and balance in older adults with chronic knee pain: a 30-month longitudinal, observational study
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Arthritis Rheum 47:141-8. 2002
    ....
  2. ncbi request reprint Influences of alignment and obesity on knee joint loading in osteoarthritic gait
    S P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA Section on Gerontology and Geriatric Medicine, Wake Forest University, School of Medicine, USA Electronic address
    Osteoarthritis Cartilage 22:912-7. 2014
    ..To determine the influences of frontal plane knee alignment and obesity on knee joint loads in older, overweight and obese adults with knee osteoarthritis (OA)...
  3. ncbi request reprint Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, North Carolina 27109, USA
    JAMA 310:1263-73. 2013
    ..Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity...
  4. ncbi request reprint Physical activity and weight loss interventions in older adults with knee osteoarthritis
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Sport Science, Wake Forest University, Winston Salem, NC 27109, USA
    N C Med J 68:436-8. 2007
  5. pmc Obesity and osteoarthritis: disease genesis and nonpharmacologic weight management
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Rheum Dis Clin North Am 34:713-29. 2008
    ....
  6. doi request reprint Risk factors and mechanisms of knee injury in runners
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Med Sci Sports Exerc 40:1873-9. 2008
    ..5 million running at least 100 d x yr(-1). Although running injuries are well understood medically, their potential risk factors are not. Thus, we presently have limited ability to identify individuals at high risk for overuse injuries...
  7. doi request reprint Obesity and osteoarthritis: disease genesis and nonpharmacologic weight management
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Med Clin North Am 93:145-59, xi-xii. 2009
    ....
  8. pmc The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA
    BMC Musculoskelet Disord 10:93. 2009
    ..This article describes the intervention, the empirical evidence to support it, and test-retest reliability data...
  9. pmc Diet and exercise for obese adults with knee osteoarthritis
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Clin Geriatr Med 26:461-77. 2010
    ....
  10. pmc Does high weight loss in older adults with knee osteoarthritis affect bone-on-bone joint loads and muscle forces during walking?
    S P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Osteoarthritis Cartilage 19:272-80. 2011
    ..The aim of this study was to examine the effects of high weight loss on knee joint loads during walking in participants with knee osteoarthritis (OA)...
  11. ncbi request reprint Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study
    S P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, United States
    Osteoarthritis Cartilage 15:1256-66. 2007
    ....
  12. ncbi request reprint Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial
    Stephen P Messier
    Claude D Pepper Older Americans Independence Center, Wake Forest University, Winston Salem, NC 27109, USA
    Arthritis Rheum 50:1501-10. 2004
    ....
  13. ncbi request reprint Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis
    Stephen P Messier
    Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Arthritis Rheum 52:2026-32. 2005
    ..To determine the relationship between change in body mass and knee-joint moments and forces during walking in overweight and obese older adults with knee osteoarthritis (OA) following an 18-month clinical trial of diet and exercise...
  14. ncbi request reprint Inflammatory markers and physical function among older adults with knee osteoarthritis
    Brenda W J H Penninx
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Rheumatol 31:2027-31. 2004
    ..To investigate whether serum concentrations of various inflammatory markers are associated with physical function and disease severity among older obese adults with knee osteoarthritis (OA)...
  15. ncbi request reprint Physical activity and physical function in older adults with knee osteoarthritis
    Elizabeth Chmelo
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Dept of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC
    J Phys Act Health 10:777-83. 2013
    ..5 ± 3.8 kg/m2), sedentary (less than 30 mins of activity, 3 days a week) individuals with knee osteoarthritis...
  16. ncbi request reprint Knee strength maintained despite loss of lean body mass during weight loss in older obese adults with knee osteoarthritis
    Xuewen Wang
    Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 62:866-71. 2007
    ..The effects of weight loss on muscle function in older adults have not been well studied. This study determined the effects of a 6-month weight-loss intervention on muscle strength and quality in older obese adults with knee osteoarthritis...
  17. ncbi request reprint Physical activity and physical function in older adults with knee osteoarthritis
    Elizabeth Chmelo
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Dept of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC
    J Phys Act Health 10:777-83. 2012
    ..Conclusions: This study demonstrates that a population who has higher levels of spontaneous activity have better overall physical function than those who engage in less activity. ..
  18. ncbi request reprint Baseline balance and functional decline in older adults with knee pain: the Observational Arthritis Study in Seniors
    Anthony P Marsh
    Department of Health and Exercise Science, Gymnasium Building Room 313, Wake Forest University, Winston Salem, NC 27109, USA
    J Am Geriatr Soc 51:331-9. 2003
    ..To examine the cross-sectional and longitudinal effect of baseline balance, independent of multiple covariates (sociodemographic variables, comorbidities), on self-reported disability and several measures of functional performance...
  19. ncbi request reprint The Arthritis, Diet and Activity Promotion Trial (ADAPT): design, rationale, and baseline results
    Gary D Miller
    Department of Health and Exercise Science Wake Forest University, Winston Salem, North Carolina 27109, USA
    Control Clin Trials 24:462-80. 2003
    ..The results from ADAPT will provide approaches clinicians should recommend for behavioral therapies that effectively reduce the incidence of disability associated with knee OA...
  20. ncbi request reprint Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis
    Gary D Miller
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Obesity (Silver Spring) 14:1219-30. 2006
    ..Physical function and body composition in older obese adults with knee osteoarthritis (OA) were examined after intensive weight loss...
  21. pmc The effect of randomization to weight loss on total mortality in older overweight and obese adults: the ADAPT Study
    M Kyla Shea
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 65:519-25. 2010
    ..Data from the Arthritis, Diet, and Activity Promotion Trial (ADAPT) were used to determine whether randomization to a weight reduction program was associated with total mortality in overweight/obese older adults...
  22. ncbi request reprint Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial
    Barbara J Nicklas
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 79:544-51. 2004
    ..Persistent, low-grade inflammation is an independent predictor of several chronic diseases and all-cause mortality...
  23. ncbi request reprint Physical function and its response to exercise: associations with cytokine gene variation in older adults with knee osteoarthritis
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 60:1292-8. 2005
    ....
  24. ncbi request reprint Do older adults with knee osteoarthritis place greater loads on the knee during gait? A preliminary study
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winton Salem, NC 27109, USA
    Arch Phys Med Rehabil 86:703-9. 2005
    ....
  25. ncbi request reprint Long-term exercise therapy resolves ethnic differences in baseline health status in older adults with knee osteoarthritis
    Capri Gabrielle Foy
    Department of Public Health Sciences, Wake Forest University, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 53:1469-75. 2005
    ....
  26. ncbi request reprint Effects of exercise adherence on physical function among overweight older adults with knee osteoarthritis
    Coen H van Gool
    Universiteit Maastricht, Maastricht, The Netherlands
    Arthritis Rheum 53:24-32. 2005
    ..To determine whether high exercise adherence improved physical function among older adults with knee osteoarthritis (OA) who were overweight or obese...
  27. ncbi request reprint Exercise, self-efficacy, and mobility performance in overweight and obese older adults with knee osteoarthritis
    Brian C Focht
    Ohio State University, Columbus, 43210, USA
    Arthritis Rheum 53:659-65. 2005
    ....
  28. ncbi request reprint Determinants of high and low attendance to diet and exercise interventions among overweight and obese older adults. Results from the arthritis, diet, and activity promotion trial
    Coen H van Gool
    Department of Health Care Studies, Section of Medical Sociology, Universiteit Maastricht, Maastricht, The Netherlands
    Contemp Clin Trials 27:227-37. 2006
    ..Therefore, we explored demographic, health-related, and social determinants of high and low attendance to diet and exercise sessions among overweight and obese patients with knee osteoarthritis (> or = 60 years; N = 206)...

Research Grants5

  1. Intensive Dietary Restriction with Exercise in Arthritis
    STEPHEN MESSIER; Fiscal Year: 2006
    ..This study could make intensive weight loss the standard-of- care for overweight and obese adults with knee OA, as it enhances our understanding of the OA disease process and weight-loss recommendations for older people generally. ..
  2. Intensive Dietary Restriction with Exercise in Arthritis
    STEPHEN MESSIER; Fiscal Year: 2007
    ..This study could make intensive weight loss the standard-of- care for overweight and obese adults with knee OA, as it enhances our understanding of the OA disease process and weight-loss recommendations for older people generally. ..
  3. Intensive Dietary Restriction with Exercise in Arthritis
    STEPHEN MESSIER; Fiscal Year: 2009
    ..This study could make intensive weight loss the standard-of- care for overweight and obese adults with knee OA, as it enhances our understanding of the OA disease process and weight-loss recommendations for older people generally. ..
  4. Intensive Dietary Restriction with Exercise in Arthritis
    Stephen P Messier; Fiscal Year: 2010
    ..This study could make intensive weight loss the standard-of- care for overweight and obese adults with knee OA, as it enhances our understanding of the OA disease process and weight-loss recommendations for older people generally. ..