Weiya Ma

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain
    Weiya Ma
    Pain Mechanism Laboratory, Department of Anaesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Eur J Neurosci 15:1037-47. 2002
  2. ncbi request reprint Intrathecal injection of cAMP response element binding protein (CREB) antisense oligonucleotide attenuates tactile allodynia caused by partial sciatic nerve ligation
    Weiya Ma
    Department of Anesthesiology, and Center for the Study of Pharmacological Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 988:97-104. 2003
  3. ncbi request reprint Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation
    W Ma
    Pain Mechanism Laboratory, Department of Anesthesiology and Center for the Study of Pharmacological Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuroscience 121:681-90. 2003
  4. ncbi request reprint Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice
    Weiya Ma
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Brain Res 970:110-8. 2003
  5. ncbi request reprint Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury
    W Ma
    Pain Mechanism Laboratory, Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Neuroscience 121:691-704. 2003
  6. ncbi request reprint Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac
    Weiya Ma
    Pain Mechanisms Laboratory, Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity, Wake Forest University School of Medicine, wisnton Salem, North Carolina 27157 1009, USA
    Anesthesiology 98:203-8. 2003
  7. ncbi request reprint Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury
    Weiya Ma
    Pain Mechanisms Laboratory, Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 937:94-9. 2002
  8. ncbi request reprint Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation
    Weiya Ma
    Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Exp Neurol 183:581-92. 2003
  9. pmc Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation
    Weiya Ma
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 1127:52-8. 2007
  10. ncbi request reprint Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain
    Xinhui Li
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 97:117-25. 2002

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain
    Weiya Ma
    Pain Mechanism Laboratory, Department of Anaesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Eur J Neurosci 15:1037-47. 2002
    ....
  2. ncbi request reprint Intrathecal injection of cAMP response element binding protein (CREB) antisense oligonucleotide attenuates tactile allodynia caused by partial sciatic nerve ligation
    Weiya Ma
    Department of Anesthesiology, and Center for the Study of Pharmacological Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 988:97-104. 2003
    ..These data suggest that phosphorylation of CREB is an important contributing event in the central plasticity of nerve injury and in the pathogenesis of neuropathic pain...
  3. ncbi request reprint Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation
    W Ma
    Pain Mechanism Laboratory, Department of Anesthesiology and Center for the Study of Pharmacological Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuroscience 121:681-90. 2003
    ....
  4. ncbi request reprint Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice
    Weiya Ma
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Brain Res 970:110-8. 2003
    ....
  5. ncbi request reprint Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury
    W Ma
    Pain Mechanism Laboratory, Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Neuroscience 121:691-704. 2003
    ..Our data strongly suggest that during the initial several months after nerve injury, peripherally over-produced prostaglandins play an important role in the maintenance of neuropathic pain...
  6. ncbi request reprint Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac
    Weiya Ma
    Pain Mechanisms Laboratory, Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity, Wake Forest University School of Medicine, wisnton Salem, North Carolina 27157 1009, USA
    Anesthesiology 98:203-8. 2003
    ....
  7. ncbi request reprint Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury
    Weiya Ma
    Pain Mechanisms Laboratory, Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 937:94-9. 2002
    ..Inhibition of spinal COX may be an important mechanism of action in treating some patients with neuropathic pain following peripheral nerve injury...
  8. ncbi request reprint Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation
    Weiya Ma
    Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Exp Neurol 183:581-92. 2003
    ..Our data suggest that following PSNL, PGE2 is one of the possible PGs overproduced in injured nerve and PG overproduction is involved in the up-regulation of EP receptors in injured nerve...
  9. pmc Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation
    Weiya Ma
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 1127:52-8. 2007
    ....
  10. ncbi request reprint Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain
    Xinhui Li
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 97:117-25. 2002
    ..These data support the hypothesis that activation of the A1 receptor by the allosteric modulator, T62, produces anti-nociception via spinal noradrenergic activation...
  11. ncbi request reprint Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine
    Weiya Ma
    Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 113:386-94. 2005
    ....
  12. ncbi request reprint Uterine cervical distension induces cFos expression in deep dorsal horn neurons of the rat spinal cord
    Chuanyao Tong
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 99:205-11. 2003
    ..The authors examined uterine cervical distension-evoked cFos immunoreactivity in rat spinal cords, and the inhibitory effect of spinal cyclo-oxygenase inhibition on cFos expression...
  13. ncbi request reprint Clonidine-induced neuronal activation in the spinal cord is altered after peripheral nerve injury
    Carlo Pancaro
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 98:748-53. 2003
    ....
  14. ncbi request reprint Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus
    Weiya Ma
    Department of Psychiatry, Douglas Hospital Research Center, McGill University, 6875 Boulevard LaSalle, Verdun, Montreal, Quebec, Canada H4H 1R3
    Pain 99:175-84. 2002
    ..In summary, our data indicate that PSNL activates ERK/MAP and JNK/MAP kinase pathways in astrocytes in the dorsal horn and the gracile nucleus, these events possibly being involved in the pathogenesis of neuropathic pain...
  15. pmc A role for adrenomedullin as a pain-related peptide in the rat
    Weiya Ma
    Douglas Hospital Research Center, and Department of Psychiatry, McGill University, Montreal, QC, Canada H4H 1R3
    Proc Natl Acad Sci U S A 103:16027-32. 2006
    ..By activating specific receptors (likely AM2) and the PI3K/Akt/GSK3beta signaling pathway, AM could play a significant role in long-lasting heat hypersensitivity and inflammatory heat hyperalgesia...
  16. ncbi request reprint Targeting invading macrophage-derived PGE2, IL-6 and calcitonin gene-related peptide in injured nerve to treat neuropathic pain
    Weiya Ma
    Douglas Hospital Research Center, McGill University, Montreal, Quebec, H4H 1R3, Canada
    Expert Opin Ther Targets 10:533-46. 2006
    ..Targeting these mediators in injured nerve may provide novel therapeutic avenues to more successfully treat nerve injury-associated neuropathic pain...
  17. ncbi request reprint Increased calcitonin gene-related peptide in neuroma and invading macrophages is involved in the up-regulation of interleukin-6 and thermal hyperalgesia in a rat model of mononeuropathy
    Weiya Ma
    Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Neurochem 98:180-92. 2006
    ..Taken together, these data show that increased levels of CGRP in injured neuroma and invading macrophages are involved in the up-regulation of IL-6 in macrophages as well as in the maintenance of neuropathic pain...
  18. ncbi request reprint Up-regulation of interleukin-6 induced by prostaglandin E from invading macrophages following nerve injury: an in vivo and in vitro study
    Weiya Ma
    Douglas Hospital Research Center, McGill University, Montreal, Canada
    J Neurochem 93:664-73. 2005
    ..Taken together, our data suggest that PGE2 is involved in mediating the up-regulation of IL-6 occurring in invading macrophages. This action is mediated through an EP4 receptor and the protein kinase C signaling pathway...
  19. ncbi request reprint Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury
    Patricia M Lavand'homme
    Department of Anesthesiology and Pain Clinic, Hôpital St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Anesthesiology 97:972-80. 2002
    ..In contrast to this notion, peripheral alpha(2)-adrenoceptor stimulation fails to induce pain in patients with chronic pain. We hypothesized that alpha(2) adrenoceptors at the site of nerve injury play an inhibitory, not excitatory role...
  20. pmc Characterization and effects on cAMP accumulation of adrenomedullin and calcitonin gene-related peptide (CGRP) receptors in dissociated rat spinal cord cell culture
    Mohammad A Takhshid
    Fasa Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
    Br J Pharmacol 148:459-68. 2006
    ..30) on cAMP accumulation. These pharmacological profiles suggest that effects of CGRP are mediated by the CGRP(1) (CLR/RAMP1) receptor in our model while those of AM are related to the activation of the AM(1) (CLR/RAMP2) receptor subtype...
  21. ncbi request reprint The ERK/MAPK pathway, as a target for the treatment of neuropathic pain
    Weiya Ma
    Douglas Hospital Research Center, McGill University, Verdun, Montreal, Quebec, H4H 1R3, Canada
    Expert Opin Ther Targets 9:699-713. 2005
    ..Thus, the regulation of ERK/MAPK can be considered as a promising therapeutic target for the treatment of neuropathic pain...
  22. ncbi request reprint Spinal modulation of calcitonin gene-related peptide by endocannabinoids in the development of opioid physical dependence
    Tuan Trang
    Department of Pharmacology and Toxicology and Anesthesiology, Queen s University Kingston, Ont, Canada K7L 3N6
    Pain 126:256-71. 2006
    ..Altogether, this study suggests that endocannabinoid activity, expressed via CB1-receptors, contributes to the induction of opioid physical dependence through spinal modulation of CGRP...
  23. ncbi request reprint Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain
    Weiya Ma
    Douglas Hospital Research Center, McGill University, Montreal, Quebec, H4H 1R3, Canada
    Expert Opin Ther Targets 11:307-20. 2007
    ....
  24. ncbi request reprint An organelle proteomic method to study neurotransmission-related proteins, applied to a neurodevelopmental model of schizophrenia
    Freya G G Vercauteren
    Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Proteomics 7:3569-79. 2007
    ..Organelle proteomic approaches have hence proved to be most useful to identify key proteins linked to a given behavior in animal models of brain diseases...
  25. doi request reprint Does COX2-dependent PGE2 play a role in neuropathic pain?
    Weiya Ma
    The Douglas Mental Health University Institute, Montreal, Quebec, Canada H4H 1R3
    Neurosci Lett 437:165-9. 2008
    ..COX2/PGE2 in injured nerves and downstream PGE2 EP receptor signaling should be considered as therapeutic targets to more effectively treat chronic NeP...
  26. doi request reprint Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway
    Jichao Qin
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5870, USA
    Cancer Res 68:4150-62. 2008
    ..Together, our results show that EGCG-mediated negative regulation of PP-2A is an important molecular event for the activation of p53-dependent apoptosis during its chemoprevention...