E Lorenz

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Toll-like receptor 2 represses nonpilus adhesin-induced signaling in acute infections with the Pseudomonas aeruginosa pilA mutant
    Eva Lorenz
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1042, USA
    Infect Immun 72:4561-9. 2004
  2. pmc Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide
    Eva Lorenz
    Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University Medical Center, Winston Salem, NC, USA
    Infect Immun 70:4892-6. 2002
  3. ncbi Association between the Asp299Gly polymorphisms in the Toll-like receptor 4 and premature births in the Finnish population
    Eva Lorenz
    Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Pediatr Res 52:373-6. 2002
  4. ncbi Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling
    Prasad Rallabhandi
    Department of Microbiology and Immunology, University of Maryland, 660 West Redwood Street, Baltimore, MD 21201, USA
    J Immunol 177:322-32. 2006
  5. pmc Differential involvement of toll-like receptors 2 and 4 in the host response to acute respiratory infections with wild-type and mutant Haemophilus influenzae strains
    Eva Lorenz
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 73:2075-82. 2005
  6. ncbi Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
    Eva Lorenz
    Pulmonary and Critical Care Medicine, Duke University Medical Center, Research Drive, Room 275 MSRB, DUMC Box 2629, Durham, NC 27710, USA
    Arch Intern Med 162:1028-32. 2002
  7. pmc Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses
    Sonja von Aulock
    Biochemical Pharmacology, University of Konstanz, 78457 Konstanz, Germany
    Infect Immun 72:1828-31. 2004
  8. ncbi Toll-like receptor 4 polymorphisms and atherogenesis
    Stefan Kiechl
    Department of Neurology, University Clinic, Innsbruck, Austria
    N Engl J Med 347:185-92. 2002
  9. ncbi Up-regulation of S100A8 and S100A9 protein in bronchial epithelial cells by lipopolysaccharide
    Markus O Henke
    Department of Pulmonary Medicine, Philipps University Marburg, Marburg, Germany
    Exp Lung Res 32:331-47. 2006
  10. ncbi Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children
    Agnes A Awomoyi
    Department of Microbiology and Immunology, University of Maryland Baltimore, 660 W Redwood Street, Baltimore, MD 21201, USA
    J Immunol 179:3171-7. 2007

Collaborators

Detail Information

Publications11

  1. pmc Toll-like receptor 2 represses nonpilus adhesin-induced signaling in acute infections with the Pseudomonas aeruginosa pilA mutant
    Eva Lorenz
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1042, USA
    Infect Immun 72:4561-9. 2004
    ..aeruginosa pilA mutant was associated with TLR4 induction and indicated that nonpilus adhesin-induced signaling was repressed by TLR2 function and, if not blocked by the host, could induce airway hyperresponsiveness...
  2. pmc Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide
    Eva Lorenz
    Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University Medical Center, Winston Salem, NC, USA
    Infect Immun 70:4892-6. 2002
    ..This gives rise to the notion that LPS from some bacterial species will utilize alternative receptors to stimulate the innate immune response...
  3. ncbi Association between the Asp299Gly polymorphisms in the Toll-like receptor 4 and premature births in the Finnish population
    Eva Lorenz
    Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Pediatr Res 52:373-6. 2002
    ..024, p = 0.028, respectively) or in premature multiples (p = 0.036, p = 0.044, respectively). According to the present results an allelic variation in the TLR4 receptor was associated with increased risk of premature birth...
  4. ncbi Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling
    Prasad Rallabhandi
    Department of Microbiology and Immunology, University of Maryland, 660 West Redwood Street, Baltimore, MD 21201, USA
    J Immunol 177:322-32. 2006
    ..A structural model that accounts for the diminished responsiveness of mutant TLR4 polymorphisms to structurally unrelated TLR4 agonists is proposed...
  5. pmc Differential involvement of toll-like receptors 2 and 4 in the host response to acute respiratory infections with wild-type and mutant Haemophilus influenzae strains
    Eva Lorenz
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 73:2075-82. 2005
    ..influenzae can favor signaling through non-TLR4 receptors, such as TLR2. The results also indicate a close interaction between TLR4 and TLR2 that tightly regulates the expression of both receptors...
  6. ncbi Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
    Eva Lorenz
    Pulmonary and Critical Care Medicine, Duke University Medical Center, Research Drive, Room 275 MSRB, DUMC Box 2629, Durham, NC 27710, USA
    Arch Intern Med 162:1028-32. 2002
    ..We recently identified a common polymorphism in toll-like receptor 4 (TLR4) that is associated with hyporesponsiveness to inhaled endotoxin or lipopolysaccharide in humans...
  7. pmc Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses
    Sonja von Aulock
    Biochemical Pharmacology, University of Konstanz, 78457 Konstanz, Germany
    Infect Immun 72:1828-31. 2004
    ..Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response...
  8. ncbi Toll-like receptor 4 polymorphisms and atherogenesis
    Stefan Kiechl
    Department of Neurology, University Clinic, Innsbruck, Austria
    N Engl J Med 347:185-92. 2002
    ..We determined whether recently discovered genetic variants of toll-like receptor 4 (TLR4) that confer differences in the inflammatory response elicited by bacterial lipopolysaccharide are related to the development of atherosclerosis...
  9. ncbi Up-regulation of S100A8 and S100A9 protein in bronchial epithelial cells by lipopolysaccharide
    Markus O Henke
    Department of Pulmonary Medicine, Philipps University Marburg, Marburg, Germany
    Exp Lung Res 32:331-47. 2006
    ..This finding suggests that S100A8 and S100A9 are involved in the innate defense of the bronchial epithelium...
  10. ncbi Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children
    Agnes A Awomoyi
    Department of Microbiology and Immunology, University of Maryland Baltimore, 660 W Redwood Street, Baltimore, MD 21201, USA
    J Immunol 179:3171-7. 2007
    ....
  11. pmc Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases
    Eva Lorenz
    Department of Rheumatology, TARC University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7280, USA
    Respir Med 102:567-73. 2008
    ..The results indicate that the regulation of human calgranulin expression and the ratio of S100A8/A9 to S100A12 may provide important insights in the mechanism of respiratory inflammation...