Affiliation: Wake Forest University School of Medicine
- Toll-like receptor 2 represses nonpilus adhesin-induced signaling in acute infections with the Pseudomonas aeruginosa pilA mutantEva Lorenz
Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1042, USA
Infect Immun 72:4561-9. 2004..aeruginosa pilA mutant was associated with TLR4 induction and indicated that nonpilus adhesin-induced signaling was repressed by TLR2 function and, if not blocked by the host, could induce airway hyperresponsiveness...
- Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharideEva Lorenz
Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University Medical Center, Winston Salem, NC, USA
Infect Immun 70:4892-6. 2002..This gives rise to the notion that LPS from some bacterial species will utilize alternative receptors to stimulate the innate immune response...
- Association between the Asp299Gly polymorphisms in the Toll-like receptor 4 and premature births in the Finnish populationEva Lorenz
Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Pediatr Res 52:373-6. 2002..024, p = 0.028, respectively) or in premature multiples (p = 0.036, p = 0.044, respectively). According to the present results an allelic variation in the TLR4 receptor was associated with increased risk of premature birth...
- Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signalingPrasad Rallabhandi
Department of Microbiology and Immunology, University of Maryland, 660 West Redwood Street, Baltimore, MD 21201, USA
J Immunol 177:322-32. 2006..A structural model that accounts for the diminished responsiveness of mutant TLR4 polymorphisms to structurally unrelated TLR4 agonists is proposed...
- Differential involvement of toll-like receptors 2 and 4 in the host response to acute respiratory infections with wild-type and mutant Haemophilus influenzae strainsEva Lorenz
Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
Infect Immun 73:2075-82. 2005..influenzae can favor signaling through non-TLR4 receptors, such as TLR2. The results also indicate a close interaction between TLR4 and TLR2 that tightly regulates the expression of both receptors...
- Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shockEva Lorenz
Pulmonary and Critical Care Medicine, Duke University Medical Center, Research Drive, Room 275 MSRB, DUMC Box 2629, Durham, NC 27710, USA
Arch Intern Med 162:1028-32. 2002..We recently identified a common polymorphism in toll-like receptor 4 (TLR4) that is associated with hyporesponsiveness to inhaled endotoxin or lipopolysaccharide in humans...
- Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responsesSonja von Aulock
Biochemical Pharmacology, University of Konstanz, 78457 Konstanz, Germany
Infect Immun 72:1828-31. 2004..Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response...
- Toll-like receptor 4 polymorphisms and atherogenesisStefan Kiechl
Department of Neurology, University Clinic, Innsbruck, Austria
N Engl J Med 347:185-92. 2002..We determined whether recently discovered genetic variants of toll-like receptor 4 (TLR4) that confer differences in the inflammatory response elicited by bacterial lipopolysaccharide are related to the development of atherosclerosis...
- Up-regulation of S100A8 and S100A9 protein in bronchial epithelial cells by lipopolysaccharideMarkus O Henke
Department of Pulmonary Medicine, Philipps University Marburg, Marburg, Germany
Exp Lung Res 32:331-47. 2006..This finding suggests that S100A8 and S100A9 are involved in the innate defense of the bronchial epithelium...
- Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young childrenAgnes A Awomoyi
Department of Microbiology and Immunology, University of Maryland Baltimore, 660 W Redwood Street, Baltimore, MD 21201, USA
J Immunol 179:3171-7. 2007....
- Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseasesEva Lorenz
Department of Rheumatology, TARC University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7280, USA
Respir Med 102:567-73. 2008..The results indicate that the regulation of human calgranulin expression and the ratio of S100A8/A9 to S100A12 may provide important insights in the mechanism of respiratory inflammation...