Research Topics
Genomes and Genes | RICHARD LOESERSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Detail Information
Publications
Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in miceRichard F Loeser
Molecular Medicine, Wake Forest University, Winston Salem, NC 27157, USA
Arthritis Rheum 64:705-17. 2012..To better understand the contribution of age to the development of osteoarthritis (OA)...- The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationaleStephen P Messier
Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA
BMC Musculoskelet Disord 10:93. 2009..This article describes the intervention, the empirical evidence to support it, and test-retest reliability data... - Regulation of chondrocyte gene expression by osteogenic protein-1Susan Chubinskaya
Department of Biochemistry, Rush University Medical Center, 1653 W, Congress Parkway, Chicago, IL 60612, USA
Arthritis Res Ther 13:R55. 2011..The objective of this study was to investigate which genes are regulated by osteogenic protein-1 (OP-1) in human articular chondrocytes using Affimetrix gene array, in order to understand the role of OP-1 in cartilage homeostasis... - Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13David Long
Section of Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina 27157, USA
Arthritis Res Ther 10:R23. 2008..The purpose of this study was to discover novel mediators of cartilage destruction using fibronectin fragments as a stimulus... - Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytesRichard F Loeser
Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Arthritis Rheum 52:3910-7. 2005..To determine the effects of basic fibroblast growth factor (bFGF) on the chondrocyte anabolic activity promoted by insulin-like growth factor 1 (IGF-1) and osteogenic protein 1 (OP-1)... - Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilageR F Loeser
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Osteoarthritis Cartilage 17:513-7. 2009..This study was designed to determine if increased methylation of the OP-1 promoter might serve as a mechanism for the age-related decline in OP-1 expression... - Mitogen-activated protein kinases as therapeutic targets in osteoarthritisRichard F Loeser
Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Curr Opin Rheumatol 20:581-6. 2008..The therapeutic potential of MAP kinase inhibition in osteoarthritis was reviewed... - Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrixR F Loeser
Section of Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Osteoarthritis Cartilage 17:971-9. 2009..This review focused on potential mechanisms by which age-related changes in the articular cartilage could contribute to the development of OA... - Age-related changes in the musculoskeletal system and the development of osteoarthritisRichard F Loeser
Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Clin Geriatr Med 26:371-86. 2010..Understanding the basic mechanisms by which aging affects joint tissues should provide new targets for slowing or preventing the development of OA... - NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragmentsJudit I Pulai
Department of Internal Medicine, Section of Rheumatology, Rush Medical College, Chicago, IL 60612, USA
J Immunol 174:5781-8. 2005..Targeting the signaling pathways activated by FN-f may be an effective means of inhibiting production of multiple mediators of cartilage destruction... - Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuliChristopher B Forsyth
Department of Internal Medicine, Rush Medical College, Rush University Medical Center, Chicago, Illinois, USA
J Gerontol A Biol Sci Med Sci 60:1118-24. 2005..These results demonstrate a significant age-related increase in chondrocyte catabolic responsiveness which could contribute to the development of osteoarthritis in older adults... 
The Arthritis, Diet and Activity Promotion Trial (ADAPT): design, rationale, and baseline resultsGary D Miller
Department of Health and Exercise Science Wake Forest University, Winston Salem, North Carolina 27109, USA
Control Clin Trials 24:462-80. 2003..The results from ADAPT will provide approaches clinicians should recommend for behavioral therapies that effectively reduce the incidence of disability associated with knee OA...- Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesisJohn D Cravero
Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Arthritis Rheum 60:492-500. 2009..This study was undertaken to determine if TRB3 is expressed in chondrocytes, and whether the chondrocyte response to IGF-1 is reduced by TRB3... 
Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapyGary D Miller
Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109 7868, USA
J Am Geriatr Soc 56:644-51. 2008..To describe the relationships between proinflammatory biomarkers and self-reported and performance-based physical function and to examine the effect of weight loss on these markers of inflammation...- Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytesRaghunatha R Yammani
Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Arthritis Rheum 60:792-800. 2009..The aim of this study was to examine the mechanism of S100A4 secretion by chondrocytes... - Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life spanWilliam E Sonntag
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1083, USA
Endocrinology 146:2920-32. 2005.... - Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trialBarbara J Nicklas
Wake Forest University School of Medicine, Winston Salem, NC, USA
Am J Clin Nutr 79:544-51. 2004..Persistent, low-grade inflammation is an independent predictor of several chronic diseases and all-cause mortality... - Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end productsRaghunatha R Yammani
Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Arthritis Rheum 54:2901-11. 2006.... - Integrins and cell signaling in chondrocytesRichard F Loeser
Department of Internal Medicine, Section of Rheumatology, Rush Medical College of Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Biorheology 39:119-24. 2002..A better understanding of chondrocyte integrin signaling is needed to define the mechanisms by which the ECM regulates chondrocyte function... - Why is osteoarthritis an age-related disease?A Shane Anderson
Section of Rheumatology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
Best Pract Res Clin Rheumatol 24:15-26. 2010..The ability to slow progression of OA in older adults will have enormous public health implications given the ageing of our population and the increase in other OA risk factors such as obesity... - Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathwaysWeihong Yin
Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Biol Chem 284:31972-81. 2009.... - Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathwayRichard F Loeser
Department of Internal Medicine, Rush Medical College, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Biol Chem 278:24577-85. 2003..studies have identified a novel pathway for the MAP kinase regulation of MMP-13 production which involves FN-f stimulation of the alpha5beta1 integrin and activation of the nonreceptor tyrosine kinase PYK2 by PKC, most likely PKCdelta.. - Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion TrialStephen P Messier
Claude D Pepper Older Americans Independence Center, Wake Forest University, Winston Salem, NC 27109, USA
Arthritis Rheum 50:1501-10. 2004.... - Intensive weight loss program improves physical function in older obese adults with knee osteoarthritisGary D Miller
Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
Obesity (Silver Spring) 14:1219-30. 2006..Physical function and body composition in older obese adults with knee osteoarthritis (OA) were examined after intensive weight loss... - Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13Keally J Miranda
Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Biol Chem 285:31517-24. 2010..Nuclear S100A4 was bound to the promoter region of MMP-13 in IL-1β-treated cells. Thus, we demonstrate a novel mechanism for sumoylated S100A4 as a regulator of expression of the MMP-13 gene... - Cell death in osteoarthritisMarcello Del Carlo
Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Curr Rheumatol Rep 10:37-42. 2008..Inhibition of cell death in OA likely will not be a sole therapeutic target but rather a desired effect of interventions designed to reverse the catabolic-anabolic imbalance occurring in OA joint tissues... - Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragmentsMarcello Del Carlo
Department of Biochemistry, Section of Rheumatology, Rush Medical College, Chicago, IL, USA
Free Radic Biol Med 42:1350-8. 2007..These results show that increased production of ROS but not nitric oxide as obligatory secondary messengers in the chondrocyte FN-f signaling pathway leads to the increased production of MMPs, including MMP-13... - Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytesHee Jeong Im
Department of Biochemistry, Rush University Medical Center, Chicago, Illinois 60612, USA
J Biol Chem 282:11110-21. 2007..We propose that deregulation of cross-talk between MAPK and PKCdelta signaling may contribute to the etiology of osteoarthritis in human patients... - Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee jointsKari J Ekenstedt
Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
Arthritis Rheum 54:3850-8. 2006..To determine the effects of chronic deficiency of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) on osteoarthritis (OA) severity... - Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collideRichard F Loeser
Arthritis Rheum 54:1357-60. 2006 - The alpha5beta1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitroJudit I Pulai
Rush Medical College of Rush Presbyterian St Luke s Medical Center, 1725 W Harrison Street, Chicago, IL 60612, USA
Arthritis Rheum 46:1528-35. 2002..The goal of the present study was to evaluate the role of the extracellular matrix (ECM) in promoting chondrocyte survival via signals through the integrin family of ECM receptors... - Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1Richard F Loeser
Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
Arthritis Rheum 46:2349-57. 2002.... - Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytesChristopher B Forsyth
Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA
Arthritis Rheum 46:2368-76. 2002..Autocrine production of IL-1 appears to result in additional MMP-13 activation. These processes may play a key role in feedback loops responsible for progressive cartilage degradation in arthritis... - Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytesHee Jeong Im
Department of Biochemistry, Section of Rheumatology, Rush Medical College, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Biol Chem 278:25386-94. 2003..We propose that IGF-1 and OP-1 could be key physiological regulators of MMP-13 gene expression and that the combination of IGF-1 and OP-1 may be useful in controlling the excess catabolic activity in arthritis... - Prolonged treatment of human osteoarthritic chondrocytes with insulin-like growth factor-I stimulates proteoglycan synthesis but not proteoglycan matrix accumulation in alginate culturesRichard F Loeser
Department of Medicine, Rush Medical College of Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Rheumatol 30:1565-70. 2003..To determine the level of anabolic response when chondrocytes isolated from human osteoarthritic cartilage are stimulated with 2 doses of insulin-like growth factor-I (IGF-I) for extended culture periods... - The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytesRichard F Loeser
Rheumatology, Rush Medical College of Rush Presbyterian St Luke s Medical Center, 1725 West Harrison, Suite 1017, Chicago, IL 60612, USA
Arthritis Rheum 48:2188-96. 2003..The aim of the current study was to compare the ability of insulin-like growth factor+(IGF-1) and osteogenic protein+(OP-1), alone and in combination, to stimulate human normal and OA chondrocytes in culture... - Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levelsMarcello Del Carlo
Rush Medical College of Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA
Arthritis Rheum 48:3419-30. 2003..This may represent an important contributing factor to the development of osteoarthritis in older adults... - IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPKBela G Starkman
Department of Biochemistry, Rush Medical College of Rush University Medical Center, Chicago, IL 60612, USA
Biochem J 389:723-9. 2005..Although IGF-I also activates the ERK/MAPK pathway, ERK activity is not required for proteoglycan synthesis and may serve as a negative regulator... - Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritisRichard F Loeser
Rush Medical College, Chicago, IL 60612, USA
Arthritis Rheum 52:2376-85. 2005..Stimulation of RAGE signaling can lead to MAP kinase activation and increased NF-kappaB activity. The objective of the present study was to determine if chondrocytes express functional RAGE... - Aging cartilage and osteoarthritis--what's the link?Richard F Loeser
Department of Medicine, Rush Medical College, Rush University Medical Center, Chicago, IL 60612, USA
Sci Aging Knowledge Environ 2004:pe31. 2004..Further elucidation of mechanisms that affect chondrocyte function with aging should lead to novel interventions designed to slow the aging process in cartilage with the goal of preventing age-associated OA... - Systemic and local regulation of articular cartilage metabolism: where does leptin fit in the puzzle?Richard F Loeser
Arthritis Rheum 48:3009-12. 2003 - Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-betaIMarcello Delcarlo
Department of Medicine, Section of Rheumatology and Department of Biochemistry, Rush Medical College, Chicago, Illinois, USA
Am J Physiol Cell Physiol 290:C802-11. 2006..Together, these results represent a novel mechanism by which ROS can initiate cell death through the activation of PKC-betaI... - Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeysKimberley D Ham
Dpartment of Veterinary Pathology, College of Veterinary Medicine, University of Minnesota, St Paul, 55108, USA
Arthritis Rheum 46:1956-64. 2002..A secondary aim was to evaluate the effect of soy phytoestrogen (SPE) treatment on the severity of OA... - Functional integrin subunits regulating cell-matrix interactions in the intervertebral discChristopher L Gilchrist
Department of Biomedical Engineering, Duke University, Durham, NC 27708 0281, USA
J Orthop Res 25:829-40. 2007..These findings suggest laminin-cell interactions may be important and unique to the nucleus pulposus region of the IVD. The results of this study provide new information on functional cell-matrix interactions in tissues of the IVD... - Toward optimal health: the experts discuss osteoarthritis in women [interviewed by Jodi Godfrey Meisler]Richard F Loeser
J Womens Health (Larchmt) 11:759-65. 2002 - Integrin-mediated adhesion of human articular chondrocytes to cartilageMelissa S Kurtis
University of California, San Diego, La Jolla, California 92093, USA
Arthritis Rheum 48:110-8. 2003..These chondrocyte integrins have a potential role in the initial adhesion and retention of chondrocytes at a cartilage defect site following clinical procedures of chondrocyte transplantation... - OsteoarthritisNajia Shakoor
Section of Rheumatology, Rush Medical College of Rush University Medical Center, Chicago, IL 60612, USA
Sci Aging Knowledge Environ 2004:dn2. 2004..Newer nonpharmacological treatment options are focusing on how to improve symptoms and prevent progression of the disease through mechanical interventions... - Aging or osteoarthritis: which is the problem?Richard F Loeser
Section of Rheumatology, Rush Medical College, Rush Presbyterian St Luke s Medical Center, 1725 West Harrison, Suite 1017, Chicago, IL 60612, USA
Rheum Dis Clin North Am 29:653-73. 2003.... - Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen speciesMarcello Del Carlo
College of Rush-Presbyterian-St. Luke's Medical Center, 1725 West Harrison Avenue, Chicago, IL 60612, USA
Arthritis Rheum 46:394-403. 2002..Chondrocyte cell death from NO occurs under conditions where other ROS are also generated...
Research Grants
- Integrin Function in CartilageRICHARD LOESER; Fiscal Year: 2007..The successful completion of this work should provide novel targets for inhibiting cartilage destruction in arthritis and prevent or slow the development of arthritis. ..
- Integrin Function in CartilageRICHARD LOESER; Fiscal Year: 2009..The successful completion of this work should provide novel targets for inhibiting cartilage destruction in arthritis and prevent or slow the development of arthritis. ..
- Integrin Function in CartilageRichard F Loeser; Fiscal Year: 2010..The successful completion of this work should provide novel targets for inhibiting cartilage destruction in arthritis and prevent or slow the development of arthritis. ..
- Aging and IGF-I in CartilageRICHARD LOESER; Fiscal Year: 2009..The results from this project should continue to provide new information needed to establish the basic cellular and molecular mechanisms which link aging to the development of OA in humans. ..
- Integrin Function in CartilageRICHARD LOESER; Fiscal Year: 2006..These studies will provide important new information needed to further develop therapies designed to inhibit cartilage matrix destruction in arthritis. ..
- AGING AND IGF 1 IN CARTILAGERICHARD LOESER; Fiscal Year: 2005..The results of these studies will provide important new information needed to better understand the link between aging and osteoarthritis, the most common cause of chronic disability in older adults. ..
- Aging and IGF-I in CartilageRICHARD LOESER; Fiscal Year: 2009..The results from this project should continue to provide new information needed to establish the basic cellular and molecular mechanisms which link aging to the development of OA in humans. ..