W C Little

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction
    William C Little
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 98:383-5. 2006
  2. pmc Heart failure with a normal left ventricular ejection fraction: diastolic heart failure
    William C Little
    Wake Forest University, School of Medicine, Winston Salem, NC 27157 1045, USA
    Trans Am Clin Climatol Assoc 119:93-99; discussion 99-102. 2008
  3. ncbi request reprint Diastolic dysfunction as a cause of exercise intolerance
    W C Little
    Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Heart Fail Rev 5:301-6. 2000
  4. ncbi request reprint Therapy for diastolic heart failure
    William C Little
    Department of Medicine, Cardiology Section, Wake Forest University School of Medicine Winston Salem, NC, USA
    Prog Cardiovasc Dis 47:380-8. 2005
  5. ncbi request reprint Pericardial disease
    William C Little
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Circulation 113:1622-32. 2006
  6. ncbi request reprint Effect of candesartan and verapamil on exercise tolerance in diastolic dysfunction
    William C Little
    Cardiology Section, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Cardiovasc Pharmacol 43:288-93. 2004
  7. ncbi request reprint The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure
    C P Cheng
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    Am J Physiol Heart Circ Physiol 280:H1853-60. 2001
  8. ncbi request reprint The pathogenesis of acute pulmonary edema associated with hypertension
    S K Gandhi
    Cardiology Section, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1045, USA
    N Engl J Med 344:17-22. 2001
  9. ncbi request reprint Utility of fast cine magnetic resonance imaging and display for the detection of myocardial ischemia in patients not well suited for second harmonic stress echocardiography
    W G Hundley
    Cardiology Section, Division of Radiological Sciences, The Wake Forest University School of Medicine, Winston Salem, NC, USA
    Circulation 100:1697-702. 1999
  10. ncbi request reprint Target lesion revascularization after bare-metal or drug-eluting stents: clinical presentations and outcomes
    Kevin R Hayes
    Wake Forest University School of Medicine, Section of Cardiology, Winston Salem, NC 27157 1045, USA
    J Invasive Cardiol 22:266-70. 2010

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction
    William C Little
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 98:383-5. 2006
    ..In conclusion, in patients with diastolic dysfunction and hypertensive responses to exercise, 6 months of losartan and HCTZ blunted systolic BP during exercise. Only losartan increased exercise tolerance and improved quality of life...
  2. pmc Heart failure with a normal left ventricular ejection fraction: diastolic heart failure
    William C Little
    Wake Forest University, School of Medicine, Winston Salem, NC 27157 1045, USA
    Trans Am Clin Climatol Assoc 119:93-99; discussion 99-102. 2008
    ..The optimal treatment of patients with heart failure and normal ejection fraction has not yet been defined, but the control of systolic hypertension and the avoidance of fluid overload are important...
  3. ncbi request reprint Diastolic dysfunction as a cause of exercise intolerance
    W C Little
    Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Heart Fail Rev 5:301-6. 2000
    ..Acute studies suggest that treatment with angiotensin II receptor blockers or verapamil may improve exercise tolerance in some patients with primary diastolic dysfunction...
  4. ncbi request reprint Therapy for diastolic heart failure
    William C Little
    Department of Medicine, Cardiology Section, Wake Forest University School of Medicine Winston Salem, NC, USA
    Prog Cardiovasc Dis 47:380-8. 2005
    ..Patients with diastolic heart failure in the absence of hypertension are very difficult to treat...
  5. ncbi request reprint Pericardial disease
    William C Little
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Circulation 113:1622-32. 2006
  6. ncbi request reprint Effect of candesartan and verapamil on exercise tolerance in diastolic dysfunction
    William C Little
    Cardiology Section, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Cardiovasc Pharmacol 43:288-93. 2004
    ..Ang II blockade increased exercise tolerance and improved QOL...
  7. ncbi request reprint The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure
    C P Cheng
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    Am J Physiol Heart Circ Physiol 280:H1853-60. 2001
    ..We conclude that in CHF, circulating ANG II and ET-1 increase to very high levels during Ex and exacerbate the diastolic dysfunction present at rest...
  8. ncbi request reprint The pathogenesis of acute pulmonary edema associated with hypertension
    S K Gandhi
    Cardiology Section, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1045, USA
    N Engl J Med 344:17-22. 2001
    ....
  9. ncbi request reprint Utility of fast cine magnetic resonance imaging and display for the detection of myocardial ischemia in patients not well suited for second harmonic stress echocardiography
    W G Hundley
    Cardiology Section, Division of Radiological Sciences, The Wake Forest University School of Medicine, Winston Salem, NC, USA
    Circulation 100:1697-702. 1999
    ..Fast cine MRI can be used to assess left ventricular contraction, but its utility for detection of myocardial ischemia in patients poorly suited for echocardiography is unknown...
  10. ncbi request reprint Target lesion revascularization after bare-metal or drug-eluting stents: clinical presentations and outcomes
    Kevin R Hayes
    Wake Forest University School of Medicine, Section of Cardiology, Winston Salem, NC 27157 1045, USA
    J Invasive Cardiol 22:266-70. 2010
    ..We sought to examine the clinical presentations and subsequent clinical outcomes of patients undergoing target lesion revascularization (TLR) after either bare-metal stent (BMS) or drug-eluting stent (DES) placement...
  11. ncbi request reprint Functional effects of endogenous bradykinin in congestive heart failure
    C P Cheng
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Am Coll Cardiol 31:1679-86. 1998
    ..The purpose of this study was to determine the level and functional effects of endogenous bradykinin in congestive heart failure (CHF)...
  12. ncbi request reprint Contribution of left ventricular diastolic dysfunction to heart failure regardless of ejection fraction
    Steffen Brucks
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 95:603-6. 2005
    ..50 is associated with mild systolic dysfunction and an increased ratio of left ventricular mass to EDVI. In HF with an ejection fraction </=0.40, systolic dysfunction and left ventricular dilation accompany diastolic dysfunction...
  13. ncbi request reprint Effect of the transmural extent of myocardial scar on left ventricular systolic wall thickening during intravenous dobutamine administration
    Pairoj Rerkpattanapipat
    Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 95:495-8. 2005
    ..The transmural extent of hyperenhancement correlated inversely with dobutamine SWT (r = -0.7, p <0.001). All segments with dobutamine SWT >/=2 mm showed a transmural extent of hyperenhancement of <50%...
  14. ncbi request reprint Diastolic mitral annular velocity during the development of heart failure
    Hiroshi Hasegawa
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Am Coll Cardiol 41:1590-7. 2003
    ..We sought to investigate the mechanism of reduced diastolic mitral annular velocity with diastolic dysfunction, despite elevated left atrial (LA) pressure...
  15. ncbi request reprint Contribution of systolic and diastolic abnormalities to heart failure with a normal and a reduced ejection fraction
    Hidekatsu Fukuta
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Prog Cardiovasc Dis 49:229-40. 2007
    ..The mechanism of the differing remodeling responses is not known, but aging, sex differences, and diabetes may contribute...
  16. ncbi request reprint Levosimendan improves LV systolic and diastolic performance at rest and during exercise after heart failure
    Hideo Tachibana
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    Am J Physiol Heart Circ Physiol 288:H914-22. 2005
    ..After CHF, LSM produced arterial vasodilatation; improved LV relaxation and diastolic filling; increased contractility, LV arterial coupling, and mechanical efficiency; and normalized the response to Ex...
  17. ncbi request reprint The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure
    William C Little
    Department of Internal Medicine, Cardiology Section, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Card Fail 11:191-5. 2005
    ..Despite its high prevalence, optimal therapy for diastolic heart failure (DHF) has not been determined. Alagebrium chloride (ALT-711) is a novel compound that breaks glucose crosslinks and may improve ventricular and arterial compliance...
  18. ncbi request reprint Usefulness of an elevated B-type natriuretic peptide in predicting survival in patients with aortic stenosis treated without surgery
    Matthew G Nessmith
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 96:1445-8. 2005
    ..In conclusion, elevated BNP indicates progressively worse survival in patients with AS treated medically. Thus, the measurement of BNP supplements the evaluation of symptoms in determining the prognoses of patients with AS...
  19. doi request reprint Orally available levosimendan dose-related positive inotropic and lusitropic effect in conscious chronically instrumented normal and heart failure dogs
    Satoshi Masutani
    Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    J Pharmacol Exp Ther 325:236-47. 2008
    ..Heart rate increased only after 0.1 mg/kg LS in normal dogs. In conclusion, oral LS produces vasodilatation and dose-dependent augmentation in LV contractility and relaxation both in normal and HF...
  20. ncbi request reprint Tachycardia exacerbates abnormal left ventricular-arterial coupling in heart failure
    Nobuyuki Ohte
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Heart Vessels 18:136-41. 2003
    ..05 ( P << 0.05). Under normal conditions, LV-arterial coupling remains optimal during increases in HR. After CHF, tachycardia exacerbates the suboptimal baseline LV-arterial coupling, reducing the efficiency of producing SW...
  21. ncbi request reprint Preprocedural white blood cell count and major adverse cardiac events late after percutaneous coronary intervention in saphenous vein grafts
    Bharathi Upadhya
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 96:515-8. 2005
    ..3% vs 72.4%; odds ratio 3.7; 95% confidence interval 2.2 to 6.3). Thus, an elevated preprocedural WBC count is associated with increased risk of MACEs in patients undergoing PCI for saphenous vein graft lesions...
  22. ncbi request reprint Allopurinol enhances the contractile response to dobutamine and exercise in dogs with pacing-induced heart failure
    T Ukai
    Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA
    Circulation 103:750-5. 2001
    ..In pacing-induced CHF, however, allopurinol improves LV systolic function at rest and during adrenergic stimulation and exercise...
  23. ncbi request reprint Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance
    W G Hundley
    Department of Internal Medicine, Cardiology Section, The Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Am Coll Cardiol 38:796-802. 2001
    ..The goal of this study was to determine if cardiac cycle-dependent changes in proximal thoracic aortic area and distensibility are associated with exercise intolerance in elderly patients with diastolic heart failure (DHF)...
  24. ncbi request reprint Propensity score analysis of vascular complications after diagnostic cardiac catheterization and percutaneous coronary intervention using thrombin hemostatic patch-facilitated manual compression
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    J Invasive Cardiol 19:164-70. 2007
    ..To evaluate the adjusted risk of vascular complications after thrombin hemostasis patch-facilitated manual compression (THP-MC) for femoral artery access site management...
  25. ncbi request reprint Diagnosis of diastolic heart failure
    Hidekatsu Fukuta
    Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Curr Cardiol Rep 9:224-8. 2007
    ..Thus, it is important to evaluate both systolic and diastolic function not only to differentiate between diastolic and systolic HF but also to identify high-risk patients...
  26. ncbi request reprint Comparison of drug-eluting versus bare metal stents on later frequency of acute myocardial infarction and death
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 99:333-8. 2007
    ....
  27. ncbi request reprint PCI with and without abciximab after upstream eptifibatide use: outcomes in high-risk patients
    Robert J Applegate
    Wake Forest University School of Medicine, Section of Cardiology, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    J Invasive Cardiol 18:604-13. 2006
    ..Whether abciximab can be used safely or effectively during PCI for high-risk patients after upstream treatment with eptifibatide in patients with acute coronary syndromes (ACS) is not known...
  28. ncbi request reprint Vascular complications in women after catheterization and percutaneous coronary intervention 1998-2005
    Robert J Applegate
    Wake Forest University School of Medicine, Section of Cardiology, Winston Salem, NC 27157 1045, USA
    J Invasive Cardiol 19:369-74. 2007
    ..Whether awareness of this gender risk or implementation of strategies to reduce the overall incidence of vascular complications has had an effect on the incidence of vascular complications in women is unknown...
  29. pmc Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial
    Dalane W Kitzman
    Cardiology Section, Department of Internal Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Circ Heart Fail 3:659-67. 2010
    ..Exercise training (ET) improves exercise intolerance and QOL in patients with HF with reduced ejection fraction (EF). However, the effect of ET in HFPEF has not been examined in a randomized controlled trial...
  30. doi request reprint Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial
    Michael R Zile
    RHJ Department of Veterans Affairs Medical Center and Medical University of South Carolina, Division of Cardiology, Department of Medicine, Charleston, SC 29425, USA
    Circulation 121:1393-405. 2010
    ....
  31. ncbi request reprint Peripartum cardiomyopathy presenting as diastolic heart failure
    Gretchen L Wells
    Section on Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Congest Heart Fail 14:52-4. 2008
  32. doi request reprint "Off-label" stent therapy 2-year comparison of drug-eluting versus bare-metal stents
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Am Coll Cardiol 51:607-14. 2008
    ..The aim was to compare 2-year outcomes with the routine use of drug-eluting stents (DES) (>75% "off-label") with a comparable group treated with bare-metal stents (BMS)...
  33. pmc A randomized double-blind trial of enalapril in older patients with heart failure and preserved ejection fraction: effects on exercise tolerance and arterial distensibility
    Dalane W Kitzman
    Cardiology Section, Department of Internal Medicine, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Circ Heart Fail 3:477-85. 2010
    ..Exercise intolerance is the primary symptom in older patients with heart failure and preserved ejection fraction (HFPEF); however, little is known regarding its mechanisms and therapy...
  34. doi request reprint Incidence of coronary stent thrombosis based on academic research consortium definitions
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 102:683-8. 2008
    ..Use of the ARC probable stent thrombosis paralleled rates of definite stent thrombosis alone, but partially masked the occurrence of late (>1 year) stent thrombosis in DESs compared with BMSs...
  35. doi request reprint Trends in vascular complications after diagnostic cardiac catheterization and percutaneous coronary intervention via the femoral artery, 1998 to 2007
    Robert J Applegate
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    JACC Cardiovasc Interv 1:317-26. 2008
    ..This study sought to evaluate trends in vascular complications after diagnostic cardiac catheterization (CATH) and percutaneous coronary intervention (PCI) from the femoral artery from 1998 to 2007...
  36. doi request reprint 3-year comparison of drug-eluting versus bare-metal stents
    Robert J Applegate
    Wake Forest University School of Medicine, Section of Cardiology, Winston Salem, North Carolina 27157 1045, USA
    JACC Cardiovasc Interv 2:231-9. 2009
    ....
  37. doi request reprint Effect of length and diameter of drug-eluting stents versus bare-metal stents on late outcomes
    Robert J Applegate
    Wake Forest University School of Medicine, Section of Cardiology, Winston Salem, NC 27157 1045, USA
    Circ Cardiovasc Interv 2:35-42. 2009
    ..Drug-eluting stents (DES) may reduce this effect in select patients; however, whether this benefit occurs in high-risk lesions and patients in routine practice is not clear...
  38. ncbi request reprint Culprit vessel PCI versus traditional cath and PCI for STEMI
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1045, USA
    J Invasive Cardiol 20:224-8. 2008
    ....
  39. ncbi request reprint Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy
    Che Ping Cheng
    Cardiology Section, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Circulation 114:226-36. 2006
    ..We evaluated the effect of angiotensin II (Ang II) type 1 receptor (AT1) blockade on the development of alcoholic cardiomyopathy...
  40. ncbi request reprint Endogenous beta3-adrenoreceptor activation contributes to left ventricular and cardiomyocyte dysfunction in heart failure
    Atsushi Morimoto
    Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Am J Physiol Heart Circ Physiol 286:H2425-33. 2004
    ..Stimulation of beta(3)-AR by endogenous catecholamine contributes to the depression of LV contraction and relaxation in CHF...
  41. ncbi request reprint Late outcomes after intervention of vein grafts in diabetics with abciximab use
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Int J Cardiol 111:136-41. 2006
    ..We sought to evaluate late clinical outcomes following elective percutaneous coronary interventions for saphenous vein graft with planned abciximab use in diabetics...
  42. ncbi request reprint Relation of cardiac prognosis to segment location with apical left ventricular ischemia
    W Gregory Hundley
    Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    Am J Cardiol 92:1206-8. 2003
    ..In this study, we find this heightened risk is present independent of the location of the distal segment within the left ventricular apex...
  43. ncbi request reprint Feasibility to detect severe coronary artery stenoses with upright treadmill exercise magnetic resonance imaging
    Pairoj Rerkpattanapipat
    Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Cardiol 92:603-6. 2003
    ..The sensitivity and specificity for detecting >70% coronary artery luminal diameter narrowings on contrast coronary angiography were 79% and 85%, respectively...
  44. ncbi request reprint Restick following initial Angioseal use
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Catheter Cardiovasc Interv 58:181-4. 2003
    ..There were no major bleeding, vascular repair, vessel occlusion, or embolizations. Three large hematomas (1.7%) were noted. These data suggest that restick can be performed safely after initial Angioseal deployment...
  45. ncbi request reprint Restenosis of a sirolimus drug-eluting stent: aorto-ostial involvement of the proximal right coronary artery
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Catheter Cardiovasc Interv 67:391-5. 2006
    ..We discuss issues relevant to management of the restenotic drug-eluting stent in the aorto-ostial location...
  46. ncbi request reprint Vascular complications with newer generations of angioseal vascular closure devices
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Interv Cardiol 19:67-74. 2006
    ..To evaluate the safety and efficacy of newer generations of a single vascular closure device (VCD), Angioseal, compared to contemporaneous manual compression...
  47. ncbi request reprint Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure
    Dalane W Kitzman
    Section of Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045
    JAMA 288:2144-50. 2002
    ..However, the pathophysiology of this disorder, presumptively termed diastolic heart failure (DHF), is not well characterized and it is unknown whether it represents true heart failure...
  48. ncbi request reprint Propensity score analysis of vascular complications after diagnostic cardiac catheterization and percutaneous coronary intervention 1998-2003
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    Catheter Cardiovasc Interv 67:556-62. 2006
    ..To evaluate the adjusted risk of vascular complications after manual compression and vascular closure devices for femoral artery access site management in a large contemporary cohort, using propensity score analysis...
  49. ncbi request reprint Vascular closure devices in patients treated with anticoagulation and IIb/IIIa receptor inhibitors during percutaneous revascularization
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Am Coll Cardiol 40:78-83. 2002
    ..The study assessed clinical outcomes of closure device use following percutaneous coronary revascularization using current standards of anticoagulation and antiplatelet therapy...
  50. ncbi request reprint The cardiovascular effects of erythropoietin
    Kyle J Smith
    Section of Cardiology, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Cardiovasc Res 59:538-48. 2003
    ..Further studies are warranted to define the role of rHuEpo in chronic heart failure and other cardiovascular settings...
  51. ncbi request reprint Relation of anemia to diastolic heart failure and the effect on outcome
    Steffen Brucks
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 93:1055-7. 2004
    ..We found that anemia is common in these patients and is associated with greater elevations in serum B-type natriuretic peptide, more severe diastolic dysfunction, and a worse prognosis...
  52. ncbi request reprint Elevated left ventricular filling pressure after maximal exercise predicts increased plasma B-type natriuretic peptide levels in patients with impaired relaxation pattern of diastolic filling
    Hidekatsu Fukuta
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Am Soc Echocardiogr 20:832-7. 2007
    ..In conclusion, elevated left ventricular filling pressure after maximal exercise predicts increased BNP levels in patients with impaired relaxation pattern...
  53. ncbi request reprint Contribution of right-sided heart enlargement to cardiomegaly on chest roentgenogram in diastolic and systolic heart failure
    Hidekatsu Fukuta
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Cardiol 99:62-7. 2007
    ..Thus, despite the substantial difference in left ventricular size and EF, there is substantial overlap in the CTR between patients with diastolic and systolic HFs and the CTR is unable to discriminate between groups...
  54. ncbi request reprint Statin therapy may be associated with lower mortality in patients with diastolic heart failure: a preliminary report
    Hidekatsu Fukuta
    Cardiology Section, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1045, USA
    Circulation 112:357-63. 2005
    ..No therapy has been shown to improve survival in heart failure (HF) with a normal ejection fraction (EF). There are plausible reasons to hypothesize that statins may be of benefit in HF with a normal EF...
  55. doi request reprint Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone
    Satoshi Masutani
    Cardiology Section, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1045, USA
    Circulation 117:1550-4. 2008
    ..We investigated whether the LV restrictive filling pattern is due to elevated LA pressure alone...
  56. ncbi request reprint Current treatment and future directions in heart failure
    Gretchen Wells
    Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Curr Opin Pharmacol 2:148-53. 2002
    ..Despite this treatment, however, mortality from heart failure remains high. Current investigation is now focused on other pathophysiological mechanisms and the interruption of these pathways...
  57. doi request reprint Acute heart failure with preserved systolic function
    Rahul Kumar
    Cardiology Section, Department of Internal Medicine, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Crit Care Med 36:S52-6. 2008
    ..Strict control of hypertension appears to be of paramount importance. Angiotensin-converting enzyme inhibitors or receptor blockers may be of benefit in preventing repeat hospitalizations...
  58. ncbi request reprint Evaluation of diastolic function
    R J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Catheter Cardiovasc Interv 53:85-93. 2001
    ..Moreover, understanding the physiology of diastolic performance remains essential to proper diagnosis and management...
  59. ncbi request reprint Diastolic dysfunction beyond distensibility: adverse effects of ventricular dilatation
    William C Little
    Circulation 112:2888-90. 2005
  60. ncbi request reprint Diastolic heart failure can be diagnosed by comprehensive two-dimensional and Doppler echocardiography
    Jae K Oh
    Mayo Clinic College of Medicine, Echocardiography Laboratory, Division of Cardiology, Rochester, Minnesota 55905 0001, USA
    J Am Coll Cardiol 47:500-6. 2006
    ..Early identification of diastolic dysfunction in asymptomatic patients by the use of echocardiography may provide an opportunity to manage the underlying etiology to prevent progression to diastolic heart failure...
  61. pmc The cardiac cycle and the physiologic basis of left ventricular contraction, ejection, relaxation, and filling
    Hidekatsu Fukuta
    Nagoya City University, Nagoya, Japan
    Heart Fail Clin 4:1-11. 2008
    ....
  62. ncbi request reprint Can left ventricular diastolic stiffness be measured noninvasively?
    Paolo Marino
    Cardiology Service, Policlinico G B Rossi, Division of Cardiology, Ospedale Maggiore, University of Verona, P le L A Scuro 10, 37134 Verona, Italy
    J Am Soc Echocardiogr 15:935-43. 2002
    ..We assessed the accuracy of this noninvasive estimate of K(lv) by comparing it with invasive measurement of K(lv) in intact patients with a wide range of LV size and function under varying loading conditions...
  63. ncbi request reprint Development and validation of a risk score for predicting death in Chagas' heart disease
    Anis Rassi
    Division of Cardiology, Anis Rassi Hospital, Goiania, Brazil
    N Engl J Med 355:799-808. 2006
    ..Chagas' disease is an important health problem in Latin America, and cardiac involvement is associated with substantial morbidity and mortality. We developed a model to predict the risk of death in patients with Chagas' heart disease...
  64. ncbi request reprint Assessment of left ventricular diastolic function and recognition of diastolic heart failure
    William H Gaasch
    Circulation 116:591-3. 2007
  65. doi request reprint Observational studies of statins in heart failure with preserved systolic function
    Hidekatsu Fukuta
    Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Heart Fail Clin 4:209-16. 2008
    ..Until the results of such studies are available, it is recommended to use statins in patients with diastolic heart failure who otherwise have an indication for statin therapy...
  66. doi request reprint Assay to mechanically tune and optically probe fibrillar fibronectin conformations from fully relaxed to breakage
    William C Little
    Department of Materials, ETH Zurich, CH 8093, Zurich, Switzerland
    Matrix Biol 27:451-61. 2008
    ..Finally, cryptic sites for fibronectin's N-terminal 70-kD fragment were found to be exposed at relatively low strain, demonstrating the assay's potential to analyze stretch-regulated protein-protein interactions...
  67. ncbi request reprint Early mitral deceleration and left atrial stiffness
    Paolo Marino
    Cardiology Service, Policlinico G B Rossi, University of Verona, Verona 37134, Italy
    Am J Physiol Heart Circ Physiol 287:H1172-8. 2004
    ..32 mmHg/ml. In conclusion, notwithstanding the significant decrement in LA volume, KLA does not change and can be considered not different from zero during DT. Thus KLA does not affect the estimation of KLV from Doppler parameters...