Claudine Legault

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Effects of tamoxifen and raloxifene on memory and other cognitive abilities: cognition in the study of tamoxifen and raloxifene
    Claudine Legault
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Clin Oncol 27:5144-52. 2009
  2. pmc Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot (SHARP-P) study, a randomized controlled trial
    Claudine Legault
    Division of Public Health Sciences, Department of Biostatistical Sciences Wachovia 21st floor, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    BMC Geriatr 11:27. 2011
  3. ncbi request reprint Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, North Carolina 27109, USA
    JAMA 310:1263-73. 2013
  4. pmc Validation of a cognitive assessment battery administered over the telephone
    Stephen R Rapp
    Department of Psychiatry and Behavioral Medicine, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 60:1616-23. 2012
  5. pmc Telephone interview for cognitive status (TICS) screening for clinical trials of physical activity and cognitive training: the seniors health and activity research program pilot (SHARP-P) study
    Mark A Espeland
    Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Int J Geriatr Psychiatry 26:135-43. 2011
  6. ncbi request reprint Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study
    Sally A Shumaker
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    JAMA 291:2947-58. 2004
  7. pmc Positive and negative affect, depression, and cognitive processes in the Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR) Trial
    Suzanne C Danhauer
    Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157 1063, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 20:532-52. 2013
  8. doi request reprint Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS)
    Laura H Coker
    Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Steroid Biochem Mol Biol 118:304-10. 2010
  9. pmc Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women's Health Initiative study of cognitive aging extension
    Mark A Espeland
    Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Am Geriatr Soc 58:1263-71. 2010
  10. ncbi request reprint Physical activity and physical function in older adults with knee osteoarthritis
    Elizabeth Chmelo
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Dept of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC
    J Phys Act Health 10:777-83. 2013

Detail Information

Publications26

  1. pmc Effects of tamoxifen and raloxifene on memory and other cognitive abilities: cognition in the study of tamoxifen and raloxifene
    Claudine Legault
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Clin Oncol 27:5144-52. 2009
    ..To compare the effects of two selective estrogen receptor modulators, tamoxifen and raloxifene, on global and domain-specific cognitive function...
  2. pmc Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot (SHARP-P) study, a randomized controlled trial
    Claudine Legault
    Division of Public Health Sciences, Department of Biostatistical Sciences Wachovia 21st floor, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    BMC Geriatr 11:27. 2011
    ..Before definitive trials are mounted, important design questions on participation/adherence, training and interventions effects must be answered to more fully inform a full-scale trial...
  3. ncbi request reprint Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, North Carolina 27109, USA
    JAMA 310:1263-73. 2013
    ..Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity...
  4. pmc Validation of a cognitive assessment battery administered over the telephone
    Stephen R Rapp
    Department of Psychiatry and Behavioral Medicine, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 60:1616-23. 2012
    ..To evaluate the validity and reliability of a cognitive test battery and questionnaires administered by telephone...
  5. pmc Telephone interview for cognitive status (TICS) screening for clinical trials of physical activity and cognitive training: the seniors health and activity research program pilot (SHARP-P) study
    Mark A Espeland
    Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Int J Geriatr Psychiatry 26:135-43. 2011
    ..To examine the performance of the Telephone Interview for Cognitive Status (TICS) for identifying participants appropriate for trials of physical activity and cognitive training interventions...
  6. ncbi request reprint Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study
    Sally A Shumaker
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    JAMA 291:2947-58. 2004
    ..The Women's Health Initiative Memory Study (WHIMS) previously found increased risk for dementia and no effect on mild cognitive impairment (MCI) in women treated with conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA)...
  7. pmc Positive and negative affect, depression, and cognitive processes in the Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR) Trial
    Suzanne C Danhauer
    Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157 1063, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 20:532-52. 2013
    ..This study examined the relationship between positive and negative affect, depressive symptoms, and cognitive performance...
  8. doi request reprint Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS)
    Laura H Coker
    Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Steroid Biochem Mol Biol 118:304-10. 2010
    ..05); frontal lobe (P=0.004); and total brain (P=0.07). HT-associated reductions in hippocampal volumes were greatest in women with baseline 3MS scores < or = 90...
  9. pmc Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women's Health Initiative study of cognitive aging extension
    Mark A Espeland
    Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Am Geriatr Soc 58:1263-71. 2010
    ..To determine whether small decrements in global cognitive function that conjugated equine estrogen (CEE) therapies have been shown to produce in older women persist after cessation and extend to specific cognitive domains...
  10. ncbi request reprint Physical activity and physical function in older adults with knee osteoarthritis
    Elizabeth Chmelo
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Dept of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC
    J Phys Act Health 10:777-83. 2013
    ..5 ± 3.8 kg/m2), sedentary (less than 30 mins of activity, 3 days a week) individuals with knee osteoarthritis...
  11. pmc Subtypes of mild cognitive impairment in older postmenopausal women: the Women's Health Initiative Memory Study
    Stephen R Rapp
    Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Alzheimer Dis Assoc Disord 24:248-55. 2010
    ..Further research is needed on the epidemiology of MCI subtypes, clinical and biologic differences between them, and rates for conversion to dementia...
  12. ncbi request reprint Physical activity and physical function in older adults with knee osteoarthritis
    Elizabeth Chmelo
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Dept of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC
    J Phys Act Health 10:777-83. 2012
    ..Conclusions: This study demonstrates that a population who has higher levels of spontaneous activity have better overall physical function than those who engage in less activity. ..
  13. ncbi request reprint Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial
    Sally A Shumaker
    Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27104, USA
    JAMA 289:2651-62. 2003
    ..On July 8, 2002, the study drugs, estrogen plus progestin, in the Women's Health Initiative (WHI) trial were discontinued because of certain increased health risks in women receiving combined hormone therapy...
  14. ncbi request reprint Follow-up care for infants with chronic lung disease: a randomized comparison of community- and center-based models
    T MICHAEL O'SHEA
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Pediatrics 119:e947-57. 2007
    ..The purpose of this work was to compare community-based follow-up, provided via telephone contacts, to traditional center-based follow-up of premature infants with chronic lung disease...
  15. ncbi request reprint Low plasma concentrations of retinol and alpha-tocopherol in hematopoietic stem cell transplant recipients: the effect of mucositis and the risk of infection
    Kevin P High
    Sections of Infectious Diseases and of Hematology and Oncology and the Comprehensive Cancer Center, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1042, USA
    Am J Clin Nutr 76:1358-66. 2002
    ..Although vitamin deficiencies are rare in the United States, acute reductions in concentrations of plasma retinol (vitamin A) or alpha-tocopherol (vitamin E) have been associated with impaired immune responses in some clinical settings...
  16. ncbi request reprint Soy protein and isoflavone effects on vasomotor symptoms in peri- and postmenopausal women: the Soy Estrogen Alternative Study
    Gregory L Burke
    Departments of Public Health Sciences, Pathology, and Obstetrics and Gynecology, Wake Forest University School of Medicine, and Lyndhurst Gynecology Associates, Winston Salem, NC 27157, USA
    Menopause 10:147-53. 2003
    ..To investigate the efficacy of dietary soy proteins containing differing amounts of isoflavones on the number and severity of vasomotor symptoms (hot flashes and night sweats) in peri- and postmenopausal women...
  17. doi request reprint Risk factors and mechanisms of knee injury in runners
    Stephen P Messier
    J B Snow Biomechanics Laboratory, Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Med Sci Sports Exerc 40:1873-9. 2008
    ..5 million running at least 100 d x yr(-1). Although running injuries are well understood medically, their potential risk factors are not. Thus, we presently have limited ability to identify individuals at high risk for overuse injuries...
  18. ncbi request reprint Perception of child vulnerability among mothers of former premature infants
    Elizabeth C Allen
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27103, USA
    Pediatrics 113:267-73. 2004
    ..The objectives of this study were to determine whether higher PPCV is correlated with worse developmental outcome in premature infants at 1-year adjusted age and to identify factors, present at neonatal discharge, that predict high PPCV...
  19. pmc The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA
    BMC Musculoskelet Disord 10:93. 2009
    ..This article describes the intervention, the empirical evidence to support it, and test-retest reliability data...
  20. ncbi request reprint Baseline health-related quality of life in postmenopausal women with coronary heart disease: the Estrogen Replacement and Atherosclerosis (ERA) trial
    Aurora M Sherman
    Department of Public Health Services, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    J Womens Health (Larchmt) 12:351-62. 2003
    ..This study examined the baseline health-related quality of life (HRQL) of 301 postmenopausal women with heart disease enrolled in the Estrogen Replacement and Atherosclerosis (ERA) trial...
  21. ncbi request reprint Caloric restriction does not reverse aging-related changes in hippocampal BDNF
    Isabel G Newton
    Department of Neurobiology, Medical Center Boulevard, Winston Salem, NC 27157 1010, USA
    Neurobiol Aging 26:683-8. 2005
    ..Furthermore, if CRs attenuation of aging-related memory changes is mediated by BDNF, then it must be through a small, CA1-specific increase and does not involve reversal of an aging-related decline in BDNF...
  22. doi request reprint Intervening on spontaneous physical activity to prevent weight regain in older adults: design of a randomized, clinical trial
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, J Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, United States
    Contemp Clin Trials 33:450-5. 2012
    ....
  23. doi request reprint A randomized, controlled pilot study of acupuncture treatment for menopausal hot flashes
    Nancy E Avis
    Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1063, USA
    Menopause 15:1070-8. 2008
    ..To investigate the feasibility of conducting a randomized trial of the effect of acupuncture in decreasing hot flashes in peri- and postmenopausal women...
  24. ncbi request reprint Creation of a grant support service within a Women's Health Center of Excellence: experiences and lessons learned
    Karen Potvin Klein
    Office of Research, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Womens Health (Larchmt) 15:127-34. 2006
    ....
  25. ncbi request reprint Attempted control of hyperglycemia during cardiopulmonary bypass fails to improve neurologic or neurobehavioral outcomes in patients without diabetes mellitus undergoing coronary artery bypass grafting
    John Butterworth
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    J Thorac Cardiovasc Surg 130:1319. 2005
    ....
  26. ncbi request reprint Intraoperative insulin therapy does not reduce the need for inotropic or antiarrhythmic therapy after cardiopulmonary bypass
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Cardiothorac Vasc Anesth 16:405-12. 2002
    ..To determine whether attempted glucose control through intraoperative insulin therapy reduces the need for inotropic or antiarrhythmic therapy after cardiopulmonary bypass (CPB)...