D Laxminarayana

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes
    D Laxminarayana
    Section on Rheumatology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 162:5639-48. 1999
  2. ncbi Transcript mutations of the alpha regulatory subunit of protein kinase A and up-regulation of the RNA-editing gene transcript in lupus T lymphocytes
    Dama Laxminarayana
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Lancet 360:842-9. 2002
  3. pmc Altered editing in RNA editing adenosine deaminase ADAR2 gene transcripts of systemic lupus erythematosus T lymphocytes
    Dama Laxminarayana
    Section on Rheumatology and Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunology 121:359-69. 2007
  4. pmc Induction of 150-kDa adenosine deaminase that acts on RNA (ADAR)-1 gene expression in normal T lymphocytes by anti-CD3-epsilon and anti-CD28
    Dama Laxminarayana
    Section on Rheumatology and Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunology 122:623-33. 2007
  5. ncbi Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production
    I U Khan
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    J Immunol 166:7600-5. 2001
  6. ncbi Mechanisms of deficient type I protein kinase A activity in lupus T lymphocytes
    Gary M Kammer
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Int Rev Immunol 23:225-44. 2004

Research Grants

  1. Mutations in PKA gene transcripts of lupus T cells
    Dama Laxminarayana; Fiscal Year: 2007

Detail Information

Publications6

  1. ncbi Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes
    D Laxminarayana
    Section on Rheumatology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 162:5639-48. 1999
    ..In conclusion, reduced expression of RIalpha and RIbeta transcripts is associated with a decrement in RIalpha and RIbeta proteins and may contribute to deficient type I protein kinase A isozyme activity in SLE T cells...
  2. ncbi Transcript mutations of the alpha regulatory subunit of protein kinase A and up-regulation of the RNA-editing gene transcript in lupus T lymphocytes
    Dama Laxminarayana
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Lancet 360:842-9. 2002
    ..We aimed to identify a molecular mechanism or mechanisms for this isozyme deficiency by assessing occurrence of mutations in transcripts of the RI alpha subunit in patients with SLE...
  3. pmc Altered editing in RNA editing adenosine deaminase ADAR2 gene transcripts of systemic lupus erythematosus T lymphocytes
    Dama Laxminarayana
    Section on Rheumatology and Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunology 121:359-69. 2007
    ..Based on these results, it is proposed that altered transcript editing contributes to the modulation of gene expression and immune functions in SLE patients...
  4. pmc Induction of 150-kDa adenosine deaminase that acts on RNA (ADAR)-1 gene expression in normal T lymphocytes by anti-CD3-epsilon and anti-CD28
    Dama Laxminarayana
    Section on Rheumatology and Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunology 122:623-33. 2007
    ....
  5. ncbi Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production
    I U Khan
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    J Immunol 166:7600-5. 2001
    ..These data demonstrate that a disorder of RIbeta translation exists, and that correction of the PKA-I deficiency may enhance T lymphocyte effector functions in SLE...
  6. ncbi Mechanisms of deficient type I protein kinase A activity in lupus T lymphocytes
    Gary M Kammer
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Int Rev Immunol 23:225-44. 2004
    ..Most mutations are clustered adjacent to GAGAG motifs and CT repeats. In conclusion, aberrant signaling via the cAMP/PKA pathway occurs in SLE T cells, and this is proposed to contribute to abnormal T cell effector functions...

Research Grants5

  1. Mutations in PKA gene transcripts of lupus T cells
    Dama Laxminarayana; Fiscal Year: 2007
    ..abstract_text> ..