Steven Kridel

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Fatty acid synthase inhibitors: new directions for oncology
    Steven J Kridel
    Wake Forest University School of Medicine, Department of Cancer Biology, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Expert Opin Investig Drugs 16:1817-29. 2007
  2. ncbi request reprint Dietary fat-gene interactions in cancer
    Yong Q Chen
    Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Cancer Metastasis Rev 26:535-51. 2007
  3. doi request reprint Fatty acid synthase activity in tumor cells
    Joy L Little
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University of Medicine, Winston Salem, NC 27157, USA
    Subcell Biochem 49:169-94. 2008
  4. ncbi request reprint Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat
    Charles W Pemble
    Center for Structural Biology and Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Struct Mol Biol 14:704-9. 2007
  5. pmc Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death
    Joy L Little
    Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, USA
    Mol Cancer Ther 7:3816-24. 2008
  6. ncbi request reprint Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells
    Joy L Little
    Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Res 67:1262-9. 2007
  7. ncbi request reprint S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
    Zezong Gu
    Center for Neuroscience and Aging, Program in Cell Adhesion and Extracellular Matrix Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 297:1186-90. 2002
  8. ncbi request reprint Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity
    Steven J Kridel
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cancer Res 64:2070-5. 2004
  9. doi request reprint 1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer
    Amy L Vavere
    Division of Radiological Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 49:327-34. 2008

Research Grants

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Fatty acid synthase inhibitors: new directions for oncology
    Steven J Kridel
    Wake Forest University School of Medicine, Department of Cancer Biology, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Expert Opin Investig Drugs 16:1817-29. 2007
    ..This review outlines the preclinical development of FASN inhibitors, their antitumor effects and the strategies underway to develop novel inhibitors...
  2. ncbi request reprint Dietary fat-gene interactions in cancer
    Yong Q Chen
    Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Cancer Metastasis Rev 26:535-51. 2007
    ..The purpose of this review is to present a more cohesive view of dietary fat-gene interactions, and outline a working hypothesis of the intricate connection between fat, genes and cancer...
  3. doi request reprint Fatty acid synthase activity in tumor cells
    Joy L Little
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University of Medicine, Winston Salem, NC 27157, USA
    Subcell Biochem 49:169-94. 2008
    ..Pharmacological blockade of FASN activity has identified a pleiotropic role for FASN in mediating aspects of proliferation, growth and survival. As a result, a clearer understanding of the role of FASN in tumor cells has been developed...
  4. ncbi request reprint Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat
    Charles W Pemble
    Center for Structural Biology and Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Struct Mol Biol 14:704-9. 2007
    ..Our findings provide a foundation for the development of new cancer drugs that target FAS...
  5. pmc Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death
    Joy L Little
    Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, USA
    Mol Cancer Ther 7:3816-24. 2008
    ..Combined, the data support the concept that the UPR balance between adaptive to stress signaling can be exploited to mediate increased cell death and suggests novel applications of FASN inhibitors for clinical use...
  6. ncbi request reprint Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells
    Joy L Little
    Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Res 67:1262-9. 2007
    ..These results provide the first evidence that FAS inhibitors induce ER stress and establish an important mechanistic link between FAS activity and ER function...
  7. ncbi request reprint S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
    Zezong Gu
    Center for Neuroscience and Aging, Program in Cell Adhesion and Extracellular Matrix Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 297:1186-90. 2002
    ..These findings suggest a potential extracellular proteolysis pathway to neuronal cell death in which S-nitrosylation activates MMPs, and further oxidation results in a stable posttranslational modification with pathological activity...
  8. ncbi request reprint Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity
    Steven J Kridel
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cancer Res 64:2070-5. 2004
    ..By virtue of its ability to inhibit fatty acid synthase, Orlistat halts tumor cell proliferation, induces tumor cell apoptosis, and inhibits the growth of PC-3 tumors in nude mice...
  9. doi request reprint 1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer
    Amy L Vavere
    Division of Radiological Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 49:327-34. 2008
    ..Fatty acid synthase (FAS) has been found to be overexpressed in prostate carcinomas, as well as other cancers, and it is possible that imaging with 1-(11)C-acetate could be a marker for its expression...

Research Grants5

  1. Fatty acid synthase inhibitors and prostate cancer
    Steven Kridel; Fiscal Year: 2007
    ..The proposed crystal structures will be instrumental to the rational design of analogs of orlistat with improved target specificity, bioavailability, and pharmacokinetics for the treatment of a variety of cancers. ..
  2. Fatty acid synthase inhibitors and prostate cancer
    Steven J Kridel; Fiscal Year: 2010
    ..The proposed crystal structures will be instrumental to the rational design of analogs of orlistat with improved target specificity, bioavailability, and pharmacokinetics for the treatment of a variety of cancers. ..