John Knight

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease
    Nikki Johnston
    Center for Voice and Swallowing Disorders, Department of Otolaryngology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1034, U S A
    Laryngoscope 114:2129-34. 2004
  2. pmc Intestinal and renal handling of oxalate loads in normal individuals and stone formers
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Urol Res 35:111-7. 2007
  3. pmc Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometry
    John Knight
    Department of Urology, Wake Forest University Medical Center, Winston Salem, NC 27157, USA
    Anal Biochem 421:121-4. 2012
  4. pmc Metabolism of fructose to oxalate and glycolate
    J Knight
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Horm Metab Res 42:868-73. 2010
  5. ncbi request reprint Mitochondrial hydroxyproline metabolism: implications for primary hyperoxaluria
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Nephrol 25:171-5. 2005
  6. pmc Metabolism of primed, constant infusions of [1,2-¹³C₂] glycine and [1-¹³C₁] phenylalanine to urinary oxalate
    John Knight
    Department of Urology, Wake Forest University Medical Center, Winston Salem, NC 27157, USA
    Metabolism 60:950-6. 2011
  7. pmc Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Nephrol Dial Transplant 21:2292-5. 2006
  8. pmc Hydroxyproline ingestion and urinary oxalate and glycolate excretion
    J Knight
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Kidney Int 70:1929-34. 2006
  9. pmc Increased protein intake on controlled oxalate diets does not increase urinary oxalate excretion
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Urol Res 37:63-8. 2009
  10. doi request reprint The impact of dietary calcium and oxalate ratios on stone risk
    Jessica N Lange
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Urology 79:1226-9. 2012

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease
    Nikki Johnston
    Center for Voice and Swallowing Disorders, Department of Otolaryngology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1034, U S A
    Laryngoscope 114:2129-34. 2004
    ..The objective was to investigate the potential use of pepsin and carbonic anhydrase isoenzyme III (CA-III) as diagnostic markers for laryngopharyngeal reflux disease...
  2. pmc Intestinal and renal handling of oxalate loads in normal individuals and stone formers
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Urol Res 35:111-7. 2007
    ..This enhanced absorption of oxalate warrants further characterization...
  3. pmc Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometry
    John Knight
    Department of Urology, Wake Forest University Medical Center, Winston Salem, NC 27157, USA
    Anal Biochem 421:121-4. 2012
    ..Low concentrations of glycolate (12-48 nmol/g) and PG (4-17 nmol/g) were detected in all tissues. The availability of this IC-MS assay will facilitate investigations of the origin, function, and metabolism of glycolate and PG in tissues...
  4. pmc Metabolism of fructose to oxalate and glycolate
    J Knight
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Horm Metab Res 42:868-73. 2010
    ..4 ± 0.9%. Our results suggest that mechanisms for stone risk associated with fructose intake may lie in factors other than those affecting the major stone risk parameters in urine...
  5. ncbi request reprint Mitochondrial hydroxyproline metabolism: implications for primary hyperoxaluria
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Nephrol 25:171-5. 2005
    ..The metabolism that leads to glyoxylate synthesis is not well defined. The aim of this study was to investigate the production of glyoxylate in liver mitochondria when they metabolize hydroxyproline...
  6. pmc Metabolism of primed, constant infusions of [1,2-¹³C₂] glycine and [1-¹³C₁] phenylalanine to urinary oxalate
    John Knight
    Department of Urology, Wake Forest University Medical Center, Winston Salem, NC 27157, USA
    Metabolism 60:950-6. 2011
    ..These data suggest that glycine and phenylalanine metabolism make only minor contributions to oxalate synthesis and urinary oxalate excretion...
  7. pmc Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Nephrol Dial Transplant 21:2292-5. 2006
    ..In this study, we have evaluated the potential of determining GR and d-glycerate dehydrogenase (DGDH) activity in blood mononuclear cells (BMC) as a diagnostic indicator of PH2...
  8. pmc Hydroxyproline ingestion and urinary oxalate and glycolate excretion
    J Knight
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Kidney Int 70:1929-34. 2006
    ..Our results also revealed that the kidney absorbs significant quantities of hydroxyproline and glycolate, and their metabolism to oxalate in this tissue warrants further consideration...
  9. pmc Increased protein intake on controlled oxalate diets does not increase urinary oxalate excretion
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Urol Res 37:63-8. 2009
    ..This is most likely due to hyperfiltration. These results indicate that as dietary protein intake increases, the catabolism of diet-derived amino acids is not associated with an increased endogenous oxalate synthesis in normal subjects...
  10. doi request reprint The impact of dietary calcium and oxalate ratios on stone risk
    Jessica N Lange
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Urology 79:1226-9. 2012
    ..To determine whether the ratio of dietary calcium and oxalate consumption at mealtime affects gastrointestinal oxalate absorption and urinary oxalate excretion...
  11. pmc 4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition
    Travis J Riedel
    Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, NC, USA
    Biochim Biophys Acta 1822:1544-52. 2012
    ..Thus, one hypothetical component of the molecular basis for the excessive oxalate production in PH3 appears to be the inhibition of GR by HOG, resulting in a phenotype similar to PH2...
  12. pmc Sensitivity of human strains of Oxalobacter formigenes to commonly prescribed antibiotics
    Jessica N Lange
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Urology 79:1286-9. 2012
    ..Oxf gut colonization has been associated with a decreased risk of forming recurrent calcium oxalate kidney stones...
  13. pmc Metabolism of [13C5]hydroxyproline in vitro and in vivo: implications for primary hyperoxaluria
    Juquan Jiang
    Department of Urology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Gastrointest Liver Physiol 302:G637-43. 2012
    ..These model systems should be valuable tools for exploring various aspects of Hyp metabolism and will be useful in determining whether blocking Hyp catabolism is an effective therapy in the treatment of primary hyperoxaluria...
  14. pmc The genetic composition of Oxalobacter formigenes and its relationship to colonization and calcium oxalate stone disease
    John Knight
    Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA
    Urolithiasis 41:187-96. 2013
    ..Elaborating the functional roles of these genes should accelerate our understanding of the organism and clarify its role in preventing stone formation...
  15. pmc Hydroxyproline metabolism in mouse models of primary hyperoxaluria
    John Knight
    Dept of Urology, Wake Forest Univ Health Sciences, Winston Salem, NC 27157, USA
    Am J Physiol Renal Physiol 302:F688-93. 2012
    ..As Hyp catabolism may make a major contribution to the oxalate produced in PH patients, Hyp feeding in these mouse models should be useful in understanding the mechanisms associated with calcium oxalate deposition in the kidney...
  16. pmc Oxalate and sucralose absorption in idiopathic calcium oxalate stone formers
    John Knight
    Department of Urology, Wake Forest University Medical Center, Winston Salem, NC 27157, USA
    Urology 78:475.e9-475.e13. 2011
    ..Oxalate has been hypothesized to undergo absorption in the large and small intestine by both paracellular and transepithelial transport. Sucralose is a chlorinated sugar that is absorbed by paracellular mechanisms...
  17. doi request reprint The effects of Oxazyme on oxalate degradation: results and implications of in vitro experiments
    Patrick W Mufarrij
    Department of Urology, Wake Forest University Baptist Medical Center, Winston Salem, NC, USA
    J Endourol 27:284-7. 2013
    ..Conclusions: These in vitro findings demonstrate that Oxazyme can metabolize oxalate in both simulated gastric and small intestinal environments...
  18. pmc Variability of Oxalobacter formigenes and oxalate in stool samples
    Sergey Prokopovich
    Department of Urology, Wake Forest University Medical School, Winston Salem, North Carolina 27157, USA
    J Urol 178:2186-90. 2007
    ..Because the oxalate content of the diet varies considerably, we hypothesized that the number of O. formigenes and amount of oxalate would vary in feces...
  19. ncbi request reprint Internet program for facilitating dietary modifications limiting kidney stone risk
    Jessica N Lange
    Wake Forest University Baptist Hospital, Winston Salem, North Carolina, USA
    Can J Urol 20:6922-6. 2013
    ..We developed an internet program to facilitate dietary compliance for stone prevention and performed a pilot study to assess its effectiveness...
  20. pmc Glyoxal formation and its role in endogenous oxalate synthesis
    Jessica N Lange
    Department of Urology, Wake Forest University Medical Center, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Adv Urol 2012:819202. 2012
    ..Endogenous sources of glyoxal include the catabolism of carbohydrates, proteins, and fats. Here, we review all the known sources of glyoxal as well as its relationship to oxalate synthesis and crystal formation...
  21. pmc Effect of soda consumption on urinary stone risk parameters
    Corey M Passman
    Division of Urology, Department of Surgery, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
    J Endourol 23:347-50. 2009
    ..Diet was not always controlled in these investigations, however. We undertook a study to determine the impact of three different fluids on urinary stone risk factors...
  22. doi request reprint Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study
    Robert M Mentzer
    Wayne State University School of Medicine, 540 East Canfield, 1241 Scott Hall, Detroit, MI 48201, USA
    Ann Thorac Surg 85:1261-70. 2008
    ..The premise was that inhibition of NHE-1 limits intracellcular Na accumulation and thereby limits Na/Ca-exchanger-mediated calcium overload to reduce infarct size...
  23. ncbi request reprint Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux
    John Knight
    Center for Voice and Swallowing Disorders, Department of Otolaryngology, Wake Forest University Health Sciences, Winston Salem, NC 27157, U S A
    Laryngoscope 115:1473-8. 2005
    ....
  24. ncbi request reprint Exploring the anatomy and physiology of ageing: Part 4--the renal system
    Maria Andrade
    School of Health Science, Swansea University
    Nurs Times 104:22-3. 2008
  25. ncbi request reprint Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study
    Steven W Boyce
    Washington Hospital Center, 106 Irving Street NW, Suite 316, South Tower, Washington, DC 20010, USA
    J Thorac Cardiovasc Surg 126:420-7. 2003
    ..To evaluate the effects of cariporide on all-cause mortality or myocardial infarction at 36 days in patients at risk of myocardial necrosis after coronary artery bypass graft surgery...