D W Kitzman

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial
    Dalane W Kitzman
    Cardiology Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina Electronic address
    J Am Coll Cardiol 62:584-92. 2013
  2. pmc Impaired aerobic capacity and physical functional performance in older heart failure patients with preserved ejection fraction: role of lean body mass
    Mark J Haykowsky
    Professor of Medicine Sections on Cardiology and Geriatrics, Medical Center Boulevard, Winston Salem, NC 27157
    J Gerontol A Biol Sci Med Sci 68:968-75. 2013
  3. pmc Carotid arterial stiffness and its relationship to exercise intolerance in older patients with heart failure and preserved ejection fraction
    Dalane W Kitzman
    Cardiology Section, Department of Medicine, Wake Forest University, Winston Salem, NC, USA
    Hypertension 61:112-9. 2013
  4. pmc Relationship of flow-mediated arterial dilation and exercise capacity in older patients with heart failure and preserved ejection fraction
    Mark J Haykowsky
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Gerontol A Biol Sci Med Sci 68:161-7. 2013
  5. pmc Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failure
    Chirapa Puntawangkoon
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Cardiovasc Magn Reson 11:48. 2009
  6. pmc Adverse effect of increased left ventricular wall thickness on five year outcomes of patients with negative dobutamine stress
    Thomas F Walsh
    Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina, USA
    J Cardiovasc Magn Reson 11:25. 2009
  7. pmc Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Med Genet 10:40. 2009
  8. pmc Exercise intolerance
    Dalane W Kitzman
    Wake Forest University Health Sciences, Winston Salem, NC, USA
    Cardiol Clin 29:461-77. 2011
  9. pmc Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial
    Dalane W Kitzman
    Cardiology Section, Department of Internal Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Circ Heart Fail 3:659-67. 2010
  10. pmc A randomized double-blind trial of enalapril in older patients with heart failure and preserved ejection fraction: effects on exercise tolerance and arterial distensibility
    Dalane W Kitzman
    Cardiology Section, Department of Internal Medicine, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Circ Heart Fail 3:477-85. 2010

Research Grants

Detail Information

Publications93

  1. pmc Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial
    Dalane W Kitzman
    Cardiology Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina Electronic address
    J Am Coll Cardiol 62:584-92. 2013
    ....
  2. pmc Impaired aerobic capacity and physical functional performance in older heart failure patients with preserved ejection fraction: role of lean body mass
    Mark J Haykowsky
    Professor of Medicine Sections on Cardiology and Geriatrics, Medical Center Boulevard, Winston Salem, NC 27157
    J Gerontol A Biol Sci Med Sci 68:968-75. 2013
    ..However, it is unknown whether skeletal muscle abnormalities contribute to exercise intolerance in HFPEF patients...
  3. pmc Carotid arterial stiffness and its relationship to exercise intolerance in older patients with heart failure and preserved ejection fraction
    Dalane W Kitzman
    Cardiology Section, Department of Medicine, Wake Forest University, Winston Salem, NC, USA
    Hypertension 61:112-9. 2013
    ..This supports the hypothesis that increased arterial stiffness contributes to exercise intolerance in HFpEF and is a potential therapeutic target...
  4. pmc Relationship of flow-mediated arterial dilation and exercise capacity in older patients with heart failure and preserved ejection fraction
    Mark J Haykowsky
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Gerontol A Biol Sci Med Sci 68:161-7. 2013
    ..However, uncertainty remains regarding whether FMD is reduced beyond the degree associated with normal aging and if this contributes to reduced peak VO(2) in elderly HFpEF patients...
  5. pmc Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failure
    Chirapa Puntawangkoon
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Cardiovasc Magn Reson 11:48. 2009
    ..We hypothesized that reduced lower extremity blood flow (LBF) due to reduced forward cardiac output would contribute to submaximal exercise intolerance in older HF patients...
  6. pmc Adverse effect of increased left ventricular wall thickness on five year outcomes of patients with negative dobutamine stress
    Thomas F Walsh
    Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina, USA
    J Cardiovasc Magn Reson 11:25. 2009
    ..To determine if patients without dobutamine induced left ventricular wall motion abnormalities (WMA) but an increased LV end-diastolic wall thickness (EDWT) exhibit a favorable cardiac prognosis...
  7. pmc Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Med Genet 10:40. 2009
    ....
  8. pmc Exercise intolerance
    Dalane W Kitzman
    Wake Forest University Health Sciences, Winston Salem, NC, USA
    Cardiol Clin 29:461-77. 2011
    ..This article focuses on the fundamental principles of exercise physiology and on the assessment, pathophysiology, and potential treatment of exercise intolerance in diastolic heart failure...
  9. pmc Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial
    Dalane W Kitzman
    Cardiology Section, Department of Internal Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Circ Heart Fail 3:659-67. 2010
    ..Exercise training (ET) improves exercise intolerance and QOL in patients with HF with reduced ejection fraction (EF). However, the effect of ET in HFPEF has not been examined in a randomized controlled trial...
  10. pmc A randomized double-blind trial of enalapril in older patients with heart failure and preserved ejection fraction: effects on exercise tolerance and arterial distensibility
    Dalane W Kitzman
    Cardiology Section, Department of Internal Medicine, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Circ Heart Fail 3:477-85. 2010
    ..Exercise intolerance is the primary symptom in older patients with heart failure and preserved ejection fraction (HFPEF); however, little is known regarding its mechanisms and therapy...
  11. ncbi request reprint Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure
    Dalane W Kitzman
    Section of Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045
    JAMA 288:2144-50. 2002
    ..However, the pathophysiology of this disorder, presumptively termed diastolic heart failure (DHF), is not well characterized and it is unknown whether it represents true heart failure...
  12. pmc Exercise intolerance
    Dalane W Kitzman
    Section of Cardiology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Heart Fail Clin 4:99-115. 2008
    ..This article focuses on the fundamental principles of exercise physiology and on the assessment, pathophysiology, and potential treatment of exercise intolerance in diastolic heart failure...
  13. ncbi request reprint Diastolic heart failure in the elderly
    Dalane W Kitzman
    Department of Internal Medicine, Wake Forest University Health Sciences Center, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Clin Geriatr Med 23:83-106. 2007
    ..The pathophysiology and treatment are not well defined. Control of systemic hypertension may be a key to prevention and treatment. Several large trials of specific agents are currently underway...
  14. ncbi request reprint Diastolic heart failure in the elderly
    Dalane W Kitzman
    Cardiology Section, Department of Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Heart Fail Rev 7:17-27. 2002
    ..Anecdotally, control of blood pressure appears to improve symptoms and reduce the frequency of acute exacerbations. In addition, non-pharmacologic intervention, including multi-disciplinary case management is useful...
  15. ncbi request reprint Heart failure with normal systolic function
    D W Kitzman
    Section of Cardiology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    Clin Geriatr Med 16:489-512. 2000
    ..Although optimal pharmacologic therapy has not been clarified, control of blood pressure; exercise conditioning; and a multidisciplinary, case management approach seem beneficial...
  16. ncbi request reprint Efficacy and safety of the novel ultrasound contrast agent perflutren (definity) in patients with suboptimal baseline left ventricular echocardiographic images
    D W Kitzman
    Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    Am J Cardiol 86:669-74. 2000
    ..These data indicate that administration of perflutren to patients with suboptimal baseline images is well tolerated and provides substantial LV cavity opacification and improvement in endocardial border delineation...
  17. ncbi request reprint Diastolic dysfunction in the elderly. Genesis and diagnostic and therapeutic implications
    D W Kitzman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cardiol Clin 18:597-617, x. 2000
    ..Further research in this area should be a high priority...
  18. ncbi request reprint Safety assessment of perflenapent emulsion for echocardiographic contrast enhancement in patients with congestive heart failure or chronic obstructive pulmonary disease
    D W Kitzman
    Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Am Heart J 139:1077-80. 2000
    ..Because of their reduced cardiopulmonary reserve, these patients might be at greater risk for adverse events...
  19. pmc Endurance exercise training in older patients with heart failure: results from a randomized, controlled, single-blind trial
    Peter H Brubaker
    Department of Health and Exercise Science, Wake Forest University, Wake Forest University, Winston Salem, NC 27109, USA
    J Am Geriatr Soc 57:1982-9. 2009
    ..To test the hypothesis that exercise training (ET) improves exercise capacity and other clinical outcomes in older persons with heart failure with reduced ejection fraction (HfrEF)...
  20. ncbi request reprint Utility of fast cine magnetic resonance imaging and display for the detection of myocardial ischemia in patients not well suited for second harmonic stress echocardiography
    W G Hundley
    Cardiology Section, Division of Radiological Sciences, The Wake Forest University School of Medicine, Winston Salem, NC, USA
    Circulation 100:1697-702. 1999
    ..Fast cine MRI can be used to assess left ventricular contraction, but its utility for detection of myocardial ischemia in patients poorly suited for echocardiography is unknown...
  21. ncbi request reprint Gender difference in diastolic function in hypertension (the HyperGEN study)
    Jonathan N Bella
    Department of Medicine, Cornell Medical Center, New York, New York 10021, USA
    Am J Cardiol 89:1052-6. 2002
    ..This gender difference in diastolic function may provide insight into gender differences in congestive heart failure and other specific cardiovascular diseases...
  22. ncbi request reprint The pathogenesis of acute pulmonary edema associated with hypertension
    S K Gandhi
    Cardiology Section, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1045, USA
    N Engl J Med 344:17-22. 2001
    ....
  23. ncbi request reprint The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure
    William C Little
    Department of Internal Medicine, Cardiology Section, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Card Fail 11:191-5. 2005
    ..Despite its high prevalence, optimal therapy for diastolic heart failure (DHF) has not been determined. Alagebrium chloride (ALT-711) is a novel compound that breaks glucose crosslinks and may improve ventricular and arterial compliance...
  24. ncbi request reprint Left ventricular diastolic filling response to stationary bicycle exercise during pregnancy and the postpartum period
    J C Veille
    Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Am J Obstet Gynecol 185:822-7. 2001
    ..This finding suggests that there is an increase in left ventricular chamber stiffness during maximal upright bicycle exercise in pregnancy...
  25. ncbi request reprint Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within five years: the Cardiovascular Health Study
    Mark H Drazner
    Heart Failure Research Unit, Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Coll Cardiol 43:2207-15. 2004
    ..Our aim in this study was to determine whether increased left ventricular mass (LVM) is a risk factor for the development of a reduced left ventricular ejection fraction (LVEF)...
  26. ncbi request reprint Left atrial systolic force and cardiac markers of preclinical disease in hypertensive patients: the Hypertension Genetic Epidemiology Network (HyperGEN) Study
    Marcello Chinali
    Department of Medicine, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Hypertens 18:899-905. 2005
    ..This study analyzes the association of increased LASF to LV geometry and function in hypertensive patients from a population study...
  27. ncbi request reprint Exercise responses of elderly patients with diastolic versus systolic heart failure
    Peter H Brubaker
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Med Sci Sports Exerc 35:1477-85. 2003
    ..Therefore, the purpose of this investigation was to compare exercise responses of elderly patients with HF due to either systolic dysfunction (SD) or DD, to age-matched healthy volunteers (HV)...
  28. ncbi request reprint VE/VCO2 slope in older heart failure patients with normal versus reduced ejection fraction compared with age-matched healthy controls
    Brian Moore
    Section on Cardiology, Department of Internal Medicine, Wake Forest University, Winston Salem, North Carolina, USA
    J Card Fail 13:259-62. 2007
    ..Therefore, the purpose of this study was to cross-sectionally examine VE/VCO2 slope in systolic heart failure (SHF) and diastolic heart failure (DHF) as well as age-matched healthy controls...
  29. pmc Effect of aldosterone antagonism on exercise tolerance, Doppler diastolic function, and quality of life in older women with diastolic heart failure
    Kurt R Daniel
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Congest Heart Fail 15:68-74. 2009
    ....
  30. ncbi request reprint Contribution of left ventricular diastolic dysfunction to heart failure regardless of ejection fraction
    Steffen Brucks
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 95:603-6. 2005
    ..50 is associated with mild systolic dysfunction and an increased ratio of left ventricular mass to EDVI. In HF with an ejection fraction </=0.40, systolic dysfunction and left ventricular dilation accompany diastolic dysfunction...
  31. ncbi request reprint Diastolic dysfunction as a cause of exercise intolerance
    W C Little
    Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Heart Fail Rev 5:301-6. 2000
    ..Acute studies suggest that treatment with angiotensin II receptor blockers or verapamil may improve exercise tolerance in some patients with primary diastolic dysfunction...
  32. ncbi request reprint Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance
    W G Hundley
    Department of Internal Medicine, Cardiology Section, The Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Am Coll Cardiol 38:796-802. 2001
    ..The goal of this study was to determine if cardiac cycle-dependent changes in proximal thoracic aortic area and distensibility are associated with exercise intolerance in elderly patients with diastolic heart failure (DHF)...
  33. ncbi request reprint Relation of aortic distensibility determined by magnetic resonance imaging in patients > or =60 years of age to systolic heart failure and exercise capacity
    Pairoj Rerkpattanapipat
    Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    Am J Cardiol 90:1221-5. 2002
    ..These data suggest that decreased aortic distensibility may contribute to exercise intolerance in older patients with HF due to LV systolic dysfunction...
  34. ncbi request reprint Chronotropic incompetence and its contribution to exercise intolerance in older heart failure patients
    Peter H Brubaker
    Section on Cardiology, Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27109, USA
    J Cardiopulm Rehabil 26:86-9. 2006
  35. pmc New York Heart Association functional class predicts exercise parameters in the current era
    Stuart D Russell
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am Heart J 158:S24-30. 2009
    ..Using baseline data from the HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing) study, we examined this relationship...
  36. ncbi request reprint Association of left ventricular hypertrophy with metabolic risk factors: the HyperGEN study
    Giovanni de Simone
    Department of Medicine, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Hypertens 20:323-31. 2002
    ..To determine whether combinations of metabolic risk factors (obesity, diabetes and hypercholesterolemia) influence the magnitude of left ventricular (LV) mass and prevalence of LV hypertrophy...
  37. ncbi request reprint Importance of heart failure with preserved systolic function in patients > or = 65 years of age. CHS Research Group. Cardiovascular Health Study
    D W Kitzman
    Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1045, USA
    Am J Cardiol 87:413-9. 2001
    ..The finding that a large proportion of elderly with CHF have preserved LV systolic function is important because there is a paucity of data to guide management in this dominant subset...
  38. ncbi request reprint Aortic root replacement with the freestyle stentless porcine aortic root bioprosthesis
    N D Kon
    Department of Cardiothoracic Surgery, Wake Forest University School of Medicine Baptist Medical Center, Winston Salem, North Carolina 27157 1096, USA
    Ann Thorac Surg 67:1609-15; discussion 1615-6. 1999
    ..Stentless porcine prosthetic valves offer several advantages over traditional valves. Among these are superior hemodynamics, laminar flow patterns, lack of need for anticoagulation and perhaps improved durability...
  39. pmc Improved detection of protruding apical thrombus with contrast echocardiography
    P Rerkpattanapipat
    Heart 89:1297. 2003
  40. ncbi request reprint Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    J Gerontol A Biol Sci Med Sci 61:28-35. 2006
    ..Age-related decreases in GH and IGF-1 may contribute to the decline in diastolic function of aging, in part through alterations in renin-angiotensin system-mediated ventricular remodeling...
  41. ncbi request reprint Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction
    William C Little
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 98:383-5. 2006
    ..In conclusion, in patients with diastolic dysfunction and hypertensive responses to exercise, 6 months of losartan and HCTZ blunted systolic BP during exercise. Only losartan increased exercise tolerance and improved quality of life...
  42. ncbi request reprint Effect of candesartan and verapamil on exercise tolerance in diastolic dysfunction
    William C Little
    Cardiology Section, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Cardiovasc Pharmacol 43:288-93. 2004
    ..Ang II blockade increased exercise tolerance and improved QOL...
  43. ncbi request reprint Abdominal obesity is an independent risk factor for chronic heart failure in older people
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 54:413-20. 2006
    ..To examine whether total and abdominal adiposity are risk factors for the development of chronic heart failure (CHF) in older men and women...
  44. ncbi request reprint Influence of fat-free mass on detection of appropriateness of left ventricular mass: the HyperGEN Study
    Giovanni de Simone
    Department of Medicine, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
    J Hypertens 21:1747-52. 2003
    ....
  45. ncbi request reprint Leg flow-mediated arterial dilation in elderly patients with heart failure and normal left ventricular ejection fraction
    W Gregory Hundley
    Department of Internal Medicine, Section on Cardiology, Wake Forest Univ School of Medicine, Bowman Gray Campus, Winston Salem, NC 27157 1045, USA
    Am J Physiol Heart Circ Physiol 292:H1427-34. 2007
    ..Many elderly patients with heart failure exhibit a normal left ventricular ejection fraction (HFNEF). It is unknown whether FMAD is severely reduced in the elderly with HFNEF...
  46. pmc Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Aging Clin Exp Res 20:302-9. 2008
    ..The purpose of this study was to determine whether physical function is independently associated with histologic and metabolic properties of skeletal muscle in elderly adults...
  47. pmc Chronic inflammation is associated with low physical function in older adults across multiple comorbidities
    Tina E Brinkley
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 64:455-61. 2009
    ....
  48. ncbi request reprint Eight-year results of aortic root replacement with the freestyle stentless porcine aortic root bioprosthesis
    Neal D Kon
    Department of Cardiothoracic Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1096, USA
    Ann Thorac Surg 73:1817-21; discussion 1821. 2002
    ..Stentless porcine aortic valves offer several advantages over traditional valves. Among these are superior hemodynamics, laminar flow patterns, lack of need for anticoagulation, and perhaps improved durability...
  49. ncbi request reprint Progressive diastolic dysfunction in the female mRen(2). Lewis rat: influence of salt and ovarian hormones
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27127 1009, USA
    J Gerontol A Biol Sci Med Sci 63:3-11. 2008
    ..These findings may explain the preponderance of diastolic dysfunction and diastolic heart failure in postmenopausal women and provide a potential animal model for evaluating prevention and treatment interventions for this disorder...
  50. pmc Decreased left ventricular distensibility in response to postural change in older patients with heart failure and preserved ejection fraction
    Jerry M John
    Division of Cardiology, Department of Medicine, University of Toledo, Toledo, Ohio, USA
    Am J Physiol Heart Circ Physiol 299:H883-9. 2010
    ..This provides further support for the hypothesis that a blunted Frank-Starling mechanism may contribute to the pathophysiology of HFPEF...
  51. pmc The effect of randomization to weight loss on total mortality in older overweight and obese adults: the ADAPT Study
    M Kyla Shea
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 65:519-25. 2010
    ..Data from the Arthritis, Diet, and Activity Promotion Trial (ADAPT) were used to determine whether randomization to a weight reduction program was associated with total mortality in overweight/obese older adults...
  52. pmc The restoration of chronotropic competence in heart failure patients with normal ejection fraction (RESET) study: rationale and design
    David A Kass
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions Baltimore, MD, USA
    J Card Fail 16:17-24. 2010
    ..Although there is considerable evidence demonstrating the benefits of rate-adaptive pacing (RAP) provided from implantable cardiac devices in patients with an impaired chronotropic response, the effect of RAP in HFpEF is unknown...
  53. ncbi request reprint Body composition and fat distribution influence systemic hemodynamics in the absence of obesity: the HyperGEN Study
    Giovanni de Simone
    Department of Medicine, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY, USA
    Am J Clin Nutr 81:757-61. 2005
    ..We have shown that increased cardiac output is related to both fat-free mass and fat mass in obesity...
  54. ncbi request reprint Prevalence and management of chronotropic incompetence in heart failure
    Peter H Brubaker
    Departments of Health and Exercise Science, Section on Internal Medicine Cardiology, Wake Forest University, Box 7628, Reynolda Station, Winston Salem, NC 27109, USA
    Curr Cardiol Rep 9:229-35. 2007
    ..Therapeutic interventions to improve chronotropic function, including endurance exercise training and rate-adaptive pacing, although promising, still warrant further investigation...
  55. ncbi request reprint Exercise intolerance
    Dalane W Kitzman
    Sections of Cardiology and Geriatrics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Prog Cardiovasc Dis 47:367-79. 2005
    ..Because it is a primary determinant of quality of life, can be quantified objectively, is reproducible, and is modifiable, exercise intolerance is an attractive therapeutic target...
  56. ncbi request reprint Bicuspid aortic valves in monozygotic twins
    Cindy Brown
    Section of Cardiology, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Echocardiography 20:183-4. 2003
    ..Identical bicuspid valve anomalies were found in monozygotic twins. Screening echocardiography should be considered for first-degree relatives of patients with bicuspid aortic valve...
  57. pmc Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing)
    Daniel R Bensimhon
    LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
    Am J Cardiol 102:712-7. 2008
    ..Therefore, in multicenter trials, there is no need to perform >1 baseline cardiopulmonary exercise test...
  58. ncbi request reprint Automated analysis of phase-contrast magnetic resonance images in the assessment of endothelium-dependent flow-mediated dilation
    Ping Tan
    Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Cardiovasc Magn Reson 5:325-32. 2003
    ..This methodology may prove useful for the rapid MRI assessment of peripheral arterial endothelial function in a clinical setting when studying patients with cardiovascular disease...
  59. ncbi request reprint Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 153:201-11. 2007
    ..Although there are limited clinical data to support the use of exercise training as a means to reduce mortality and morbidity in patients with heart failure, current guidelines state that exercise is beneficial...
  60. ncbi request reprint Challenges and controversies in the prevention and treatment of cardiovascular disease in very elderly patients
    Dalane W Kitzman
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Geriatr Cardiol 12:343. 2003
  61. ncbi request reprint Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study
    Lawrence Liao
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 153:245-52. 2007
    ..In a prospective, longitudinal cohort of community-dwelling elderly from 4 regions, we examined the long-term costs and resource use of elderly patients with HF...
  62. pmc Outcomes in ambulatory chronic systolic and diastolic heart failure: a propensity score analysis
    Ali Ahmed
    University of Alabama at Birmingham and VA Medical Center, Birmingham, AL 35294 2041, USA
    Am Heart J 152:956-66. 2006
    ..In this analysis, we examined long-term mortality and hospitalization in a propensity score matched cohort of ambulatory chronic systolic and diastolic HF patients...
  63. ncbi request reprint Associations of aortic and mitral regurgitation with body composition and myocardial energy expenditure in adults with hypertension: the Hypertension Genetic Epidemiology Network study
    Vittorio Palmieri
    Weill Medical College of Cornell University, New York, NY, USA
    Am Heart J 145:1071-7. 2003
    ..However, the relations of valvular regurgitation to body composition and myocardial bioenergetic expenditure have not been previously investigated in a population-based sample...
  64. ncbi request reprint Association of inappropriate left ventricular mass with systolic and diastolic dysfunction: the HyperGEN study
    Giovanni de Simone
    Weill Medical College of Cornell University, New York, New York, USA
    Am J Hypertens 17:828-33. 2004
    ..No information is available on whether inappropriate LVM is associated with alterations of LV diastolic properties in unselected population-based studies...
  65. pmc Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial
    Ali Ahmed
    University of Alabama at Birmingham, 1530 3rd Ave S, CH 19, Suite 219, Birmingham AL 35294 2041, USA
    Circulation 114:397-403. 2006
    ..Although digoxin was tested in an appreciable number of diastolic heart failure patients in the Digitalis Investigation Group ancillary trial, detailed findings from this important study have not previously been published...
  66. ncbi request reprint Aortic valve sclerosis is associated with preclinical cardiovascular disease in hypertensive adults: the Hypertension Genetic Epidemiology Network study
    Felizen S Agno
    Weill Medical College of Cornell University, New York, New York, USA
    J Hypertens 23:867-73. 2005
    ..However, whether AVS is associated with preclinical cardiovascular disease among adults at high risk because of hypertension has not been determined in a population-based sample...
  67. ncbi request reprint Relation of insulin to left ventricular geometry and function in African American and white hypertensive adults: the HyperGEN study
    Richard B Devereux
    Division of Cardiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Hypertens 15:1029-35. 2002
    ....
  68. ncbi request reprint Survival associated with two sets of diagnostic criteria for congestive heart failure
    Gina D Schellenbaum
    Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
    Am J Epidemiol 160:628-35. 2004
    ..Compared with Cardiovascular Health Study central adjudication, Framingham criteria for CHF identified a larger group of participants with incident CHF, but all-cause mortality rates were similar across these diagnostic classifications...
  69. ncbi request reprint Outcome of congestive heart failure in elderly persons: influence of left ventricular systolic function. The Cardiovascular Health Study
    John S Gottdiener
    St Francis Hospital, Roslyn, New York Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 137:631-9. 2002
    ..Most persons with congestive heart failure are elderly, and many elderly persons with congestive heart failure have normal left ventricular systolic function...
  70. ncbi request reprint Limited utility of the subcostal view for the echocardiographic evaluation of left ventricular mass in epidemiological studies of older persons
    Mauro Di Bari
    Unit of Gerontology and Geriatrics, Department of Critical Care Medicine and Surgery, University of Florence and Azienda Ospedaliera Careggi, Via delle Oblate, 4, 50141 Florence, Italy
    Int J Cardiol 97:521-7. 2004
    ..This study was undertaken to assess whether the subcostal view is a valid alternative to estimate left ventricular mass in an unselected older population...
  71. ncbi request reprint Sibling resemblance for left ventricular structure, contractility, and diastolic filling
    Weihong Tang
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA
    Hypertension 40:233-8. 2002
    ..These data have potential importance in understanding heritability of LV diastolic function in hypertension...
  72. ncbi request reprint Linkage of left ventricular early diastolic peak filling velocity to chromosome 5 in hypertensive African Americans: the HyperGEN echocardiography study
    Weihong Tang
    Department of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    Am J Hypertens 15:621-7. 2002
    ..The aim of this study was to identify chromosomal regions contributing to variation of LV transmitral early and late peak filling velocities (E and A velocities), Doppler echocardiographic measures of LV diastolic filling...
  73. ncbi request reprint Left ventricular concentric geometry is associated with impaired relaxation in hypertension: the HyperGEN study
    Giovanni de Simone
    Weill Medical College of Cornell University, New York, NY, USA
    Eur Heart J 26:1039-45. 2005
    ..We tested the hypothesis that abnormal left ventricular (LV) relaxation is associated with concentric LV geometry...
  74. ncbi request reprint Associations between angiotensinogen gene variants and left ventricular mass and function in the HyperGEN study
    Weihong Tang
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Am Heart J 143:854-60. 2002
    ..We investigated whether 2 tightly linked polymorphisms of angiotensinogen gene, M235T and G-6A, are associated with LV mass and function in a large population-based sample, composed mostly of patients with hypertension...
  75. ncbi request reprint Blood pressure responses to acute stress and left ventricular mass (The Hypertension Genetic Epidemiology Network Study)
    Mustafa al'Absi
    Departments of Behavioral Sciences, Physiology, and Family Medicine, University of Minnesota School of Medicine, Duluth, Minnesota 55812, USA
    Am J Cardiol 89:536-40. 2002
    ..Positive associations of systolic BP responses with RWT suggest that exaggerated reactivity may particularly be related to LV changes influenced by vascular tonus...
  76. ncbi request reprint Imagent improves endocardial border delineation, inter-reader agreement, and the accuracy of segmental wall motion assessment
    Navin C Nanda
    University of Alabama at Birmingham, Heart Station SW S102, 619 19th Street, Birmingham, AL 35249, USA
    Echocardiography 20:151-61. 2003
    ..This was achieved by analysis of inter-reader agreement by echocardiography and comparison with an independent imaging technique, magnetic resonance imaging (MRI)...
  77. ncbi request reprint Differences in left ventricular structure between black and white hypertensive adults: the Hypertension Genetic Epidemiology Network study
    Jorge R Kizer
    Division of Cardiology, Weill Medical College of Cornell University, New York, USA
    Hypertension 43:1182-8. 2004
    ..Whether such differences relate to distinct ambulatory pressure profiles or an ethnic propensity to cardiac hypertrophy requires further investigation...
  78. pmc Hospitalizations due to unstable angina pectoris in diastolic and systolic heart failure
    Ali Ahmed
    University of Alabama at Birmingham, Alabama, USA
    Am J Cardiol 99:460-4. 2007
    ..As in patients with systolic HF, those with diastolic HF should be routinely evaluated for myocardial ischemia and managed accordingly...
  79. pmc A whole genome scan for pulse pressure/stroke volume ratio in African Americans: the HyperGEN study
    Richard Sherva
    University of Minnesota, Minneapolis, Minnesota, USA
    Am J Hypertens 20:398-402. 2007
    ..Linkage analysis has identified genomic regions that likely harbor genes contributing to its phenotypic expression. We sought to identify loci contributing to arterial stiffness in a large group of African-American hypertensive families...
  80. ncbi request reprint The relationship of a 6-min walk to VO(2 peak) and VT in older heart failure patients
    Sara Maldonado-Martin
    Faculty of Physical Activity and Sport Sciences, University of Basque Country, Vitoria Gasteiz, Araba, Basque Country, Spain
    Med Sci Sports Exerc 38:1047-53. 2006
    ..and to develop a new equation to improve the prediction of VO(2 peak) from 6-MWT...
  81. ncbi request reprint Assessment of the interaction of heritability of volume load and left ventricular mass: the HyperGEN offspring study
    Giovanni de Simone
    Weill Medical College of Cornell University, New York, NY, USA
    J Hypertens 25:1397-402. 2007
    ..Left ventricular mass (LVM) is more closely associated with volume load than pressure load. We assessed whether part of the genetic heritability of LVM can be explained by stroke volume (SV) inheritance...
  82. ncbi request reprint The Arg16Gly polymorphism of the beta2-adrenergic receptor and left ventricular systolic function
    Weihong Tang
    Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Am J Hypertens 16:945-51. 2003
    ..This study examined the association of the beta2-AR Arg16Gly polymorphism with left ventricular (LV) systolic function in a biethnic population-based sample...
  83. ncbi request reprint Ventricular structure and function in hypertensive participants with heart failure and a normal ejection fraction: the Cardiovascular Health Study
    Mathew S Maurer
    Clinical Cardiovascular Research Laboratory for the Elderly, Columbia University, College of Physicians and Surgeons, Allen Pavilion of New York Presbyterian Hospital, New York, New York 10034, USA
    J Am Coll Cardiol 49:972-81. 2007
    ..The purpose of this study was to evaluate left ventricular (LV) size and structure in elderly subjects with hypertension (HTN) and heart failure who have a normal ejection fraction (HFNEF) in a large population-based sample...
  84. doi request reprint Diastolic dysfunction: one piece of the heart failure with normal ejection fraction puzzle
    Dalane W Kitzman
    Circulation 117:2044-6. 2008
  85. ncbi request reprint Costs for heart failure with normal vs reduced ejection fraction
    Lawrence Liao
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Arch Intern Med 166:112-8. 2006
    ..However, there are few data regarding the costs of HF with normal EF. In a prospective, population-based cohort of elderly participants, we compared the costs and resource use of patients with HF and normal and reduced EF...
  86. ncbi request reprint Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons > or =65 years of age (the cardiovascular health study)
    John S Gottdiener
    Division of Cardiology, University of Maryland Medical Center, Baltimore, Maryland, USA
    Am J Cardiol 97:83-9. 2006
    ..LA size is associated with the new development of HF. These findings highlight the important role of the left atrium in HF, with or without a decreased ejection fraction...
  87. ncbi request reprint Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships: the Hypertension Genetic Epidemiology Network Study
    Jonathan N Bella
    Weill Medical College, Cornell University, New York, NY, USA
    Hypertension 49:453-60. 2007
    ..1-q22.3 and suggestive linkage to chromosome 19p13.11-p11 and identifies several other promising genomic regions that may contain specific susceptibility loci for valve calcification...
  88. ncbi request reprint Guidelines of the Cardiogeriatrics Department of the Brazilian Cardiology Society: commentary by Editorial Board Members of The American Journal of Geriatric Cardiology
    Nanette K Wenger
    Emory University School of Medicine, Atlanta, GA 30303, USA
    Am J Geriatr Cardiol 13:209-16. 2004
  89. ncbi request reprint Congestive heart failure incidence and prognosis: case identification using central adjudication versus hospital discharge diagnoses
    Gina D Schellenbaum
    Department of Epidemiology, University of Washington, Seattle, WA 98101, and Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
    Ann Epidemiol 16:115-22. 2006
    ..We compared hospitalized congestive heart failure (CHF) incidence and prognosis estimates using hospital discharge diagnoses or central adjudication...
  90. ncbi request reprint The association of alcohol consumption and incident heart failure: the Cardiovascular Health Study
    Chris L Bryson
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    J Am Coll Cardiol 48:305-11. 2006
    ..We investigated the association between alcohol consumption and incident congestive heart failure (CHF) both overall and after adjusting for incident myocardial infarction (MI)...
  91. ncbi request reprint Heart failure: a rose by any other name?
    Margaret M Redfield
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Congest Heart Fail 12:166-8. 2006
  92. ncbi request reprint A genome scan for linkage with aortic root diameter in hypertensive African Americans and whites in the Hypertension Genetic Epidemiology Network (HyperGEN) study
    Amy I Lynch
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Hypertens 18:627-32. 2005
    ..Aortic root dilation is a prominent feature in several cardiovascular diseases. This study seeks to identify genomic regions linked to variation in the aortic root diameter (ARD) in hypertensive African American and white individuals...
  93. ncbi request reprint Application of assessing care of vulnerable elders-3 quality indicators to patients with advanced dementia and poor prognosis
    Neil S Wenger
    RAND Health, Santa Monica, CA 90407 2138, USA
    J Am Geriatr Soc 55:S457-63. 2007
    ..To use a formal decision-making strategy to reach clinically appropriate, internally consistent decisions on the application of quality indicators (QIs) to vulnerable elders (VEs) with advanced dementia (AD) or poor prognosis (PP)...

Research Grants7

  1. EXERCISE INTOLERANCE IN ELDERLY DIASTOLIC HEART FAILURE
    Dalane Kitzman; Fiscal Year: 2004
    ..abstract_text> ..
  2. EXERCISE INTOLERANCE IN ELDERLY DIASTOLIC HEART FAILURE
    Dalane Kitzman; Fiscal Year: 2007
    ....
  3. CHF TRIAL INVESTIGATING OUTCOMES OF EXERCISE TRAINING
    Dalane Kitzman; Fiscal Year: 2007
    ..abstract_text> ..