Kylie Kavanagh

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Naturally occurring menopause in cynomolgus monkeys: changes in hormone, lipid, and carbohydrate measures with hormonal status
    Kylie Kavanagh
    Department of Pathology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Med Primatol 34:171-7. 2005
  2. pmc Characterization and validation of a streptozotocin-induced diabetes model in the vervet monkey
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Pharmacol Toxicol Methods 63:296-303. 2011
  3. pmc Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys
    Kylie Kavanagh
    Dept of Pathology, Section on Comparative Medicine and Lipid Sciences, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Endocrinol Metab 300:E894-901. 2011
  4. pmc Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in mice
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nutr Res 30:418-26. 2010
  5. pmc Fetal and maternal factors associated with infant mortality in vervet monkeys
    K Kavanagh
    Pathology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC, USA
    J Med Primatol 40:27-36. 2011
  6. ncbi request reprint Fluid compartmental shifts with efficacious pioglitazone therapy in overweight monkeys: implications for peroxisome proliferator-activated receptor-gamma agonist use in prediabetes
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27127, USA
    Metabolism 59:914-20. 2010
  7. pmc Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeys
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 29:1471-7. 2009
  8. ncbi request reprint High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University, Winston Salem, NC 27107, USA
    Nutr Res 28:368-76. 2008
  9. pmc Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys
    K Kavanagh
    Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
    Cell Stress Chaperones 14:291-9. 2009
  10. ncbi request reprint Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys
    Kylie Kavanagh
    Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Obesity (Silver Spring) 15:1675-84. 2007

Detail Information

Publications22

  1. ncbi request reprint Naturally occurring menopause in cynomolgus monkeys: changes in hormone, lipid, and carbohydrate measures with hormonal status
    Kylie Kavanagh
    Department of Pathology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Med Primatol 34:171-7. 2005
    ..E(2) treatment restored estrogen levels and induced improvements in the lipid profile of PM females...
  2. pmc Characterization and validation of a streptozotocin-induced diabetes model in the vervet monkey
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Pharmacol Toxicol Methods 63:296-303. 2011
    ..Streptozotocin (STZ), preferentially toxic to pancreatic beta cells, is commonly used to model Type 1 diabetes mellitus (DM) in numerous species, including nonhuman primates...
  3. pmc Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys
    Kylie Kavanagh
    Dept of Pathology, Section on Comparative Medicine and Lipid Sciences, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Endocrinol Metab 300:E894-901. 2011
    ..We conclude that increasing HSP70, potentially through targeting hyperglycemia-related deficits in HSF1 induction and activation in the liver, is a potent and viable strategy to improve glucose tolerance...
  4. pmc Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in mice
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nutr Res 30:418-26. 2010
    ..Trans-fatty acid surprisingly retarded growth and adiposity while still adversely affecting glucose metabolism...
  5. pmc Fetal and maternal factors associated with infant mortality in vervet monkeys
    K Kavanagh
    Pathology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC, USA
    J Med Primatol 40:27-36. 2011
    ..Causes of infant death remain unknown in significant proportions of human and non-human primate pregnancies...
  6. ncbi request reprint Fluid compartmental shifts with efficacious pioglitazone therapy in overweight monkeys: implications for peroxisome proliferator-activated receptor-gamma agonist use in prediabetes
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27127, USA
    Metabolism 59:914-20. 2010
    ..We conclude that thiazolidinedione-related plasma volume expansion occurs in nondiabetic primates and that fluid retention is detectable when compartments are directly measured...
  7. pmc Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeys
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 29:1471-7. 2009
    ..This study aimed to determine estrogen-induced changes in hepatic cholesterol metabolism, plasma lipoproteins, and the relationship of these changes to atherosclerosis extent...
  8. ncbi request reprint High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University, Winston Salem, NC 27107, USA
    Nutr Res 28:368-76. 2008
    ..These study results demonstrate that consumption of soy containing high isoflavone levels is not associated with changes in insulin sensitivity in the high estrogen milieu of the premenopausal female...
  9. pmc Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys
    K Kavanagh
    Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
    Cell Stress Chaperones 14:291-9. 2009
    ..Pancreas maintains HSP levels despite hyperglycemia, likely in an attempt to protect vulnerable beta cells from exocrine pancreatic damage and from stress associated with insulin hypersecretion...
  10. ncbi request reprint Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys
    Kylie Kavanagh
    Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Obesity (Silver Spring) 15:1675-84. 2007
    ..The effect of moderately high intake of dietary monounsaturated TFAs on body composition and indices of glucose metabolism was evaluated to determine any pro-diabetic effect in the absence of weight gain...
  11. ncbi request reprint Characterization and heritability of obesity and associated risk factors in vervet monkeys
    Kylie Kavanagh
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Obesity (Silver Spring) 15:1666-74. 2007
    ..The objective was to determine the prevalence and heritability of obesity and risk factors associated with metabolic syndrome (MS) in a pedigreed colony of vervet monkeys...
  12. ncbi request reprint A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Pharmacol Exp Ther 333:844-53. 2010
    ....
  13. doi request reprint A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
    J Pharmacol Exp Ther 335:103-13. 2010
    ..Similar to humans, monkeys treated with the CB(1) receptor antagonist exhibited decreased body weight and body fat, a substantial portion of which seemed to be independent of the effects on food intake...
  14. pmc Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Metabolism 57:S24-31. 2008
    ..Further studies are needed to determine the mechanisms involved in these effects of a high-soy isoflavone diet and to optimize dietary isoflavone content for maximal health benefits in male subjects...
  15. pmc Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates
    Kylie Kavanagh
    Department of Pathology Section on Comparative Medicine and Lipid Sciences, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27127, USA
    Am J Clin Nutr 98:349-57. 2013
    ..Animal studies have suggested that fructose impairs intestinal integrity and leads to hepatic steatosis (HS)...
  16. pmc Short-term hyperglycemia increases arterial superoxide production and iron dysregulation in atherosclerotic monkeys
    Patrick A Rowe
    Department of Pathology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Metabolism 60:1070-80. 2011
    ..Further studies are needed to determine if increases in iron stores and arterial iron deposition promote hydroxyl radical formation from superoxide and accelerate diabetic vascular damage...
  17. pmc Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 67:1014-21. 2012
    ..In conclusion, a low-fat diet may preserve tissue HSP70 and health with aging, whereas high-fat diets, insulin resistance, and genetic factors may be more important than age for determining HSP70 levels...
  18. pmc Enhanced cholinergic response in pancreata of nonhuman primates with impaired glucose tolerance shown on [18F]fluorobenzyltrozamicol positron emission tomography
    Paige B Clark
    Department of Radiology Nuclear Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Diabetes Technol Ther 11:451-5. 2009
    ..In this study, we utilize [18F]FBT PET to demonstrate pancreatic cholinergic activity before and after dextrose infusion in nonhuman primates with normal (NGT) and impaired (IGT) glucose tolerance...
  19. ncbi request reprint Old world nonhuman primate models of type 2 diabetes mellitus
    Janice E Wagner
    Department of Pathology Wake Forest University School of Medicine, Winston Salem, NC, USA
    ILAR J 47:259-71. 2006
    ..Thus, Old World NHPs are a valuable animal model of type 2 diabetes to study disease progression, associated risk factors, and potential new treatments...
  20. pmc Liver fat and SHBG affect insulin resistance in midlife women: the Study of Women's Health Across the Nation (SWAN)
    Kylie Kavanagh
    Department of Pathology, Wake Forest School of Medicine, North Carolina, Winston Salem, USA
    Obesity (Silver Spring) 21:1031-8. 2013
    ..Our objective was to explore whether lower SHBG was associated with ectopic liver fat and mediated its effect on insulin resistance in The Study of Women's Health Across the Nation (SWAN)...
  21. ncbi request reprint Muscle Heat Shock Protein 70 Predicts Insulin Resistance With Aging
    Lee Chichester
    DVM, MS, Department of Pathology, Section on Comparative Medicine and Lipid Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27127
    J Gerontol A Biol Sci Med Sci . 2014
    ..Results from aged humans confirmed this positive association of plasma HSP70 and insulin. In conclusion, higher levels of SkM HSP70 protect against insulin resistance development during healthy aging...
  22. ncbi request reprint Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue
    Melanie K Shadoan
    Department of Endocrinology, Lexicon Pharmaceuticals, The Woodlands, TX 77381, USA
    Metabolism 56:830-7. 2007
    ....