Research Topics
| Kylie KavanaghSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Detail Information
Publications
Naturally occurring menopause in cynomolgus monkeys: changes in hormone, lipid, and carbohydrate measures with hormonal statusKylie Kavanagh
Department of Pathology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
J Med Primatol 34:171-7. 2005..E(2) treatment restored estrogen levels and induced improvements in the lipid profile of PM females...
Characterization and validation of a streptozotocin-induced diabetes model in the vervet monkeyKylie Kavanagh
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Pharmacol Toxicol Methods 63:296-303. 2011..Streptozotocin (STZ), preferentially toxic to pancreatic beta cells, is commonly used to model Type 1 diabetes mellitus (DM) in numerous species, including nonhuman primates...- Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeysKylie Kavanagh
Dept of Pathology, Section on Comparative Medicine and Lipid Sciences, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
Am J Physiol Endocrinol Metab 300:E894-901. 2011..We conclude that increasing HSP70, potentially through targeting hyperglycemia-related deficits in HSF1 induction and activation in the liver, is a potent and viable strategy to improve glucose tolerance... - Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in miceKylie Kavanagh
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Nutr Res 30:418-26. 2010..Trans-fatty acid surprisingly retarded growth and adiposity while still adversely affecting glucose metabolism... - Fetal and maternal factors associated with infant mortality in vervet monkeysK Kavanagh
Pathology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC, USA
J Med Primatol 40:27-36. 2011..Causes of infant death remain unknown in significant proportions of human and non-human primate pregnancies... 
Fluid compartmental shifts with efficacious pioglitazone therapy in overweight monkeys: implications for peroxisome proliferator-activated receptor-gamma agonist use in prediabetesKylie Kavanagh
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27127, USA
Metabolism 59:914-20. 2010..We conclude that thiazolidinedione-related plasma volume expansion occurs in nondiabetic primates and that fluid retention is detectable when compartments are directly measured...- Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeysKylie Kavanagh
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Arterioscler Thromb Vasc Biol 29:1471-7. 2009..This study aimed to determine estrogen-induced changes in hepatic cholesterol metabolism, plasma lipoproteins, and the relationship of these changes to atherosclerosis extent... - High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primatesKylie Kavanagh
Department of Pathology, Section on Comparative Medicine, Wake Forest University, Winston Salem, NC 27107, USA
Nutr Res 28:368-76. 2008..These study results demonstrate that consumption of soy containing high isoflavone levels is not associated with changes in insulin sensitivity in the high estrogen milieu of the premenopausal female... - Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeysKylie Kavanagh
Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Obesity (Silver Spring) 15:1675-84. 2007..The effect of moderately high intake of dietary monounsaturated TFAs on body composition and indices of glucose metabolism was evaluated to determine any pro-diabetic effect in the absence of weight gain... - Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeysK Kavanagh
Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
Cell Stress Chaperones 14:291-9. 2009..Pancreas maintains HSP levels despite hyperglycemia, likely in an attempt to protect vulnerable beta cells from exocrine pancreatic damage and from stress associated with insulin hypersecretion... - Characterization and heritability of obesity and associated risk factors in vervet monkeysKylie Kavanagh
Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Obesity (Silver Spring) 15:1666-74. 2007..The objective was to determine the prevalence and heritability of obesity and risk factors associated with metabolic syndrome (MS) in a pedigreed colony of vervet monkeys... - A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeysJanice D Wagner
Department of Pathology, Wake Forest University, Winston Salem, North Carolina 27157, USA
J Pharmacol Exp Ther 333:844-53. 2010.... - A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeysJanice D Wagner
Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
J Pharmacol Exp Ther 335:103-13. 2010..Similar to humans, monkeys treated with the CB(1) receptor antagonist exhibited decreased body weight and body fat, a substantial portion of which seemed to be independent of the effects on food intake... - Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeysJanice D Wagner
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Metabolism 57:S24-31. 2008..Further studies are needed to determine the mechanisms involved in these effects of a high-soy isoflavone diet and to optimize dietary isoflavone content for maximal health benefits in male subjects... - Short-term hyperglycemia increases arterial superoxide production and iron dysregulation in atherosclerotic monkeysPatrick A Rowe
Department of Pathology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Metabolism 60:1070-80. 2011..Further studies are needed to determine if increases in iron stores and arterial iron deposition promote hydroxyl radical formation from superoxide and accelerate diabetic vascular damage... - Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistanceKylie Kavanagh
Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
J Gerontol A Biol Sci Med Sci 67:1014-21. 2012..In conclusion, a low-fat diet may preserve tissue HSP70 and health with aging, whereas high-fat diets, insulin resistance, and genetic factors may be more important than age for determining HSP70 levels... - Enhanced cholinergic response in pancreata of nonhuman primates with impaired glucose tolerance shown on [18F]fluorobenzyltrozamicol positron emission tomographyPaige B Clark
Department of Radiology Nuclear Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
Diabetes Technol Ther 11:451-5. 2009..In this study, we utilize [18F]FBT PET to demonstrate pancreatic cholinergic activity before and after dextrose infusion in nonhuman primates with normal (NGT) and impaired (IGT) glucose tolerance... - Old world nonhuman primate models of type 2 diabetes mellitusJanice E Wagner
Department of Pathology Wake Forest University School of Medicine, Winston-Salem, NC, USA
ILAR J 47:259-71. 2006..Thus, Old World NHPs are a valuable animal model of type 2 diabetes to study disease progression, associated risk factors, and potential new treatments... - Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissueMelanie K Shadoan
Department of Endocrinology, Lexicon Pharmaceuticals, The Woodlands, TX 77381, USA
Metabolism 56:830-7. 2007....