JAY KAPLAN

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists
    Virginia M Miller
    Departments of Surgery, Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    Biol Sex Differ 2:14. 2011
  2. ncbi request reprint Status, stress, and atherosclerosis: the role of environment and individual behavior
    J R Kaplan
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Ann N Y Acad Sci 896:145-61. 1999
  3. pmc The relationship between social status and atherosclerosis in male and female monkeys as revealed by meta-analysis
    Jay R Kaplan
    Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Winston Salem, North Carolina NC 27157 1040, USA
    Am J Primatol 71:732-41. 2009
  4. doi request reprint Origins and health consequences of stress-induced ovarian dysfunction
    Jay R Kaplan
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Interdiscip Top Gerontol 36:162-85. 2008
  5. pmc Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet
    J R Kaplan
    Wake Forest University Primate Center, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Hum Reprod 25:3083-94. 2010
  6. ncbi request reprint Ovarian dysfunction and the premenopausal origins of coronary heart disease
    Jay R Kaplan
    Wake Forest University Primate Center, Winston Salem, NC 27157, USA
    Menopause 15:768-76. 2008
  7. ncbi request reprint Central nervous system monoamine correlates of social dominance in cynomolgus monkeys (Macaca fascicularis)
    Jay R Kaplan
    Pathology Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Neuropsychopharmacology 26:431-43. 2002
  8. ncbi request reprint Premenopausal social status and hormone exposure predict postmenopausal atherosclerosis in female monkeys
    J R Kaplan
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Obstet Gynecol 99:381-8. 2002
  9. pmc Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden
    Sara E Walker
    Wake Forest University Primate Center, Section on Comparative, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 15:950-7. 2008
  10. pmc Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes
    F Salih Muhammad
    Animal Resources Program, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Comp Med 59:46-59. 2009

Collaborators

Detail Information

Publications43

  1. pmc Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists
    Virginia M Miller
    Departments of Surgery, Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    Biol Sex Differ 2:14. 2011
    ..abstract:..
  2. ncbi request reprint Status, stress, and atherosclerosis: the role of environment and individual behavior
    J R Kaplan
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Ann N Y Acad Sci 896:145-61. 1999
    ....
  3. pmc The relationship between social status and atherosclerosis in male and female monkeys as revealed by meta-analysis
    Jay R Kaplan
    Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Winston Salem, North Carolina NC 27157 1040, USA
    Am J Primatol 71:732-41. 2009
    ..On the contrary, we found that dominant females developed reliably less atherosclerosis than subordinates...
  4. doi request reprint Origins and health consequences of stress-induced ovarian dysfunction
    Jay R Kaplan
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Interdiscip Top Gerontol 36:162-85. 2008
    ..g. sedentary lifestyle, high-fat diet) permissive to the development of chronic disease...
  5. pmc Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet
    J R Kaplan
    Wake Forest University Primate Center, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Hum Reprod 25:3083-94. 2010
    ..We hypothesized that reproductive compromise and adverse health outcomes would be induced in subordinate when compared with dominant monkeys and be mitigated by exposure to soy...
  6. ncbi request reprint Ovarian dysfunction and the premenopausal origins of coronary heart disease
    Jay R Kaplan
    Wake Forest University Primate Center, Winston Salem, NC 27157, USA
    Menopause 15:768-76. 2008
    ....
  7. ncbi request reprint Central nervous system monoamine correlates of social dominance in cynomolgus monkeys (Macaca fascicularis)
    Jay R Kaplan
    Pathology Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Neuropsychopharmacology 26:431-43. 2002
    ..05). The Dominance-HVA association observed here is consistent with recent speculation that social extraversion, a dominance-related personality trait in humans, may also reflect heightened central nervous system dopaminergic activity...
  8. ncbi request reprint Premenopausal social status and hormone exposure predict postmenopausal atherosclerosis in female monkeys
    J R Kaplan
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Obstet Gynecol 99:381-8. 2002
    ..To determine whether premenopausal social subordination in female monkeys predicts postmenopausal atherosclerosis, and whether any such effect is altered by chronic exposure to contraceptive steroids or postmenopausal hormone replacement...
  9. pmc Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden
    Sara E Walker
    Wake Forest University Primate Center, Section on Comparative, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 15:950-7. 2008
    ..The objective of this study was to determine the effects of dietary soy protein isolate (SPI) and social status on atherogenesis and arterial gene expression in a premenopausal monkey model...
  10. pmc Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes
    F Salih Muhammad
    Animal Resources Program, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Comp Med 59:46-59. 2009
    ..However, because adult rats were more sensitive to the irritant properties of VCD, the use of a lower dose should be considered...
  11. ncbi request reprint Cyclic changes in the mammary gland of cynomolgus macaques
    Petra Stute
    The Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Fertil Steril 82:1160-70. 2004
    ..To evaluate the influence of hormonal changes during the menstrual cycle on the mammary gland of female cynomolgus monkeys...
  12. ncbi request reprint Ovarian dysfunction, stress, and disease: a primate continuum
    Jay R Kaplan
    Department of Pathology, Wake Forest University, School of Medicine, Winston Salem, NC, USA
    ILAR J 45:89-115. 2004
    ..g., sedentary lifestyle, high-fat diet) permissive to the development of chronic disease...
  13. doi request reprint Effects of long-term dietary soy treatment on female urethral morphology and function in ovariectomized nonhuman primates
    Christian Gratzke
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Urol 180:2247-53. 2008
    ..Whether such effects can be achieved by soy based phytoestrogen diets is unclear. We studied the effects of chronic phytoestrogen treatment on the structural and functional properties of the urethra in ovariectomized monkeys...
  14. doi request reprint Smooth-muscle-specific gene transfer with the human maxi-k channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys
    George J Christ
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Primate Center, Department of Comparative Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Eur Urol 56:1055-66. 2009
    ..Despite the advent of effective oral therapies for erectile dysfunction (ED), many patients are not successfully treated, and side effects have been documented...
  15. ncbi request reprint Bone mass and soy isoflavones in socially housed, premenopausal macaques
    Cynthia J Lees
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 040, USA
    Am J Clin Nutr 86:245-50. 2007
    ..It is not known whether premenopausal soy exposure initiated in adulthood can increase bone mass and thereby reduce fracture risk...
  16. pmc Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Metabolism 57:S24-31. 2008
    ..Further studies are needed to determine the mechanisms involved in these effects of a high-soy isoflavone diet and to optimize dietary isoflavone content for maximal health benefits in male subjects...
  17. pmc Serum antim├╝llerian hormone predicts ovarian reserve in a monkey model
    Susan E Appt
    Wake Forest University Primate Center, Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 16:597-601. 2009
    ..Here, we describe the relationship between AMH and ovarian reserve in cynomolgus monkeys (Macaca fascicularis) estimated to be 12 to 15 years of age (approximately 36-45 y in women)...
  18. pmc The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis)
    Susan E Appt
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Menopause 17:741-8. 2010
    ..The aim of this study was to determine the relationships among dietary protein source, cardiovascular risk, reproductive hormones, and ovarian aging...
  19. pmc Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis)
    Susan E Appt
    Department of Pathology Comparative Medicine, Wake Forest University Primate Center, Winston Salem, North Carolina, USA
    Comp Med 60:380-8. 2010
    ..These data indicate that VCD treatment markedly reduced primordial follicles while preserving larger estradiol- and testosterone-producing follicles and ovarian stroma, a condition that mimics ROR in women...
  20. doi request reprint Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring
    Janice D Wagner
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Am J Primatol 71:802-11. 2009
    ....
  21. ncbi request reprint Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition
    Susan E Appt
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Fertil Steril 86:1210-6. 2006
    ....
  22. ncbi request reprint Effects of exercise on cardiovascular outcomes in monkeys with risk factors for coronary heart disease
    J Koudy Williams
    Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 23:864-71. 2003
    ..However, the mechanisms mediating the beneficial effects of exercise remain ambiguous. In particular, it is uncertain whether exercise inhibits the development of atherosclerosis, a major pathobiologic process underlying heart disease...
  23. ncbi request reprint Soy protein containing isoflavones reduces the size of atherosclerotic plaques without affecting coronary artery reactivity in adult male monkeys
    Michael R Adams
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 135:2852-6. 2005
    ....
  24. ncbi request reprint Reproductive hormones and cardiovascular disease mechanism of action and clinical implications
    Janice D Wagner
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Obstet Gynecol Clin North Am 29:475-93. 2002
    ..The remainder of the study groups including an estrogen-only arm, are expected to continue until 2005...
  25. ncbi request reprint Adrenocortical effects of oral estrogens and soy isoflavones in female monkeys
    Charles E Wood
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 89:2319-25. 2004
    ..These findings suggest that long-term estrogen treatment may contribute to an androgen-deficient and hypercortisolemic state...
  26. ncbi request reprint Effects of soy isoflavones and conjugated equine estrogens on inflammatory markers in atherosclerotic, ovariectomized monkeys
    Thomas C Register
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 90:1734-40. 2005
    ..The sites of IF inhibitory effects on sVCAM-1 production are not known, but likely candidates include the liver and/or the cardiovascular system...
  27. ncbi request reprint Effects of soy on the mammary glands of premenopausal female monkeys
    Charles E Wood
    Section on Comparative Medicine, The Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Fertil Steril 85:1179-86. 2006
    ..To evaluate the interactive effects of dietary soy and menstrual cycle phase on breast proliferation, apoptosis, and sex steroid receptor expression in premenopausal female cynomolgus monkeys...
  28. ncbi request reprint Modeling women's health with nonhuman primates and other animals
    Jay R Kaplan
    Department of Pathology, Wake Forest University, School of Medicine, Winston Salem, NC, USA
    ILAR J 45:83-8. 2004
  29. pmc Endometrial profile of tamoxifen and low-dose estradiol combination therapy
    Charles E Wood
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Clin Cancer Res 16:946-56. 2010
    ..The goal of this study was to evaluate the endometrial profile of low-dose estradiol and the SERM tamoxifen alone and in combination...
  30. ncbi request reprint Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 5:169-74. 2002
    ..These data demonstrate that alterations in an organism's environment can produce profound biological changes that have important behavioral associations, including vulnerability to cocaine addiction...
  31. ncbi request reprint Type 2 diabetes-an introduction to the development and use of animal models
    Jay R Kaplan
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    ILAR J 47:181-5. 2006
    ..The individual contributions comprising this issue of ILAR Journal review the research that has been conducted on many of these animals...
  32. ncbi request reprint Genetics of monoamine metabolites in baboons: overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid
    Jeffrey Rogers
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Biol Psychiatry 55:739-44. 2004
    ..Further genetic analysis can help explain phenotypic correlations among monoamine levels and might eventually help identify genes involved in response to therapy or risk of psychopathology...
  33. ncbi request reprint Increased aggressive behavior and decreased affiliative behavior in adult male monkeys after long-term consumption of diets rich in soy protein and isoflavones
    Neal G Simon
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Horm Behav 45:278-84. 2004
    ..The results indicate that long-term consumption of a diet rich in soy isoflavones can have marked influences on patterns of aggressive and social behavior...
  34. ncbi request reprint Concentrations of isoflavones in macaques consuming standard laboratory monkey diet
    Fawn C Stroud
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    J Am Assoc Lab Anim Sci 45:20-3. 2006
    ..These data argue for the use of soy-free diets in studies investigating estrogenic effects on physiologic or behavioral endpoints...
  35. ncbi request reprint Practical measurement of total and bioavailable estradiol in female macaques
    Karen Pazol
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Clin Chim Acta 340:117-26. 2004
    ..However, while these techniques are useful for humans, they have yet to be evaluated systematically for macaques-species which are frequently used to model estrogen effects on women's health...
  36. ncbi request reprint Approach to a social stranger is associated with low central nervous system serotonergic responsivity in female cynomolgus monkeys (Macaca fascicularis)
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Primatol 61:187-94. 2003
    ..We conclude that in female cynomolgus monkeys, social impulsivity (vs. inhibition) correlates inversely with individual differences in CNS serotonergic activity, as assessed by neuroendocrine challenge...
  37. ncbi request reprint Estrogens, progestins, and atherosclerosis
    Michael R Adams
    Arterioscler Thromb Vasc Biol 24:e190; author reply e190-1. 2004
  38. ncbi request reprint ERbeta protein expression in female cynomolgus monkey and CF-1 mouse brain: Western analysis
    Shan Hu
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    J Neurobiol 64:298-309. 2005
    ..Elucidating the functions of these ERbeta isoforms in the CNS will facilitate our understanding of the tissue- and promoter-specific actions of estrogen...
  39. pmc Polymorphisms in the serotonin reuptake transporter gene modify the consequences of social status on metabolic health in female rhesus monkeys
    Holly Jarrell
    Division of Psychobiology, Yerkes National Primate Research Center, Emory University, USA
    Physiol Behav 93:807-19. 2008
    ..These findings suggest that genetic factors modify the responses of monkeys to social subordination and perhaps other psychosocial stressors...
  40. ncbi request reprint Sequence variation in the primate dopamine transporter gene and its relationship to social dominance
    Cassandra M Miller-Butterworth
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, USA
    Mol Biol Evol 25:18-28. 2008
    ..This suggests that the DAT gene has followed different evolutionary trajectories during primate speciation...
  41. ncbi request reprint Multidetector computed tomographic morphology of ovaries in cynomolgus macaques (Macaca fascicularis)
    Jeryl C Jones
    Department of Small Animal Clinical Sciences, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic and State University, Blacksburg, VA, USA
    J Am Assoc Lab Anim Sci 46:54-63. 2007
    ..41 to 0.67 ml compared with 0.40 to 0.65 ml by water displacement. MDCT is a promising technique for measuring longitudinal changes in macaque ovarian morphology reliably and noninvasively...
  42. ncbi request reprint The serotonin transporter: sequence variation in Macaca fascicularis and its relationship to dominance
    Cassandra M Miller-Butterworth
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, A300 Crabtree Hall, 130 De Soto Street, Pittsburgh, PA, USA
    Behav Genet 37:678-96. 2007
    ..No individual variants or haplotypes were significantly associated with social rank or 5-HIAA concentrations; however, certain serotonin transporter diplotypes may modulate acquisition of dominance status...
  43. ncbi request reprint Old world nonhuman primate models of type 2 diabetes mellitus
    Janice E Wagner
    Department of Pathology Wake Forest University School of Medicine, Winston Salem, NC, USA
    ILAR J 47:259-71. 2006
    ..Thus, Old World NHPs are a valuable animal model of type 2 diabetes to study disease progression, associated risk factors, and potential new treatments...

Research Grants20

  1. Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic Diseases
    JAY KAPLAN; Fiscal Year: 2009
    ....
  2. Vervet Research Colony as a Biomedical Resource
    JAY KAPLAN; Fiscal Year: 2009
    ....
  3. Sequencing the Microbiome in Two Primate Species Under Two Dietary Conditions
    JAY KAPLAN; Fiscal Year: 2009
    ....
  4. Vervet Research Colony as a Biomedical Resource
    JAY KAPLAN; Fiscal Year: 2009
    ..abstract_text> ..
  5. SOY, LIFE STAGE, STRESS AND ATHEROSCLEROSIS IN FEMALES
    JAY KAPLAN; Fiscal Year: 2009
    ....
  6. MODELING THE MENOPAUSAL TRANSITION AND MENOPAUSE
    JAY KAPLAN; Fiscal Year: 2007
    ..Therefore the proposed program is directly relevant to the missions of multiple NIHInstitutes, including - butnot limited to - NIA, NICHD, NHLBI, NIDDKand NIMH. ..
  7. Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic Diseases
    JAY KAPLAN; Fiscal Year: 2007
    ....
  8. Vervet Research Colony as a Biomedical Resource
    Jay R Kaplan; Fiscal Year: 2010
    ..Finally, it is anticipated that the vervet will have available the first genome wide, single nucleotide polymorphism resource available for any nonhuman primate. ..