Gary Kammer

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Abnormal T lymphocyte signal transduction in systemic lupus erythematosus
    Gary M Kammer
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, N C, USA
    Curr Dir Autoimmun 5:131-50. 2002
  2. ncbi request reprint Abnormal T cell signal transduction in systemic lupus erythematosus
    Gary M Kammer
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Arthritis Rheum 46:1139-54. 2002
  3. ncbi request reprint Deficient protein kinase a in systemic lupus erythematosus: a disorder of T lymphocyte signal transduction
    Gary M Kammer
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Ann N Y Acad Sci 968:96-105. 2002
  4. ncbi request reprint Abnormal B cell signal transduction in systemic lupus erythematosus
    Islam U Khan
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, N C, USA
    Curr Dir Autoimmun 6:89-104. 2003
  5. ncbi request reprint Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta
    Michael R Elliott
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Immunol 172:7804-12. 2004
  6. ncbi request reprint Protein kinase A and signal transduction in T lymphocytes: biochemical and molecular methods
    Islam U Khan
    Department of Internal Medicine, Wake Forst University Health Sciences, Winston Salem, NC, USA
    Methods Mol Med 102:73-85. 2004
  7. ncbi request reprint Mechanisms of deficient type I protein kinase A activity in lupus T lymphocytes
    Gary M Kammer
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Int Rev Immunol 23:225-44. 2004
  8. ncbi request reprint Protein kinase A regulatory subunit type II beta directly interacts with and suppresses CREB transcriptional activity in activated T cells
    Michael R Elliott
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 171:3636-44. 2003
  9. ncbi request reprint Transcript mutations of the alpha regulatory subunit of protein kinase A and up-regulation of the RNA-editing gene transcript in lupus T lymphocytes
    Dama Laxminarayana
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Lancet 360:842-9. 2002
  10. ncbi request reprint Immunotherapy tackles lupus
    Gary M Kammer
    Nat Med 8:1356-8. 2002

Research Grants

Collaborators

  • George C Tsokos
  • Yuang Taung Juang
  • Islam U Khan
  • Bruce Richardson
  • A Perl
  • M Tolnay
  • G Gilkeson
  • Naomi Rothfield
  • Paul Emery
  • Joan Merrill
  • Mariana Kaplan
  • Michelle Petri
  • Susan M Manzi
  • J Sibilia
  • D Laxminarayana
  • Philip Mease
  • D J Wallace
  • L Moreland
  • R Ramsey-Goldman
  • Michael R Elliott
  • Mario H Cardiel
  • Seth H Lourie
  • James Jakes
  • Stefano Bombardieri
  • Mohamed A El Shahawy
  • William J Shergy
  • Bryan C Pogue
  • Christine Kovacs
  • Thomas Geppert
  • Michael Liebling
  • Kevin Martin
  • Stephanie Ensworth
  • Alastair Kennedy
  • Claudia E Hura
  • John Donohue
  • James Loveless
  • Howard M Kenney
  • Jennifer Grossman
  • Joachim R Kalden
  • Cynthia Weaver
  • Maria Fondal
  • John J Cush
  • Richard A Furie
  • Neil A Kurtzman
  • Jill Buyon
  • Douglas Smith
  • Moges Sisay
  • Anitha Vijayan
  • Ellen Ginzler
  • Mahesh Krishnan
  • H Michael Belmont
  • Deborah Desir
  • Mary E Cronin
  • STANLEY BALLOU
  • Ronald van Vollenhoven
  • Yvonne Sherrer
  • Adrian Jaffer
  • Elizabeth A Tindall
  • Miguel Vilardell Tarres
  • Gunnar Sturfelt
  • Paul Fortin
  • Charles Moritz
  • Paul Howard
  • Tenshang Joh
  • William Surbeck
  • Michael A Becker
  • Falk Hiepe
  • Gerald B Appel
  • Raphael DeHoratius
  • John J Condemi
  • James A Tumlin
  • Jacob Aelion
  • Michael Edwards
  • Micha Abeles
  • James McKay
  • Rosalind Ramsey Goldman
  • James Brodeur
  • Matthew D Linnik
  • Eugene P Boling
  • Moses Spira
  • Michael P Stevens
  • Robert Katz
  • Matthias Schneider
  • Arnold Roth
  • Stanley Kaplan
  • Bruce Spinowitz
  • Munther Khamashta
  • Arnaldo Torres
  • Gary W Williams
  • Robert J Quinet

Detail Information

Publications12

  1. ncbi request reprint Abnormal T lymphocyte signal transduction in systemic lupus erythematosus
    Gary M Kammer
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, N C, USA
    Curr Dir Autoimmun 5:131-50. 2002
  2. ncbi request reprint Abnormal T cell signal transduction in systemic lupus erythematosus
    Gary M Kammer
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Arthritis Rheum 46:1139-54. 2002
  3. ncbi request reprint Deficient protein kinase a in systemic lupus erythematosus: a disorder of T lymphocyte signal transduction
    Gary M Kammer
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Ann N Y Acad Sci 968:96-105. 2002
    ..In conclusion, distinct mechanisms account for deficient PKA-I and PKA-II isozyme activities in SLE T cells...
  4. ncbi request reprint Abnormal B cell signal transduction in systemic lupus erythematosus
    Islam U Khan
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, N C, USA
    Curr Dir Autoimmun 6:89-104. 2003
  5. ncbi request reprint Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta
    Michael R Elliott
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Immunol 172:7804-12. 2004
    ..In summary, our data demonstrate a novel mechanism by which serine 114 phosphorylation and nuclear localization of RIIbeta controls the regulation of gene expression in T cells...
  6. ncbi request reprint Protein kinase A and signal transduction in T lymphocytes: biochemical and molecular methods
    Islam U Khan
    Department of Internal Medicine, Wake Forst University Health Sciences, Winston Salem, NC, USA
    Methods Mol Med 102:73-85. 2004
    ..Although our emphasis in the chapter is T cells, these methods may be useful for investigation of signaling via PKA in other cell types as well...
  7. ncbi request reprint Mechanisms of deficient type I protein kinase A activity in lupus T lymphocytes
    Gary M Kammer
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Int Rev Immunol 23:225-44. 2004
    ..Most mutations are clustered adjacent to GAGAG motifs and CT repeats. In conclusion, aberrant signaling via the cAMP/PKA pathway occurs in SLE T cells, and this is proposed to contribute to abnormal T cell effector functions...
  8. ncbi request reprint Protein kinase A regulatory subunit type II beta directly interacts with and suppresses CREB transcriptional activity in activated T cells
    Michael R Elliott
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 171:3636-44. 2003
    ..We conclude that nuclear RIIbeta can act as a repressor of CREB transcriptional activity in T cells, providing a potential functional significance for aberrant levels of nuclear RIIbeta in systemic lupus erythematosus T cells...
  9. ncbi request reprint Transcript mutations of the alpha regulatory subunit of protein kinase A and up-regulation of the RNA-editing gene transcript in lupus T lymphocytes
    Dama Laxminarayana
    Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Lancet 360:842-9. 2002
    ..We aimed to identify a molecular mechanism or mechanisms for this isozyme deficiency by assessing occurrence of mutations in transcripts of the RI alpha subunit in patients with SLE...
  10. ncbi request reprint Immunotherapy tackles lupus
    Gary M Kammer
    Nat Med 8:1356-8. 2002
  11. pmc Altered regulation of IL-2 production in systemic lupus erythematosus: an evolving paradigm
    Gary M Kammer
    Arthritis Associates Inc, Willoughby, Ohio 44094, USA
    J Clin Invest 115:836-40. 2005
    ..Because IL-2 may contribute to the maintenance of T cell tolerance, deficient IL-2 production could promote a breach of T cell tolerance that results in autoantibody production in SLE...
  12. doi request reprint Abetimus sodium for renal flare in systemic lupus erythematosus: results of a randomized, controlled phase III trial
    Mario H Cardiel
    Hospital General Dr Miguel Silva, Morelia, Michoacan, Mexico
    Arthritis Rheum 58:2470-80. 2008
    ....

Research Grants7

  1. T LYMPHOCYTE DYSFUNCTION IN LUPUS ERYTHEMATOSUS
    Gary Kammer; Fiscal Year: 2001
    ..The Principal Investigator will study 14 families with 3 generations available - beginning with a lupus proband with a mutation. ..
  2. T LYMPHOCYTE DYSFUNCTION IN LUPUS ERYTHEMATOSUS
    Gary Kammer; Fiscal Year: 2002
    ..Thus, the significance of this research is its potential to explain how defective signaling circuitry within the T cell can lead to the aberrant T cell effector functions that result in lupus immunopathogenesis. ..
  3. Protein Kinase A-II in the Pathogenesis of Lupus
    Gary Kammer; Fiscal Year: 2003
    ..abstract_text> ..