J A Ibdah

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: variable expressivity of maternal illness during pregnancy and unusual presentation with infantile cholestasis and hypocalcaemia
    J A Ibdah
    Division of Gastroenterology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Inherit Metab Dis 22:811-4. 1999
  2. ncbi request reprint Liver disease in pregnancy and fetal fatty acid oxidation defects
    J A Ibdah
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Mol Genet Metab 71:182-9. 2000
  3. pmc Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death
    J A Ibdah
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Clin Invest 107:1403-9. 2001
  4. ncbi request reprint Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance
    Jamal A Ibdah
    Division of Gastroenterology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Gastroenterology 128:1381-90. 2005
  5. ncbi request reprint Molecular prenatal diagnosis in families with fetal mitochondrial trifunctional protein mutations
    J A Ibdah
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    J Pediatr 138:396-9. 2001
  6. ncbi request reprint Late presentation of esophageal injury after transesophageal echocardiography
    Drew A MacGregor
    Department of Anesthesia, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 99:41-4. 2004
  7. ncbi request reprint Post-mortem analysis for two prevalent beta-oxidation mutations in sudden infant death
    Zi Yang
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Pediatr Int 49:883-7. 2007
  8. pmc Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic Ren2 rats
    Yongzhong Wei
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Am J Pathol 174:1329-37. 2009
  9. ncbi request reprint Maternal heterozygosity for a mitochondrial trifunctional protein mutation as a cause for liver disease in pregnancy
    Kimberly R Blish
    Division of Gastroenterology, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Med Hypotheses 64:96-100. 2005
  10. ncbi request reprint Intestinal pseudo-obstruction as a manifestation of impaired mitochondrial fatty acid oxidation
    Jeffrey Gilbert
    Division of Gastroenterology, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Med Hypotheses 64:586-9. 2005

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: variable expressivity of maternal illness during pregnancy and unusual presentation with infantile cholestasis and hypocalcaemia
    J A Ibdah
    Division of Gastroenterology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Inherit Metab Dis 22:811-4. 1999
    ..The maternal pregnancy history documents that fetal LCHAD deficiency is associated with a spectrum of maternal illnesses ranging from pre-eclampsia to life-threatening AFLP...
  2. ncbi request reprint Liver disease in pregnancy and fetal fatty acid oxidation defects
    J A Ibdah
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Mol Genet Metab 71:182-9. 2000
    ..Finally, the potential implications of our current knowledge for families with pediatric LCHAD deficiency and for women who develop AFLP and HELLP syndrome are discussed...
  3. pmc Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death
    J A Ibdah
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Clin Invest 107:1403-9. 2001
    ..Deficiency of MTP causes fetal growth retardation, neonatal hypoglycemia, and sudden death...
  4. ncbi request reprint Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance
    Jamal A Ibdah
    Division of Gastroenterology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Gastroenterology 128:1381-90. 2005
    ..In this study, we investigated effects of heterozygosity for the MTP defect on hepatic oxidative stress, insulin resistance, and development of NAFLD in mice...
  5. ncbi request reprint Molecular prenatal diagnosis in families with fetal mitochondrial trifunctional protein mutations
    J A Ibdah
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    J Pediatr 138:396-9. 2001
    ..Women heterozygous for TFP alpha-subunit mutations who carry fetuses with wild-type or heterozygous genotypes have uncomplicated pregnancies...
  6. ncbi request reprint Late presentation of esophageal injury after transesophageal echocardiography
    Drew A MacGregor
    Department of Anesthesia, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 99:41-4. 2004
    ..The differential diagnosis of postoperative pleural effusion or anemia must include esophageal injury from TEE, even 6 days after the procedure...
  7. ncbi request reprint Post-mortem analysis for two prevalent beta-oxidation mutations in sudden infant death
    Zi Yang
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Pediatr Int 49:883-7. 2007
    ..MCAD catalyzes the first step of medium-chain fatty acid oxidation while MTP catalyzes the last three steps of long-chain fatty acid oxidation...
  8. pmc Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic Ren2 rats
    Yongzhong Wei
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Am J Pathol 174:1329-37. 2009
    ..These results document that ANG II induces mitochondrial oxidative damage and impairs mitochondrial beta-oxidation, contributing to liver steatosis...
  9. ncbi request reprint Maternal heterozygosity for a mitochondrial trifunctional protein mutation as a cause for liver disease in pregnancy
    Kimberly R Blish
    Division of Gastroenterology, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Med Hypotheses 64:96-100. 2005
    ....
  10. ncbi request reprint Intestinal pseudo-obstruction as a manifestation of impaired mitochondrial fatty acid oxidation
    Jeffrey Gilbert
    Division of Gastroenterology, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Med Hypotheses 64:586-9. 2005
    ....
  11. pmc Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats
    Yongzhong Wei
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Hepatol 49:417-28. 2008
    ..The renin-angiotensin system (RAS) plays a vital role in blood pressure regulation and appears to promote hepatic fibrogenesis. We hypothesized that increased RAS activity causes NAFLD due to increased hepatic oxidative stress...
  12. ncbi request reprint Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species
    Yongzhong Wei
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Am J Physiol Regul Integr Comp Physiol 294:R673-80. 2008
    ..This review is focused on the effects of inflammatory cytokines and oxidative stress on insulin signaling in skeletal muscle and consequent development of insulin resistance...
  13. ncbi request reprint Nonalcoholic steatohepatitis and the cardiometabolic syndrome
    Mohammad Bosem Abdeen
    Department of Internal Medicine, 2 University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    J Cardiometab Syndr 1:36-40. 2006
    ..Expert opinion emphasizes the importance of exercise, weight loss in obese and overweight individuals, treatment of hyperlipidemia, and glucose control...
  14. ncbi request reprint Prospective screening for pediatric mitochondrial trifunctional protein defects in pregnancies complicated by liver disease
    Zi Yang
    Division of Gastroenterology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    JAMA 288:2163-6. 2002
    ....
  15. ncbi request reprint Mitochondrial trifunctional protein defects: molecular basis and novel therapeutic approaches
    J Angdisen
    Division of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Curr Drug Targets Immune Endocr Metabol Disord 5:27-40. 2005
    ..Finally, we have shown that the fusion protein can cross the placenta and was detectable in the fetus and newborn pups. The practical therapeutic implications of this novel approach will be discussed...
  16. ncbi request reprint Fetal genotypes and pregnancy outcomes in 35 families with mitochondrial trifunctional protein mutations
    Zi Yang
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Obstet Gynecol 187:715-20. 2002
    ..Trifunctional protein has 3 enzymatic activities that include long-chain 3-hydroxyacyl-CoA dehydrogenase, which catalyzes long-chain fatty acid beta-oxidation...
  17. pmc Low aerobic capacity and high-fat diet contribute to oxidative stress and IRS-1 degradation in the kidney
    E Matthew Morris
    Department of Internal Medicine, University of Missouri Columbia, Columbia, MO 65212, USA
    Am J Nephrol 30:112-9. 2009
    ..Thereby, we hypothesized intrinsically high aerobic fitness would protect against high-fat diet (HFD)-induced reactive oxygen species (ROS) and IRS-1 degradation...
  18. ncbi request reprint Impaired fatty acid oxidation as a cause of liver disease associated with hyperemesis gravidarum
    William M Outlaw
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA
    Med Hypotheses 65:1150-3. 2005
    ..The rationale for this hypothesis is discussed...
  19. doi request reprint Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats
    R Scott Rector
    Division of Gastroenterology and Hepatology, University of Missouri Columbia, Columbia, MO 65212, USA
    Am J Physiol Gastrointest Liver Physiol 294:G619-26. 2008
    ....
  20. ncbi request reprint Role of genetic screening in identifying susceptibility to acute fatty liver of pregnancy
    Jamal A Ibdah
    Medical Pharmacology and Physiology, University of Missouri Columbia, 65212, USA
    Nat Clin Pract Gastroenterol Hepatol 2:494-5. 2005
  21. pmc Non-alcoholic fatty liver disease and the metabolic syndrome: an update
    R Scott Rector
    Division of Gastroenterology and Hepatology, University of Missouri Columbia, Columbia, MO 65212, United States
    World J Gastroenterol 14:185-92. 2008
    ..While no therapy has been proven effective for treating NAFLD/NASH, common recommendations will be discussed...
  22. pmc Nonalcoholic fatty liver disease and mitochondrial dysfunction
    Yongzhong Wei
    Division of Gastroenterology and Hepatology, Harry S Truman VA Medical Center, Columbia, MO 65212, United States
    World J Gastroenterol 14:193-9. 2008
    ..Accumulating evidence indicate that hepatic mitochondrial dysfunction is crucial to the pathogenesis of NAFLD. This review is focused on the significant role of mitochondria in the development of NAFLD...