Research Topics
| WILLIAM HUNDLEYSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failureChirapa Puntawangkoon
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Cardiovasc Magn Reson 11:48. 2009..We hypothesized that reduced lower extremity blood flow (LBF) due to reduced forward cardiac output would contribute to submaximal exercise intolerance in older HF patients...- Adverse effect of increased left ventricular wall thickness on five year outcomes of patients with negative dobutamine stressThomas F Walsh
Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina, USA
J Cardiovasc Magn Reson 11:25. 2009..To determine if patients without dobutamine induced left ventricular wall motion abnormalities (WMA) but an increased LV end-diastolic wall thickness (EDWT) exhibit a favorable cardiac prognosis... - The 20 year evolution of dobutamine stress cardiovascular magnetic resonanceCharaslak Charoenpanichkit
Department of Internal Medicine Section on Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
J Cardiovasc Magn Reson 12:59. 2010..This article traces these developments and reviews the data utilized to substantiate this relatively new noninvasive imaging procedure... - Society for Cardiovascular Magnetic Resonance guidelines for reporting cardiovascular magnetic resonance examinationsW Gregory Hundley
Department of Internal Medicine, Section on Cardiology and Radiology, Wake Forest University School of Medicine, Winston Salem, USA
J Cardiovasc Magn Reson 11:5. 2009.... 
Relation of cardiac prognosis to segment location with apical left ventricular ischemiaW Gregory Hundley
Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
Am J Cardiol 92:1206-8. 2003..In this study, we find this heightened risk is present independent of the location of the distal segment within the left ventricular apex...- Visualization and functional assessment of proximal and middle left anterior descending coronary stenoses in humans with magnetic resonance imagingW G Hundley
Department of Internal Medicine, The Wake Forest University Baptist Medical Center, Winston Salem, NC, USA
Circulation 99:3248-54. 1999..Although magnetic resonance imaging (MRI) has been used to visualize coronary arteries and to measure flow reserve noninvasively, the utility of MRI for detecting significant LAD stenoses is unknown... - Magnetic resonance imaging determination of cardiac prognosisW Gregory Hundley
Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
Circulation 106:2328-33. 2002.... - Leg flow-mediated arterial dilation in elderly patients with heart failure and normal left ventricular ejection fractionW Gregory Hundley
Department of Internal Medicine, Section on Cardiology, Wake Forest Univ School of Medicine, Bowman Gray Campus, Winston Salem, NC 27157 1045, USA
Am J Physiol Heart Circ Physiol 292:H1427-34. 2007..Many elderly patients with heart failure exhibit a normal left ventricular ejection fraction (HFNEF). It is unknown whether FMAD is severely reduced in the elderly with HFNEF... - Utility of fast cine magnetic resonance imaging and display for the detection of myocardial ischemia in patients not well suited for second harmonic stress echocardiographyW G Hundley
Cardiology Section, Division of Radiological Sciences, The Wake Forest University School of Medicine, Winston Salem, NC, USA
Circulation 100:1697-702. 1999..Fast cine MRI can be used to assess left ventricular contraction, but its utility for detection of myocardial ischemia in patients poorly suited for echocardiography is unknown... - Assessment of coronary arterial restenosis with phase-contrast magnetic resonance imaging measurements of coronary flow reserveW G Hundley
Department of Internal Medicine, Wake Forest University Baptist Medical Center, Winston Salem, NC, USA
Circulation 101:2375-81. 2000..This study was performed to determine if phase-contrast MRI (PC-MRI) could be used to detect restenosis noninvasively in patients with recurrent chest pain after percutaneous revascularization... - Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intoleranceW G Hundley
Department of Internal Medicine, Cardiology Section, The Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
J Am Coll Cardiol 38:796-802. 2001..The goal of this study was to determine if cardiac cycle-dependent changes in proximal thoracic aortic area and distensibility are associated with exercise intolerance in elderly patients with diastolic heart failure (DHF)... - Magnetic resonance imaging assessment of cardiac functionW Gregory Hundley
Section on Cardiology, Wake Forest University School of Medicine, Bowman Gray Campus, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
Curr Cardiol Rep 5:69-74. 2003..This relatively new development may enhance a physician's ability to provide care to patients with cardiovascular disease... - Dobutamine cardiac magnetic resonance results predict cardiac prognosis in women with known or suspected ischemic heart diseaseEric L Wallace
Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
JACC Cardiovasc Imaging 2:299-307. 2009..The purpose of this study was to determine the prognostic utility of dobutamine cardiac magnetic resonance (DCMR) stress test results in women... - The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failureWilliam C Little
Department of Internal Medicine, Cardiology Section, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, USA
J Card Fail 11:191-5. 2005..CONCLUSION: Sixteen weeks of treatment with the glucose crosslink breaker, alagebrium, resulted in a decrease in left ventricular mass and improvements in left ventricular diastolic filling and quality of life in patient with DHF... - Relation of aortic distensibility determined by magnetic resonance imaging in patients > or =60 years of age to systolic heart failure and exercise capacityPairoj Rerkpattanapipat
Internal Medicine (Cardiology Section, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1045, USA
Am J Cardiol 90:1221-5. 2002..These data suggest that decreased aortic distensibility may contribute to exercise intolerance in older patients with HF due to LV systolic dysfunction... - Effect of the transmural extent of myocardial scar on left ventricular systolic wall thickening during intravenous dobutamine administrationPairoj Rerkpattanapipat
Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Am J Cardiol 95:495-8. 2005..The transmural extent of hyperenhancement correlated inversely with dobutamine SWT (r = -0.7, p <0.001). All segments with dobutamine SWT >/=2 mm showed a transmural extent of hyperenhancement of <50%... - Submaximal exercise coronary artery flow increases in postmenopausal women without coronary artery disease after estrogen and atorvastatinChirapa Puntawangkoon
Department of Internal Medicine, Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC, USA
Menopause 17:114-20. 2010.... - Assessment of ventricular function with cardiovascular magnetic resonanceThomas F Walsh
Department of Internal Medicine, Wake Forest University School of Medicine, Bowman Gray Campus, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
Cardiol Clin 25:15-33, v. 2007..This article reviews CMR methods used to assess regional and global ventricular function... 
Prediction of cardiac events in patients with reduced left ventricular ejection fraction with dobutamine cardiovascular magnetic resonance assessment of wall motion score indexErica Dall'Armellina
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
J Am Coll Cardiol 52:279-86. 2008..The purpose of this study was to assess the utility of dobutamine cardiovascular magnetic resonance (DCMR) results for predicting cardiac events in individuals with reduced left ventricular ejection fraction (LVEF)...- Location of arterial stiffening differs in those with impaired fasting glucose versus diabetes: implications for left ventricular hypertrophy from the Multi-Ethnic Study of AtherosclerosisPairoj Rerkpattanapipat
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Diabetes 58:946-53. 2009.... - Novel approach to early detection of doxorubicin cardiotoxicity by gadolinium-enhanced cardiovascular magnetic resonance imaging in an experimental modelJames C Lightfoot
Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, NC, USA
Circ Cardiovasc Imaging 3:550-8. 2010.... - Modification of the effect of glycemic status on aortic distensibility by age in the multi-ethnic study of atherosclerosisR Brandon Stacey
Wake Forest University Health Sciences, Cardiology Section, Winston Salem, NC 27157, USA
Hypertension 55:26-32. 2010..However, age modified the effect of glucose status such that differences between the groups diminished with advancing age... - Noninterleaved velocity encodings for improved temporal and spatial resolution in phase-contrast magnetic resonance imagingCraig A Hamilton
Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, NC 27157 1022, USA
J Comput Assist Tomogr 34:570-4. 2010..5-T GE Echospeed scanner, using both interleaved and noninterleaved velocity encodings. The results demonstrate that the use of noninterleaved velocity encodings reduces spatial and temporal blur by improving the temporal resolution... - A randomized double-blind trial of enalapril in older patients with heart failure and preserved ejection fraction: effects on exercise tolerance and arterial distensibilityDalane W Kitzman
Cardiology Section, Department of Internal Medicine, Wake Forest University Health Sciences, Winston Salem, NC, USA
Circ Heart Fail 3:477-85. 2010..Exercise intolerance is the primary symptom in older patients with heart failure and preserved ejection fraction (HFPEF); however, little is known regarding its mechanisms and therapy... - Assessment of preoperative cardiac risk with magnetic resonance imagingPairoj Rerkpattanapipat
Department of Internal Medicine (Cardiology Section, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1045, USA
Am J Cardiol 90:416-9. 2002 - Feasibility to detect severe coronary artery stenoses with upright treadmill exercise magnetic resonance imagingPairoj Rerkpattanapipat
Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Am J Cardiol 92:603-6. 2003..The sensitivity and specificity for detecting >70% coronary artery luminal diameter narrowings on contrast coronary angiography were 79% and 85%, respectively... - Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and womenBarbara J Nicklas
Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Aging Clin Exp Res 20:302-9. 2008..The purpose of this study was to determine whether physical function is independently associated with histologic and metabolic properties of skeletal muscle in elderly adults... - Relationship between arterial stiffness and subclinical aortic atherosclerosisDavid M Herrington
Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Circulation 110:432-7. 2004..Noninvasive measures of arterial compliance may be useful for the detection of subclinical atherosclerosis... - Diabetic cardiomyopathy and subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA)Alain G Bertoni
Wake Forest University Health Sciences, Department of Public Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
Diabetes Care 29:588-94. 2006..We examined whether diabetic cardiomyopathy is associated with subclinical atherosclerosis and if abnormalities are found with impaired fasting glucose (IFG)... - Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failureDalane W Kitzman
Section of Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045
JAMA 288:2144-50. 2002..However, the pathophysiology of this disorder, presumptively termed diastolic heart failure (DHF), is not well characterized and it is unknown whether it represents true heart failure... - Detection of pseudoaneurysm of the left ventricle by fast imaging employing steady-state acquisition (FIESTA) magnetic resonance imagingPairoj Rerkpattanapipat
Department of Internal Medicine, Section on Cardiology, Wake Forest University School of Medicine, Bowman Gray Campus, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
J Cardiovasc Magn Reson 5:399-402. 2003..With heightened image clarity, physicians unexpectedly identified a LV pseudoaneurysm... - Left ventricular hypertrophy influences cardiac prognosis in patients undergoing dobutamine cardiac stress testingCharaslak Charoenpanichkit
Departments of Internal Medicine Cardiology Section, Public Health Sciences, Biomedical Engineering, and Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
Circ Cardiovasc Imaging 3:392-7. 2010..This study was performed to determine the utility of dobutamine stress test results for predicting myocardial infarction (MI) and cardiac death in patients with chest pain and left ventricular hypertrophy (LVH)... - Effects of phase encode order and segment interpolation methods on the quality and accuracy of myocardial tags during assessment of left ventricular contractionTiffany B Salido
Department of Medical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
J Cardiovasc Magn Reson 4:245-54. 2002.... - Stress cardiac magnetic resonance imaging with observation unit care reduces cost for patients with emergent chest pain: a randomized trialChadwick D Miller
Department of Emergency Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
Ann Emerg Med 56:209-219.e2. 2010.... - Left ventricular spherical remodeling and apical myocardial relaxation: cardiovascular MR imaging measurement of myocardial segmentsMonravee Tumkosit
Department of Internal Medicine, Wake Forest University School of Medicine, Bowman Gray Campus, Medical Center Blvd, Winston Salem, NC 27157 1045, USA
Radiology 244:411-8. 2007..To prospectively evaluate left ventricular (LV) shape and regional relaxation to determine if rapid, early relaxation of the LV is lost with spherical remodeling of the LV... - Left ventricular infarct size assessed with 0.1 mmol/kg of gadobenate dimeglumine correlates with that assessed with 0.2 mmol/kg of gadopentetate dimeglumineMonravee Tumkosit
Department of Internal Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
J Comput Assist Tomogr 33:328-33. 2009..To determine myocardial infarct (MI) size during cardiovascular magnetic resonance at 1.5 Tesla using 0.1 mmol/kg body weight of gadobenate dimeglumine (Gd-BOPTA) and 0.2 mmol/kg body weight of gadopentetate dimeglumine (Gd-DTPA)... - Heart failure prevalence, incidence, and mortality in the elderly with diabetesAlain G Bertoni
Department of Public Health Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
Diabetes Care 27:699-703. 2004..CONCLUSIONS: These data demonstrate alarmingly high prevalence, incidence, and mortality for heart failure in individuals with diabetes. Prevention of heart failure should be a research and clinical priority... - Cardiovascular magnetic resonance imagingStephen N Darty
Department of Internal Medicine, Section on Cardiology, Wake Forest University School of Nursing, Winston-Salem, NC 27157-1045, USA
Am J Nurs 102:34-8; quiz 39. 2002 - Assessment of cardiac function with MR imagingPairoj Rerkpattanapipat
Cardiology Section, Wake Forest University School of Medicine, The Bowman Gray Campus, Winston-Salem, NC 27157-1045, USA
Magn Reson Imaging Clin N Am 11:67-80. 2003..In addition to providing information about LV function at rest, these techniques provide diagnostic and prognostic information regarding myocardial ischemia and viability during MR imaging stress tests... - Automated analysis of phase-contrast magnetic resonance images in the assessment of endothelium-dependent flow-mediated dilationPing Tan
Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
J Cardiovasc Magn Reson 5:325-32. 2003..This methodology may prove useful for the rapid MRI assessment of peripheral arterial endothelial function in a clinical setting when studying patients with cardiovascular disease... - Renal sinus fat and poor blood pressure control in middle-aged and elderly individuals at risk for cardiovascular eventsHaroon L Chughtai
Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, NC, USA
Hypertension 56:901-6. 2010..These results indicate that further studies are warranted to determine whether fat accumulation in the RS promotes hypertension... - Aortic stiffness increases upon receipt of anthracycline chemotherapyNarumol Chaosuwannakit
Wake Forest University Health Sciences, Bowman Gray Campus, Medical Center Blvd, Winston Salem, North Carolina 27157 1045, USA
J Clin Oncol 28:166-72. 2010..These results indicate that previously regarded cardiotoxic cancer therapy adversely increases thoracic aortic stiffness, a known independent predictor of adverse cardiovascular events... - Dobutamine cardiovascular magnetic resonance: a reviewSangeeta Mandapaka
Cardiology Section, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
J Magn Reson Imaging 24:499-512. 2006..This article reviews the performance and utility of DCMR, its association with dobutamine stress echocardiography (DSE), and areas of active investigative research...
Research Grants
- Vascular Stiffness and Pulmonary CongestionWilliam Gregory Hundley; Fiscal Year: 2010..With this understanding, we will gain mechanistic insight into the pathophysiology of flash PE that will be useful for developing interventions to prevent the morbidity and mortality associated with this disorder. ..
- Vascular Stiffness and Pulmonary CongestionWILLIAM HUNDLEY; Fiscal Year: 2007..With this understanding, we will gain mechanistic insight into the pathophysiology of flash PE that will be useful for developing interventions to prevent the morbidity and mortality associated with this disorder. ..
- MRI Detection of Doxorubicin Induced CardiotoxicityWILLIAM HUNDLEY; Fiscal Year: 2007..In addition, further animal studies will be designed to identify treatment strategies for Doxorubicin induced cardiotoxicity. ..
- Optimized CMR imaging of chemotherapy cardiotoxicityWILLIAM HUNDLEY; Fiscal Year: 2007..Each phase (R21 & R33) contains separate sections A-D, and as directed by the instructions, we designate (but do not repeat or re-type) the components of sections A through D of the R21 phase that are applicable to the R33 phase. ..
- Vascular Stiffness and Pulmonary CongestionWILLIAM HUNDLEY; Fiscal Year: 2009..With this understanding, we will gain mechanistic insight into the pathophysiology of flash PE that will be useful for developing interventions to prevent the morbidity and mortality associated with this disorder. ..