J J Hu

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function
    Kristin L Lockett
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Cancer Res 64:6344-8. 2004
  2. ncbi request reprint DNA damage levels in prostate cancer cases and controls
    Kristin L Lockett
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 27:1187-93. 2006
  3. ncbi request reprint Deficient nucleotide excision repair capacity enhances human prostate cancer risk
    Jennifer J Hu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 64:1197-201. 2004
  4. ncbi request reprint Alpha-tocopherol dietary supplement decreases titers of antibody against 5-hydroxymethyl-2'-deoxyuridine (HMdU)
    J J Hu
    Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Epidemiol Biomarkers Prev 8:693-8. 1999
  5. ncbi request reprint Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity
    J J Hu
    Department of Cancer Biology and Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 22:917-22. 2001
  6. ncbi request reprint Genetic regulation of ionizing radiation sensitivity and breast cancer risk
    Jennifer J Hu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Environ Mol Mutagen 39:208-15. 2002
  7. ncbi request reprint Symposium overview: genetic polymorphisms in DNA repair and cancer risk
    J J Hu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Toxicol Appl Pharmacol 185:64-73. 2002
  8. ncbi request reprint DNA-repair genetic polymorphisms and breast cancer risk
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 12:1200-4. 2003
  9. ncbi request reprint Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis
    J J Hu
    Lombardi Cancer Center, Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
    Pharmacogenetics 7:309-16. 1997
  10. pmc Prostate cancer risk associated loci in African Americans
    Jianfeng Xu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 18:2145-9. 2009

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function
    Kristin L Lockett
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Cancer Res 64:6344-8. 2004
    ..This study is the first to provide evidence that the ADPRT V762A-genetic variant contributes to CaP susceptibility and altered ADPRT/PARP-1 enzyme function in response to oxidative damage...
  2. ncbi request reprint DNA damage levels in prostate cancer cases and controls
    Kristin L Lockett
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 27:1187-93. 2006
    ..However, larger case-control and follow-up studies are warranted to further evaluate the potential application of the alkaline Comet assay in CaP risk assessment and prevention...
  3. ncbi request reprint Deficient nucleotide excision repair capacity enhances human prostate cancer risk
    Jennifer J Hu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 64:1197-201. 2004
    ..09 (95% CI, 0.46-2.59); 1.81 (95% CI, 0.77-4.27); and 2.63 (95% CI, 1.17-5.95), respectively. This pilot study is the first direct evidence associating deficient NERC with human CaP risk...
  4. ncbi request reprint Alpha-tocopherol dietary supplement decreases titers of antibody against 5-hydroxymethyl-2'-deoxyuridine (HMdU)
    J J Hu
    Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Epidemiol Biomarkers Prev 8:693-8. 1999
    ..Our results demonstrate an inverse relationship between alpha-tocopherol and anti-HMdU Abs in plasma; oxidative DNA damage can be modulated by short-term dietary supplementation of alpha-tocopherol in some subjects...
  5. ncbi request reprint Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity
    J J Hu
    Department of Cancer Biology and Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 22:917-22. 2001
    ..9; P = 0.001). These results suggest that amino acid substitution variants of XRCC1 and APE1 may contribute to IR hypersensitivity...
  6. ncbi request reprint Genetic regulation of ionizing radiation sensitivity and breast cancer risk
    Jennifer J Hu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Environ Mol Mutagen 39:208-15. 2002
    ..001). Although larger studies are needed to validate the results, our data suggest that an inherited hypersensitivity to IR may contribute to human breast carcinogenesis...
  7. ncbi request reprint Symposium overview: genetic polymorphisms in DNA repair and cancer risk
    J J Hu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Toxicol Appl Pharmacol 185:64-73. 2002
    ....
  8. ncbi request reprint DNA-repair genetic polymorphisms and breast cancer risk
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 12:1200-4. 2003
    ..We provide evidence that variants of XRCC1, XRCC3, and ERCC4/XPF genes, particularly in combination, contribute to breast cancer susceptibility...
  9. ncbi request reprint Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis
    J J Hu
    Lombardi Cancer Center, Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
    Pharmacogenetics 7:309-16. 1997
    ....
  10. pmc Prostate cancer risk associated loci in African Americans
    Jianfeng Xu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 18:2145-9. 2009
    ..However, studies with larger numbers of AA subjects are needed, and this will likely require a major collaborative effort to combine multiple AA study populations...
  11. ncbi request reprint Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy
    Peter E Clark
    Department of Urology and Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Urology 67:1257-61. 2006
    ..To report a prospective trial of lycopene supplementation in biochemically relapsed prostate cancer...
  12. ncbi request reprint Analysis of G/A polymorphism in the androgen response element I of the PSA gene and its interactions with the androgen receptor polymorphisms
    Anuradha Rao
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Urology 61:864-9. 2003
    ..Data are conflicting regarding the association of PSA promoter alleles with serum PSA in men...
  13. ncbi request reprint Nucleotide-excision repair and prostate cancer risk
    Kristin L Lockett
    Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Lett 220:125-35. 2005
    ....
  14. ncbi request reprint Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics and the Department of Public Health, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Genet 32:321-5. 2002
    ..009). Among African American men, these values were 12.5% and 1.8%, respectively (P = 0.01). These results show that MSR1 may be important in susceptibility to prostate cancer in men of both African American and European descent...
  15. ncbi request reprint Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Lett 190:183-90. 2003
    ..74; 95% CI=1.13-67.53). Although larger studies are needed to validate the study results, our data suggest that amino acid substitution variants of XRCC1 and XRCC3 genes may contribute to breast cancer susceptibility...
  16. ncbi request reprint DNA damage and breast cancer risk
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Carcinogenesis 24:883-9. 2003
    ....
  17. pmc Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancer
    Beth O Van Emburgh
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Mol Carcinog 47:88-99. 2008
    ....
  18. pmc Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer
    Beth O Van Emburgh
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Oncol Rep 19:1311-21. 2008
    ..97; 95% CI=1.27-12.40). These results suggest the importance of estrogen/carcinogen metabolic enzymes in the etiology of breast cancer, especially in women before the age of 60, as well as preventative measures such as smoking cessation...
  19. doi request reprint Comparison of multivariate adaptive regression splines and logistic regression in detecting SNP-SNP interactions and their application in prostate cancer
    Hui Yi Lin
    Medical Statistics Section, University of Alabama at Birmingham, Birmingham, AL, USA
    J Hum Genet 53:802-11. 2008
    ..The best model with one two-way and one three-way interaction was selected using MARS. The findings supported that MARS may provide a useful tool for exploring SNP-SNP interactions...
  20. doi request reprint Interactions of cytokine gene polymorphisms in prostate cancer risk
    Jovanny Zabaleta
    Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar Street, CSRB 455, New Orleans, LA 70112, USA
    Carcinogenesis 29:573-8. 2008
    ..92, 95% CI = 1.13-7.55) and the genotype combination of TNF-238GG plus IL10-592AA (OR = 2.14, 95% CI = 1.05-4.38). Our results highlight the importance of cytokine SNPs and their interactions in CaP risk...