Research Topics
Genomes and GenesSpecies | Timothy D HowardSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Publications
Evaluation of self-reported ethnicity in a case-control population: the stroke prevention in young women studyJesse B Mez
Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
BMC Res Notes 2:260. 2009..Here we apply a model-based clustering approach to our case-control study of stroke among young women to examine if self-reported ethnicity can serve as a proxy for genetic ancestry...- CLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severityCarol J Blaisdell
Department of Genetics, School of Medicine, University of Maryland, Howard Hall 596, 660 W, Redwood St, Baltimore, Maryland, USA
BMC Med Genet 5:26. 2004..The objectives of this study are to identify single nucleotide polymorphisms (SNPs) in the airway epithelial chloride channel, CLC-2, and correlate these polymorphisms with CF lung disease... - Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHETimothy D Howard
Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Environ Health Perspect 118:1395-9. 2010..To understand fully the links between pesticide exposure and potential human disease, analyses must be able to consider genetic variability in pesticide metabolism... - Epigenetic changes with dietary soy in cynomolgus monkeysTimothy D Howard
Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
PLoS ONE 6:e26791. 2011..These data support the use of the HumanMethylation27 BeadChip in cynomolgus monkeys and identify epigenetic changes associated with dietary interventions with soy protein that may potentially affect the etiology of complex diseases... - Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black womenTimothy D Howard
The Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Stroke 36:1848-51. 2005..Endothelial nitric oxide exerts a variety of protective effects on endothelial cells and blood vessels, and therefore the nitric oxide synthase 3 gene (NOS3) is a logical candidate gene for stroke susceptibility... 
Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populationsTimothy D Howard
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 112:717-22. 2003..Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33 (ADAM33), was implicated in asthma susceptibility...- The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthmaGregory A Hawkins
Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 130:510-5.e1. 2012..The SNP rs4129267 is in linkage disequilibrium (r(2) = 1) with the IL6R coding SNP rs2228145 (Asp(358)Ala). This IL6R coding change increases IL-6 receptor (IL-6R) shedding and promotes IL-6 transsignaling... - Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseasesXingnan Li
Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 130:861-8.e7. 2012.... - Job activities and respiratory symptoms among farmworkers in North CarolinaMaria C Mirabelli
Department of Epidemiology and Prevention, Divisionof Public Health Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1063, USA
Arch Environ Occup Health 66:178-82. 2011..The odds were decreased among individuals who reported harvesting activities (odds ratio: 0.3, 95% confidence interval: 0.1, 1.0). Among Latino farmworkers, respiratory symptoms may be associated with work activities... 
Single-nucleotide polymorphisms in the TNF gene are associated with obesity-related phenotypes in vervet monkeysStanton B Gray
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Obesity (Silver Spring) 19:1427-32. 2011..05), and high-density lipoprotein-cholesterol (HDL-C) (P < 0.01). This study provides additional validation of the St Kitts-origin vervet model of obesity by demonstrating genetic associations analogous to that shown in humans...- Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthmaTimothy D Howard
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Hum Genet 70:230-6. 2002..0004). These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interaction between IL4RA and IL13 markedly increases an individual's susceptibility to asthma... - A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjectsMonica J Basehore
Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 114:80-7. 2004..This cytokine is important in IgE isotype switching and the regulation of allergic inflammation; however, published studies have not delineated the specific role of variation in this gene in allergic disorders... - Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary diseaseDavid M Herrington
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
N Engl J Med 346:967-74. 2002.... - Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28Timothy D Howard
Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
J Allergy Clin Immunol 110:743-51. 2002..0009). No significant associations were observed for SNPs in CD28. CONCLUSION: These data suggest that the costimulatory pathway, specifically CTLA4, is important in the development of atopy and asthma... - Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive proteinDavid M Herrington
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
Circulation 105:1879-82. 2002..This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive protein (CRP) and to explore possible mechanisms by which this polymorphism might influence estrogen action... - Factor V Leiden, hormone replacement therapy, and risk of venous thromboembolic events in women with coronary diseaseDavid M Herrington
Department of Internal Medicine, Sections on Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Arterioscler Thromb Vasc Biol 22:1012-7. 2002..If factor V Leiden genotyping becomes less expensive, it could be cost effective to screen for the presence of the mutation before instituting HRT in women with coronary disease... - Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12Jianfeng Xu
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, 27157, USA
Am J Hum Genet 71:646-50. 2002..06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits... - Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panelGregory A Hawkins
Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
DNA Seq 15:167-73. 2004..This data shows the variability of NR3C1 polymorphism frequencies between racial groups and confirms that NR3C1 non-synonymous coding polymorphisms are generally rare in mild/moderate asthmatics and unaffected controls... - The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart StudySusan G Lakoski
Department of Internal Medicine Cardiology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Exp Mol Pathol 82:280-3. 2007..Evidence suggests that interleukin-1 receptor-associated kinase-1 (IRAK1), fundamental in the toll-like receptor pathway (TLR), may play a more specific role in atherosclerosis... - Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposureDeborah A Meyers
Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 115:1169-75. 2005..Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma... - Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in miceZheng Cui
Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Proc Natl Acad Sci U S A 100:6682-7. 2003..The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer... - Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regionsXingnan Li
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 125:328-335.e11. 2010..Genome-wide association studies (GWASs) represent a powerful approach to investigate the association of DNA variants with disease susceptibility. To date, few GWASs for asthma have been reported... - From presumed benefit to potential harm--hormone therapy and heart diseaseDavid M Herrington
Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
N Engl J Med 349:519-21. 2003 - Importance of hedgehog interacting protein and other lung function genes in asthmaXingnan Li
Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 127:1457-65. 2011..The importance of these genes in lung function in white and African American subjects with asthma is unknown... - Comparative analyses of single-nucleotide polymorphisms in the TNF promoter region provide further validation for the vervet monkey model of obesityStanton B Gray
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Comp Med 59:580-8. 2009..More broadly, the sequence data and comparative analyses reported herein facilitates study of the evolution of regulatory sequences of inflammatory and immune-related genes... - Genome-wide search for atopy susceptibility genes in Dutch families with asthmaGerard H Koppelman
Department of Pulmonary Rehabilitation, Beatrixoord, Haren, The Netherlands
J Allergy Clin Immunol 109:498-506. 2002..CONCLUSIONS: Atopic phenotypes show familial aggregation, although family members may differ in expression of atopy. Specific chromosomal regions appear to be important in susceptibility to different phenotypes of atopic responsiveness... - Genomewide screen for pulmonary function in 200 families ascertained for asthmaDirkje S Postma
Department of Pulmonology, University Hospital, Hanzeplein 3, 9731 GZ Groningen, The Netherlands
Am J Respir Crit Care Med 172:446-52. 2005..Thus, there may be multiple genes on chromosome 2q that are important in determining presence and degree of airflow limitation in families ascertained for obstructive airway disease... - Estrogen receptor 1 polymorphisms are associated with airway hyperresponsiveness and lung function decline, particularly in female subjects with asthmaAntoon Dijkstra
Department of PulmonologyUniversity Medical Center Groningen, The Netherlands
J Allergy Clin Immunol 117:604-11. 2006..Sex hormones may contribute to the higher prevalence and severity of adult asthma in women compared with men... - Common beta-adrenergic receptor polymorphisms are not associated with risk of sudden cardiac death in patients with coronary artery diseaseZian H Tseng
Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco, USA
Heart Rhythm 5:814-21. 2008.... - Mapping susceptibility genes for allergic diseasesTimothy D Howard
Department of Pediatrics, Center for Human Genomics, Wake Forest University, Health Science, Winston-Salem, NC 27157, USA
Chest 123:363S-8S. 2003..Understanding the basic interactions that lead to the development of allergy and asthma will lead to new therapeutic approaches that will be used to modify the development and clinical progression of these common disorders... - Effect of genetic variations in platelet glycoproteins Ibalpha and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapyPaul F Bray
Jefferson Medical College and the Cardeza Foundation for Hematologic Research, Philadelphia, PA 19107, USA
Blood 109:1862-9. 2007..It will be important to replicate these findings in other studies...
Research Grants
- Genetic analysis of organophosphate metabolism in NC farmworkersTimothy Howard; Fiscal Year: 2007....
- Genetic evaluation of nitric oxide regulating genes in ischemic strokeTimothy Howard; Fiscal Year: 2007....