Timothy D Howard

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Evaluation of self-reported ethnicity in a case-control population: the stroke prevention in young women study
    Jesse B Mez
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Res Notes 2:260. 2009
  2. pmc CLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severity
    Carol J Blaisdell
    Department of Genetics, School of Medicine, University of Maryland, Howard Hall 596, 660 W, Redwood St, Baltimore, Maryland, USA
    BMC Med Genet 5:26. 2004
  3. pmc Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE
    Timothy D Howard
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Environ Health Perspect 118:1395-9. 2010
  4. pmc Epigenetic changes with dietary soy in cynomolgus monkeys
    Timothy D Howard
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 6:e26791. 2011
  5. pmc Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 132:313-20.e15. 2013
  6. pmc Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women
    Timothy D Howard
    The Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Stroke 36:1848-51. 2005
  7. ncbi request reprint Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 112:717-22. 2003
  8. pmc The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    Gregory A Hawkins
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:510-5.e1. 2012
  9. pmc Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:861-8.e7. 2012
  10. pmc Job activities and respiratory symptoms among farmworkers in North Carolina
    Maria C Mirabelli
    Department of Epidemiology and Prevention, Divisionof Public Health Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1063, USA
    Arch Environ Occup Health 66:178-82. 2011

Detail Information

Publications36

  1. pmc Evaluation of self-reported ethnicity in a case-control population: the stroke prevention in young women study
    Jesse B Mez
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Res Notes 2:260. 2009
    ..Here we apply a model-based clustering approach to our case-control study of stroke among young women to examine if self-reported ethnicity can serve as a proxy for genetic ancestry...
  2. pmc CLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severity
    Carol J Blaisdell
    Department of Genetics, School of Medicine, University of Maryland, Howard Hall 596, 660 W, Redwood St, Baltimore, Maryland, USA
    BMC Med Genet 5:26. 2004
    ..The objectives of this study are to identify single nucleotide polymorphisms (SNPs) in the airway epithelial chloride channel, CLC-2, and correlate these polymorphisms with CF lung disease...
  3. pmc Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE
    Timothy D Howard
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Environ Health Perspect 118:1395-9. 2010
    ..To understand fully the links between pesticide exposure and potential human disease, analyses must be able to consider genetic variability in pesticide metabolism...
  4. pmc Epigenetic changes with dietary soy in cynomolgus monkeys
    Timothy D Howard
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 6:e26791. 2011
    ..These data support the use of the HumanMethylation27 BeadChip in cynomolgus monkeys and identify epigenetic changes associated with dietary interventions with soy protein that may potentially affect the etiology of complex diseases...
  5. pmc Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 132:313-20.e15. 2013
    ..Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function...
  6. pmc Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women
    Timothy D Howard
    The Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Stroke 36:1848-51. 2005
    ..Endothelial nitric oxide exerts a variety of protective effects on endothelial cells and blood vessels, and therefore the nitric oxide synthase 3 gene (NOS3) is a logical candidate gene for stroke susceptibility...
  7. ncbi request reprint Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 112:717-22. 2003
    ..Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33 (ADAM33), was implicated in asthma susceptibility...
  8. pmc The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    Gregory A Hawkins
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:510-5.e1. 2012
    ..The SNP rs4129267 is in linkage disequilibrium (r(2) = 1) with the IL6R coding SNP rs2228145 (Asp(358)Ala). This IL6R coding change increases IL-6 receptor (IL-6R) shedding and promotes IL-6 transsignaling...
  9. pmc Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:861-8.e7. 2012
    ....
  10. pmc Job activities and respiratory symptoms among farmworkers in North Carolina
    Maria C Mirabelli
    Department of Epidemiology and Prevention, Divisionof Public Health Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1063, USA
    Arch Environ Occup Health 66:178-82. 2011
    ..The odds were decreased among individuals who reported harvesting activities (odds ratio: 0.3, 95% confidence interval: 0.1, 1.0). Among Latino farmworkers, respiratory symptoms may be associated with work activities...
  11. doi request reprint Single-nucleotide polymorphisms in the TNF gene are associated with obesity-related phenotypes in vervet monkeys
    Stanton B Gray
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 19:1427-32. 2011
    ..05), and high-density lipoprotein-cholesterol (HDL-C) (P < 0.01). This study provides additional validation of the St Kitts-origin vervet model of obesity by demonstrating genetic associations analogous to that shown in humans...
  12. ncbi request reprint A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects
    Monica J Basehore
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 114:80-7. 2004
    ..This cytokine is important in IgE isotype switching and the regulation of allergic inflammation; however, published studies have not delineated the specific role of variation in this gene in allergic disorders...
  13. ncbi request reprint Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease
    David M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    N Engl J Med 346:967-74. 2002
    ....
  14. pmc Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
    ..0004). These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interaction between IL4RA and IL13 markedly increases an individual's susceptibility to asthma...
  15. ncbi request reprint Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28
    Timothy D Howard
    Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 110:743-51. 2002
    ..Two candidate genes, CTLA4 and CD28, important homeostatic regulators of T-cell activation and subsequent IgE production, map within this candidate region...
  16. pmc Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, 27157, USA
    Am J Hum Genet 71:646-50. 2002
    ..06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits...
  17. ncbi request reprint Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel
    Gregory A Hawkins
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    DNA Seq 15:167-73. 2004
    ..This data shows the variability of NR3C1 polymorphism frequencies between racial groups and confirms that NR3C1 non-synonymous coding polymorphisms are generally rare in mild/moderate asthmatics and unaffected controls...
  18. ncbi request reprint Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein
    David M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Circulation 105:1879-82. 2002
    ..This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive protein (CRP) and to explore possible mechanisms by which this polymorphism might influence estrogen action...
  19. ncbi request reprint Factor V Leiden, hormone replacement therapy, and risk of venous thromboembolic events in women with coronary disease
    David M Herrington
    Department of Internal Medicine, Sections on Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 22:1012-7. 2002
    ..If factor V Leiden genotyping becomes less expensive, it could be cost effective to screen for the presence of the mutation before instituting HRT in women with coronary disease...
  20. pmc The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study
    Susan G Lakoski
    Department of Internal Medicine Cardiology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Exp Mol Pathol 82:280-3. 2007
    ..Evidence suggests that interleukin-1 receptor-associated kinase-1 (IRAK1), fundamental in the toll-like receptor pathway (TLR), may play a more specific role in atherosclerosis...
  21. pmc Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 100:6682-7. 2003
    ..The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer...
  22. ncbi request reprint Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure
    Deborah A Meyers
    Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 115:1169-75. 2005
    ..Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma...
  23. pmc Lifetime and current pesticide exposure among Latino farmworkers in comparison to other Latino immigrants
    Thomas A Arcury
    Department of Family and Community Medicine, Center for Worker Health, Wake Forest School of Medicine, Winston Salem, North Carolina
    Am J Ind Med 57:776-87. 2014
    ..Pesticide exposure poses a health risk for farmworkers. This analysis documents lifetime and current pesticide exposure of North Carolina Latino migrant farmworkers, with comparison to non-farmworker Latino immigrants...
  24. pmc Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Sidharth A Shah
    Section on Cardiology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Ann Noninvasive Electrocardiol 18:29-40. 2013
    ..We used the Multi-Ethnic Study of Atherosclerosis to examine association of QT with NOS1AP variants in an ethnically diverse cohort...
  25. ncbi request reprint From presumed benefit to potential harm--hormone therapy and heart disease
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    N Engl J Med 349:519-21. 2003
  26. pmc Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions
    Xingnan Li
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 125:328-335.e11. 2010
    ..Genome-wide association studies (GWASs) represent a powerful approach to investigate the association of DNA variants with disease susceptibility. To date, few GWASs for asthma have been reported...
  27. pmc DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver
    Timothy D Howard
    Center for Genomics and Personalized Medicine Research, Center for Public Health Genomics, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 9:e97510. 2014
    ..In support of this hypothesis, methylation levels of the most significant probe were strongly associated with FADS1 and, to a lesser degree, FADS2 activities...
  28. pmc Methylomics of gene expression in human monocytes
    Yongmei Liu
    Wake Forest School of Medicine, Winston Salem, NC, USA
    Hum Mol Genet 22:5065-74. 2013
    ..These data may help prioritize interrogation of biologically relevant methylation loci and provide new insights into the epigenetic basis of human health and diseases. ..
  29. pmc Importance of hedgehog interacting protein and other lung function genes in asthma
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 127:1457-65. 2011
    ..The importance of these genes in lung function in white and African American subjects with asthma is unknown...
  30. pmc Comparative analyses of single-nucleotide polymorphisms in the TNF promoter region provide further validation for the vervet monkey model of obesity
    Stanton B Gray
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Comp Med 59:580-8. 2009
    ..More broadly, the sequence data and comparative analyses reported herein facilitates study of the evolution of regulatory sequences of inflammatory and immune-related genes...
  31. ncbi request reprint Genome-wide search for atopy susceptibility genes in Dutch families with asthma
    Gerard H Koppelman
    Department of Pulmonary Rehabilitation, Beatrixoord, Haren, The Netherlands
    J Allergy Clin Immunol 109:498-506. 2002
    ..Atopy is a phenotype associated with asthma that has a heritable component. However, the role of atopysusceptibility genes in the development and expression of asthma and allergic disorders is not understood...
  32. ncbi request reprint Mapping susceptibility genes for allergic diseases
    Timothy D Howard
    Department of Pediatrics, Center for Human Genomics, Wake Forest University, Health Science, Winston Salem, NC 27157, USA
    Chest 123:363S-8S. 2003
    ..Understanding the basic interactions that lead to the development of allergy and asthma will lead to new therapeutic approaches that will be used to modify the development and clinical progression of these common disorders...
  33. pmc Genomewide screen for pulmonary function in 200 families ascertained for asthma
    Dirkje S Postma
    Department of Pulmonology, University Hospital, Hanzeplein 3, 9731 GZ Groningen, The Netherlands
    Am J Respir Crit Care Med 172:446-52. 2005
    ..Thus, there may be multiple genes on chromosome 2q that are important in determining presence and degree of airflow limitation in families ascertained for obstructive airway disease...
  34. ncbi request reprint Estrogen receptor 1 polymorphisms are associated with airway hyperresponsiveness and lung function decline, particularly in female subjects with asthma
    Antoon Dijkstra
    Department of PulmonologyUniversity Medical Center Groningen, The Netherlands
    J Allergy Clin Immunol 117:604-11. 2006
    ..Sex hormones may contribute to the higher prevalence and severity of adult asthma in women compared with men...
  35. pmc Common beta-adrenergic receptor polymorphisms are not associated with risk of sudden cardiac death in patients with coronary artery disease
    Zian H Tseng
    Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco, USA
    Heart Rhythm 5:814-21. 2008
    ....
  36. pmc Effect of genetic variations in platelet glycoproteins Ibalpha and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy
    Paul F Bray
    Jefferson Medical College and the Cardeza Foundation for Hematologic Research, Philadelphia, PA 19107, USA
    Blood 109:1862-9. 2007
    ..It will be important to replicate these findings in other studies...

Research Grants4