ROSS HOLMES

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. doi request reprint The role of renal water channels in health and disease
    Ross P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, Medical Center Blvd, NC 27157, USA
    Mol Aspects Med 33:547-52. 2012
  2. ncbi request reprint Dietary oxalate loads and renal oxalate handling
    Ross P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Urol 174:943-7; discussion 947. 2005
  3. ncbi request reprint Oxalate synthesis in humans: assumptions, problems, and unresolved issues
    R P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Mol Urol 4:329-32. 2000
  4. ncbi request reprint Contribution of dietary oxalate to urinary oxalate excretion
    R P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1094, USA
    Kidney Int 59:270-6. 2001
  5. ncbi request reprint Glycolate metabolism by Hep G2 cells
    R P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1094, USA
    J Am Soc Nephrol 10:S345-7. 1999
  6. ncbi request reprint Estimation of the oxalate content of foods and daily oxalate intake
    R P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Kidney Int 57:1662-7. 2000
  7. ncbi request reprint Glycolate and glyoxylate metabolism in HepG2 cells
    Paul R S Baker
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Physiol Cell Physiol 287:C1359-65. 2004
  8. pmc Effect of soda consumption on urinary stone risk parameters
    Corey M Passman
    Division of Urology, Department of Surgery, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
    J Endourol 23:347-50. 2009
  9. pmc Increased protein intake on controlled oxalate diets does not increase urinary oxalate excretion
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Urol Res 37:63-8. 2009
  10. pmc Intestinal and renal handling of oxalate loads in normal individuals and stone formers
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Urol Res 35:111-7. 2007

Research Grants

  1. Glyoxylate Reductase and Primary Hyperoxaluria
    Ross P Holmes; Fiscal Year: 2010
  2. Endogenous Oxalate Synthesis
    ROSS HOLMES; Fiscal Year: 2009
  3. Endogenous Oxalate Synthesis
    ROSS HOLMES; Fiscal Year: 2007
  4. Glyoxylate Reductase and Primary Hyperoxaluria
    ROSS HOLMES; Fiscal Year: 2005
  5. D-GLYCERATE DEHYDROGENASE AND PRIMARY HYPEROXALURIA
    ROSS HOLMES; Fiscal Year: 2001
  6. Glyoxylate Reductase and Primary Hyperoxaluria
    Ross P Holmes; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. doi request reprint The role of renal water channels in health and disease
    Ross P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, Medical Center Blvd, NC 27157, USA
    Mol Aspects Med 33:547-52. 2012
    ..As a result a number of chronic kidney and systemic diseases produce changes in the abundance of AQPs. The more recent developments in this field are reviewed...
  2. ncbi request reprint Dietary oxalate loads and renal oxalate handling
    Ross P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Urol 174:943-7; discussion 947. 2005
    ..We examined changes in plasma and urinary oxalate following oral crystalline oxalate loading under controlled dietary conditions to further define the renal handling of oxalate by normal adults...
  3. ncbi request reprint Oxalate synthesis in humans: assumptions, problems, and unresolved issues
    R P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Mol Urol 4:329-32. 2000
    ..The recognition of these assumptions and the testing of their validity should advance our knowledge of the pathways involved, their regulation, and their physiologic significance...
  4. ncbi request reprint Contribution of dietary oxalate to urinary oxalate excretion
    R P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1094, USA
    Kidney Int 59:270-6. 2001
    ..An understanding of the actual contribution of dietary oxalate to urinary oxalate excretion is important, as it is potentially modifiable...
  5. ncbi request reprint Glycolate metabolism by Hep G2 cells
    R P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1094, USA
    J Am Soc Nephrol 10:S345-7. 1999
    ..A detailed examination of glycolate metabolism in these cells should help clarify the terminal steps associated with oxalate synthesis and aid in our understanding of two-carbon metabolism...
  6. ncbi request reprint Estimation of the oxalate content of foods and daily oxalate intake
    R P Holmes
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Kidney Int 57:1662-7. 2000
    ..Reliable food tables listing the oxalate content of foods are currently not available. The aim of this research was to develop an accurate and reliable method to measure the food content of oxalate...
  7. ncbi request reprint Glycolate and glyoxylate metabolism in HepG2 cells
    Paul R S Baker
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Physiol Cell Physiol 287:C1359-65. 2004
    ..Expression of AGT2 mRNA in HepG2 cells was confirmed by RT-PCR. These results indicate that HepG2 cells will be useful in clarifying the nonperoxisomal metabolism associated with oxalate synthesis in human hepatocytes...
  8. pmc Effect of soda consumption on urinary stone risk parameters
    Corey M Passman
    Division of Urology, Department of Surgery, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
    J Endourol 23:347-50. 2009
    ..Diet was not always controlled in these investigations, however. We undertook a study to determine the impact of three different fluids on urinary stone risk factors...
  9. pmc Increased protein intake on controlled oxalate diets does not increase urinary oxalate excretion
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Urol Res 37:63-8. 2009
    ..This is most likely due to hyperfiltration. These results indicate that as dietary protein intake increases, the catabolism of diet-derived amino acids is not associated with an increased endogenous oxalate synthesis in normal subjects...
  10. pmc Intestinal and renal handling of oxalate loads in normal individuals and stone formers
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Urol Res 35:111-7. 2007
    ..This enhanced absorption of oxalate warrants further characterization...
  11. pmc Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Nephrol Dial Transplant 21:2292-5. 2006
    ..In this study, we have evaluated the potential of determining GR and d-glycerate dehydrogenase (DGDH) activity in blood mononuclear cells (BMC) as a diagnostic indicator of PH2...
  12. ncbi request reprint Mitochondrial hydroxyproline metabolism: implications for primary hyperoxaluria
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Nephrol 25:171-5. 2005
    ..The metabolism that leads to glyoxylate synthesis is not well defined. The aim of this study was to investigate the production of glyoxylate in liver mitochondria when they metabolize hydroxyproline...
  13. ncbi request reprint Genetic and dietary factors in urinary citrate excretion
    Ojas Shah
    Department of Urology, Wake Forest University Health Sciences Center, Winston Salem, North Carolina 27157, USA
    J Endourol 19:177-82. 2005
    ..Hypocitraturia, an important risk factor for calcium oxalate nephrolithiasis, is the result of numerous factors. We studied citrate excretion by patients with and without stones consuming normal and controlled formula diets...
  14. ncbi request reprint The impact of dietary oxalate on kidney stone formation
    Ross P Holmes
    Department of Urology, Wake Forest University Medical School, Medical Center Blvd, Winston Salem, NC 27157, USA
    Urol Res 32:311-6. 2004
    ..Such research, together with more extensive examinations of intestinal oxalate absorption, should help clarify the role of dietary oxalate in stone formation...
  15. pmc Variability of Oxalobacter formigenes and oxalate in stool samples
    Sergey Prokopovich
    Department of Urology, Wake Forest University Medical School, Winston Salem, North Carolina 27157, USA
    J Urol 178:2186-90. 2007
    ..Because the oxalate content of the diet varies considerably, we hypothesized that the number of O. formigenes and amount of oxalate would vary in feces...
  16. pmc Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design
    Michael S Murray
    Center for Structural Biology and Department of Biochemistry, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Biochemistry 47:2439-49. 2008
    ....
  17. pmc Effect of dietary control of urinary uric acid excretion in calcium oxalate stone formers and non-stone-forming controls
    Vernon M Pais
    Division of Urology, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536, USA
    J Endourol 21:232-5. 2007
    ..With the recognition that dietary differences may induce variations in urinary uric acid excretion, we evaluated excretion of this compound in stone formers and controls consuming a standardized diet...
  18. pmc Oxalobacter formigenes and its potential role in human health
    Sylvia H Duncan
    Gut Microbiology and Immunology Division, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    Appl Environ Microbiol 68:3841-7. 2002
    ....
  19. pmc Quantitative assessment of citric acid in lemon juice, lime juice, and commercially-available fruit juice products
    Kristina L Penniston
    Department of Surgery, Division of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792 3236, USA
    J Endourol 22:567-70. 2008
    ..Information on the citric acid content of fruit juices and commercially-available formulations is not widely known. We evaluated the citric acid concentration of various fruit juices...

Research Grants16

  1. Glyoxylate Reductase and Primary Hyperoxaluria
    Ross P Holmes; Fiscal Year: 2010
    ..These studies will increase our understanding of the metabolism associated with oxalate synthesis and will potentially identify novel therapeutic strategies to decrease oxalate synthesis in primary hyperoxaluria. ..
  2. Endogenous Oxalate Synthesis
    ROSS HOLMES; Fiscal Year: 2009
    ..abstract_text> ..
  3. Endogenous Oxalate Synthesis
    ROSS HOLMES; Fiscal Year: 2007
    ....
  4. Glyoxylate Reductase and Primary Hyperoxaluria
    ROSS HOLMES; Fiscal Year: 2005
    ..These studies will increase our understanding of the metabolism associated with oxalate synthesis and will identify new therapeutic strategies to decrease it. ..
  5. D-GLYCERATE DEHYDROGENASE AND PRIMARY HYPEROXALURIA
    ROSS HOLMES; Fiscal Year: 2001
    ....
  6. Glyoxylate Reductase and Primary Hyperoxaluria
    Ross P Holmes; Fiscal Year: 2010
    ..These studies will increase our understanding of the metabolism associated with oxalate synthesis and will potentially identify novel therapeutic strategies to decrease oxalate synthesis in primary hyperoxaluria. ..