Research Topics
| K P HighSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
A randomized, controlled trial of Panax quinquefolius extract (CVT-E002) to reduce respiratory infection in patients with chronic lymphocytic leukemiaKevin P High
Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1042, USA
J Support Oncol 10:195-201. 2012..Chronic lymphocytic leukemia (CLL) patients are at high risk for acute respiratory illness (ARI)...
Infection as a cause of age-related morbidity and mortalityKevin P High
Sections of Infectious Diseases and Hematology/Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157-1042, USA
Ageing Res Rev 3:1-14. 2004- A new paradigm for clinical investigation of infectious syndromes in older adults: assessment of functional status as a risk factor and outcome measureKevin P High
Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University Health Sciences, Winston Salem, NC, USA
Clin Infect Dis 40:114-22. 2005.... - A new paradigm for clinical investigation of infectious syndromes in older adults: assessing functional status as a risk factor and outcome measureKevin High
Department of Internal Medicine, Sections of Infectious Diseases and Hematology Oncology, Wake Forest University Health Sciences, Winston Salem, NC, USA
J Am Geriatr Soc 53:528-35. 2005.... - Intraindividual variability and the effect of acute illness on immune senescence markersKevin P High
Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
J Am Geriatr Soc 53:1761-6. 2005..To determine the intraindividual variability and effect of acute illness on two markers of immune senescence... - Pneumonia in older adults. New categories add complexity to diagnosis and careKevin P High
Section of Infectious Diseases, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Postgrad Med 118:18-20, 25-8. 2005..Here, Dr High examines the diagnostic and treatment strategies that are needed in older adults and outlines preventive methods that may greatly reduce the risk of illness in this population... - Immunizations in older adultsKevin High
Section on Infectious Diseases, Wake Forest University Health Sciences, 100 Medical Center Boulevard, Winston Salem, NC 27157 1042, USA
Clin Geriatr Med 23:669-85, viii-ix. 2007.... - Outcome and immune responses after Brucella abortus infection in young adult and aged miceKevin P High
Section of Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Biogerontology 8:583-93. 2007..Brucella in aged mice... 
Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities: 2008 update by the Infectious Diseases Society of AmericaKevin P High
Section on Infectious Diseases, Wake Forest University Health Sciences, Winston Salem, 100 Medical Center Blvd, Winston Salem, NC 27157 1042, USA
Clin Infect Dis 48:149-71. 2009..Finally, a general outline of how a suspected outbreak of a specific infectious disease should be investigated in an LTCF is provided...- Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities: 2008 update by the Infectious Diseases Society of AmericaKevin P High
Section on Infectious Diseases, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1042, USA
J Am Geriatr Soc 57:375-94. 2009..Finally, a general outline of how a suspected outbreak of a specific infectious disease should be investigated in an LTCF is provided... - Overcoming barriers to adult immunizationKevin P High
Section of Infectious Diseases, Wake Forest University, Winston Salem, NC 27157 1042, USA
J Am Osteopath Assoc 109:S25-8. 2009..However, certain barriers unique to zoster vaccination (eg, reimbursement concerns) will need to be addressed... - Workshop on immunizations in older adults: identifying future research agendasKevin P High
Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
J Am Geriatr Soc 58:765-76. 2010.... - Advanced age, but not anergy, is associated with altered serum polyunsaturated fatty acid levelsK P High
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1042, USA
J Nutr Health Aging 7:378-84. 2003..However, there was no association of serum PUFA concentrations with DTH status among older adults... - Low plasma concentrations of retinol and alpha-tocopherol in hematopoietic stem cell transplant recipients: the effect of mucositis and the risk of infectionKevin P High
Sections of Infectious Diseases and of Hematology and Oncology and the Comprehensive Cancer Center, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1042, USA
Am J Clin Nutr 76:1358-66. 2002..Although vitamin deficiencies are rare in the United States, acute reductions in concentrations of plasma retinol (vitamin A) or alpha-tocopherol (vitamin E) have been associated with impaired immune responses in some clinical settings... - Micronutrient supplementation and immune function in the elderlyK P High
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1042, USA
Clin Infect Dis 28:717-22. 1999..This review summarizes the prevalence of vitamin and mineral deficiencies in older adults and highlights the outcomes of trials of micronutrient supplementation to augment immune function in the elderly... - Infection in an ageing worldKevin P High
Sections on Infectious Diseases and Haematology/Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157-1042, USA
Lancet Infect Dis 2:655. 2002 - Atherosclerosis and infection due to Chlamydia pneumoniae or cytomegalovirus: weighing the evidenceK P High
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1042, USA
Clin Infect Dis 28:746-9. 1999..pneumoniae, but these findings require confirmation in larger studies. A lack of clinically relevant animal models has hampered investigations regarding biological mechanisms, particularly for C. pneumoniae... - Integrating geriatrics into clinical training, research training, board certification, and continuing education in infectious diseases: meeting review and commentaryK P High
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1042, USA
Clin Infect Dis 28:753-6. 1999..This article summarizes the recent meeting focused on integrating geriatric principles within ID training at all levels. The ID/geriatric interface as an attractive area for basic and clinical research is emphasized... - Nutritional strategies to boost immunity and prevent infection in elderly individualsK P High
Section of Infectious Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Clin Infect Dis 33:1892-900. 2001..Drug-nutrient interactions are common in elderly individuals, and care providers should be aware of these interactions. Future research should evaluate important clinical end points rather than merely surrogate markers of immunity... - Acute kidney injury in older adultsSharon Anderson
Section on Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, 100 Medical Center Boulevard, Winston Salem, NC 27157 1042, USA
J Am Soc Nephrol 22:28-38. 2011..Answering these questions will facilitate the integration of geriatric issues into future mechanistic and clinical studies that affect management and care of acute kidney injury... - Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cellsC E Clay
Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1042, USA
J Investig Med 49:413-20. 2001..These data may explain, at least in part, some of the discordant results previously reported... - Early de novo gene expression is required for 15-deoxy-Delta 12,14-prostaglandin J2-induced apoptosis in breast cancer cellsC E Clay
Department of Internal Medicine, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
J Biol Chem 276:47131-5. 2001..These data show that de novo gene transcription is necessary for 15dPGJ(2)-induced apoptosis in breast cancer cells. Critical candidate genes are likely to be revealed through analysis of differential cDNA array expression... - Enhancement of mast cell survival: a novel function of some secretory phospholipase A(2) isotypesA N Fonteh
Department of Internal Medicine, Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Immunol 167:4161-71. 2001.... - 5-Oxo-ETE analogs and the proliferation of cancer cellsJOSEPH T O'FLAHERTY
Department of Internal Medicine, Section on Infectious Diseases, Wake Forest University Medical Center, Medical Center Boulevard, Winston Salem, NC 27156, USA
Biochim Biophys Acta 1736:228-36. 2005..These results are the first to implicate the OXE receptor in malignant cell growth and to show that 5-oxo-ETEs activate cell death programs as well as PPARgamma independently of this receptor... - Antineoplastic properties of arachidonic acid and its metabolitesA M Monjazeb
Department of Cancer Biology, Wake Forest University Baptist Medical Center, School of Medicine, Winston-Salem, NC, USA
Prostaglandins Leukot Essent Fatty Acids 66:5-12. 2002 - Why should the infectious diseases community focus on aging and care of the older adult?Kevin P High
Clin Infect Dis 37:196-200. 2003 - Age-related changes in cell surface and senescence markers in the spleen of DBA/2 mice: a flow cytometric analysisAbbie C Connoy
Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University Health Sciences, 100 Medical Center Blvd, Winston Salem, NC 27157-1042, USA
Exp Gerontol 41:225-9. 2006..The senescence marker p16INK4a increases in B cells and CD8+T cells within the spleen and can be measured by flow cytometry... - The importance of geriatric-specific instruments and functional status assessment in infectious diseases research: time to start preaching to the congregation instead of the choirKevin P High
J Am Geriatr Soc 52:1768-70. 2004 - Gatifloxacin in community-based treatment of acute respiratory tract infections in the elderlySusan C Nicholson
Bristol Myers Squibb Company, Plainsboro, New Jersey, USA
Diagn Microbiol Infect Dis 44:109-16. 2002..Gatifloxacin is efficacious and well tolerated in adult outpatients of any age with respiratory tract infections and is an important therapeutic option, particularly in communities with a high prevalence of resistant pathogens... - Expanding geriatrics into subspecialty internal medicine healthcare, research and education: caring for older adults and the T. Franklin Williams Career Development AwardsKevin P High
Am J Med 113:533-6. 2002 - 15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cellsCarl E Clay
Department of Cancer Biology, Wake Forest University Baptist Medical Center, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Lipid Res 43:1818-28. 2002..Other likely mechanisms through which cyclopentenone prostaglandins induce apoptosis of cancer cells are discussed... - Chronic infection and frailty: surrogate markers, associations, and causalityKevin P High
J Am Geriatr Soc 53:906-8. 2005 - Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directionsRita B Effros
David Geffen School of Medicine at the University of California, Los Angeles, USA
Clin Infect Dis 47:542-53. 2008..Answers to the questions posed are likely to help prioritize and balance strategies to slow the progression of HIV infection, to address comorbidities and drug toxicity, and to enhance understanding about both HIV infection and aging... - Preventing herpes zoster and postherpetic neuralgia through vaccinationKevin P High
Section on Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA
J Fam Pract 56:51A-57A; quiz 58A. 2007 - Inhibitors of arachidonic acid metabolism act synergistically to signal apoptosis in neoplastic cellsArta M Monjazeb
Department of Cancer Biology, Wake Forest University Baptist Medical Center, Winston-Salem, NC 27157, USA
Prostaglandins Leukot Essent Fatty Acids 73:463-74. 2005..Further study is required to determine the downstream pathway(s) whereby high cellular burdens of unesterified AA promote apoptosis... - Immune reconstitution after hematopoietic stem-cell transplantation and its influence on respiratory infectionsMelissa Matulis
Sections of Hematology/Oncology and Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157-1042, USA
Semin Respir Infect 17:130-9. 2002.... - An evaluation of geriatrics activities within internal medicine subspecialtiesIrene S Sonu
Association of Specialty Professors, Washington, DC, USA
Am J Med 119:995-1000. 2006 - Arachidonic acid-induced gene expression in colon cancer cellsArta M Monjazeb
Department of Cancer Biology, Wake Forest University Baptist Medical Center, Winston-Salem, NC 27157, USA
Carcinogenesis 27:1950-60. 2006..Together, these studies reveal that the generation of intracellular AA and its subsequent impact on gene expression probably represents a critical step that regulates colon cancer cell proliferation...
Research Grants
- DIETARY FATTY CONTROL OF INFLAMMATIONKevin High; Fiscal Year: 2002..Health relateness: Answering these fundamental questions will shed critical light on the feasibility of utilizing dietary fatty acids to regulate AA metabolism and related clinical disorders. ..
- Functional Senescence of Innate Immunity and PneumoniaKevin High; Fiscal Year: 2003..These data are essential to design meaningful studies using the case-control method, the most effective means of studying the link between immune senescence and infection risk. ..
- Brucella, Aging and Role of IL-17 in Host DefenseKevin High; Fiscal Year: 2005..The data generated in this proposal will form the foundation of future R01 proposals aimed at enhancing immunity vs. intracellular pathogens in our aging population. ..