D Herrington

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Comparative analysis of methods for detecting interacting loci
    Li Chen
    Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Genomics 12:344. 2011
  2. ncbi Individual and combined effects of estrogen/progestin therapy and lovastatin on lipids and flow-mediated vasodilation in postmenopausal women with coronary artery disease
    D M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Am Coll Cardiol 33:2030-7. 1999
  3. ncbi Role of estrogen receptor-alpha in pharmacogenetics of estrogen action
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Opin Lipidol 14:145-50. 2003
  4. ncbi Arterial compliance adds to conventional risk factors for prediction of angiographic coronary artery disease
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Am Heart J 146:662-7. 2003
  5. ncbi Cardiovascular genomics: outcomes and implications
    David M Herrington
    Wake Forest University School of Medicine, Internal Medicine Section on Cardiology, Winston Salem, North Carolina 27157, USA
    Can J Cardiol 26:60A-63A. 2010
  6. ncbi Statin therapy, cardiovascular events, and total mortality in the Heart and Estrogen/Progestin Replacement Study (HERS)
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circulation 105:2962-7. 2002
  7. ncbi Factor V Leiden, hormone replacement therapy, and risk of venous thromboembolic events in women with coronary disease
    David M Herrington
    Department of Internal Medicine, Sections on Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 22:1012-7. 2002
  8. ncbi ER-alpha variants and the cardiovascular effects of hormone replacement therapy
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, NC 27157, USA
    Pharmacogenomics 4:269-77. 2003
  9. ncbi Cardiovascular trials of estrogen replacement therapy
    D M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Ann N Y Acad Sci 949:153-62. 2001
  10. ncbi Cardiovascular effects of droloxifene, a new selective estrogen receptor modulator, in healthy postmenopausal women
    D M Herrington
    Departments of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Arterioscler Thromb Vasc Biol 20:1606-12. 2000

Research Grants

Detail Information

Publications87

  1. pmc Comparative analysis of methods for detecting interacting loci
    Li Chen
    Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Genomics 12:344. 2011
    ..Given the importance of detecting gene-gene and gene-environment interactions, a rigorous, comprehensive comparison of performance and limitations of available interaction detection methods is warranted...
  2. ncbi Individual and combined effects of estrogen/progestin therapy and lovastatin on lipids and flow-mediated vasodilation in postmenopausal women with coronary artery disease
    D M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    J Am Coll Cardiol 33:2030-7. 1999
    ..We sought to examine the individual and combined effects of estrogen/progestin therapy versus lovastatin on lipids and flow-mediated vasodilation in postmenopausal women with heart disease...
  3. ncbi Role of estrogen receptor-alpha in pharmacogenetics of estrogen action
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Opin Lipidol 14:145-50. 2003
    ..To summarize recent data regarding the role of estrogen receptor-alpha polymorphisms in determining the response to estrogen therapy or the risk of clinical cardiovascular events...
  4. ncbi Arterial compliance adds to conventional risk factors for prediction of angiographic coronary artery disease
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Am Heart J 146:662-7. 2003
    ..We sought to assess the relation between lower extremity arterial compliance and presence of angiographically defined coronary artery disease...
  5. ncbi Cardiovascular genomics: outcomes and implications
    David M Herrington
    Wake Forest University School of Medicine, Internal Medicine Section on Cardiology, Winston Salem, North Carolina 27157, USA
    Can J Cardiol 26:60A-63A. 2010
    ..Therefore, clinicians should continue to make use of family history to augment risk stratification and emphasize established forms of prevention for their patients with, or at risk for, cardiovascular disease...
  6. ncbi Statin therapy, cardiovascular events, and total mortality in the Heart and Estrogen/Progestin Replacement Study (HERS)
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circulation 105:2962-7. 2002
    ..Although effects of statins on cardiovascular outcomes are well established in men, fewer data exist for women. Furthermore, the effects of statins plus hormone replacement therapy (HRT) on cardiovascular outcomes are uncertain...
  7. ncbi Factor V Leiden, hormone replacement therapy, and risk of venous thromboembolic events in women with coronary disease
    David M Herrington
    Department of Internal Medicine, Sections on Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 22:1012-7. 2002
    ..If factor V Leiden genotyping becomes less expensive, it could be cost effective to screen for the presence of the mutation before instituting HRT in women with coronary disease...
  8. ncbi ER-alpha variants and the cardiovascular effects of hormone replacement therapy
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, NC 27157, USA
    Pharmacogenomics 4:269-77. 2003
    ..More detailed haplotype and genome-wide studies of many of the major HRT clinical trial cohorts are currently underway and these efforts promise to clarify many outstanding issues concerning estrogen action and cardiovascular disease...
  9. ncbi Cardiovascular trials of estrogen replacement therapy
    D M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Ann N Y Acad Sci 949:153-62. 2001
    ..Trials that are under way are also described and discussed...
  10. ncbi Cardiovascular effects of droloxifene, a new selective estrogen receptor modulator, in healthy postmenopausal women
    D M Herrington
    Departments of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Arterioscler Thromb Vasc Biol 20:1606-12. 2000
    ..It remains unknown whether droloxifene can confer a true cardiovascular benefit...
  11. ncbi Estrogen replacement and brachial artery flow-mediated vasodilation in older women
    D M Herrington
    Department of Internal Medicine, Sections on Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 21:1955-61. 2001
    ..These data emphasize the importance of ongoing efforts to determine the role of hormone replacement therapy for primary prevention of cardiovascular disease...
  12. ncbi Relationship between arterial stiffness and subclinical aortic atherosclerosis
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circulation 110:432-7. 2004
    ..Noninvasive measures of arterial compliance may be useful for the detection of subclinical atherosclerosis...
  13. ncbi The HERS trial results: paradigms lost? Heart and Estrogen/progestin Replacement Study
    D M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1045, USA
    Ann Intern Med 131:463-6. 1999
    ..The HERS results remind us of the need for clinical trials to evaluate both the benefits and risks of new therapies. They also illustrate how much more we need to know about the cardiovascular effects of hormone replacement therapy...
  14. ncbi Statins, hormones, and women: benefits and drawbacks for atherosclerosis and osteoporosis
    D M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Curr Atheroscler Rep 3:35-42. 2001
    ..Finally, new data suggest that statins may also reduce the risk of osteoporotic fractures, a provocative finding still in need of verification by clinical trials...
  15. ncbi Role of estrogens, selective estrogen receptor modulators and phytoestrogens in cardiovascular protection
    D Herrington
    Wake Forest University, Winston Salem, NC 27157 1045, USA
    Can J Cardiol 16:5E-9E. 2000
    ..The extent to which selective estrogen receptor modulators and phytoestrogens share in the beneficial and potentially harmful effects of estrogen is not yet established...
  16. ncbi The estrogen replacement and atherosclerosis (ERA) study: study design and baseline characteristics of the cohort
    D M Herrington
    Departments of Internal Medicine Cardiology, Winston Salem, NC 27157 1040, USA
    Control Clin Trials 21:257-85. 2000
    ..Control Clin Trials 2000;21:257-285..
  17. pmc Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis
    Joseph Yeboah
    Department of Internal Medicine Cardiology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Circulation 120:502-9. 2009
    ..We assessed the predictive value of FMD for incident CVD events in the Multi-Ethnic Study of Atherosclerosis (MESA)...
  18. ncbi Diabetes, the metabolic syndrome, and angiographic progression of coronary arterial disease in postmenopausal women
    Philip B Mellen
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 26:189-93. 2006
    ..We sought to determine whether the MS predicts angiographic progression of coronary heart disease in a cohort of postmenopausal women...
  19. ncbi Effects of estrogen replacement with and without medroxyprogesterone acetate on brachial flow-mediated vasodilator responses in postmenopausal women with coronary artery disease
    Joseph Yeboah
    Department of Internal Medicine Cardiology and Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 153:439-44. 2007
    ..Estrogen has been shown to enhance endothelial-dependent flow-mediated vasodilation (FMD) in healthy and younger women. The effect of estrogen on older and less healthy postmenopausal women with atherosclerosis is unclear...
  20. ncbi Pulse pressure and coronary atherosclerosis progression in postmenopausal women
    Girish V Nair
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hypertension 45:53-7. 2005
    ..In postmenopausal women with coronary disease, increased levels of baseline pulse pressure are associated with subsequent progression of coronary atherosclerosis in postmenopausal women. HRT had no detectable effect on pulse pressure...
  21. ncbi Pulse pressure and cardiovascular events in postmenopausal women with coronary heart disease
    Girish V Nair
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 127:1498-506. 2005
    ..We sought to examine the relationship between PP and risk for cardiovascular events, and to determine the effect of hormone therapy on PP in postmenopausal women with coronary heart disease (CHD)...
  22. ncbi Association of protein tyrosine phosphatase-N1 polymorphisms with coronary calcified plaque in the Diabetes Heart Study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 55:651-8. 2006
    ..53 +/- 0.1 to 0.57 +/- 0.1 (P = 8.1 x 10(-10)), suggesting a modest but detectable effect of this gene on the phenotype of CorCP in type 2 diabetic patients...
  23. ncbi Racial differences in endothelial function in postmenopausal women
    Laura R Loehr
    Department of Internal Medicine, Sections on Section on Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 148:606-11. 2004
    ..To further study differences in endothelial function between African American and Caucasian women, we analyzed measures of brachial artery flow-mediated dilation (FMD) in women enrolled in the Cardiovascular Health Study (CHS)...
  24. ncbi Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study
    Leslie A Lange
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Hum Genet 70:717-25. 2006
    ..While the APOE locus shows evidence of contributing to CRP levels, no evidence of CRP gene polymorphism association with CRP levels was observed...
  25. pmc Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 123:333-41. 2008
    ..We have identified a novel region of the ESR1 gene that may contain important functional polymorphisms in relation to susceptibility to T2DM and/or diabetic nephropathy...
  26. doi Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 57:1108-14. 2008
    ..We sought to replicate the finding that genetic variants in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene are associated with QT interval duration in a type 2 diabetes-enriched sample of European ancestry...
  27. pmc Association of plasma sphingomyelin levels and incident coronary heart disease events in an adult population: Multi-Ethnic Study of Atherosclerosis
    Joseph Yeboah
    Department of Internal Medicine Cardiology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 30:628-33. 2010
    ..We wanted to assess the predictive value of plasma sphingomyelin levels for incident coronary heart disease (CHD) events in the Multi-Ethnic Study of Atherosclerosis...
  28. ncbi Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease
    David M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    N Engl J Med 346:967-74. 2002
    ....
  29. ncbi Hormone therapy, C-reactive protein, and progression of atherosclerosis: data from the Estrogen Replacement on Progression of Coronary Artery Atherosclerosis (ERA) trial
    Susan G Lakoski
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 150:907-11. 2005
    ....
  30. ncbi Recruitment of participants for the Estrogen Replacement and Atherosclerosis (ERA) trial. a comparison of costs, yields, and participant characteristics from community- and hospital-based recruitment strategies
    S Folmar
    Department of Anthropology, Wake Forest University, Winston Salem, NC 27109, USA
    Control Clin Trials 22:13-25. 2001
    ..Costs of community-based recruitment were less than hospital-based recruitment; however, screening costs were higher. Overall, screening and recruitment averaged $2508 per randomized participant. Control Clin Trials 2001;22:13-25..
  31. ncbi Randomized clinical trials of hormone replacement therapy for treatment or prevention of cardiovascular disease: a review of the findings
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Atherosclerosis 166:203-12. 2003
    ..This article will review the findings to date of these long-term randomized clinical trials of HRT for prevention or treatment of CHD...
  32. ncbi Gender and C-reactive protein: data from the Multiethnic Study of Atherosclerosis (MESA) cohort
    Susan G Lakoski
    Department of Internal Medicine Cardiology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 152:593-8. 2006
    ..Determining gender-specific differences in CRP may alter how CRP levels are interpreted and used to determine risk...
  33. ncbi Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study
    Joseph Yeboah
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circulation 115:2390-7. 2007
    ..We assessed the hypothesis that FMD predicts incident cardiovascular events in a population-based cohort of older adults...
  34. ncbi Whole grain intake and cardiovascular disease: a meta-analysis
    Philip B Mellen
    Department of Internal Medicine, Section of General Medicine, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Nutr Metab Cardiovasc Dis 18:283-90. 2008
    ..This study sought to quantitate the available observational evidence on whole grain intake and clinical cardiovascular events...
  35. pmc The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study
    Susan G Lakoski
    Department of Internal Medicine Cardiology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Exp Mol Pathol 82:280-3. 2007
    ..Evidence suggests that interleukin-1 receptor-associated kinase-1 (IRAK1), fundamental in the toll-like receptor pathway (TLR), may play a more specific role in atherosclerosis...
  36. ncbi Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study
    Philip B Mellen
    Department of Internal Medicine, Section of General Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Clin Nutr 85:1495-502. 2007
    ..Whole-grain intake has been shown to be inversely associated with cardiovascular events, but an association with atherosclerosis is less well established...
  37. ncbi Leg flow-mediated arterial dilation in elderly patients with heart failure and normal left ventricular ejection fraction
    W Gregory Hundley
    Department of Internal Medicine, Section on Cardiology, Wake Forest Univ School of Medicine, Bowman Gray Campus, Winston Salem, NC 27157 1045, USA
    Am J Physiol Heart Circ Physiol 292:H1427-34. 2007
    ..Many elderly patients with heart failure exhibit a normal left ventricular ejection fraction (HFNEF). It is unknown whether FMAD is severely reduced in the elderly with HFNEF...
  38. ncbi Implications of C-reactive protein or coronary artery calcium score as an adjunct to global risk assessment for primary prevention of CHD
    Susan G Lakoski
    Department of Internal Medicine Cardiology, 12 Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Atherosclerosis 193:401-7. 2007
    ..In the Multi-Ethnic Study of Atherosclerosis (MESA), we estimated the proportion of intermediate-risk participants whose risk status might change based on additional testing using CRP and/or CAC score...
  39. ncbi Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study
    Philip B Mellen
    Section of General Medicine, Department of Internal Medicine, Division of Public Health Sciences, Wake Forest University, Winston Salem, NC 27157, USA
    Hypertension 48:1037-42. 2006
    ..More research is warranted concerning the physiological and clinical consequences of hyperuricemia, especially in blacks...
  40. pmc Low plasma levels of FGF-2 and PDGF-BB are associated with cardiovascular events in type II diabetes mellitus (diabetes heart study)
    Joseph Yeboah
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Dis Markers 23:173-8. 2007
    ..We tested associations of the growth factors VEGF, FGF-2, HGF and PDGF-BB with coronary artery calcium scores and cardiovascular events (CVD) in type 2 diabetes mellitus (T2DM)...
  41. pmc Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Ann Noninvasive Electrocardiol 14:72-9. 2009
    ..It is unclear whether these genetic variants remain relevant in subjects with underlying conditions such as diabetes that are associated with prolonged QT interval...
  42. pmc Location of arterial stiffening differs in those with impaired fasting glucose versus diabetes: implications for left ventricular hypertrophy from the Multi-Ethnic Study of Atherosclerosis
    Pairoj Rerkpattanapipat
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 58:946-53. 2009
    ....
  43. ncbi Maintenance warfarin dose varies according to two haplotypes of the vitamin K epoxide reductase gene
    Jerry M John
    Wake Forest University School of Medicine, Department of Internal Medicine, Division of Cardiology, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Future Cardiol 2:29-32. 2006
    ....
  44. ncbi Coronary artery calcium scores and risk for cardiovascular events in women classified as "low risk" based on Framingham risk score: the multi-ethnic study of atherosclerosis (MESA)
    Susan G Lakoski
    Department of Internal Medicine Cardiology, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Arch Intern Med 167:2437-42. 2007
    ..Based on population survey data, 95% of American women are considered at low risk based on FRS...
  45. ncbi Relationship between brachial flow-mediated dilation and carotid intima-media thickness in an elderly cohort: the Cardiovascular Health Study
    Joseph Yeboah
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States
    Atherosclerosis 197:840-5. 2008
    ..The aim of this study was to determine the relationship between brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT) in a large multi-ethnic elderly cohort...
  46. doi Effects of hormone therapy on soluble cell adhesion molecules in postmenopausal women with coronary artery disease
    Joseph Yeboah
    Department of Internal Medicine Cardiology and Public Health, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Menopause 15:1060-4. 2008
    ..We assessed the effect of HT on soluble cell adhesion molecules in the Estrogen Replacement and Atherosclerosis trial...
  47. ncbi Association between brachial artery reactivity and cardiovascular disease status in an elderly cohort: the cardiovascular health study
    Joseph Yeboah
    Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, United States
    Atherosclerosis 197:768-76. 2008
    ..We assessed the association of FMD and the presence or absence of subclinical and clinical CVD in a population based cohort of older adults...
  48. pmc Interleukin-10 concentration and coronary heart disease (CHD) event risk in the estrogen replacement and atherosclerosis (ERA) study
    Susan G Lakoski
    Department of Internal Medicine Cardiology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 197:443-7. 2008
    ..Limited biochemical and clinical evidence suggest a link between IL-10 and coronary heart disease (CHD). However, more data are needed to clarify the relationship between IL-10 and risk for CHD events...
  49. pmc Relation of omega-3 fatty acid and dietary fish intake with brachial artery flow-mediated vasodilation in the Multi-Ethnic Study of Atherosclerosis
    Jennifer S Anderson
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27127, USA
    Am J Clin Nutr 92:1204-13. 2010
    ..The relation between dietary fish intake and brachial artery measures, including brachial artery flow-mediated dilation (FMD), has not been well established across sex and racial-ethnic groups...
  50. pmc Coronary calcium score and prediction of all-cause mortality in diabetes: the diabetes heart study
    Subhashish Agarwal
    Department of Internal Medicine, Division of Cardiology, Wake Forest University, Winston Salem, North Carolina, USA
    Diabetes Care 34:1219-24. 2011
    ..In diabetes, it remains unclear whether the coronary artery calcium (CAC) score provides additional information about total mortality risk beyond traditional risk factors...
  51. pmc Submaximal exercise coronary artery flow increases in postmenopausal women without coronary artery disease after estrogen and atorvastatin
    Chirapa Puntawangkoon
    Department of Internal Medicine, Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Menopause 17:114-20. 2010
    ....
  52. ncbi Subgroup interactions in the Heart and Estrogen/Progestin Replacement Study: lessons learned
    Curt D Furberg
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1063, USA
    Circulation 105:917-22. 2002
    ..We analyzed the HERS data to determine whether there were specific subgroups of women who responded differently to treatment, either during the first year or in the overall study...
  53. ncbi From presumed benefit to potential harm--hormone therapy and heart disease
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    N Engl J Med 349:519-21. 2003
  54. ncbi The impact of pedigree structure on heritability estimates for pulse pressure in three studies
    Fang Chi Hsu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Hered 60:63-72. 2005
    ....
  55. ncbi The relationship between blood pressure and C-reactive protein in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Susan G Lakoski
    Department of Internal Medicine Cardiology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    J Am Coll Cardiol 46:1869-74. 2005
    ..The goal of this study was to determine the relationship between resting blood pressure (BP) and C-reactive protein (CRP) in a multi-ethnic cohort of men and women from the Multi-Ethnic Study of Atherosclerosis (MESA)...
  56. ncbi The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS)
    Donald W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 150:1032-8. 2005
    ..Epidemiological studies suggest that levels of C-reactive protein (CRP) predict cardiovascular disease (CVD). We have evaluated the relationship between CRP and subclinical CVD in a study cohort at high risk of CVD...
  57. ncbi Effect of estrogen plus progestin on progression of carotid atherosclerosis in postmenopausal women with heart disease: HERS B-mode substudy
    Robert P Byington
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1063, USA
    Arterioscler Thromb Vasc Biol 22:1692-7. 2002
    ..In addition to the events trial, a carotid ultrasound substudy was established in 1993 to be conducted concurrently to determine whether hormone therapy affects the progression of the underlying atherosclerotic process...
  58. ncbi Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein
    David M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Circulation 105:1879-82. 2002
    ..This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive protein (CRP) and to explore possible mechanisms by which this polymorphism might influence estrogen action...
  59. ncbi C-reactive protein concentration and incident hypertension in young adults: the CARDIA study
    Susan G Lakoski
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Arch Intern Med 166:345-9. 2006
    ..However, it is unknown whether a similar relationship exists in younger individuals...
  60. ncbi Effects of estrogens and selective estrogen receptor modulators on indicators of cardiovascular health in postmenopausal women
    Karen Potvin Klein
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina, USA
    Medscape Womens Health 7:2. 2002
  61. doi Associations between electrocardiographic interval durations and coronary artery calcium scores: the Diabetes Heart Study
    Matthew R Nelson
    Department of Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Pacing Clin Electrophysiol 31:314-21. 2008
    ..We examined the relationship between coronary artery disease, measured by coronary artery calcified plaque (CAC), and the duration of QRS, JT, and QT intervals, among predominantly type two diabetic participants...
  62. ncbi Baseline health-related quality of life in postmenopausal women with coronary heart disease: the Estrogen Replacement and Atherosclerosis (ERA) trial
    Aurora M Sherman
    Department of Public Health Services, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    J Womens Health (Larchmt) 12:351-62. 2003
    ..This study examined the baseline health-related quality of life (HRQL) of 301 postmenopausal women with heart disease enrolled in the Estrogen Replacement and Atherosclerosis (ERA) trial...
  63. ncbi Vascular effects of dietary L-arginine supplementation
    Robert B Preli
    Department of Internal Medicine Cardiology, School of Medicine, Wake Forest University, Medical Center Boulevard, Winston Salem, NC 27157 1045, USA
    Atherosclerosis 162:1-15. 2002
    ..Long-term randomized clinical trials are needed to more definitively address whether oral L-arginine supplementation could be advantageous for vascular health...
  64. ncbi No effect of an L-arginine-enriched medical food (HeartBars) on endothelial function and platelet aggregation in subjects with hypercholesterolemia
    Abdelhamed I Abdelhamed
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 145:E15. 2003
    ....
  65. ncbi Pharmacogenomics of blood pressure response to antihypertensive treatment
    Philip B Mellen
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Hypertens 23:1311-25. 2005
    ..With the advent of new technologies and genomic knowledge, more investigators are seeking to identify genetic determinants of blood pressure response to therapy...
  66. ncbi Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with Type 2 diabetes mellitus: the Diabetes Heart Study
    K P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 23:228-34. 2006
    ....
  67. pmc Effect of muscadine grape seed supplementation on vascular function in subjects with or at risk for cardiovascular disease: a randomized crossover trial
    Philip B Mellen
    Hypertension Center of Excellence, Hattiesburg Clinic, Hattiesburg, Mississippi, USA
    J Am Coll Nutr 29:469-75. 2010
    ..Muscadine grape seeds have high concentrations of polyphenolic compounds with antioxidant and other properties that would be expected to have favorable effects on endothelial function...
  68. ncbi Matrix metalloproteinases: a review of their structure and role in acute coronary syndrome
    Charles B Jones
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cardiovasc Res 59:812-23. 2003
    ..To summarize the structure, function, and regulation of matrix metalloproteinases (MMPs) and to review the literature to date on their potential role in the pathogenesis of acute coronary syndromes...
  69. ncbi beta(2)-Adrenergic receptor polymorphisms and determinants of cardiovascular risk: the Cardiovascular Health Study
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Am J Hypertens 18:392-7. 2005
    ....
  70. ncbi Relationship of peripheral arterial compliance and standard cardiovascular risk factors
    Howard J Willens
    University of Miami School of Medicine, Miami, FL, USA
    Vasc Endovascular Surg 37:197-206. 2003
    ....
  71. pmc Effect of genetic variations in platelet glycoproteins Ibalpha and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy
    Paul F Bray
    Jefferson Medical College and the Cardeza Foundation for Hematologic Research, Philadelphia, PA 19107, USA
    Blood 109:1862-9. 2007
    ..It will be important to replicate these findings in other studies...
  72. ncbi Hormone replacement therapy and heart disease: replacing dogma with data
    David M Herrington
    Circulation 107:2-4. 2003
  73. ncbi Randomized trial of hormone therapy in women after coronary bypass surgery. Evidence of differential effect of hormone therapy on angiographic progression of disease in saphenous vein grafts and native coronary arteries
    Pamela Ouyang
    Johns Hopkins University School of Medicine, John Hopkins Bayview Medical Center, Division of Cardiology, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Atherosclerosis 189:375-86. 2006
    ..This study suggests that hormone treatment may slow SVG disease progression while accelerating atherosclerosis in non-bypassed native coronary arteries...
  74. ncbi Progestins affect mechanism of estrogen-induced C-reactive protein stimulation
    David B Reuben
    Multicampus Program in Geriatric Medicine and Gerontology, David Geffen School of Medicine at University of California, Los Angeles 90095 1687, USA
    Am J Med 119:167.e1-8. 2006
    ..To determine whether the mechanisms of C-reactive protein production differ depending on the presence or absence of a progestin in the regimen...
  75. ncbi Conjugated equine estrogens and peripheral arterial disease risk: the Women's Health Initiative
    Judith Hsia
    Department of Medicine, George Washington University, Washington, DC, USA
    Am Heart J 152:170-6. 2006
    ..Estradiol reduced progression of ultrasonographic carotid disease in a randomized trial. No trials of unopposed estrogen for prevention of lower extremity arterial disease or aortic aneurysm have been conducted...
  76. pmc Dietary patterns are associated with biochemical markers of inflammation and endothelial activation in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Jennifer A Nettleton
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Am J Clin Nutr 83:1369-79. 2006
    ..Dietary patterns may influence cardiovascular disease risk through effects on inflammation and endothelial activation...
  77. ncbi Cereal fiber and whole-grain intake are associated with reduced progression of coronary-artery atherosclerosis in postmenopausal women with coronary artery disease
    Arja T Erkkilä
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am Heart J 150:94-101. 2005
    ..The aim was to examine the association between intakes of total fiber and fiber from different dietary sources and progression of coronary-artery atherosclerosis among women with established CAD...
  78. ncbi C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: the Cardiovascular Health Study
    Jie J Cao
    Henry Ford Heart and Vascular Institute, Detroit, Mich, USA
    Circulation 108:166-70. 2003
    ..We investigated whether elevated CRP is a risk factor for ischemic stroke independent of carotid IMT and studied the interaction between CRP and IMT...
  79. ncbi Estrogen and HDL: all that glitters is not gold
    David M Herrington
    Arterioscler Thromb Vasc Biol 24:1741-2. 2004
  80. ncbi Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease
    Arja T Erkkilä
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 80:626-32. 2004
    ..However, limited data exist on the effect of fish intake on actual measures of progression of coronary artery atherosclerosis...
  81. ncbi Comparison of the relation of triglyceride-rich lipoproteins and muscular artery compliance in healthy women versus healthy men
    Ngoc Anh Le
    Atlanta Veterans Affairs Hospital and Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Cardiol 95:1049-54. 2005
    ..These results are consistent with previous findings that triglyceride measurements are more strongly related to clinical vascular events in women than in men...
  82. ncbi Effects of conjugated oestrogen and droloxifene on the renin-angiotensin system, blood pressure and renal blood flow in postmenopausal women
    Ellen W Seely
    Endocrine Hypertension Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachussets 02115, USA
    Clin Endocrinol (Oxf) 60:315-21. 2004
    ....
  83. doi Plasma levels of HDL subpopulations and remnant lipoproteins predict the extent of angiographically-defined coronary artery disease in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:575-9. 2008
    ..The association of coronary heart disease (CHD) with subpopulations of triglyceride (TG)-rich lipoproteins and high-density lipoproteins (HDL) is established in men, but has not been well characterized in women...
  84. ncbi Sleep apnea and markers of vascular endothelial function in a large community sample of older adults
    F Javier Nieto
    Department of Population Health Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53705 2397, USA
    Am J Respir Crit Care Med 169:354-60. 2004
    ..Whether these relationships are entirely independent of obesity is unclear. This association might be one of the mechanisms explaining the relationship between sleep apnea, hypertension, and cardiovascular disease...
  85. ncbi Usefulness of arterial compliance in the thigh in predicting exercise capacity in individuals without coronary heart disease
    Howard J Willens
    Department of Medicine, University of Miami School of Medicine, Miami, FL, USA
    Am J Cardiol 96:306-10. 2005
    ..In conclusion, thigh compliance measured with a simple-to-use, fully automated device independently predicts aerobic fitness in patients with a wide range of cardiovascular risk but without CHD...
  86. ncbi The effects of hormone therapy on the markers of inflammation and endothelial function and plasma matrix metalloproteinase-9 level in postmenopausal women: the postmenopausal estrogen progestin intervention (PEPI) trial
    Peifeng Hu
    Multicampus Program in Geriatric Medicine and Gerontology, UCLA School of Medicine, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095 1687, USA
    Atherosclerosis 185:347-52. 2006
    ....
  87. ncbi The relationship of cardiovascular risk factors to microalbuminuria in older adults with or without diabetes mellitus or hypertension: the cardiovascular health study
    Joshua I Barzilay
    Kaiser Permanente of Georgia, Tucker, GA 30084, USA
    Am J Kidney Dis 44:25-34. 2004
    ..Microalbuminuria is a risk factor for coronary heart disease (CHD). It occurs most commonly in the settings of diabetes and hypertension. The mechanisms by which it increases CHD risk are uncertain...

Research Grants17

  1. Machine Learning to Identify Complex Interactions in Genome-Wide Association Data
    David Herrington; Fiscal Year: 2007
    ..Determining specific genetic and/or environmental factors that influence a person's risk of disease may help doctors reduce risk for disease and reveal new treatments for disease. (End of Abstract) ..
  2. CVD Epidemiology Training Program
    David Herrington; Fiscal Year: 2007
    ....
  3. SNPs and Extent of Atherosclerosis (SEA) Study
    David Herrington; Fiscal Year: 2007
    ..In addition, identification of variants that predispose to atherosclerosis may suggest novel pathophysiologic pathways that could be explored as potential targets for new therapeutic interventions. ..
  4. Estrogen Receptor Variants,HDL, and Atherosclerosis
    David Herrington; Fiscal Year: 2005
    ....
  5. Estrogen Receptor Variance and CHD Risk in HERS
    David Herrington; Fiscal Year: 2004
    ..In addition, this information could lead to fundamentally important new knowledge about mechanisms of estrogen action, regulation of HDL cholesterol, and pathogenesis of CHD. ..
  6. Thrombosis Gene Polymorphisms and Early CHD Risk in HERS
    David Herrington; Fiscal Year: 2004
    ....
  7. ESTROGEN, INFLAMMATION AND ATHEROSCLEROSIS
    David Herrington; Fiscal Year: 2001
    ....
  8. Machine Learning to Identify Complex Interactions in Genome-Wide Association Data
    David Herrington; Fiscal Year: 2009
    ..Determining specific genetic and/or environmental factors that influence a person's risk of disease may help doctors reduce risk for disease and reveal new treatments for disease. (End of Abstract) ..