SCOTT EDWARDS HEMBY

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration
    Glen Acosta
    Department of Physiology and Pharmacology, Wake Forest University Winston Salem, NC, USA
    Front Psychiatry 2:72. 2011
  2. pmc De novo protein sequence analysis of Macaca mulatta
    Nilesh S Tannu
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    BMC Genomics 8:270. 2007
  3. pmc Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurochem 95:1785-93. 2005
  4. pmc Differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA
    Brain Res 1064:75-82. 2005
  5. ncbi request reprint Assessment of genome and proteome profiles in cocaine abuse
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Prog Brain Res 158:173-95. 2006
  6. ncbi request reprint Ethanol-induced regulation of GABA-A subunit mRNAs in prefrontal fields of cynomolgus monkeys
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Alcohol Clin Exp Res 30:1978-85. 2006
  7. pmc Modeling substance abuse for applications in proteomics
    Scott E Hemby
    Department of Physiology and Pharmacology and Psychiatry, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Methods Mol Biol 566:69-83. 2009
  8. pmc Cocainomics: new insights into the molecular basis of cocaine addiction
    Scott E Hemby
    Department of Physiology and Pharmacology, Center for the Neurobiology of Addiction and Treatment, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Neuroimmune Pharmacol 5:70-82. 2010
  9. pmc Ethanol self-administration modulation of NMDA receptor subunit and related synaptic protein mRNA expression in prefrontal cortical fields in cynomolgus monkeys
    Glen Acosta
    Department of Physiology and Pharmacology, Wake Forest University, Winston Salem, NC 27157, USA
    Brain Res 1318:144-54. 2010
  10. ncbi request reprint Methods for proteomics in neuroscience
    Nilesh S Tannu
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Prog Brain Res 158:41-82. 2006

Research Grants

Detail Information

Publications27

  1. pmc Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration
    Glen Acosta
    Department of Physiology and Pharmacology, Wake Forest University Winston Salem, NC, USA
    Front Psychiatry 2:72. 2011
    ..Additional studies examining the cellular localization of such effects in the framework of primate prefrontal cortical circuitry are warranted...
  2. pmc De novo protein sequence analysis of Macaca mulatta
    Nilesh S Tannu
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    BMC Genomics 8:270. 2007
    ..Therefore, it becomes necessary to determine partial or complete amino acid sequences using either manual or automated de novo peptide sequence analysis methods...
  3. pmc Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurochem 95:1785-93. 2005
    ..Furthermore, these changes may mediate persistent drug intake and craving in the human cocaine abuser...
  4. pmc Differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA
    Brain Res 1064:75-82. 2005
    ....
  5. ncbi request reprint Assessment of genome and proteome profiles in cocaine abuse
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Prog Brain Res 158:173-95. 2006
    ....
  6. ncbi request reprint Ethanol-induced regulation of GABA-A subunit mRNAs in prefrontal fields of cynomolgus monkeys
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Alcohol Clin Exp Res 30:1978-85. 2006
    ....
  7. pmc Modeling substance abuse for applications in proteomics
    Scott E Hemby
    Department of Physiology and Pharmacology and Psychiatry, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Methods Mol Biol 566:69-83. 2009
    ..Examples of cocaine-induced alterations in the abundances of ionotropic glutamate receptor subunits in reinforcement-related brain regions are provided...
  8. pmc Cocainomics: new insights into the molecular basis of cocaine addiction
    Scott E Hemby
    Department of Physiology and Pharmacology, Center for the Neurobiology of Addiction and Treatment, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Neuroimmune Pharmacol 5:70-82. 2010
    ....
  9. pmc Ethanol self-administration modulation of NMDA receptor subunit and related synaptic protein mRNA expression in prefrontal cortical fields in cynomolgus monkeys
    Glen Acosta
    Department of Physiology and Pharmacology, Wake Forest University, Winston Salem, NC 27157, USA
    Brain Res 1318:144-54. 2010
    ..Further studies examining the expression and cellular localization of subunit proteins and receptor pharmacology would shed more light on the findings reported here...
  10. ncbi request reprint Methods for proteomics in neuroscience
    Nilesh S Tannu
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Prog Brain Res 158:41-82. 2006
    ..While there are many challenges in neuroproteomics, this field promises many returns in the future...
  11. pmc MRI-guided dissection of the nonhuman primate brain: a case study
    James Bernard Daunais
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Methods 50:199-204. 2010
    ..These results clearly demonstrate that the accuracy of targeting specific brain areas can be improved with high-resolution MR imaging...
  12. ncbi request reprint Self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine
    James E Smith
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Wake Forest University, Winston Salem, NC, USA
    Neuropsychopharmacology 31:139-50. 2006
    ....
  13. pmc Quantitation in two-dimensional fluorescence difference gel electrophoresis: effect of protein fixation
    Nilesh Tannu
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27501, USA
    Electrophoresis 27:2011-5. 2006
    ....
  14. pmc Two-dimensional fluorescence difference gel electrophoresis for comparative proteomics profiling
    Nilesh S Tannu
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Protoc 1:1732-42. 2006
    ..This protocol can be completed in 3-5 weeks depending on the sample size of the experiment and the level of expertise of the investigator...
  15. ncbi request reprint Region specific regulation of NR1 in rhesus monkeys following chronic antipsychotic drug administration
    Joann A O'connor
    Yerkes National Primate Research Center, Neuroscience Division, Atlanta, Georgia, USA
    Biol Psychiatry 60:659-62. 2006
    ..Altered NMDA receptor subunit protein levels have been reported in various regions of the schizophrenic brain; however, chronic antipsychotic administration in schizophrenic subjects may confound interpretation...
  16. ncbi request reprint Molecular mapping of striatal subdivisions in juvenile Macaca Mulata
    Joann O'Connor
    Molecular and Systems Pharmacology Program, Graduate Division of Biological and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 198:326-37. 2006
    ..Subregion specific transcription profiles support the anatomical differentiation and potential disease vulnerabilities of the respective subregions...
  17. pmc Molecular profiling of midbrain dopamine regions in cocaine overdose victims
    Wen Xue Tang
    Department of Pharmacology and Psychiatry Behavioral Sciences, Yerkes National Primate Research Center, Neuroscience Division, Emory University School of Medicine, 954 Gatewood Road, Atlanta, GA 30329, USA
    J Neurochem 85:911-24. 2003
    ....
  18. pmc Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats
    Wenxue Tang
    Department of Pharmacology, Yerkes National Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    J Neurochem 89:1021-33. 2004
    ..Because subunit composition determines the functional properties of iGluRs, the observed changes may indicate alterations in the excitability of dopamine transmission underlying long-term biochemical and behavioral effects of cocaine...
  19. pmc Time-dependent changes in gene expression profiles of midbrain dopamine neurons following haloperidol administration
    Wendy H Fasulo
    Department of Pharmacology, Yerkes National Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, GA, USA
    J Neurochem 87:205-19. 2003
    ..Understanding how gene expression is altered over a clinically relevant time course of haloperidol administration may provide insight into the development of antipsychotic efficacy as well as the underlying pathology of schizophrenia...
  20. ncbi request reprint Discrete cell gene profiling of ventral tegmental dopamine neurons after acute and chronic cocaine self-administration
    Eric Backes
    Department of Pharmacology, Neuroscience Division, Emory University School of Medicine, Atlanta, GA, USA
    J Pharmacol Exp Ther 307:450-9. 2003
    ....
  21. pmc Functional genomics and psychiatric illness
    Wendy Hasenkamp
    Departments of Pharmacology and Psychiatry Behavioral Sciences, Yerkes Regional Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, GA 30329, USA
    Prog Brain Res 138:375-93. 2002
  22. ncbi request reprint Neuron-specific age-related decreases in dopamine receptor subtype mRNAs
    Scott E Hemby
    Department of Pharmacology and Psychiatry Behavioral Sciences, Yerkes National Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    J Comp Neurol 456:176-83. 2003
    ..Furthermore, these results support the hypothesis that alterations in dopaminergic function may also be related to behavioral abnormalities, such as psychosis, that occur with aging...
  23. doi request reprint Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Arch Intern Med 168:1188-99. 2008
    ..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...
  24. ncbi request reprint Single-cell gene expression analysis: implications for neurodegenerative and neuropsychiatric disorders
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, New York 10962, USA
    Neurochem Res 29:1053-64. 2004
    ..This focused review illustrates the potential power of single-cell gene expression studies within the CNS in relation to neurodegenerative and neuropsychiatric disorders such as Alzheimer's disease (AD) and schizophrenia, respectively...
  25. pmc Proteomics for protein expression profiling in neuroscience
    Willard M Freeman
    Department of Pharmacology, Yerkes National Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    Neurochem Res 29:1065-81. 2004
    ..Although there are many challenges in proteomic neuroscience, this field promises many rewards in the future...
  26. ncbi request reprint Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamus
    J Martin Verkuyl
    Swammerdam Institute for Life Sciences, Neurobiology Section, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 20:1665-73. 2004
    ....
  27. ncbi request reprint Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortex
    Scott E Hemby
    Department of Pharmacology, Yerkes Regional Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, GA, USA
    Arch Gen Psychiatry 59:631-40. 2002
    ..We used single-cell gene expression technologies to assess coordinate changes in the expression of multiple genes, including neuronal signaling and synaptic-related markers in EC layer II stellate neurons...

Research Grants17

  1. Molecular Fingerprint of Cocaine Abuse Analysis
    Scott Hemby; Fiscal Year: 2001
    ..In addition, identification of differentially expressed genes may provide novel targets for the pharmacotherapeutic development and/or the refinement of existent pharmacotherapies. ..
  2. Entorhinal Transcriptome in Schizophrenia
    Scott Hemby; Fiscal Year: 2009
    ..To date, the treatment regimen, necropsy and tissue harvesting have been completed with both fresh frozen and paraffin-embedded EC available. ..
  3. NEUROBIOLOGY OF SPEEDBALL SELF-ADMINISTRATION
    Scott Hemby; Fiscal Year: 2009
    ..Clearly, knowledge of the mechanisms of this enhancement could be helpful in the development of therapeutic strategies to treat this co-abuse. ..
  4. Entorhinal Transcriptome in Schizophrenia
    Scott Hemby; Fiscal Year: 2007
    ..To date, the treatment regimen, necropsy and tissue harvesting have been completed with both fresh frozen and paraffin-embedded EC available. ..
  5. Entorhinal Transcriptome in Schizophrenia
    Scott Hemby; Fiscal Year: 2006
    ..To date, the treatment regimen, necropsy and tissue harvesting have been completed with both fresh frozen and paraffin-embedded EC available. ..
  6. Accumbens-pallidal GABA and morphine reinforcement
    Scott Hemby; Fiscal Year: 2005
    ..Changes in the expression levels of multiple genes will be assessed in terms of morphine reinforcement and direct pharmacological effects of the drug. ..
  7. Entorhinal Transcriptome in Schizophrenia
    Scott Hemby; Fiscal Year: 2005
    ..To date, the treatment regimen, necropsy and tissue harvesting have been completed with both fresh frozen and paraffin-embedded EC available. ..
  8. Accumbens-pallidal GABA and morphine reinforcement
    Scott Hemby; Fiscal Year: 2004
    ..Changes in the expression levels of multiple genes will be assessed in terms of morphine reinforcement and direct pharmacological effects of the drug. ..
  9. Molecular Fingerprint of Cocaine Abuse Analysis
    Scott Hemby; Fiscal Year: 2003
    ..In addition, identification of differentially expressed genes may provide novel targets for the pharmacotherapeutic development and/or the refinement of existent pharmacotherapies. ..
  10. Accumbens-pallidal GABA and morphine reinforcement
    Scott Hemby; Fiscal Year: 2003
    ..Changes in the expression levels of multiple genes will be assessed in terms of morphine reinforcement and direct pharmacological effects of the drug. ..
  11. Accumbens-pallidal GABA and morphine reinforcement
    Scott Hemby; Fiscal Year: 2002
    ..Changes in the expression levels of multiple genes will be assessed in terms of morphine reinforcement and direct pharmacological effects of the drug. ..
  12. Molecular Fingerprint of Cocaine Abuse Analysis
    Scott Hemby; Fiscal Year: 2002
    ..In addition, identification of differentially expressed genes may provide novel targets for the pharmacotherapeutic development and/or the refinement of existent pharmacotherapies. ..
  13. Accumbens-pallidal GABA and morphine reinforcement
    Scott Hemby; Fiscal Year: 2001
    ..Changes in the expression levels of multiple genes will be assessed in terms of morphine reinforcement and direct pharmacological effects of the drug. ..
  14. NEUROBIOLOGY OF SPEEDBALL SELF-ADMINISTRATION
    SCOTT EDWARDS HEMBY; Fiscal Year: 2010
    ..Clearly, knowledge of the mechanisms of this enhancement could be helpful in the development of therapeutic strategies to treat this co-abuse. ..