KENICHIRO HAYASHIDA

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Multiplicative interactions to enhance gabapentin to treat neuropathic pain
    Ken ichiro Hayashida
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Eur J Pharmacol 598:21-6. 2008
  2. pmc Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats
    Ken ichiro Hayashida
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 1317:80-6. 2010
  3. ncbi request reprint Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Anesthesiology 106:1213-9. 2007
  4. pmc Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat
    Christopher M Peters
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 1352:83-93. 2010
  5. ncbi request reprint Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, North Carolina 27157 1009, USA
    Anesthesiology 106:557-62. 2007
  6. pmc Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
    Ken ichiro Hayashida
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 109:1077-84. 2008
  7. ncbi request reprint Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism
    Bridgette A Clayton
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 106:1019-25. 2007
  8. pmc Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for the Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 136:348-55. 2008

Research Grants

  1. Mechanisms and Consequences of Locus Coeruleus Activation
    KENICHIRO HAYASHIDA; Fiscal Year: 2010

Collaborators

Detail Information

Publications8

  1. pmc Multiplicative interactions to enhance gabapentin to treat neuropathic pain
    Ken ichiro Hayashida
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Eur J Pharmacol 598:21-6. 2008
    ..The current study provides the rationale for clinical study of the combination of gabapentin, donepezil and duloxetine to treat neuropathic pain...
  2. pmc Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats
    Ken ichiro Hayashida
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 1317:80-6. 2010
    ....
  3. ncbi request reprint Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Anesthesiology 106:1213-9. 2007
    ....
  4. pmc Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat
    Christopher M Peters
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 1352:83-93. 2010
    ....
  5. ncbi request reprint Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, North Carolina 27157 1009, USA
    Anesthesiology 106:557-62. 2007
    ..Here, the authors tested the role of spinal noradrenergic inhibition in gabapentin's analgesia for postoperative pain...
  6. pmc Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
    Ken ichiro Hayashida
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 109:1077-84. 2008
    ..The authors hypothesized that gabapentin activates noradrenergic neurons in the locus coeruleus (LC) by a local action...
  7. ncbi request reprint Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism
    Bridgette A Clayton
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 106:1019-25. 2007
    ..Here, the authors tested whether donepezil, a central nervous system penetrant cholinesterase inhibitor with a low incidence of gastrointestinal side effects, would relieve hypersensitivity in an animal model of neuropathic pain...
  8. pmc Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for the Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 136:348-55. 2008
    ....

Research Grants2

  1. Mechanisms and Consequences of Locus Coeruleus Activation
    KENICHIRO HAYASHIDA; Fiscal Year: 2010
    ..In this proposal, we will study how gabapentin stimulates a natural pain-relief mechanism to reduce pain but also to cause side effects. ..