Research Topics
Genomes and Genes
| Gregory A HawkinsSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Asthma pharmacogenomicsGregory A Hawkins
Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Immunol Allergy Clin North Am 25:723-42. 2005..Whether pharmacogenomics becomes common practice may not depend on the availability of tests, but on factors such as affordability, ease of application, and ease of interpreting the results...
The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroidsGregory A Hawkins
Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 123:1376-83.e7. 2009..Corticosteroids exert their anti-inflammatory action by binding and activating the intracellular glucocorticoid receptor heterocomplex...- Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panelGregory A Hawkins
Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
DNA Seq 15:167-73. 2004..This data shows the variability of NR3C1 polymorphism frequencies between racial groups and confirms that NR3C1 non-synonymous coding polymorphisms are generally rare in mild/moderate asthmatics and unaffected controls... - Identification of coding polymorphisms in human circadian rhythm genes PER1, PER2, PER3, CLOCK, ARNTL, CRY1, CRY2 and TIMELESS in a multi-ethnic screening panelGregory A Hawkins
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
DNA Seq 19:44-9. 2008..In this study, the exonic regions of the circadian rhythm genes PER1, PER2, PER3, CLOCK, ARNTL, CRY1, CRY2 and TIMELESS were re-sequenced and coding changes identified in a panel of 95 individuals varying in ethnicity... - Clinical consequences of ADRbeta2 polymorphismsGregory A Hawkins
Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Pharmacogenomics 9:349-58. 2008.... 
The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthmaGregory A Hawkins
Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 130:510-5.e1. 2012..The SNP rs4129267 is in linkage disequilibrium (r(2) = 1) with the IL6R coding SNP rs2228145 (Asp(358)Ala). This IL6R coding change increases IL-6 receptor (IL-6R) shedding and promotes IL-6 transsignaling...- Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control studyGregory A Hawkins
Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Am J Respir Crit Care Med 174:1101-9. 2006.... - Polymorphisms in the CYP1A1 gene are associated with prostate cancer riskBao Li Chang
Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 USA
Int J Cancer 106:375-8. 2003..These findings suggest that genetic polymorphisms in CYP1A1 may modify the risk for CaP... - Sequence variants in the human 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) gene are not associated with prostate cancer riskGregory A Hawkins
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Prostate 53:175-8. 2002..25-hydroxyvitamin D(3) 1-alpha-hydroxylase, the enzyme that catalyzes the final step of vitamin D synthesis, converting 25-hydroxyvitamin D(3) to 1,25-dihydroxyvitamin D(3), is expressed in the prostate... - Mutational analysis of PINX1 in hereditary prostate cancerGregory A Hawkins
Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
Prostate 60:298-302. 2004..The most common variants Thr220Ala and Ser254Cys were not significantly over-transmitted from affected parent to affected offspring. CONCLUSIONS: Based on these results, we conclude that PINX1 is not a major factor for HPC risk... - Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levelsScott D Cramer
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Natl Cancer Inst 95:1044-53. 2003..However, polymorphisms associated with variations in PSA levels have not been identified... - Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer riskJianfeng Xu
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Hum Genet 72:208-12. 2003..These results consistently suggest that MSR1 may play an important role in prostate carcinogenesis... - Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokersAlireza Sadeghnejad
Center for Human Genomics and Department of Medicine and Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Respir Res 10:21. 2009..We evaluated the association between polymorphisms in ADAM33 gene with COPD and lung function in long term tobacco smokers... - Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer riskSiqun L Zheng
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Cancer Res 62:6485-8. 2002..00006), especially in the subset of families whose probands carry the "A-A" haplotype of M9V and D175G (log of odds = 4.34; P = 0.000008). These results suggest that sequence variants in AMACR may be associated with CaP risk... - Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer riskBao Li Chang
Center for Human Genomics, Wake Forest University School of Medicine, Winton Salem, NC 27157, USA
Hum Genet 110:122-9. 2002..Further studies on this polymorphism in other independent data sets and functional analysis of the GGC repeat length on AR activity are warranted... - Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association studySiqun L Zheng
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Mutat Res 528:45-53. 2003..These results suggest that DLC1 is unlikely to play an important role in prostate cancer susceptibility... - Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive proteinDavid M Herrington
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
Circulation 105:1879-82. 2002..This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive protein (CRP) and to explore possible mechanisms by which this polymorphism might influence estrogen action... - Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28Timothy D Howard
Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
J Allergy Clin Immunol 110:743-51. 2002..0009). No significant associations were observed for SNPs in CD28. CONCLUSION: These data suggest that the costimulatory pathway, specifically CTLA4, is important in the development of atopy and asthma... - Associations between hOGG1 sequence variants and prostate cancer susceptibilityJianfeng Xu
Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
Cancer Res 62:2253-7. 2002..These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1... - A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjectsMonica J Basehore
Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 114:80-7. 2004..This cytokine is important in IgE isotype switching and the regulation of allergic inflammation; however, published studies have not delineated the specific role of variation in this gene in allergic disorders... - Pharmacogenetics of asthmaGregory A Hawkins
Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Methods Mol Biol 448:359-78. 2008.... - Identification of podocin (NPHS2) gene mutations in African Americans with nondiabetic end-stage renal diseaseJudith A Engeler Dusel
Department of Internal Medicine, Center for Human Genomics, Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
Kidney Int 68:256-62. 2005..Evidence for linkage of end-stage renal disease (ESRD) to chromosome 1q25-31 in the region of NPHS2 has been identified in a genome-wide scan in African American (AA) siblings... - Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene clusterJeannette T Bensen
The Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Genomics 82:194-217. 2003..0015) and a 4-bp insertion/deletion within the 3'UTR, rs16347-2 (p=0.0024), among African Americans with non-T2DM-associated ESRD... - Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseasesXingnan Li
Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 130:861-8.e7. 2012.... - Single-nucleotide polymorphisms in the TNF gene are associated with obesity-related phenotypes in vervet monkeysStanton B Gray
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Obesity (Silver Spring) 19:1427-32. 2011..05), and high-density lipoprotein-cholesterol (HDL-C) (P < 0.01). This study provides additional validation of the St Kitts-origin vervet model of obesity by demonstrating genetic associations analogous to that shown in humans... - Importance of hedgehog interacting protein and other lung function genes in asthmaXingnan Li
Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 127:1457-65. 2011..The importance of these genes in lung function in white and African American subjects with asthma is unknown... - Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study populationRichard S Smith
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
DNA Seq 18:47-53. 2007..Two-thirds of the polymorphisms reported in dbSNP were not identified in our screening panel. Although similar in sequence, HSPAIA and HSPAIB do not share common patterns of polymorphisms... - Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumorsKimberly R Blish
Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Exp Clin Cancer Res 29:147. 2010.... - Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary diseaseDavid M Herrington
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
N Engl J Med 346:967-74. 2002.... - A human bone morphogenetic protein antagonist is down-regulated in renal cancerKimberly Rose Blish
Section on Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 0001, USA
Mol Biol Cell 19:457-64. 2008..Because SOSTDC1 suppresses proliferation of renal carcinoma cells, restoration of SOSTDC1 signaling may represent a novel target in treatment of renal clear cell carcinoma... - Pharmacogenetics of the beta 2-adrenergic receptor geneVictor E Ortega
Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Immunol Allergy Clin North Am 27:665-84; vii. 2007..Meanwhile, the conflicting data concerning LABAs may be caused by such factors as small sample sizes of study populations and differences in experimental design... - IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonistRebecca E Slager
Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 130:516-22.e4. 2012..We analyzed genomic DNA from participants in a 12-week placebo-controlled efficacy trial of pitrakinra (1, 3, or 10 mg twice daily), a novel IL-4/IL-13 pathway antagonist (Clinicaltrials.govNCT00801853)... - Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancerAli Mallakin
Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
Cancer Cell 12:381-94. 2007..Thus, DMP1 is a pivotal tumor suppressor for both human and murine lung cancers... - Germline sequence variants of the LZTS1 gene are associated with prostate cancer riskGregory A Hawkins
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Cancer Genet Cytogenet 137:1-7. 2002..Four of these SNP were statistically significant for association with prostate cancer (P < or = 0.04). These results add evidence supporting a role of LZTS1 in prostate cancer risk... - Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer riskJianfeng Xu
Center for Human Genomics and the Department of Public Health, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Nat Genet 32:321-5. 2002..009). Among African American men, these values were 12.5% and 1.8%, respectively (P = 0.01). These results show that MSR1 may be important in susceptibility to prostate cancer in men of both African American and European descent... - Comparative analyses of single-nucleotide polymorphisms in the TNF promoter region provide further validation for the vervet monkey model of obesityStanton B Gray
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Comp Med 59:580-8. 2009..More broadly, the sequence data and comparative analyses reported herein facilitates study of the evolution of regulatory sequences of inflammatory and immune-related genes... - Genetics of asthma susceptibility and severityRebecca E Slager
Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Clin Chest Med 33:431-43. 2012..Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy... - Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family StudyDonald W Bowden
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Hum Mol Genet 19:4112-20. 2010..This approach is applicable to a wide range of family studies and has potential to be a discovery tool for identification of novel genes influencing complex traits... - Variability of serum soluble intercellular adhesion molecule-1 measurements attributable to a common polymorphismThomas C Register
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Clin Chem 50:2185-7. 2004 - Suppression of Tak1 promotes prostate tumorigenesisMin Wu
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Cancer Res 72:2833-43. 2012..Together, our findings functionally validate the proposed tumor suppressor role of Tak1 in prostate cancer... 
Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and beta2-agonist useAnnette T Hastie
Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Respir Res 7:25. 2006....- G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin toleranceMohamed El Gazzar
Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
J Biol Chem 283:32198-208. 2008.... - Altered editing in cyclic nucleotide phosphodiesterase 8A1 gene transcripts of systemic lupus erythematosus T lymphocytesRobert J Orlowski
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Immunology 125:408-19. 2008..Such altered editing may contribute to the modulation of gene regulation and ultimately, immune functions in SLE and play an important role in the initiation and propagation of SLE pathogenesis... - Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in miceZheng Cui
Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Proc Natl Acad Sci U S A 100:6682-7. 2003..The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer... - Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibilityBao Li Chang
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Cancer Res 62:1784-9. 2002..Most importantly, the subset of hereditary prostate cancer probands, whose families provided evidence for linkage at 1p13, predominantly contributed to the observed association. Additional studies are warranted to confirm these findings... - Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulationAlfredo Panebra
Cardiopulmonary Genomics Program, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201 1075, USA
Am J Physiol Lung Cell Mol Physiol 294:L190-5. 2008.... - IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expressionSally E Wenzel
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 175:570-6. 2007..However, an effect on exacerbations and tissue inflammation has not been shown... - ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohortsAugusto A Litonjua
Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 178:688-94. 2008..However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients... - Severe prekallikrein deficiency associated with homozygosity for an Arg94Stop nonsense mutationD Wynne Jones
Department of Biosciences, University of Kent and Kent Haemophilia Centre, Kent and Canterbury Hospital, Canterbury, Kent, UK
Br J Haematol 127:220-3. 2004..This is the first description of a kindred in which absence of expression of one or both PK alleles has been confirmed by genotype...
Research Grants
- Severe Asthma and the Glucocorticoid Receptor ComplexGregory Hawkins; Fiscal Year: 2006..This will also lay the ground work for future functional studies using coding sequence variants identified in the GR complex proteins. ..