Gregory A Hawkins

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel
    Gregory A Hawkins
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    DNA Seq 15:167-73. 2004
  2. ncbi request reprint Identification of coding polymorphisms in human circadian rhythm genes PER1, PER2, PER3, CLOCK, ARNTL, CRY1, CRY2 and TIMELESS in a multi-ethnic screening panel
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    DNA Seq 19:44-9. 2008
  3. doi request reprint The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids
    Gregory A Hawkins
    Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 123:1376-83.e7. 2009
  4. ncbi request reprint Asthma pharmacogenomics
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Immunol Allergy Clin North Am 25:723-42. 2005
  5. doi request reprint Clinical consequences of ADRbeta2 polymorphisms
    Gregory A Hawkins
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Pharmacogenomics 9:349-58. 2008
  6. pmc The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    Gregory A Hawkins
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:510-5.e1. 2012
  7. pmc Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 174:1101-9. 2006
  8. ncbi request reprint Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 USA
    Int J Cancer 106:375-8. 2003
  9. ncbi request reprint Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels
    Scott D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Natl Cancer Inst 95:1044-53. 2003
  10. pmc Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 72:208-12. 2003

Research Grants

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel
    Gregory A Hawkins
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    DNA Seq 15:167-73. 2004
    ..This data shows the variability of NR3C1 polymorphism frequencies between racial groups and confirms that NR3C1 non-synonymous coding polymorphisms are generally rare in mild/moderate asthmatics and unaffected controls...
  2. ncbi request reprint Identification of coding polymorphisms in human circadian rhythm genes PER1, PER2, PER3, CLOCK, ARNTL, CRY1, CRY2 and TIMELESS in a multi-ethnic screening panel
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    DNA Seq 19:44-9. 2008
    ..In this study, the exonic regions of the circadian rhythm genes PER1, PER2, PER3, CLOCK, ARNTL, CRY1, CRY2 and TIMELESS were re-sequenced and coding changes identified in a panel of 95 individuals varying in ethnicity...
  3. doi request reprint The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids
    Gregory A Hawkins
    Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 123:1376-83.e7. 2009
    ..Corticosteroids exert their anti-inflammatory action by binding and activating the intracellular glucocorticoid receptor heterocomplex...
  4. ncbi request reprint Asthma pharmacogenomics
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Immunol Allergy Clin North Am 25:723-42. 2005
    ..Whether pharmacogenomics becomes common practice may not depend on the availability of tests, but on factors such as affordability, ease of application, and ease of interpreting the results...
  5. doi request reprint Clinical consequences of ADRbeta2 polymorphisms
    Gregory A Hawkins
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Pharmacogenomics 9:349-58. 2008
    ....
  6. pmc The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    Gregory A Hawkins
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:510-5.e1. 2012
    ..The SNP rs4129267 is in linkage disequilibrium (r(2) = 1) with the IL6R coding SNP rs2228145 (Asp(358)Ala). This IL6R coding change increases IL-6 receptor (IL-6R) shedding and promotes IL-6 transsignaling...
  7. pmc Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 174:1101-9. 2006
    ....
  8. ncbi request reprint Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 USA
    Int J Cancer 106:375-8. 2003
    ..These findings suggest that genetic polymorphisms in CYP1A1 may modify the risk for CaP...
  9. ncbi request reprint Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels
    Scott D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Natl Cancer Inst 95:1044-53. 2003
    ..However, polymorphisms associated with variations in PSA levels have not been identified...
  10. pmc Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 72:208-12. 2003
    ..These results consistently suggest that MSR1 may play an important role in prostate carcinogenesis...
  11. ncbi request reprint Mutational analysis of PINX1 in hereditary prostate cancer
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 60:298-302. 2004
    ..The PinX1 gene is located within chromosomal region 8p22-23, a region associated with LOH and potentially linked to increased prostate cancer risk...
  12. ncbi request reprint Sequence variants in the human 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) gene are not associated with prostate cancer risk
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 53:175-8. 2002
    ..25-hydroxyvitamin D(3) 1-alpha-hydroxylase, the enzyme that catalyzes the final step of vitamin D synthesis, converting 25-hydroxyvitamin D(3) to 1,25-dihydroxyvitamin D(3), is expressed in the prostate...
  13. pmc Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers
    Alireza Sadeghnejad
    Center for Human Genomics and Department of Medicine and Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Respir Res 10:21. 2009
    ..We evaluated the association between polymorphisms in ADAM33 gene with COPD and lung function in long term tobacco smokers...
  14. ncbi request reprint Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Winton Salem, NC 27157, USA
    Hum Genet 110:122-9. 2002
    ..Further studies on this polymorphism in other independent data sets and functional analysis of the GGC repeat length on AR activity are warranted...
  15. ncbi request reprint Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk
    Siqun L Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Res 62:6485-8. 2002
    ..00006), especially in the subset of families whose probands carry the "A-A" haplotype of M9V and D175G (log of odds = 4.34; P = 0.000008). These results suggest that sequence variants in AMACR may be associated with CaP risk...
  16. ncbi request reprint Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein
    David M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Circulation 105:1879-82. 2002
    ..This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive protein (CRP) and to explore possible mechanisms by which this polymorphism might influence estrogen action...
  17. ncbi request reprint A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects
    Monica J Basehore
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 114:80-7. 2004
    ..This cytokine is important in IgE isotype switching and the regulation of allergic inflammation; however, published studies have not delineated the specific role of variation in this gene in allergic disorders...
  18. ncbi request reprint Associations between hOGG1 sequence variants and prostate cancer susceptibility
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Cancer Res 62:2253-7. 2002
    ..These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1...
  19. ncbi request reprint Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28
    Timothy D Howard
    Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 110:743-51. 2002
    ..Two candidate genes, CTLA4 and CD28, important homeostatic regulators of T-cell activation and subsequent IgE production, map within this candidate region...
  20. ncbi request reprint Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study
    Siqun L Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Mutat Res 528:45-53. 2003
    ..These results suggest that DLC1 is unlikely to play an important role in prostate cancer susceptibility...
  21. doi request reprint Pharmacogenetics of asthma
    Gregory A Hawkins
    Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Methods Mol Biol 448:359-78. 2008
    ....
  22. pmc Genetics of asthma susceptibility and severity
    Rebecca E Slager
    Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Clin Chest Med 33:431-43. 2012
    ..Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy...
  23. ncbi request reprint Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene cluster
    Jeannette T Bensen
    The Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Genomics 82:194-217. 2003
    ..0015) and a 4-bp insertion/deletion within the 3'UTR, rs16347-2 (p=0.0024), among African Americans with non-T2DM-associated ESRD...
  24. ncbi request reprint Identification of podocin (NPHS2) gene mutations in African Americans with nondiabetic end-stage renal disease
    Judith A Engeler Dusel
    Department of Internal Medicine, Center for Human Genomics, Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 68:256-62. 2005
    ..Evidence for linkage of end-stage renal disease (ESRD) to chromosome 1q25-31 in the region of NPHS2 has been identified in a genome-wide scan in African American (AA) siblings...
  25. pmc Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:861-8.e7. 2012
    ....
  26. doi request reprint Single-nucleotide polymorphisms in the TNF gene are associated with obesity-related phenotypes in vervet monkeys
    Stanton B Gray
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 19:1427-32. 2011
    ..05), and high-density lipoprotein-cholesterol (HDL-C) (P < 0.01). This study provides additional validation of the St Kitts-origin vervet model of obesity by demonstrating genetic associations analogous to that shown in humans...
  27. ncbi request reprint Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population
    Richard S Smith
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    DNA Seq 18:47-53. 2007
    ..Two-thirds of the polymorphisms reported in dbSNP were not identified in our screening panel. Although similar in sequence, HSPAIA and HSPAIB do not share common patterns of polymorphisms...
  28. pmc Importance of hedgehog interacting protein and other lung function genes in asthma
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 127:1457-65. 2011
    ..The importance of these genes in lung function in white and African American subjects with asthma is unknown...
  29. pmc Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors
    Kimberly R Blish
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Exp Clin Cancer Res 29:147. 2010
    ....
  30. pmc Pharmacogenetics of the beta 2-adrenergic receptor gene
    Victor E Ortega
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunol Allergy Clin North Am 27:665-84; vii. 2007
    ..Meanwhile, the conflicting data concerning LABAs may be caused by such factors as small sample sizes of study populations and differences in experimental design...
  31. pmc A human bone morphogenetic protein antagonist is down-regulated in renal cancer
    Kimberly Rose Blish
    Section on Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 0001, USA
    Mol Biol Cell 19:457-64. 2008
    ..Because SOSTDC1 suppresses proliferation of renal carcinoma cells, restoration of SOSTDC1 signaling may represent a novel target in treatment of renal clear cell carcinoma...
  32. ncbi request reprint Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease
    David M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    N Engl J Med 346:967-74. 2002
    ....
  33. doi request reprint IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist
    Rebecca E Slager
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:516-22.e4. 2012
    ..We analyzed genomic DNA from participants in a 12-week placebo-controlled efficacy trial of pitrakinra (1, 3, or 10 mg twice daily), a novel IL-4/IL-13 pathway antagonist (Clinicaltrials.govNCT00801853)...
  34. pmc Comparative analyses of single-nucleotide polymorphisms in the TNF promoter region provide further validation for the vervet monkey model of obesity
    Stanton B Gray
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Comp Med 59:580-8. 2009
    ..More broadly, the sequence data and comparative analyses reported herein facilitates study of the evolution of regulatory sequences of inflammatory and immune-related genes...
  35. ncbi request reprint Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics and the Department of Public Health, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Genet 32:321-5. 2002
    ..009). Among African American men, these values were 12.5% and 1.8%, respectively (P = 0.01). These results show that MSR1 may be important in susceptibility to prostate cancer in men of both African American and European descent...
  36. pmc Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer
    Ali Mallakin
    Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Cell 12:381-94. 2007
    ..Thus, DMP1 is a pivotal tumor suppressor for both human and murine lung cancers...
  37. ncbi request reprint Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Cancer Genet Cytogenet 137:1-7. 2002
    ..Four of these SNP were statistically significant for association with prostate cancer (P < or = 0.04). These results add evidence supporting a role of LZTS1 in prostate cancer risk...
  38. pmc Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study
    Donald W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Mol Genet 19:4112-20. 2010
    ..This approach is applicable to a wide range of family studies and has potential to be a discovery tool for identification of novel genes influencing complex traits...
  39. ncbi request reprint Variability of serum soluble intercellular adhesion molecule-1 measurements attributable to a common polymorphism
    Thomas C Register
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Clin Chem 50:2185-7. 2004
  40. pmc Suppression of Tak1 promotes prostate tumorigenesis
    Min Wu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 72:2833-43. 2012
    ..Together, our findings functionally validate the proposed tumor suppressor role of Tak1 in prostate cancer...
  41. pmc Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and beta2-agonist use
    Annette T Hastie
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Respir Res 7:25. 2006
    ....
  42. pmc Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 100:6682-7. 2003
    ..The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer...
  43. pmc Altered editing in cyclic nucleotide phosphodiesterase 8A1 gene transcripts of systemic lupus erythematosus T lymphocytes
    Robert J Orlowski
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunology 125:408-19. 2008
    ..Such altered editing may contribute to the modulation of gene regulation and ultimately, immune functions in SLE and play an important role in the initiation and propagation of SLE pathogenesis...
  44. pmc G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance
    Mohamed El Gazzar
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Biol Chem 283:32198-208. 2008
    ....
  45. ncbi request reprint Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Res 62:1784-9. 2002
    ..Most importantly, the subset of hereditary prostate cancer probands, whose families provided evidence for linkage at 1p13, predominantly contributed to the observed association. Additional studies are warranted to confirm these findings...
  46. ncbi request reprint Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation
    Alfredo Panebra
    Cardiopulmonary Genomics Program, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201 1075, USA
    Am J Physiol Lung Cell Mol Physiol 294:L190-5. 2008
    ....
  47. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
    ..However, an effect on exacerbations and tissue inflammation has not been shown...
  48. pmc ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts
    Augusto A Litonjua
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 178:688-94. 2008
    ..However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients...
  49. ncbi request reprint Severe prekallikrein deficiency associated with homozygosity for an Arg94Stop nonsense mutation
    D Wynne Jones
    Department of Biosciences, University of Kent and Kent Haemophilia Centre, Kent and Canterbury Hospital, Canterbury, Kent, UK
    Br J Haematol 127:220-3. 2004
    ..This is the first description of a kindred in which absence of expression of one or both PK alleles has been confirmed by genotype...

Research Grants1

  1. Severe Asthma and the Glucocorticoid Receptor Complex
    Gregory Hawkins; Fiscal Year: 2006
    ..This will also lay the ground work for future functional studies using coding sequence variants identified in the GR complex proteins. ..