Annette T Hastie

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and beta2-agonist use
    Annette T Hastie
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Respir Res 7:25. 2006
  2. pmc Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes
    Annette T Hastie
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 125:1028-1036.e13. 2010
  3. pmc Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 132:313-20.e15. 2013
  4. pmc Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting β agonist treatment in a multiethnic asthma population: a genetic study
    Victor E Ortega
    Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA
    Lancet Respir Med 2:204-13. 2014
  5. pmc Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
    Annette T Hastie
    Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 132:72-80. 2013
  6. pmc Clinical heterogeneity in the severe asthma research program
    Wendy C Moore
    1 Wake Forest University School of Medicine, Center for Human Genomics, Winston Salem, North Carolina and
    Ann Am Thorac Soc 10:S118-24. 2013
  7. pmc The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    Gregory A Hawkins
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:510-5.e1. 2012
  8. ncbi request reprint Modulation of vasodilator-stimulated phosphoprotein in vivo in human epithelial cells by segmental allergen challenge and beta2-agonist therapy
    Annette T Hastie
    Thomas Jefferson University, Philadelphia, PA 19107, USA
    Chest 123:377S. 2003
  9. ncbi request reprint Concentration of cytokines and growth factors in BAL fluid after allergen challenge in asthmatics and their effect on alpha-smooth muscle actin and collagen III synthesis by human lung fibroblasts
    Vikas Batra
    Thomas Jefferson University, Philadelphia, PA, USA
    Chest 123:398S-9S. 2003
  10. ncbi request reprint Asthmatic epithelial cell proliferation and stimulation of collagen production: human asthmatic epithelial cells stimulate collagen type III production by human lung myofibroblasts after segmental allergen challenge
    Annette T Hastie
    Department of Medicine, Division of Critical Care, Pulmonary, Allergic and Immunologic Diseases, and Division of Clinical Pharmacology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania
    Am J Respir Crit Care Med 165:266-72. 2002

Collaborators

Detail Information

Publications10

  1. pmc Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and beta2-agonist use
    Annette T Hastie
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Respir Res 7:25. 2006
    ....
  2. pmc Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes
    Annette T Hastie
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 125:1028-1036.e13. 2010
    ..Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma...
  3. pmc Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 132:313-20.e15. 2013
    ..Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function...
  4. pmc Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting β agonist treatment in a multiethnic asthma population: a genetic study
    Victor E Ortega
    Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA
    Lancet Respir Med 2:204-13. 2014
    ..We hypothesise that rare ADRB2 variants modulate therapeutic responses to LABA therapy and contribute to rare, severe adverse events...
  5. pmc Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
    Annette T Hastie
    Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 132:72-80. 2013
    ..Availability and ease of measurement are useful characteristics, but accuracy in predicting airway eosinophil and neutrophil percentages either individually or combined is not established...
  6. pmc Clinical heterogeneity in the severe asthma research program
    Wendy C Moore
    1 Wake Forest University School of Medicine, Center for Human Genomics, Winston Salem, North Carolina and
    Ann Am Thorac Soc 10:S118-24. 2013
    ..This is extremely important for subjects with severe asthma who may be on the "edge" of two phenotypes that may be driven by different pathobiologic mechanisms that warrant different therapeutic approaches. ..
  7. pmc The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    Gregory A Hawkins
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:510-5.e1. 2012
    ..The SNP rs4129267 is in linkage disequilibrium (r(2) = 1) with the IL6R coding SNP rs2228145 (Asp(358)Ala). This IL6R coding change increases IL-6 receptor (IL-6R) shedding and promotes IL-6 transsignaling...
  8. ncbi request reprint Modulation of vasodilator-stimulated phosphoprotein in vivo in human epithelial cells by segmental allergen challenge and beta2-agonist therapy
    Annette T Hastie
    Thomas Jefferson University, Philadelphia, PA 19107, USA
    Chest 123:377S. 2003
  9. ncbi request reprint Concentration of cytokines and growth factors in BAL fluid after allergen challenge in asthmatics and their effect on alpha-smooth muscle actin and collagen III synthesis by human lung fibroblasts
    Vikas Batra
    Thomas Jefferson University, Philadelphia, PA, USA
    Chest 123:398S-9S. 2003
  10. ncbi request reprint Asthmatic epithelial cell proliferation and stimulation of collagen production: human asthmatic epithelial cells stimulate collagen type III production by human lung myofibroblasts after segmental allergen challenge
    Annette T Hastie
    Department of Medicine, Division of Critical Care, Pulmonary, Allergic and Immunologic Diseases, and Division of Clinical Pharmacology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania
    Am J Respir Crit Care Med 165:266-72. 2002
    ..Epithelial cell proliferation appears dependent upon infiltrating inflammatory cells, but stimulation of collagen type III does not...