L Groban

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Diastolic dysfunction in the older heart
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    J Cardiothorac Vasc Anesth 19:228-36. 2005
  2. pmc Differential effects of late-life initiation of low-dose enalapril and losartan on diastolic function in senescent Fischer 344 x Brown Norway male rats
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Age (Dordr) 34:831-43. 2012
  3. ncbi request reprint Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    J Gerontol A Biol Sci Med Sci 61:28-35. 2006
  4. ncbi request reprint Transesophageal echocardiographic evaluation of diastolic function
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Chest 128:3652-63. 2005
  5. ncbi request reprint Intrathecal morphine reduces infarct size in a rat model of ischemia-reperfusion injury
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 98:903-9, table of contents. 2004
  6. ncbi request reprint Progressive diastolic dysfunction in the female mRen(2). Lewis rat: influence of salt and ovarian hormones
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27127 1009, USA
    J Gerontol A Biol Sci Med Sci 63:3-11. 2008
  7. ncbi request reprint Central nervous system and cardiac effects from long-acting amide local anesthetic toxicity in the intact animal model
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Reg Anesth Pain Med 28:3-11. 2003
  8. ncbi request reprint Does local anesthetic stereoselectivity or structure predict myocardial depression in anesthetized canines?
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Reg Anesth Pain Med 27:460-8. 2002
  9. pmc Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1009, USA
    J Gerontol A Biol Sci Med Sci 63:911-20. 2008
  10. doi request reprint Prognostic value of tissue Doppler-Derived E/e' on early morbid events after cardiac surgery
    Leanne Groban
    Departments of Anesthesiology and Cardiothoracic Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Echocardiography 27:131-8. 2010

Research Grants

Detail Information

Publications34

  1. ncbi request reprint Diastolic dysfunction in the older heart
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    J Cardiothorac Vasc Anesth 19:228-36. 2005
  2. pmc Differential effects of late-life initiation of low-dose enalapril and losartan on diastolic function in senescent Fischer 344 x Brown Norway male rats
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Age (Dordr) 34:831-43. 2012
    ....
  3. ncbi request reprint Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    J Gerontol A Biol Sci Med Sci 61:28-35. 2006
    ..Age-related decreases in GH and IGF-1 may contribute to the decline in diastolic function of aging, in part through alterations in renin-angiotensin system-mediated ventricular remodeling...
  4. ncbi request reprint Transesophageal echocardiographic evaluation of diastolic function
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Chest 128:3652-63. 2005
    ..This review summarizes the conventional and new echocardiographic modalities for evaluating diastolic function in the perioperative setting...
  5. ncbi request reprint Intrathecal morphine reduces infarct size in a rat model of ischemia-reperfusion injury
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 98:903-9, table of contents. 2004
    ..Changes in arterial blood pressure were similar among groups. These results indicate that IT morphine reduces infarct size in rats, and this benefit is as great as that provided by IV morphine administration...
  6. ncbi request reprint Progressive diastolic dysfunction in the female mRen(2). Lewis rat: influence of salt and ovarian hormones
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27127 1009, USA
    J Gerontol A Biol Sci Med Sci 63:3-11. 2008
    ..These findings may explain the preponderance of diastolic dysfunction and diastolic heart failure in postmenopausal women and provide a potential animal model for evaluating prevention and treatment interventions for this disorder...
  7. ncbi request reprint Central nervous system and cardiac effects from long-acting amide local anesthetic toxicity in the intact animal model
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Reg Anesth Pain Med 28:3-11. 2003
    ....
  8. ncbi request reprint Does local anesthetic stereoselectivity or structure predict myocardial depression in anesthetized canines?
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Reg Anesth Pain Med 27:460-8. 2002
    ....
  9. pmc Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1009, USA
    J Gerontol A Biol Sci Med Sci 63:911-20. 2008
    ..Thus, the signaling pathway underlying the lusitropic benefit of short-term habitual exercise in the aged rat may be distinct from GH-mediated benefits and independent of the cardiac RAS...
  10. doi request reprint Prognostic value of tissue Doppler-Derived E/e' on early morbid events after cardiac surgery
    Leanne Groban
    Departments of Anesthesiology and Cardiothoracic Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Echocardiography 27:131-8. 2010
    ..Further, patients with elevated preoperative E/e' may need more careful peri- and postoperative management than those patients with E/e' <8...
  11. ncbi request reprint Effects of moderate and deep hypothermia on Ca2+ signaling in rat ventricular myocytes
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Cell Physiol Biochem 12:101-10. 2002
    ....
  12. pmc Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation
    L Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Growth Horm IGF Res 21:81-8. 2011
    ..The aim of the study was to evaluate the effects of long standing GHD and peri-pubertal or continuous GH replacement therapy on diastolic function in the adult dwarf rat...
  13. ncbi request reprint Ventricular arrhythmias with or without programmed electrical stimulation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine
    L Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 91:1103-11. 2000
    ....
  14. ncbi request reprint Thoracic epidural anesthesia reduces infarct size in a canine model of myocardial ischemia and reperfusion injury
    L Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    J Cardiothorac Vasc Anesth 13:579-85. 1999
    ..To determine the effects of thoracic epidural anesthesia on myocardial infarct size, regional myocardial blood flow (RMBF), and plasma norepinephrine in an anesthetized canine model of ischemia reperfusion injury with infarction...
  15. ncbi request reprint Perioperative management of chronic heart failure
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Anesth Analg 103:557-75. 2006
    ....
  16. ncbi request reprint Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs
    L Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 92:37-43. 2001
    ....
  17. ncbi request reprint Cloricromene reduces infarct size and alters postischaemic blood flow defects in dog myocardium
    L Groban
    Department of Anesthesiology, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina 27157 1009, USA
    Clin Exp Pharmacol Physiol 25:417-23. 1998
    ..Postischaemic blood flow patterns are significantly different in cloricromene-treated dogs. Cloricromene-mediated reductions in infarct size, neutrophil accumulation and adherence may play a role in this effect...
  18. ncbi request reprint Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat
    Liliya M Yamaleyeva
    Hypertension and Vascular Research Center, Wake Forest University Health Sciences, Winston Salem, NC 27157 1095, USA
    Am J Physiol Heart Circ Physiol 293:H2064-71. 2007
    ..05, n = 6]. We conclude that ovariectomy in the older female mRen2. Lewis rat conveys protection against salt-dependent increase in renal injury...
  19. pmc Dual ACE-inhibition and AT1 receptor antagonism improves ventricular lusitropy without affecting cardiac fibrosis in the congenic mRen2.Lewis rat
    Jewell A Jessup
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Ther Adv Cardiovasc Dis 3:245-57. 2009
    ....
  20. pmc Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
    Aaron J Trask
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Hypertens 23:687-93. 2010
    ....
  21. pmc Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Ther Adv Cardiovasc Dis 4:17-25. 2010
    ..Therefore, the present study examined the changes in cardiac angiotensin-(1-7), its forming enzyme angiotensin converting enzyme 2 (ACE2) and receptor mas in response to a high salt diet in spontaneously hypertensive rats (SHR)...
  22. doi request reprint Does lidocaine more effectively prevent pain upon induction with propofol or etomidate when given preemptively than when mixed with the drug?
    Margaret F Brock
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    J Clin Anesth 22:505-9. 2010
    ..To compare the efficacy of 2% lidocaine "timing" on alleviation of pain upon induction using propofol or etomidate...
  23. ncbi request reprint Dexmedetomidine-induced sedation in volunteers decreases regional and global cerebral blood flow
    Richard C Prielipp
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesth Analg 95:1052-9, table of contents. 2002
    ....
  24. pmc Exercise intolerance
    Dalane W Kitzman
    Section of Cardiology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Heart Fail Clin 4:99-115. 2008
    ..This article focuses on the fundamental principles of exercise physiology and on the assessment, pathophysiology, and potential treatment of exercise intolerance in diastolic heart failure...
  25. ncbi request reprint Reduced regional and global cerebral blood flow during fenoldopam-induced hypotension in volunteers
    R C Prielipp
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 93:45-52. 2001
    ....
  26. pmc Diastolic dysfunction, cardiovascular aging, and the anesthesiologist
    David Sanders
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Anesthesiol Clin 27:497-517. 2009
    ..With a directed preoperative assessment that focuses on certain aspects of the cardiovascular system, and the assistance of powerful echocardiographic tools such as tissue Doppler, this can be achieved...
  27. doi request reprint Sevoflurane modulation of Ca2+ regulation in skeletal muscle sarcoplasmic reticulum vesicles from young and mature rabbits
    Matthias König
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Paediatr Anaesth 19:1166-74. 2009
    ....
  28. pmc Tetrahydrobiopterin restores diastolic function and attenuates superoxide production in ovariectomized mRen2.Lewis rats
    Jewell A Jessup
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1009, USA
    Endocrinology 152:2428-36. 2011
    ..Whether BH₄ supplementation is a therapeutic option for the management of diastolic dysfunction in postmenopausal women will require direct testing in humans...
  29. pmc Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats
    Susan Sergeant
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    J Gerontol A Biol Sci Med Sci 66:521-33. 2011
    ..These data raise the possibility that FO supplementation for purposes of cardiac and brain protection may need to occur earlier in the life span...
  30. ncbi request reprint Intraoperative insulin therapy does not reduce the need for inotropic or antiarrhythmic therapy after cardiopulmonary bypass
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Cardiothorac Vasc Anesth 16:405-12. 2002
    ..To determine whether attempted glucose control through intraoperative insulin therapy reduces the need for inotropic or antiarrhythmic therapy after cardiopulmonary bypass (CPB)...
  31. ncbi request reprint Local anesthetic-induced cardiac toxicity: a survey of contemporary practice strategies among academic anesthesiology departments
    William Corcoran
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Anesth Analg 103:1322-6. 2006
    ..We conclude that there are differences in the management and preparedness for treatment of LA toxicity among institutions, but the safety implications of these differences are undetermined...
  32. ncbi request reprint Diagnosis of a unicuspid aortic valve using transesophageal echocardiography
    Bryant A Murphy
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Cardiothorac Vasc Anesth 17:82-3. 2003
  33. ncbi request reprint Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats
    Emanuele Marzetti
    Department of Aging and Geriatrics, Institute on Aging, Division of Biology of Aging, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Am J Physiol Regul Integr Comp Physiol 294:R558-67. 2008
    ..In contrast, short-term administration of GH late in life does not provide any protection against functional decline or muscle aging and may even accelerate apoptosis in slow-twitch muscles, such as the soleus...
  34. ncbi request reprint Lipid reversal of bupivacaine toxicity: has the silver bullet been identified?
    Leanne Groban
    Reg Anesth Pain Med 28:167-9. 2003

Research Grants5

  1. Role of IGF-1 In Diastolic Dysfunction of Aging
    Leanne Groban; Fiscal Year: 2003
    ..This study will provide the groundwork for future studies examining how IGF-1 signaling may modulate the programming and gene expression of the senescent myocardium. ..
  2. Growth Hormone, Angiotensin II, and Cardiac Aging
    Leanne Groban; Fiscal Year: 2007
    ..abstract_text> ..
  3. Estrogen, Angiotensin-(1-7), and Diastolic Function
    Leanne Groban; Fiscal Year: 2009
    ..Our results will help clarify optimal treatment of diastolic heart disease in postmenopausal women. ..
  4. Estrogen, Angiotensin-(1-7), and Diastolic Function
    Leanne Groban; Fiscal Year: 2010
    ..Our results will help clarify optimal treatment of diastolic heart disease in postmenopausal women. ..