P E Gallagher

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Estrogen regulation of angiotensin-converting enzyme mRNA
    P E Gallagher
    Hypertension and Vascular Disease Center, Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Hypertension 33:323-8. 1999
  2. ncbi request reprint Inhibition of human lung cancer cell growth by angiotensin-(1-7)
    Patricia E Gallagher
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Carcinogenesis 25:2045-52. 2004
  3. pmc MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides
    Patricia E Gallagher
    The Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1032, USA
    Am J Physiol Cell Physiol 295:C1169-74. 2008
  4. ncbi request reprint Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes
    Patricia E Gallagher
    The Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1032, USA
    Am J Physiol Cell Physiol 290:C420-6. 2006
  5. pmc Angiotensin peptides and lung cancer
    Patricia E Gallagher
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Cancer Drug Targets 11:394-404. 2011
  6. ncbi request reprint Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats
    Jewell A Jessup
    Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 291:H2166-72. 2006
  7. pmc Regulation of ACE2 in cardiac myocytes and fibroblasts
    Patricia E Gallagher
    The Hypertension and Vascular Research Center, Wake Forest Univ School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1032, USA
    Am J Physiol Heart Circ Physiol 295:H2373-9. 2008
  8. ncbi request reprint Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors
    Yuichiro Ishiyama
    Hypertension and Vascular Disease Center, Wake Forest University Health Science Center, Winston Salem, NC 27157, USA
    Hypertension 43:970-6. 2004
  9. ncbi request reprint Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats
    Michiya Igase
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 289:H1013-9. 2005
  10. ncbi request reprint Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat
    Liliya M Yamaleyeva
    Hypertension and Vascular Research Center, Wake Forest University Health Sciences, Winston Salem, NC 27157 1095, USA
    Am J Physiol Heart Circ Physiol 293:H2064-71. 2007

Research Grants

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Estrogen regulation of angiotensin-converting enzyme mRNA
    P E Gallagher
    Hypertension and Vascular Disease Center, Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Hypertension 33:323-8. 1999
    ....
  2. ncbi request reprint Inhibition of human lung cancer cell growth by angiotensin-(1-7)
    Patricia E Gallagher
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Carcinogenesis 25:2045-52. 2004
    ..The results of this study suggest that Ang-(1-7) inhibits lung cancer cell growth through the activation of an angiotensin peptide receptor and may represent a novel chemotherapeutic and chemopreventive treatment for lung cancer...
  3. pmc MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides
    Patricia E Gallagher
    The Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1032, USA
    Am J Physiol Cell Physiol 295:C1169-74. 2008
    ..The modulatory role of ANG-(1-7) in the regulation of ACE2 by ANG II suggests a complex interplay between the two peptides that is mediated by specific receptors to activate distinct signaling pathways...
  4. ncbi request reprint Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes
    Patricia E Gallagher
    The Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1032, USA
    Am J Physiol Cell Physiol 290:C420-6. 2006
    ..Furthermore, the modulatory role of ANG-(1-7) in the transcriptional regulation of ACE2 by ANG II suggests a complex interplay between these peptides that is mediated by distinct receptor systems...
  5. pmc Angiotensin peptides and lung cancer
    Patricia E Gallagher
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Cancer Drug Targets 11:394-404. 2011
    ..This review focuses on studies examining the renin-angiotensin system in pulmonary cancers and whether clinical intervention of this pathway may serve as an effective chemotherapeutic and/or chemopreventive modality for lung cancer...
  6. ncbi request reprint Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats
    Jewell A Jessup
    Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 291:H2166-72. 2006
    ..Tg(mRen2) congenic rats, a failure of compensatory ACE2 and ANG-(1-7)-dependent vasodepressor mechanisms may contribute both to the development and progression of hypertension driven by increased formation of endogenous ANG II...
  7. pmc Regulation of ACE2 in cardiac myocytes and fibroblasts
    Patricia E Gallagher
    The Hypertension and Vascular Research Center, Wake Forest Univ School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1032, USA
    Am J Physiol Heart Circ Physiol 295:H2373-9. 2008
    ....
  8. ncbi request reprint Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors
    Yuichiro Ishiyama
    Hypertension and Vascular Disease Center, Wake Forest University Health Science Center, Winston Salem, NC 27157, USA
    Hypertension 43:970-6. 2004
    ..These results provide evidence for an effect of angiotensin II blockade on cardiac ACE 2 mRNA that may be due to direct blockade of AT1a receptors or a modulatory effect of increased angiotensin-(1-7)...
  9. ncbi request reprint Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats
    Michiya Igase
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 289:H1013-9. 2005
    ....
  10. ncbi request reprint Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat
    Liliya M Yamaleyeva
    Hypertension and Vascular Research Center, Wake Forest University Health Sciences, Winston Salem, NC 27157 1095, USA
    Am J Physiol Heart Circ Physiol 293:H2064-71. 2007
    ..05, n = 6]. We conclude that ovariectomy in the older female mRen2. Lewis rat conveys protection against salt-dependent increase in renal injury...
  11. pmc Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia
    Lauren Anton
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Hypertension 51:1066-72. 2008
    ..Elevated angiotensin II, acting through the AT(1) receptor, may favor vasoconstriction in placental chorionic villi and contribute to impaired fetal blood flow and decreased fetal nutrition observed during preeclampsia...
  12. pmc Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain
    Jonathan A Cohen
    Hypertension and Vascular Research Center, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1095, USA
    Am J Physiol Renal Physiol 299:F35-42. 2010
    ..We conclude that the increase in uAGT with estrogen depletion or HS likely may be a biomarker for glomerular damage reflecting filtration of the circulating protein in the mRen2...
  13. pmc The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancy
    Lauren Anton
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1032, USA
    Endocrinology 150:4316-25. 2009
    ..This would lead to decreased maternal-fetal oxygen exchange and fetal nutrition, a known characteristic of preeclampsia...
  14. ncbi request reprint Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen
    Atsushi Sakima
    Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157 1032, USA
    Am J Physiol Heart Circ Physiol 292:H1412-9. 2007
    ....
  15. ncbi request reprint Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2. Lewis rats
    Liliya M Yamaleyeva
    Hypertension and Vascular Disease Center, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1095, USA
    Am J Physiol Regul Integr Comp Physiol 292:R819-26. 2007
    ..Lewis rats was associated with the discoordinate regulation of renal NOS isoforms. Estrogen sensitivity in this congenic strain may involve the influence of NO through the regulation of both eNOS and nNOS...
  16. ncbi request reprint Impaired heart rate baroreflex in older rats: role of endogenous angiotensin-(1-7) at the nucleus tractus solitarii
    Atsushi Sakima
    The Hypertension and Vascular Disease Center, Department of General Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Hypertension 46:333-40. 2005
    ..The attenuated counterbalancing effect of Ang-(1-7) on baroreflex function is lost in older rats, which may be attributable to diminished production of the peptide from neprilysin...
  17. pmc Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
    Aaron J Trask
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Hypertens 23:687-93. 2010
    ....
  18. pmc Angiotensin-(1-7) inhibits tumor angiogenesis in human lung cancer xenografts with a reduction in vascular endothelial growth factor
    David R Soto-Pantoja
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Mol Cancer Ther 8:1676-83. 2009
    ..Taken together, this study shows that Ang-(1-7) exhibits significant antiangiogenic activity and may be a novel therapeutic agent for lung cancer treatment targeting a specific AT((1-7)) receptor...
  19. ncbi request reprint Angiotensin II stimulates arachidonic acid release from bone marrow stromal cells
    Renee S Richmond
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Renin Angiotensin Aldosterone Syst 5:176-82. 2004
    ..To further elucidate the mechanisms of Ang II-regulated haematopoiesis, we determined whether Ang II-stimulation alters arachidonic acid release and MCSF secretion from MSC...
  20. ncbi request reprint Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems
    Sherry O Kasper
    Hypertension and Vascular Disease Center, Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1032, USA
    Physiol Genomics 23:311-7. 2005
    ..These data implicate glial angiotensinogen in the regulation of body metabolism as well as hormonal mechanisms regulating blood pressure...
  21. ncbi request reprint ACE2 and ANG-(1-7) in the rat uterus during early and late gestation
    Liomar A A Neves
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Am J Physiol Regul Integr Comp Physiol 294:R151-61. 2008
    ....
  22. ncbi request reprint Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Kidney Int 68:2189-96. 2005
    ....
  23. ncbi request reprint Estrogen or the AT1 antagonist olmesartan reverses the development of profound hypertension in the congenic mRen2. Lewis rat
    Mark C Chappell
    Hypertension and Vascular Disease Center, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1095, USA
    Hypertension 42:781-6. 2003
    ..We conclude that the ovary exerts considerable influence on the regulation of the blood pressure in the mRen2. Lewis strain, possibly by limiting activation of the renin-angiotensin system...
  24. pmc Phase I and pharmacokinetic study of angiotensin-(1-7), an endogenous antiangiogenic hormone
    W Jeffrey Petty
    Department of Medicine, Section on Hematology and Oncology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Clin Cancer Res 15:7398-404. 2009
    ..Secondary objectives were to assess toxicities, pharmacokinetics, clinical activity, and plasma biomarkers...
  25. pmc Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Ther Adv Cardiovasc Dis 4:17-25. 2010
    ..Therefore, the present study examined the changes in cardiac angiotensin-(1-7), its forming enzyme angiotensin converting enzyme 2 (ACE2) and receptor mas in response to a high salt diet in spontaneously hypertensive rats (SHR)...
  26. ncbi request reprint Angiotensin peptides as neurotransmitters/neuromodulators in the dorsomedial medulla
    Debra I Diz
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1032, USA
    Clin Exp Pharmacol Physiol 29:473-82. 2002
    ..Moreover, alterations in substance P pathways may contribute to the actions of AngII on reflex function...
  27. doi request reprint Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors
    Katherine L Cook
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Res 70:8319-28. 2010
    ..Together, our findings indicate that Ang-(1-7) targets the tumor microenvironment to inhibit CAF growth and tumor fibrosis...
  28. pmc Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats
    Sarah Hoffmann Lindsey
    The Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1032, USA
    Endocrinology 150:3753-8. 2009
    ..We conclude that the novel estrogen receptor GPR30 may contribute to the beneficial cardiovascular actions of estrogen in female mRen2.Lewis rats through regulation of vascular components of the renin-angiotensin system...
  29. ncbi request reprint Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cells
    William B Strawn
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Haematol 126:120-6. 2004
    ..The presence of Ang II receptors in both haematopoietic-lineage BMC and MSC, and the de novo synthesis of Ang II by MSC suggest a potential autocrine-paracrine mechanism for local RAS-mediated regulation of haematopoiesis...
  30. pmc Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats
    Debra I Diz
    Hypertension and Vascular Research Center, Division of Surgical Sciences, Department of General Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    J Cardiovasc Pharmacol 51:542-8. 2008
    ..In (mRen2)27 renin transgenic rats [(mRen2)], there is overexpression of the mouse Ren2 gene in brain, leading to elevated Ang II and reduced Ang-(1-7) in brain medullary, and associated with hypertension and impaired BRS...
  31. pmc Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats
    Debra I Diz
    The Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1032, USA
    Exp Physiol 93:694-700. 2008
    ..These findings support the concept that within the NTS, local synthesis of Ang(1-7) from Ang II is required for normal sensitivity for the baroreflex control of heart rate in response to increases in arterial pressure...
  32. ncbi request reprint Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor
    E Ann Tallant
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1032, USA
    Am J Physiol Heart Circ Physiol 289:H1560-6. 2005
    ....
  33. ncbi request reprint Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circulation 111:2605-10. 2005
    ..As the only known human homolog of ACE, the demonstration that ACE2 is insensitive to blockade by ACE inhibitors prompted us to define the effect of ACE inhibition on the ACE2 gene...
  34. pmc AT1, AT2, and AT1-7 receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy
    L M Yamaleyeva
    Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Placenta 34:497-502. 2013
    ..We investigated the expression of angiotensin receptors in early pregnancy and established whether normal pregnancy or preeclampsia alters the expression and distribution of the uteroplacental AT1R, AT2R and mas/AT1-7R at late gestation...
  35. ncbi request reprint Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2
    Jyotsana Menon
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1032, USA
    Cancer Res 67:2809-15. 2007
    ..Because Ang-(1-7), a peptide with antithrombotic properties, reduces growth through activation of a selective AT((1-7)) receptor, our results suggest that the heptapeptide represents a novel treatment for lung cancer by reducing COX-2...
  36. ncbi request reprint Effect of estrogen on neprilysin expression in uterus and kidney of Sprague-Dawley normotensive and heterozygous (mRen2)27-transgenic hypertensive rats
    L A A Neves
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1932, USA
    Peptides 27:2912-8. 2006
    ..In addition, these studies showed that there is tissue-specific regulation of NEP with estrogen treatment that is strain independent...
  37. ncbi request reprint The renin-angiotensin system and the exocrine pancreas
    M C Chappell
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1032, USA
    JOP 2:33-9. 2001
    ..Thus, these cells may be of particular value to study the interplay of the AT1 and AT2 receptors to regulate cell growth and potentially exocrine function...
  38. pmc Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus
    Amy C Arnold
    Hypertension and Vascular Research Center and Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Hypertension 54:1001-8. 2009
    ..Baroreflex inhibition was enhanced in animals with evidence of increased leptin receptor and relevant signaling pathway mRNA...
  39. ncbi request reprint Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat
    Adam T Whaley-Connell
    Department of Internal Medicine, University of Missouri School of Medicine, 1 Hospital Dr, MA410 Medical Science Bldg, Columbia, MO 65212, USA
    Am J Physiol Renal Physiol 291:F1308-14. 2006
    ..Thus reductions in blood pressure, albuminuria, and tissue oxidative stress with AT1R blockade were associated with improved indexes of glomerular filtration barrier integrity and renal RAS in Ren2 rats...
  40. ncbi request reprint Depletion of tissue angiotensin-converting enzyme differentially influences the intrarenal and urinary expression of angiotensin peptides
    J Gregory Modrall
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9157, USA
    Hypertension 43:849-53. 2004
    ..Sustained intrarenal levels of angiotensin-(1-7) may contribute to chronic hypotension and polyuria in tisACE-/- mice, particularly in the context of depleted angiotensin II in the kidney...

Research Grants4

  1. Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)
    Patricia Gallagher; Fiscal Year: 2007
    ..The regulation of ACE2 may be critical to maintaining the normal function of the renin-angiotensin system in the brain. ..
  2. Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)
    Patricia Gallagher; Fiscal Year: 2009
    ..The regulation of ACE2 may be critical to maintaining the normal function of the renin-angiotensin system in the brain. ..