Barry Freedman

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    BMC Med Genet 11:22. 2010
  2. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
  3. doi request reprint Hypertension-associated kidney disease: perhaps no more
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Am Soc Nephrol 19:2047-51. 2008
  4. ncbi request reprint Genetic factors in diabetic nephropathy
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Clin J Am Soc Nephrol 2:1306-16. 2007
  5. ncbi request reprint A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans
    Barry I Freedman
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Nephrol Dial Transplant 22:1131-5. 2007
  6. ncbi request reprint Genetic susceptibility contributes to renal and cardiovascular complications of type 2 diabetes mellitus
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Hypertension 48:8-13. 2006
  7. pmc Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD
    Barry I Freedman
    1Internal Medicine Nephrology, 2Biochemistry, 3Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 24:3366-71. 2009
  8. doi request reprint Genome-wide linkage scans for renal function and albuminuria in Type 2 diabetes mellitus: the Diabetes Heart Study
    B I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Diabet Med 25:268-76. 2008
  9. ncbi request reprint Genetic factors in common complex renal and cardiovascular diseases
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, The Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Adv Chronic Kidney Dis 13:105-9. 2006
  10. ncbi request reprint The impact of ethnicity and sex on subclinical cardiovascular disease: the Diabetes Heart Study
    B I Freedman
    Wake Forest University School of Medicine, Department of Internal Medicine Section on Nephrology, Medical Center Boulevard, 27157 1053, Winston Salem, NC 27157 1053, USA
    Diabetologia 48:2511-8. 2005

Collaborators

Detail Information

Publications62

  1. pmc Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    BMC Med Genet 11:22. 2010
    ..Ordered subset linkage analysis (OSA) revealed a linkage peak on chromosome 7p in the subset of families with earlier age of T2D diagnosis...
  2. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
    ....
  3. doi request reprint Hypertension-associated kidney disease: perhaps no more
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Am Soc Nephrol 19:2047-51. 2008
    ....
  4. ncbi request reprint Genetic factors in diabetic nephropathy
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Clin J Am Soc Nephrol 2:1306-16. 2007
    ..It seems likely that the risk for diabetes-associated kidney disease is magnified by inheriting risk alleles at several susceptibility loci, in the presence of hyperglycemia...
  5. ncbi request reprint A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans
    Barry I Freedman
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Nephrol Dial Transplant 22:1131-5. 2007
    ..A trinucleotide repeat sequence in exon 2 of the carnosinase gene (CNDP1) residing on 18q22.3 was subsequently associated with DN in European Caucasians and Arabs...
  6. ncbi request reprint Genetic susceptibility contributes to renal and cardiovascular complications of type 2 diabetes mellitus
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Hypertension 48:8-13. 2006
  7. pmc Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD
    Barry I Freedman
    1Internal Medicine Nephrology, 2Biochemistry, 3Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 24:3366-71. 2009
    ....
  8. doi request reprint Genome-wide linkage scans for renal function and albuminuria in Type 2 diabetes mellitus: the Diabetes Heart Study
    B I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Diabet Med 25:268-76. 2008
    ..We performed a genome-wide linkage scan in 416 Diabetes Heart Study (DHS) families to detect loci that contributed to renal function and albuminuria...
  9. ncbi request reprint Genetic factors in common complex renal and cardiovascular diseases
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, The Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Adv Chronic Kidney Dis 13:105-9. 2006
    ..Nonetheless, developments have been made in this important area...
  10. ncbi request reprint The impact of ethnicity and sex on subclinical cardiovascular disease: the Diabetes Heart Study
    B I Freedman
    Wake Forest University School of Medicine, Department of Internal Medicine Section on Nephrology, Medical Center Boulevard, 27157 1053, Winston Salem, NC 27157 1053, USA
    Diabetologia 48:2511-8. 2005
    ..We evaluated whether ethnic differences in subclinical cardiovascular disease, coronary and carotid artery calcified plaque and carotid artery intima-medial thickness (IMT) were present in members of The Diabetes Heart Study families...
  11. ncbi request reprint Population-based screening for family history of end-stage renal disease among incident dialysis patients
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 25:529-35. 2005
    ....
  12. ncbi request reprint Relationship between albuminuria and cardiovascular disease in Type 2 diabetes
    Barry I Freedman
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Am Soc Nephrol 16:2156-61. 2005
    ..004) and carotid artery calcium (P = 0.0004). Albuminuria is strongly associated with calcified plaque in the coronary and carotid arteries in white individuals with type 2 diabetes and relatively preserved renal function...
  13. pmc Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 29:626-32. 2009
    ....
  14. pmc Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans
    Barry I Freedman
    Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 75:736-45. 2009
    ..Our study shows that gene-environment and/or gene-gene interactions may initiate kidney disease in genetically susceptible individuals, because African Americans homozygous for MYH9 risk alleles do not universally develop kidney disease...
  15. doi request reprint Glycated albumin and risk of death and hospitalizations in diabetic dialysis patients
    Barry I Freedman
    Department of Internal Medicine Nephrology, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
    Clin J Am Soc Nephrol 6:1635-43. 2011
    ..We determined the association between GA, HbA(₁c), and glucose levels with survival and hospitalizations in diabetic dialysis patients...
  16. doi request reprint The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Am Soc Nephrol 21:1422-6. 2010
    ..This association likely explains racial disparities in nondiabetic nephropathy as a result of the high prevalence of risk alleles in individuals of African ancestry...
  17. pmc The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 32:66-72. 2010
    ..Since MYH9 underlies approximately 40% of end-stage renal disease (ESRD) in AA, we tested for genetic association with LN...
  18. pmc Potential effects of MYH9-associated nephropathy on dialysis and kidney transplant outcomes
    Barry I Freedman
    Section on Nephrology, Department of Internal Medicine, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Semin Dial 23:244-7. 2010
    ..MYH9 polymorphisms may affect treatment outcomes in severe kidney disease and such gene effects are rarely encountered in practice...
  19. pmc Genetic basis of nondiabetic end-stage renal disease
    Barry I Freedman
    Section on Nephrology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Semin Nephrol 30:101-10. 2010
    ..Genetic screening, gene-environment, and gene-gene interactions are also addressed...
  20. pmc Vitamin d, adiposity, and calcified atherosclerotic plaque in african-americans
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
    J Clin Endocrinol Metab 95:1076-83. 2010
    ..Prospective trials are needed to determine the cardiovascular effects of supplemental vitamin D in this ethnic group...
  21. doi request reprint Comparison of glycated albumin and hemoglobin A1c concentrations in diabetic subjects on peritoneal and hemodialysis
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Perit Dial Int 30:72-9. 2010
    ..Relative to hemoglobin A(1c) (HbA(1c)), percentage of glycated albumin (GA%) more accurately reflects recent glycemic control in diabetic hemodialysis (HD) patients...
  22. pmc Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation
    B I Freedman
    Departments of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Transplant 9:2435-40. 2009
    ..The impact of transplanting kidneys from donors with multiple MYH9 risk alleles into recipients with similar genetic background at high risk for recurrent kidney disease needs to be determined...
  23. pmc Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Bone Miner Res 24:1719-27. 2009
    ..0143). Polymorphisms in BMP7 are associated with inverse relationships between bone mineralization and VC in the coronary, carotid, and abdominal aorta in a diabetes-enriched cohort of European Americans...
  24. ncbi request reprint Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families
    B I Freedman
    Department of Internal Medicine, Section on Nephrology, The Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Diabetologia 48:661-8. 2005
    ..The heritability of fasting serum insulin and glucose concentrations in non-diabetic members of multiplex hypertensive families is unknown...
  25. ncbi request reprint A genome scan for all-cause end-stage renal disease in African Americans
    Barry I Freedman
    Department of Internal Medicine Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Nephrol Dial Transplant 20:712-8. 2005
    ....
  26. ncbi request reprint Familial clustering of end-stage renal disease in blacks with HIV-associated nephropathy
    B I Freedman
    Internal Medicine Infectious Diseases, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Kidney Dis 34:254-8. 1999
    ..Although environmental factors cannot be excluded, it is possible an inherited susceptibility to renal failure is present in many blacks with HIV infection who subsequently develop nephropathy...
  27. ncbi request reprint Design and baseline characteristics for the aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II)
    B I Freedman
    Department of Internal Medicine Nephrology, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157 1053, USA
    Control Clin Trials 20:493-510. 1999
    ..This trial will contribute to our understanding of the natural history of type 2 diabetes mellitus-associated nephropathy and determine whether aminoguanidine will slow the progression of established diabetic renal disease...
  28. ncbi request reprint Racial variation in autosomal dominant polycystic kidney disease
    B I Freedman
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Kidney Dis 35:35-9. 2000
    ..001) but not black families (P = 0.80). We conclude that blacks with ADPKD-associated ESRD are less likely than whites to have relatives with ESRD, and there is no correlation in age at onset of ADPKD-ESRD in black families...
  29. ncbi request reprint Genes and renal disease
    B I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Curr Opin Nephrol Hypertens 9:273-7. 2000
    ..This manuscript reviews the developments in genetic epidemiology and molecular genetics of chronic renal failure...
  30. ncbi request reprint Family history of end-stage renal disease does not predict dialytic survival
    B I Freedman
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Kidney Dis 38:547-52. 2001
    ..We conclude that familial clustering of ESRD does not significantly impact on dialytic survival after controlling for the competing effects of patient race, age of ESRD onset, and the presence of diabetes mellitus...
  31. ncbi request reprint Linkage heterogeneity of end-stage renal disease on human chromosome 10
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, The Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Kidney Int 62:770-4. 2002
    ....
  32. ncbi request reprint Susceptibility genes for hypertension and renal failure
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Soc Nephrol 14:S192-4. 2003
    ..This manuscript reviews the evidence in support of genetic factors that contribute to the common, complex causes of chronic renal failure...
  33. ncbi request reprint A genome-wide scan for urinary albumin excretion in hypertensive families
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Hypertension 42:291-6. 2003
    ..They suggest that a gene(s) associated with urinary ACR may be present on human chromosomes 19 and 12...
  34. ncbi request reprint Renal artery calcified plaque associations with subclinical renal and cardiovascular disease
    Barry I Freedman
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 65:2262-7. 2004
    ..The prognostic significance of renal artery calcified plaque (RAC) and its relationship with renal function, albuminuria, and systemic atherosclerosis are unknown...
  35. ncbi request reprint A genome scan for ESRD in black families enriched for nondiabetic nephropathy
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Am Soc Nephrol 15:2719-27. 2004
    ..1 and 13q33.3 as contributing to early-onset ESRD and ESRD in the presence of increased BMI, respectively. These regions should receive priority in the search for loci that contribute susceptibility to nondiabetic nephropathy...
  36. ncbi request reprint Fructose-1,6-bisphosphatase: genetic and physical mapping to human chromosome 9q22.3 and evaluation in non-insulin-dependent diabetes mellitus
    C B Rothschild
    Department of Biochemistry, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    Genomics 29:187-94. 1995
    ..Although FBP is a rate-limiting enzyme in gluconeogenesis, using both parametric and nonparametric analysis there was no evidence for linkage of FBP to diabetes in these families...
  37. pmc Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1
    J L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Genomics 92:226-34. 2008
    ..We found substantial heterogeneity between study results...
  38. doi request reprint Short-term renal outcomes in African American and Caucasian donors following live kidney donation
    A Reeves-Daniel
    Departments of Internal Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Clin Transplant 24:717-22. 2010
    ..Although African Americans (AA) are considered higher risk kidney donors than Caucasians, limited data are available regarding outcomes of AA donors...
  39. ncbi request reprint Loci contributing to adult height and body mass index in African American families ascertained for type 2 diabetes
    M M Sale
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem NC 27157, USA
    Ann Hum Genet 69:517-27. 2005
    ....
  40. ncbi request reprint Heritability of spinal trabecular volumetric bone mineral density measured by QCT in the Diabetes Heart Study
    L Lenchik
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Calcif Tissue Int 75:305-12. 2004
    ..31-0.33, all P < 0.05). These data suggest that, like areal BMD, volumetric BMD is highly heritable and may be used in designing linkage studies to locate genes governing bone metabolism...
  41. ncbi request reprint Candidate gene analysis in African Americans with renal failure
    V M Buckalew
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Ren Fail 21:403-7. 1999
    ..The study employs a candidate gene strategy initially, followed by a genome-wide search for linkage between polymorphic markers and the phenotype "ESRD."..
  42. ncbi request reprint Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease
    H Yu
    Department of Biochemistry, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157 1053, USA
    Hypertension 31:906-11. 1998
    ..00014 and .0087, respectively). The association of KLK3b alleles with ESRD raises the possibility that polymorphisms in KLK3 may play a role in ESRD susceptibility. The lack of linkage might reflect our relatively small family set...
  43. ncbi request reprint Genetic initiation of hypertensive and diabetic nephropathy
    B I Freedman
    Department of Internal Medicine/Nephrology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157-1053, USA
    Am J Hypertens 11:251-7. 1998
    ..The identification of human renal failure genes would provide useful markers for disease susceptibility and speed the development of novel therapeutic strategies...
  44. doi request reprint The impact of sickle cell trait on glycated haemoglobin in diabetes mellitus
    A J Bleyer
    Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabet Med 27:1012-6. 2010
    ..To determine the effect of sickle cell trait on measurement of glycated haemoglobin (HbA(1c)) in African American patients with diabetes mellitus...
  45. ncbi request reprint Identification and characterization of PRKCBP1, a candidate RACK-like protein
    S C Fossey
    Molecular Genetics Program, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Mamm Genome 11:919-25. 2000
    ..The results of this analysis suggest that PRKCBP1 coding variations are uncommon and do not contribute to Type II diabetes in the general population...
  46. ncbi request reprint Ethnic variation in the correlation between random serum glucose concentration and glycated haemoglobin
    A J Bleyer
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 26:128-33. 2009
    ..To determine if the relationship between serum glucose concentration and glycated haemoglobin is different between African-Americans and whites...
  47. ncbi request reprint Familial aggregation of coronary artery calcium in families with type 2 diabetes
    L E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Diabetes 50:861-6. 2001
    ..In these data, CAC seems heritable and may serve as an important feature in designing studies to map genes contributing to both atherosclerosis and type 2 diabetes...
  48. ncbi request reprint Hormone replacement therapy is associated with increased C-reactive protein in women with Type 2 diabetes in the Diabetes Heart Study
    D W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 23:763-7. 2006
    ..The aim of this study was to determine the influence of HRT on women with diabetes in a large cross-sectional study...
  49. ncbi request reprint Type 2 diabetes is not independently associated with spinal trabecular volumetric bone mineral density measured by QCT in the Diabetes Heart Study
    T C Register
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Bone 39:628-33. 2006
    ..05), although the differences disappeared after additional adjustment for BMI. These data suggest that areal BMD measured by DXA and trabecular volumetric BMD measured by QCT are not associated with type 2 diabetes independently from BMI...
  50. doi request reprint Genetic epidemiology of subclinical cardiovascular disease in the diabetes heart study
    D W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Ann Hum Genet 72:598-610. 2008
    ..Additional loci on chromosomes 1, 2, 7, 10, 13, and 21 had LODs > 2.0. The identification of trait-determining polymorphisms underlying these linkages will help delineate risk factors for CVD in T2DM and the general population...
  51. ncbi request reprint Racial differences in HLA antigen frequency and hypertensive renal failure
    B I Freedman
    Department of Medicine/Nephrology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103
    Am J Hypertens 4:393-8. 1991
    ..White cases compared to white controls had lower HLA-A1 and B8 frequencies (21.2% v 30.6%, P = .0005 and 13.7% v 22.3%, P = .001, respectively) and a greater HLA-B35 frequency (20.7% v 14.2%, P = .02).(ABSTRACT TRUNCATED AT 250 WORDS)..
  52. ncbi request reprint Non-diabetic nodular glomerulosclerosis associated with p-ANCA seropositivity: a case report and review of the literature
    S G Satko
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Clin Nephrol 56:69-74. 2001
    ..For this reason, we urge caution in the empiric cytotoxic treatment of p-ANCA-associated renal disease in stable patients. When possible, a tissue diagnosis should be made...
  53. ncbi request reprint Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with Type 2 diabetes mellitus: the Diabetes Heart Study
    K P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 23:228-34. 2006
    ....
  54. ncbi request reprint Adiponectin as a novel determinant of bone mineral density and visceral fat
    L Lenchik
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Bone 33:646-51. 2003
    ..1). These data suggest that adiponectin may play a role in the protective effects of visceral fat on BMD...
  55. ncbi request reprint HLA associations in end-stage renal disease due to membranous glomerulonephritis: HLA-DR3 associations with progressive renal injury. Southeastern Organ Procurement Foundation
    B I Freedman
    Department of Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27157 1053
    Am J Kidney Dis 23:797-802. 1994
    ..The novel association of HLA-DR5 may reflect the fact that the MGN cases in this study all had ESRD.(ABSTRACT TRUNCATED AT 250 WORDS)..
  56. pmc Variants in intron 13 of the ELMO1 gene are associated with diabetic nephropathy in African Americans
    T S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Ann Hum Genet 73:152-9. 2009
    ..5 x 10(-5)- P = 0.05). No associations were seen with these SNPs in those with T2DM lacking nephropathy or with ESRD due to non-diabetic causes. Variants in intron 13 of the ELMO1 gene appear to confer risk for diabetic nephropathy in AA...
  57. ncbi request reprint A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20
    S C Fossey
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Genomics 76:45-57. 2001
    ..The combination of the BAC transcript map, YAC-to-BAC scaffold, and reference Human Genome Project sequence provides a powerful integrated resource for future genomic analysis of this region...
  58. ncbi request reprint Uremic pruritus is associated with higher kt/V and serum calcium concentration
    M I Duque
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Clin Nephrol 66:184-91. 2006
    ..The prevalence and characteristics of uremic pruritus have not recently been investigated in a US dialysis cohort. This study examined uremic pruritus and associated risk factors in hemodialysis patients treated in the year 2005...
  59. doi request reprint Comparison of glycated albumin and hemoglobin A(1c) levels in diabetic subjects on hemodialysis
    T P Peacock
    Section of Nephrology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 73:1062-8. 2008
    ..Our results show that in diabetic hemodialysis patients, hemoglobin A(1c) levels significantly underestimate glycemic control while those of glycated albumin more accurately reflect this control...
  60. ncbi request reprint Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease
    H Yu
    Department of Biochemistry, Department of Internal Medicine, Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Genomics 69:225-34. 2000
    ..This observation suggests that other sequences within or near KLKB1, or another gene nearby, may contribute to ESRD susceptibility...
  61. pmc Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study
    Jasmin Divers
    Department of Public Health Sciences, Center for Diabetes Research, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
    J Clin Endocrinol Metab 95:5382-9. 2010
    ..Because pericardial adipose tissue (PAT) is associated with CP in the neighboring coronary arteries, we explored ethnic-specific relationships between PAT and CP...
  62. pmc Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: the African American-diabetes heart study
    Jasmin Divers
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes Care 33:131-8. 2010
    ..We explored ethnicity-specific relationships between albuminuria and calcified plaque involving the infrarenal aorta, coronary artery, and carotid artery in 835 European American and 393 African American subjects with type 2 diabetes...

Research Grants14

  1. GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRD
    Barry Freedman; Fiscal Year: 1999
    ..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..
  2. Subclinical CVD in African American Type 2 Diabetics
    BARRY IRA FREEDMAN; Fiscal Year: 2010
    ....
  3. Natural History of MYH9-Associated Nephropathy
    Barry Freedman; Fiscal Year: 2009
    ..This will benefit individuals at risk who could benefit from therapeutic intervention to alleviate disease at an earlier stage. The anticipated benefits to the population at large outweigh the minimal risk involved in the study. ..
  4. Subclinical CVD in African American Type 2 Diabetics
    Barry Freedman; Fiscal Year: 2009
    ....
  5. Genetic Analysis of African American Hypertensive End-Stage Renal Disease
    Barry Freedman; Fiscal Year: 2009
    ....
  6. Subclinical CVD in African American Type 2 Diabetics
    Barry Freedman; Fiscal Year: 2007
    ....
  7. Genetic Analysis of African American Hypertensive End-Stage Renal Disease
    Barry Freedman; Fiscal Year: 2007
    ....
  8. Continuation of the FIND Study
    Barry Freedman; Fiscal Year: 2006
    ..The identification of genes that cause diabetic complications will take us one step closer to finding treatments that may have the potential to slow or prevent the development of these serious complications of diabetes mellitus ..
  9. Genetic Analysis of African American Hypertensive End-Stage Renal Disease
    Barry Freedman; Fiscal Year: 2006
    ....
  10. GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRD
    Barry Freedman; Fiscal Year: 2001
    ..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..
  11. GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRD
    Barry Freedman; Fiscal Year: 2000
    ..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..
  12. Natural History of MYH9-Associated Nephropathy
    BARRY IRA FREEDMAN; Fiscal Year: 2010
    ..This will benefit individuals at risk who could benefit from therapeutic intervention to alleviate disease at an earlier stage. The anticipated benefits to the population at large outweigh the minimal risk involved in the study. ..