Carlos Ferrario

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi ACE2: more of Ang-(1-7) or less Ang II?
    Carlos M Ferrario
    Department of General Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Nephrol Hypertens 20:1-6. 2011
  2. ncbi Addressing the theoretical and clinical advantages of combination therapy with inhibitors of the renin-angiotensin-aldosterone system: antihypertensive effects and benefits beyond BP control
    Carlos M Ferrario
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1032, United States
    Life Sci 86:289-99. 2010
  3. ncbi Highlights of the Twelfth Annual COSEHC National Scientific Session
    Carlos M Ferrario
    Wake Forest University Health Sciences Center, Winston-Salem, North Carolina 27157-1032, USA
    Am J Med Sci 331:59. 2006
  4. ncbi Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hypertension 47:515-21. 2006
  5. ncbi Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Kidney Int 68:2189-96. 2005
  6. ncbi Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 289:H2281-90. 2005
  7. ncbi Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circulation 111:2605-10. 2005
  8. ncbi Novel angiotensin peptides
    C M Ferrario
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cell Mol Life Sci 61:2720-7. 2004
  9. ncbi The role of angiotensin antagonism in stroke prevention in patients with hypertension: focus on losartan
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157 1032, USA
    Curr Med Res Opin 20:1797-804. 2004
  10. ncbi Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 98:121-8. 2006

Research Grants

  1. ATHEROGENESIS AND THE BONE MARROW ANGIOTENSIN SYSTEM
    Carlos Ferrario; Fiscal Year: 2004

Detail Information

Publications82

  1. ncbi ACE2: more of Ang-(1-7) or less Ang II?
    Carlos M Ferrario
    Department of General Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Nephrol Hypertens 20:1-6. 2011
    ....
  2. ncbi Addressing the theoretical and clinical advantages of combination therapy with inhibitors of the renin-angiotensin-aldosterone system: antihypertensive effects and benefits beyond BP control
    Carlos M Ferrario
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1032, United States
    Life Sci 86:289-99. 2010
    ....
  3. ncbi Highlights of the Twelfth Annual COSEHC National Scientific Session
    Carlos M Ferrario
    Wake Forest University Health Sciences Center, Winston-Salem, North Carolina 27157-1032, USA
    Am J Med Sci 331:59. 2006
  4. ncbi Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hypertension 47:515-21. 2006
    ....
  5. ncbi Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Kidney Int 68:2189-96. 2005
    ....
  6. ncbi Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 289:H2281-90. 2005
    ....
  7. ncbi Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circulation 111:2605-10. 2005
    ..As the only known human homolog of ACE, the demonstration that ACE2 is insensitive to blockade by ACE inhibitors prompted us to define the effect of ACE inhibition on the ACE2 gene...
  8. ncbi Novel angiotensin peptides
    C M Ferrario
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cell Mol Life Sci 61:2720-7. 2004
    ....
  9. ncbi The role of angiotensin antagonism in stroke prevention in patients with hypertension: focus on losartan
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157 1032, USA
    Curr Med Res Opin 20:1797-804. 2004
    ..The relevance of these molecular properties of losartan over other Ang II antagonists is further supported by comparison of the outcomes obtained in clinical trials employing two other Ang II antagonists, valsartan and candesartan...
  10. ncbi Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 98:121-8. 2006
    ....
  11. ncbi Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research
    Carlos M Ferrario
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    J Renin Angiotensin Aldosterone Syst 7:3-14. 2006
    ..It is hoped that the next 100 years of research into the RAS will uncover hitherto unimaginable therapeutic opportunities...
  12. ncbi Role of olmesartan in combination therapy in blood pressure control and vascular function
    Carlos M Ferrario
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Vasc Health Risk Manag 6:701-9. 2010
    ....
  13. ncbi The ANG-(1-7)/ACE2/mas axis in the regulation of nephron function
    Carlos M Ferrario
    Hypertension and Vascular Disease Research Center and Department of Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Physiol Renal Physiol 298:F1297-305. 2010
    ..This review summarizes the evolving knowledge of the counterregulatory arm of the renin-angiotensin system in the control of nephron function and renal disease...
  14. ncbi Individualizing hypertension treatment with impedance cardiography: a meta-analysis of published trials
    Carlos M Ferrario
    Hypertension and Vascular Research Center, Wake Forest University Medical Center, Winston Salem, North Carolina, USA
    Ther Adv Cardiovasc Dis 4:5-16. 2010
    ..We therefore undertook a quantitative analysis of the trials evaluating the role of ICG as an adjunct to therapeutic decision-making in the treatment of hypertension and the attainment of BP control...
  15. ncbi Effect of angiotensin receptor blockade on endothelial function: focus on olmesartan medoxomil
    Carlos Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Vasc Health Risk Manag 5:301-14. 2009
    ..Importantly, the impact of olmesartan medoxomil on endothelial dysfunction is thought to be independent of BP lowering...
  16. ncbi Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy
    Carlos M Ferrario
    The Hypertension and Vascular Research Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 296:H1184-92. 2009
    ..These changes were accompanied by significant increases in p47(phox), Rac1, and Nox4 isoform expression. In conclusion, ANG-(1-12) may be a functional precursor for angiotensin peptide formation in the absence of circulating renin...
  17. ncbi The role of noninvasive hemodynamic monitoring in the evaluation and treatment of hypertension
    Carlos M Ferrario
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Ther Adv Cardiovasc Dis 1:113-8. 2007
    ....
  18. ncbi COSEHC global vascular risk management quality improvement program: rationale and design
    Carlos M Ferrario
    Department of General Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Vasc Health Risk Manag 6:1135-45. 2010
    ....
  19. ncbi Cost-effectiveness of impedance cardiography testing in uncontrolled hypertension
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart Hosp J 4:279-89. 2006
    ..The use of ICG testing to reduce blood pressure in uncontrolled hypertensive patients is cost-effective from both a short- and long-term perspective...
  20. ncbi Highlights of the Tenth Annual COSEHC National Scientific Session
    Carlos M Ferrario
    Consortium for Southeastern Hypertension Control, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1032, USA
    Am J Med Sci 327:234-5. 2004
  21. ncbi COSEHC overview
    Carlos M Ferrario
    Consortium for Southeastern Hypertension Control, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1032, USA
    Am J Med Sci 327:233. 2004
  22. ncbi Sexual dysfunction in patients with hypertension: implications for therapy
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Clin Hypertens (Greenwich) 4:424-32. 2002
    ..The favorable effects of these agents on sexual function may be related, in part, to their ability to block angiotensin II, which has recently become recognized as an important mediator of detumescence and possibly erectile dysfunction...
  23. ncbi Renin-angiotensin system as a therapeutic target in managing atherosclerosis
    Carlos M Ferrario
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical School Boulevard, Winston Salem, NC 27157, USA
    Am J Ther 11:44-53. 2004
    ..In light of a causal and central role of Ang II in atherogenesis, blockade of the RAS represents an important therapeutic consideration in the prevention and treatment of atherosclerotic disease...
  24. ncbi Contribution of angiotensin-(1-7) to cardiovascular physiology and pathology
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University Health Science Center, Winston Salem, NC 27157, USA
    Curr Hypertens Rep 5:129-34. 2003
    ..The studies suggest that the renin-angiotensin system acts as a humoral mechanism for blood pressure control through the generation of several distinct forms of angiotensin peptides that may bind to diverse receptor subtypes...
  25. ncbi Effects of omapatrilat on the renin-angiotensin system in salt-sensitive hypertension
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Hypertens 15:557-64. 2002
    ..We suggest that Ang-(1-7) may be a component of the mechanisms by which omapatrilat induces an antihypertensive response in salt sensitive hypertension...
  26. ncbi The hypertension-lipid connection: insights into the relation between angiotensin II and cholesterol in atherogenesis
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Med Sci 323:17-24. 2002
    ....
  27. ncbi AII antagonists in hypertension, heart failure, and diabetic nephropathy: focus on losartan
    Carlos Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Curr Med Res Opin 20:279-93. 2004
    ....
  28. ncbi Angiotensin-(1-7): a bioactive fragment of the renin-angiotensin system
    C M Ferrario
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Regul Pept 78:13-8. 1998
    ..Ang-(1-7) mediates it antihypertensive effects by stimulating synthesis and release of vasodilator prostaglandins, and nitric oxide and potentiating the hypotensive effects of bradykinin...
  29. ncbi Use of angiotensin II receptor blockers in animal models of atherosclerosis
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1032, USA
    Am J Hypertens 15:9S-13S. 2002
    ....
  30. ncbi Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors
    Yuichiro Ishiyama
    Hypertension and Vascular Disease Center, Wake Forest University Health Science Center, Winston Salem, NC 27157, USA
    Hypertension 43:970-6. 2004
    ..These results provide evidence for an effect of angiotensin II blockade on cardiac ACE 2 mRNA that may be due to direct blockade of AT1a receptors or a modulatory effect of increased angiotensin-(1-7)...
  31. ncbi Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis rats
    Karl D Pendergrass
    Hypertension and Vascular Disease Ctr, Wake Forest Univ Health Sciences, Winston Salem, NC 27157 1095, USA
    Am J Physiol Heart Circ Physiol 295:H10-20. 2008
    ..The enhanced activity of the RAAS in male congenics may contribute to the higher pressure and tissue injury evident in the strain...
  32. ncbi Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy
    Hiroshi Yokoyama
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Am J Hypertens 18:922-9. 2005
    ....
  33. ncbi Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats
    Jewell A Jessup
    Hypertension and Vascular Disease Center, Wake Forest Univ. School of Medicine, Winston-Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 291:H2166-72. 2006
    ..Tg(mRen2) congenic rats, a failure of compensatory ACE2 and ANG-(1-7)-dependent vasodepressor mechanisms may contribute both to the development and progression of hypertension driven by increased formation of endogenous ANG II...
  34. ncbi Regulation of ACE2 in cardiac myocytes and fibroblasts
    Patricia E Gallagher
    The Hypertension and Vascular Research Center, Wake Forest Univ School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1032, USA
    Am J Physiol Heart Circ Physiol 295:H2373-9. 2008
    ....
  35. ncbi Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen
    Amy C Arnold
    Hypertension and Vascular Research Center and Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Hypertension 51:1326-31. 2008
    ..These results suggest a novel mechanism for the preservation of baroreflex sensitivity during aging...
  36. ncbi Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats
    Michiya Igase
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 289:H1013-9. 2005
    ....
  37. ncbi Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7)
    Carlos M Ferrario
    Hypertension and Vascular Disease Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Adv Pharmacol 59:197-233. 2010
    ....
  38. ncbi Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart
    Paul J Garabelli
    The Hypertension and Vascular Disease Center, Winston Salem, NC, USA
    Exp Physiol 93:613-21. 2008
    ....
  39. ncbi Divergent regulation of circulating and intrarenal renin-angiotensin systems in response to long-term blockade
    Sherry O Kasper
    Hypertension and Vascular Disease Center and Physiology/Pharmacology Department, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Am J Nephrol 25:335-41. 2005
    ..CONCLUSION: The reduction in urinary Ang peptides with losartan and enalapril treatment suggests that blockade of intrarenal AngII may be an important mechanism underlying the renoprotection seen with such treatments...
  40. ncbi Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR
    Shigefumi Nakamura
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Am J Physiol Regul Integr Comp Physiol 284:R164-73. 2003
    ..Combined blockade of AT(2) and AT((1-7)) receptors and ANG II neutralization by the ANG II antibody reversed as much as 67% of the blood pressure-lowering effect of losartan...
  41. ncbi Vasopeptidase inhibition and Ang-(1-7) in the spontaneously hypertensive rat
    Carlos M Ferrario
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Kidney Int 62:1349-57. 2002
    ..These findings provide further evidence for a contribution of Ang-(1-7) to the regulation of renal function and blood pressure...
  42. ncbi Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia
    Lauren Anton
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Hypertension 51:1066-72. 2008
    ..Elevated angiotensin II, acting through the AT(1) receptor, may favor vasoconstriction in placental chorionic villi and contribute to impaired fetal blood flow and decreased fetal nutrition observed during preeclampsia...
  43. ncbi Impaired heart rate baroreflex in older rats: role of endogenous angiotensin-(1-7) at the nucleus tractus solitarii
    Atsushi Sakima
    The Hypertension and Vascular Disease Center, Department of General Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Hypertension 46:333-40. 2005
    ..The attenuated counterbalancing effect of Ang-(1-7) on baroreflex function is lost in older rats, which may be attributable to diminished production of the peptide from neprilysin...
  44. ncbi Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
    Aaron J Trask
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Hypertens 23:687-93. 2010
    ....
  45. ncbi Angiotensin II stimulates arachidonic acid release from bone marrow stromal cells
    Renee S Richmond
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    J Renin Angiotensin Aldosterone Syst 5:176-82. 2004
    ....
  46. ncbi Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen
    Atsushi Sakima
    Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157 1032, USA
    Am J Physiol Heart Circ Physiol 292:H1412-9. 2007
    ....
  47. ncbi Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2.Lewis rat
    Karl D Pendergrass
    Hypertension and Vascular Disease Ctr, Wake Forest Univ. Health Sciences, Medical Center Blvd, Winston-Salem, NC 27157-1095, USA
    Am J Physiol Renal Physiol 290:F1497-506. 2006
    ..Lewis. The downregulation of AT1 sites in the mRen2.Lewis rats may reflect a compensatory response to dampen the elevated levels of intrarenal ANG II...
  48. ncbi Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats
    Katsunori Isa
    Hypertension and Vascular Research Center, Wake Forest University Health Science, Winston Salem, North Carolina 27157 1032, USA
    Am J Physiol Regul Integr Comp Physiol 297:R111-5. 2009
    ..The antihypertensive effects produced by endogenous neutralization of brain ANG-(1-12) suggest that ANG-(1-12) is functionally active in brain pathways regulating blood pressure...
  49. ncbi ACE2 and ANG-(1-7) in the rat uterus during early and late gestation
    Liomar A A Neves
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Am J Physiol Regul Integr Comp Physiol 294:R151-61. 2008
    ....
  50. ncbi Angiotensin-(1-12) requires angiotensin converting enzyme and AT1 receptors for cardiovascular actions within the solitary tract nucleus
    Amy C Arnold
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1032, USA
    Am J Physiol Heart Circ Physiol 299:H763-71. 2010
    ....
  51. ncbi Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II
    Hossam A Shaltout
    Department of Obstetrics and Gynecology, Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1095, USA
    Am J Physiol Renal Physiol 292:F82-91. 2007
    ..In conclusion, sheep tissues contain abundant ACE2 activity that converts ANG II to ANG-(1-7) but does not participate in the processing of ANG I into ANG-(1-9)...
  52. ncbi Value of noninvasive hemodynamics to achieve blood pressure control in hypertensive subjects
    Ronald D Smith
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA
    Hypertension 47:771-7. 2006
    ..0001). These study results indicate that antihypertensive therapy guided by impedance cardiography in uncontrolled hypertensive patients on >/=1 medications is more effective than standard care...
  53. ncbi Blood pressure-independent attenuation of cardiac hypertrophy by AT(1)R-AS gene therapy
    Alok S Pachori
    Hypertension Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA
    Hypertension 39:969-75. 2002
    ..Collectively, these results provide further proof of the concept and indicate that antisense gene therapy could successfully target the local tissues' renin-angiotensin system to produce beneficial cardiovascular outcomes...
  54. ncbi Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems
    Sherry O Kasper
    Hypertension and Vascular Disease Center, Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1032, USA
    Physiol Genomics 23:311-7. 2005
    ..These data implicate glial angiotensinogen in the regulation of body metabolism as well as hormonal mechanisms regulating blood pressure...
  55. ncbi Noninvasive hemodynamic profiles in hypertensive subjects
    Abdelhammed I Abdelhammed
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1032, USA
    Am J Hypertens 18:51S-59S. 2005
    ..Hemodynamic measurements with ICG characterize hemodynamic status and may be helpful in diagnostic, prognostic, and therapeutic decision making in hypertensive subjects...
  56. ncbi Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Ther Adv Cardiovasc Dis 4:17-25. 2010
    ..Therefore, the present study examined the changes in cardiac angiotensin-(1-7), its forming enzyme angiotensin converting enzyme 2 (ACE2) and receptor mas in response to a high salt diet in spontaneously hypertensive rats (SHR)...
  57. ncbi The impact of changing ICD code on hypertension-related mortality in the southeastern United States from 1994-2005
    JaNae Joyner-Grantham
    Consortium for Southeastern Hypertension Control COSEHC and Wake Forest University Hypertension and Vascular Research Center, Winston Salem, NC 27113 5097, USA
    J Clin Hypertens (Greenwich) 12:213-22. 2010
    ..Primary care health providers should question the impact and comparability of ICD revision before accepting mortality trend conclusions...
  58. ncbi Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats
    Jewell A Jessup
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 294:H2614-8. 2008
    ..In addition, we show that increased cardiac angiotensin-(1-12) concentrations in SHR is associated with a small, but statistically significant, reduction in renal angiotensin-(1-12) levels...
  59. ncbi New angiotensins
    Jasmina Varagic
    The Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Mol Med (Berl) 86:663-71. 2008
    ..This review focuses on angiotensin-(1-7) and its important contribution to cardiovascular function and growth, while introducing angiotensin-(1-12) as a potential novel angiotensin precursor...
  60. ncbi Angiotensin-(1-7) in normal and preeclamptic pregnancy
    David C Merrill
    Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Endocrine 18:239-45. 2002
    ..In preeclampsia the decreased plasma Ang-(1-7) in the presence of elevated Ang II is consistent with the development of hypertension...
  61. ncbi The protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling (The VIOS study): rationale and baseline characteristics
    Ronald D Smith
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiovasc Drugs 6:335-42. 2006
    ..Remodeling of small resistance vessels may be the earliest pathologic finding associated with hypertension. It may predate the onset of clinically apparent hypertension...
  62. ncbi Estrogen or the AT1 antagonist olmesartan reverses the development of profound hypertension in the congenic mRen2. Lewis rat
    Mark C Chappell
    Hypertension and Vascular Disease Center, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1095, USA
    Hypertension 42:781-6. 2003
    ..We conclude that the ovary exerts considerable influence on the regulation of the blood pressure in the mRen2. Lewis strain, possibly by limiting activation of the renin-angiotensin system...
  63. ncbi Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy
    K Bridget Brosnihan
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1032, USA
    Hypertension 42:749-53. 2003
    ..The findings suggest that ACE2 may contribute to the local production and overexpression of angiotensin-(1-7) in the kidney during pregnancy...
  64. ncbi Alterations in sympathetic ganglionic transmission in response to angiotensin II in (mRen2)27 transgenic rats
    Azeez A Aileru
    Biomedical Research Infrastructure Center, Winston Salem State University, 115 S Chestnut St, Winston Salem, NC 27101, USA
    Hypertension 43:270-5. 2004
    ..We suggest that functional Ang II receptors in SCG mediate physiological actions of Ang II on ganglionic transmission and may play a pivotal role in hypertension...
  65. ncbi Vascular responses to Angiotensin-(1-7) during the estrous cycle
    Liomar A A Neves
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA
    Endocrine 24:161-5. 2004
    ..Estrogen replacement restores a significant dilator response to Ang-(1-7) in OVX rats that is mediated by a D-[Ala7]-Ang-(1-7) sensitive site...
  66. ncbi Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University, Winston Salem, NC 27157, USA
    Am J Nephrol 32:557-66. 2010
    ....
  67. ncbi Angiotensin-(1-7): pharmacology and new perspectives in cardiovascular treatments
    Aaron J Trask
    The Hypertension and Vascular Research Center, Wake Forest University Health Science Center, Winston Salem, North Carolina 27157, USA
    Cardiovasc Drug Rev 25:162-74. 2007
    ..This review encompasses the pharmacology of Ang-(1-7) and expounds upon the peptide's potential as a therapeutic agent against pathological processes both within and outside the cardiovascular continuum...
  68. ncbi Self-reported influences of hopelessness, health literacy, lifestyle action, and patient inertia on blood pressure control in a hypertensive emergency department population
    JaNae Joyner-Grantham
    Consortium for Southeastern Hypertension Control, Winston Salem, North Carolina 27113 5097, USA
    Am J Med Sci 338:368-72. 2009
    ..This approach, termed patient inertia (PtInert), is defined as an individual's failure to take responsibility for health conditions and proactive change...
  69. ncbi Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression
    Mihaela C Blendea
    Department of Internal Medicine, University of Missouri, Columbia, MO 65201, USA
    Am J Physiol Endocrinol Metab 288:E353-9. 2005
    ..Improvements in skeletal muscle insulin-dependent glucose uptake and whole body IR in rats overexpressing ANG II by ARB or SOD mimetic indicate that oxidative stress plays an important role in ANG II-mediated insulin resistance...
  70. ncbi Angiotensin peptides modulate bradykinin levels in the interstitium of the dog heart in vivo
    Chih-Chang Wei
    Birmingham Veteran Affairs Medical Center, Department of Medicine, Hypertension and Vascular Biology Program, University of Alabama, Birmingham 35294-0005, USA
    J Pharmacol Exp Ther 300:324-9. 2002
    ....
  71. ncbi Does angiotensin-(1-7) contribute to cardiac adaptation and preservation of endothelial function in heart failure?
    Carlos M Ferrario
    Circulation 105:1523-5. 2002
  72. ncbi Reduced circulating levels of angiotensin-(1--7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control
    Alberto Pignone
    Department of Medicine and Surgery, Division of Medicine I and II and Rheumatology, Villa Monna Tessa, University of Florence, Florence, Italy
    Ann Rheum Dis 66:1305-10. 2007
    ..Our aim was to assess, in patients with SSc, circulating levels of Ang I, Ang II and Ang-(1-7), with their metabolising enzymes ACE and NEP, and levels of NO and PGI2, and to correlate them to the main characteristics of SSc...
  73. ncbi Increased hypothalamic angiotensin-(1-7) levels in rats with aortic coarctation-induced hypertension
    Mariela M Gironacci
    Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Peptides 28:1580-5. 2007
    ..The increased central levels of Ang-(1-7) in the CH rats suggest a potential mitigating role of this peptide in central control of the hypertensive process...
  74. ncbi Comparison of inhibitory effects of irbesartan and atorvastatin treatment on the renin angiotensin system (RAS) in veins: a randomized double-blind crossover trial in healthy subjects
    Christoph Schindler
    Institute of Clinical Pharmacology, Medical Faculty of the University of Technology, Fiedlerstrasse 27, D 01307 Dresden, Germany
    J Clin Pharmacol 47:112-20. 2007
    ..The data indicate that atorvastatin does not inhibit Ang II-induced venoconstriction in vivo and point toward a supportive role of Ang-(1-7) in contributing to the antihypertensive and beneficial vascular effects of irbesartan...
  75. ncbi NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat
    Yongzhong Wei
    University of Missouri Columbia, Harry S Truman VA Medical Center, Columbia, MO, USA
    Hypertension 50:384-91. 2007
    ..Collectively, these data suggest that increased angiotensin type 1 receptor/NADPH oxidase activation/reactive oxygen species contribute to vascular insulin resistance, endothelial dysfunction, apoptosis, and inflammation...
  76. ncbi Angiotensin-converting enzyme 2 is an essential regulator of heart function
    Michael A Crackower
    Amgen Research Institute Ontario Cancer Institute and Department of Medical Biophysics and Immunology, University of Toronto, University Avenue, Toronto, Ontario M5G 2M9, Canada
    Nature 417:822-8. 2002
    ..But disruption of ACER, a Drosophila ACE2 homologue, results in a severe defect of heart morphogenesis. These genetic data for ACE2 show that it is an essential regulator of heart function in vivo...
  77. ncbi Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat
    Adam Whaley-Connell
    The University of Missouri School of Medicine, Department of Medicine, Columbia, Missouri, USA
    Am J Physiol Endocrinol Metab 295:E103-9. 2008
    ..Collectively, these data suggest that both reduce changes driven, in part, by Ang II-mediated increases in NADPH oxidase and, in part, increases in blood pressure...
  78. ncbi Increased expression of angiotensin converting enzyme 2 in conjunction with reduction of neointima by angiotensin II type 1 receptor blockade
    Michiya Igase
    Department of Geriatric Medicine, Ehime University School of Medicine, Toon, Japan
    Hypertens Res 31:553-9. 2008
    ..These studies suggest that changes in ACE2 within the vascular system of SHR are regulated by a factor other than arterial pressure...
  79. ncbi Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart
    Walmor C De Mello
    Department of Pharmacology, Medical Sciences Campus, School of Medicine, UPR, PR, USA
    J Renin Angiotensin Aldosterone Syst 8:74-80. 2007
    ..The presence of Angiotensin (1-7) (Ang 1-7) and ACE 2 in the ventricle of cardiomyopathic hamsters as well as the influence of Ang (1-7) on membrane potential, impulse propagation and cardiac excitability were investigated...
  80. ncbi Left ventricular geometric patterns after 1 year of antihypertensive treatment
    Manuel Luque
    Hypertension Unit, Hospital Clinico San Carlos, Madrid, Spain
    J Clin Hypertens (Greenwich) 7:333-8. 2005
    ..The authors conclude that these patients should be considered as a subgroup at high risk and should be treated more aggressively...
  81. ncbi Aging and the brain renin-angiotensin system: insights from studies in transgenic rats
    Debra I Diz
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Cleve Clin J Med 74:S95-8. 2007
  82. ncbi Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats
    Matthew J Huentelman
    Department of Physiology and Functional Genomics, University of Florida, College of Medicine, PO Box 100274, Gainesville, FL 32610, USA
    Exp Physiol 90:783-90. 2005
    ..These observations demonstrate that ACE2 overexpression results in protective effects on angiotensin II-induced cardiac hypertrophy and fibrosis...

Research Grants5

  1. ATHEROGENESIS AND THE BONE MARROW ANGIOTENSIN SYSTEM
    Carlos Ferrario; Fiscal Year: 2004
    ..The proposed research will uncover novel mechanisms of atherogenesis that may have significant impact in the development of new therapeutic modalities applicable to cardiovascular and blood vessel diseases. ..