Research Topics
| Mark EspelandSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: a cardiovascular magnetic resonance studyHunter R Underhill
Department of Radiology University of Washington, Seattle, WA, USA
J Cardiovasc Magn Reson 10:31. 2008....- Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot (SHARP-P) study, a randomized controlled trialClaudine Legault
Division of Public Health Sciences, Department of Biostatistical Sciences Wachovia 21st floor, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
BMC Geriatr 11:27. 2011..Before definitive trials are mounted, important design questions on participation/adherence, training and interventions effects must be answered to more fully inform a full-scale trial... - Designing clinical trials of interventions for mobility disability: results from the lifestyle interventions and independence for elders pilot (LIFE-P) trialMark A Espeland
Department of Biostatistical Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Gerontol A Biol Sci Med Sci 62:1237-43. 2007..Clinical trials to assess interventions for mobility disability are critically needed; however, data for efficiently designing such trials are lacking... 
Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory StudyMark A Espeland
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
JAMA 291:2959-68. 2004..The effect of estrogen-alone therapy, also evaluated in WHIMS, on cognition has not been established for this population...- Association between reported alcohol intake and cognition: results from the Women's Health Initiative Memory StudyMark A Espeland
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Epidemiol 161:228-38. 2005..Moderate levels of alcohol intake may be associated with better cognition and reduced risk of significant cognitive decline; however, confounding associations with unmeasured factors cannot be ruled out... - Measurement characteristics of the ankle-brachial index: results from the Action for Health in Diabetes studyMark A Espeland
Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Vasc Med 13:225-33. 2008..Replicating SBP measurements reduces the error and bias of ABI. Averaging leg-specific values may increase power for characterizing cardiovascular disease risk... - Association between alcohol intake and domain-specific cognitive function in older womenMark A Espeland
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Neuroepidemiology 27:1-12. 2006..However, our observational study cannot rule out confounding associations with unmeasured factors... - Benchmarks for designing two-stage studies using modified mini-mental state examinations: experience from the Women's Health Initiative Memory StudyMark A Espeland
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Clin Trials 3:99-106. 2006..The modified mini-mental state examination (3MS) is commonly used as this initial screen in such two-stage designs, however its properties for this role require further study... - Consent for genetics studies among clinical trial participants: findings from Action for Health in Diabetes (Look AHEAD)M A Espeland
Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Clin Trials 3:443-56. 2006..Increasingly, genetic specimens are collected to expand the value of clinical trials through study of genetic effects on disease incidence, progression or response to interventions... - Statistical issues in analyzing 24-hour dietary recall and 24-hour urine collection data for sodium and potassium intakesM A Espeland
Section on Biostatistics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Epidemiol 153:996-1006. 2001.... - Brain volumes, cognitive impairment, and conjugated equine estrogensMark A Espeland
Department of Biostatistical Sciences, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Gerontol A Biol Sci Med Sci 64:1243-50. 2009.... 
Telephone interview for cognitive status (TICS) screening for clinical trials of physical activity and cognitive training: the seniors health and activity research program pilot (SHARP-P) studyMark A Espeland
Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC, USA
Int J Geriatr Psychiatry 26:135-43. 2011..To examine the performance of the Telephone Interview for Cognitive Status (TICS) for identifying participants appropriate for trials of physical activity and cognitive training interventions...- Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women's Health Initiative study of cognitive aging extensionMark A Espeland
Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
J Am Geriatr Soc 58:1263-71. 2010..To determine whether small decrements in global cognitive function that conjugated equine estrogen (CEE) therapies have been shown to produce in older women persist after cessation and extend to specific cognitive domains... - Relative effects of tamoxifen, raloxifene, and conjugated equine estrogens on cognitionMark A Espeland
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Womens Health (Larchmt) 19:371-9. 2010..To compare the relative effects of conjugated equine estrogens (CEE), raloxifene, and tamoxifen therapies on cognition among women aged > or =65 years... - Describing patterns of weight changes using principal components analysis: results from the Action for Health in Diabetes (Look AHEAD) research groupMark A Espeland
Department of Biostatistical Sciences, Wake Forest University School of Medicine and Winston Salem, NC 27157, USA
Ann Epidemiol 19:701-10. 2009..To demonstrate how principal components analysis can be used to describe patterns of weight changes in response to an intensive lifestyle intervention... - Changes in cognitive function in a randomized trial of physical activity: results of the lifestyle interventions and independence for elders pilot studyJeff D Williamson
Roena Kulynych Center for Memory and Cognition Research, Department of Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27151, USA
J Gerontol A Biol Sci Med Sci 64:688-94. 2009.... - The Lifestyle Interventions and Independence for Elders Pilot (LIFE-P): 2-year follow-upW Jack Rejeski
Department of Health and Exercise Science, Wake Forest University School of Medicine, Winston Salem, NC 27109, USA
J Gerontol A Biol Sci Med Sci 64:462-7. 2009.... - Coronary artery calcium outperforms carotid artery intima-media thickness as a noninvasive index of prevalent coronary artery stenosisJames G Terry
Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Arterioscler Thromb Vasc Biol 25:1723-8. 2005..CONCLUSIONS: HCT-measured CAC compares favorably with carotid IMT measured by B-mode ultrasound as a noninvasive index of prevalent CAD... - Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trialsDavid L Mount
Wake Forest University School of Medicine, Winston Salem, NC, USA
Clin Trials 6:416-29. 2009..Comparing findings from separate trials is necessary to choose among treatment options, however differences among study cohorts may impede these comparisons... - Physical activity in prefrail older adults: confidence and satisfaction related to physical functionW Jack Rejeski
Department of Health and Exercise Science, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
J Gerontol B Psychol Sci Soc Sci 63:P19-26. 2008..This is an important finding in light of the importance of these process variables in behavior change and quality of life... - Healthy Living Partnerships to Prevent Diabetes (HELP PD): design and methodsJeffrey A Katula
Department of Health and Exercise Science, Wake Forest University, PO Box 7868, Winston Salem, NC 27109, USA
Contemp Clin Trials 31:71-81. 2010.... - Why African-American women are at greater risk for pregnancy-related deathMargaret Harper
Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston Salem, NC, USA
Ann Epidemiol 17:180-5. 2007..Our study aim was to identify factors that may contribute to the racial disparity in pregnancy-related mortality... - Action for Health in Diabetes (Look AHEAD) trial: baseline evaluation of selected nutrients and food group intakeMara Z Vitolins
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27104, USA
J Am Diet Assoc 109:1367-75. 2009..Little has been reported regarding food and nutrient intake in individuals diagnosed with type 2 diabetes, and most reports have been based on findings in select groups or individuals who self-reported having diabetes... - Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS)Laura H Coker
Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
J Steroid Biochem Mol Biol 118:304-10. 2010..05); frontal lobe (P=0.004); and total brain (P=0.07). HT-associated reductions in hippocampal volumes were greatest in women with baseline 3MS scores < or = 90... - A uniform approach to modeling risk factor relationships for ischemic lesion prevalence and extent: the Women's Health Initiative Magnetic Resonance Imaging studyJanet A Tooze
Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Neuroepidemiology 34:55-62. 2010..Typically these associations have been explored separately, but an integrated modeling approach would allow the separate relationships to be consistently described and contrasted... - The relationship between cognitive function and physical performance in older women: results from the women's health initiative memory studyHal H Atkinson
Wake Forest University School of Medicine, Sticht Center on Aging, Roena Kulynych Center for Memory and Cognition Research, and Department of Internal Medicine Gerontology and Geriatric Medicine, Winston Salem, North Carolina 27157, USA
J Gerontol A Biol Sci Med Sci 65:300-6. 2010..Cognitive function and physical performance are associated, but the common sequence of cognitive and physical decline remains unclear... - The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)Jingzhong Ding
Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
Am J Clin Nutr 90:499-504. 2009..Cross-sectional studies suggest that pericardial fat is positively associated with coronary artery disease independent of total body fat... - Enrollment in a brain magnetic resonance study: results from the Women's Health Initiative Memory Study Magnetic Resonance Imaging Study (WHIMS-MRI)Sarah A Jaramillo
Division of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Acad Radiol 14:603-12. 2007..We use data from a large MRI study to identify factors associated with differential enrollment and to examine potential biases this may produce in study results... - Virtual colonoscopy using oral contrast compared with colonoscopy for the detection of patients with colorectal polypsBenoit C Pineau
Department of Internal Medicine, Section of Gastroenterology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 USA
Gastroenterology 125:304-10. 2003..This trial used conventional colonoscopy with segmental unblinding to determine the ability of virtual colonoscopy to identify patients with colorectal lesions who need conventional colonoscopy... - Site-specific progression of carotid artery intimal-medial thicknessMark A Espeland
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Atherosclerosis 171:137-43. 2003..To characterize the intercorrelation of changes in intimal-medial thickness (IMT) among carotid artery sites and examine the influence of diabetes and sex on these correlations... - Racial disparity in pregnancy-related mortality following a live birth outcomeMargaret A Harper
Department of Obstetrics and Gynecology M A H, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Ann Epidemiol 14:274-9. 2004..We conducted this study to determine if differences in a combination of socioeconomic and medical risk factors may explain this racial disparity in pregnancy-related death... - Racial differences in endothelial function in postmenopausal womenLaura R Loehr
Department of Internal Medicine, Sections on Section on Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Am Heart J 148:606-11. 2004..The increased CVD risk in African American women may be related to impaired endothelial function. It remains to be determined whether African American women may uniquely benefit by interventions designed to improve endothelial health... - Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trialStephen R Rapp
Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
JAMA 289:2663-72. 2003..On July 8, 2002, the estrogen plus progestin therapy in the WHI trial was discontinued because of certain increased health risks for women... - Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- miceJennifer A Cann
Department of Pathology, Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Winston Salem, NC 27157, United States
Atherosclerosis 201:43-52. 2008..These results suggest that a period of estrogen deficiency followed by reintroduction alters the immunologic environment of atherosclerotic lesions as well as plaque progression... - Diabetes and progression of carotid atherosclerosis: the insulin resistance atherosclerosis studyLynne E Wagenknecht
Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1063, USA
Arterioscler Thromb Vasc Biol 23:1035-41. 2003..We sought to determine the rate of progression of carotid atherosclerosis in persons with normal glucose tolerance, impaired glucose tolerance, and undiagnosed and diagnosed type 2 diabetes... - Pregnancy-related death and health care servicesMargaret A Harper
Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Obstet Gynecol 102:273-8. 2003..To examine the association between health care services variables and pregnancy-related death using a contemporary geographically defined population and enhanced methods for case identification... - Intensive lifestyle intervention improves physical function among obese adults with knee pain: findings from the Look AHEAD trialCapri G Foy
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Obesity (Silver Spring) 19:83-93. 2011..The ILI condition also resulted in significant weight loss and improved fitness, which are possible mechanisms through which the ILI condition improved physical function... - Electrolyte intake and nonpharmacologic blood pressure controlMark A Espeland
Department of Biostatistics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Ann Epidemiol 12:587-95. 2002..CONCLUSIONS: Sodium and potassium intakes exert independent graded influences on nonpharmacologic blood pressure control. Correlated measurement error may spuriously introduce a dependency among these relationships... - Carotid arterial structure in patients with documented coronary artery disease and disease-free control subjectsJames G Terry
Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1047, USA
Circulation 107:1146-51. 2003..The association of increased IMT with arterial dimensions varies in a manner that is segment-specific for the common and internal carotid arteries... - Associations of extracranial carotid atherosclerosis progression with coronary status and risk factors in patients with and without coronary artery diseaseJohn R Crouse
Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Circulation 106:2061-6. 2002..CONCLUSIONS: Patients with CAD have more rapid progression of IMT than CAD-free controls, and risk factors are related to progression in them... - Effects of combination estrogen plus progestin hormone treatment on cognition and affectSusan M Resnick
National Institute on Aging, Baltimore, Maryland 21224 6825, USA
J Clin Endocrinol Metab 91:1802-10. 2006..Some studies of hormone treatment in postmenopausal women suggest benefits on specific cognitive functions, particularly memory... - Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetesDonna H Ryan
Pennington Biomedical Research Center
Control Clin Trials 24:610-28. 2003..Other outcomes include components of CVD risk, cost and cost-effectiveness, diabetes control and complications, hospitalizations, intervention processes, and quality of life... - Ethnic comparison of weight loss in the Trial of Nonpharmacologic Interventions in the ElderlyShiriki K Kumanyika
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Obes Res 10:96-106. 2002..To compare weight loss in blacks and whites in the Trial of Nonpharmacologic Interventions in the Elderly (TONE)... - The Women's Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive declineSusan M Resnick
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
Clin Trials 1:440-50. 2004.... - A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmenopausal women: the Women's Health Initiative Memory StudyKaren C Johnson
Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennesse 38163, USA
J Am Geriatr Soc 56:1449-58. 2008..To examine the relationship between baseline hypertension, blood pressure, and the development of cognitive decline in participants in the Women's Health Initiative Memory Study (WHIMS)... - Preventing cognitive decline in usual agingMark A Espeland
Arch Intern Med 166:2433-4. 2006 - Functional outcomes for clinical trials in frail older persons: time to be movingShalender Bhasin
J Gerontol A Biol Sci Med Sci 63:160-4. 2008 - Association of angiotensin-converting enzyme DD genotype with blood pressure sensitivity to weight lossJohn B Kostis
UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
Am Heart J 144:625-9. 2002..Salt sensitivity--the degree of blood pressure change in response to a change in sodium load--has been extensively explored. However, the determinants of the extent of blood pressure change after weight reduction have not been evaluated... - Erratum to "Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study"Mark S Chambers
Department of Head and Neck Surgery, Department of Radiation Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
Oral Oncol 43:98-105. 2007..It would be more convenient than the daily home application of a tray of 0.4% stannous fluoride or 1.1% sodium fluoride gel, and avoids the problem of variable patient compliance... - Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trialXavier Pi-Sunyer
St Luke s Roosevelt Hospital Center, USA
Diabetes Care 30:1374-83. 2007..This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events... - Treatment of corticosteroid-responsive autoimmune inner ear disease with methotrexate: a randomized controlled trialJeffrey P Harris
Division of Otolaryngology Head and Neck Surgery, University of California, San Diego, CA 92103 8895, USA
JAMA 290:1875-83. 2003..Methotrexate has emerged as the benchmark agent but has not been rigorously evaluated for hearing improvement in patients with AIED...
Research Grants
- Look AHEAD: Action for Health in DiabetesMark Espeland; Fiscal Year: 2007..These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. ..
- Seniors Health and Activity Research Program Pilot (SHARP-P)Mark Espeland; Fiscal Year: 2007....
- Look AHEAD: Action for Health in DiabetesMark Espeland; Fiscal Year: 2007..These procedures will enable us to analyze the effects of the intervention on serious cardiovascular events, on CVD risk factors, diabetes related factors and complications, and cost-effectiveness of the intervention. ..
- Prevention of Weight Gain in Young AdultsMark Espeland; Fiscal Year: 2009..Rena Wing, The Miriam Hospital, and a Data Coordinating Center, submitted by Dr. Mark Espeland, Wake Forest University School of Medicine...