J C Eisenach

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:29-34. 2002
  2. ncbi request reprint alpha2-adrenoceptors inhibit the intracellular Ca2+ response to electrical stimulation in normal and injured sensory neurons, with increased inhibition of calcitonin gene-related peptide expressing neurons after injury
    J C Eisenach
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuroscience 131:189-97. 2005
  3. ncbi request reprint Dose response of intrathecal adenosine in experimental pain and allodynia
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salen, North Carolina 27157, USA
    Anesthesiology 97:938-42. 2002
  4. ncbi request reprint Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia
    J C Eisenach
    Department of Anesthesiology, Wake Forest University Medical Center, Winston Salem, NC 27157 1009, USA
    Pain 84:57-64. 2000
  5. ncbi request reprint Antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, MPV-2426, in sheep
    J C Eisenach
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 91:1425-36. 1999
  6. ncbi request reprint Phase I safety assessment of intrathecal ketorolac
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 99:599-604. 2002
  7. ncbi request reprint Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 105:65-70. 2003
  8. ncbi request reprint Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Pain 101:89-95. 2003
  9. ncbi request reprint Intrathecal but not intravenous opioids release adenosine from the spinal cord
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    J Pain 5:64-8. 2004
  10. ncbi request reprint Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:24-8. 2002

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:29-34. 2002
    ..The purpose of this study was to screen for efficacy of a different formulation of adenosine marketed in the US, using both acute noxious stimulation and capsaicin-evoked mechanical hypersensitivity...
  2. ncbi request reprint alpha2-adrenoceptors inhibit the intracellular Ca2+ response to electrical stimulation in normal and injured sensory neurons, with increased inhibition of calcitonin gene-related peptide expressing neurons after injury
    J C Eisenach
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuroscience 131:189-97. 2005
    ..There is a shift in phenotype of sensory neurons which are inhibited by clonidine after nerve injury, which may explain clonidine's increased potency in the treatment of neuropathic compared with acute pain...
  3. ncbi request reprint Dose response of intrathecal adenosine in experimental pain and allodynia
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salen, North Carolina 27157, USA
    Anesthesiology 97:938-42. 2002
    ..We studied two doses of intrathecal adenosine in humans with experimental hypersensitivity and the ability of the adenosine receptor antagonist, aminophylline, to reverse adenosine's effects...
  4. ncbi request reprint Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia
    J C Eisenach
    Department of Anesthesiology, Wake Forest University Medical Center, Winston Salem, NC 27157 1009, USA
    Pain 84:57-64. 2000
    ....
  5. ncbi request reprint Antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, MPV-2426, in sheep
    J C Eisenach
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 91:1425-36. 1999
    ..This study determined the antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, MPV-2426, in sheep...
  6. ncbi request reprint Phase I safety assessment of intrathecal ketorolac
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 99:599-604. 2002
    ..There were no long-term side effects 6 months after study. These data suggest that intrathecal ketorolac does not produce a high incidence of serious adverse events, and they support further investigation for analgesia...
  7. ncbi request reprint Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 105:65-70. 2003
    ..Given the modest effect and common side effects, the role for intrathecal adenosine as a sole agent for the treatment of neuropathic pain may be limited...
  8. ncbi request reprint Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Pain 101:89-95. 2003
    ..These limited data support the hypothesis that human visceral afferents express KOR and that peripherally restricted KOR agonists produce analgesia in patients with chronic visceral pain...
  9. ncbi request reprint Intrathecal but not intravenous opioids release adenosine from the spinal cord
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    J Pain 5:64-8. 2004
    ..In contrast, adenosine concentrations were unaffected by intravenous remifentanil. These results suggest that intrathecal but not systemic opioid analgesia in humans is associated with spinal release of adenosine...
  10. ncbi request reprint Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:24-8. 2002
    ..We performed a phase I safety trial of intrathecal injection of the American formulation of adenosine, which lacks mannitol...
  11. pmc Effects of intrathecal ketorolac on human experimental pain
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 112:1216-24. 2010
    ..We used a spinal injection of small doses of the cyclooxygenase inhibitor ketorolac to survey the role of spinal cyclooxygenase in human experimental pain and hypersensitivity states...
  12. ncbi request reprint Cephalad movement of morphine and fentanyl in humans after intrathecal injection
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 99:166-73. 2003
    ..The purpose of this study was to examine differences between two often used opioids, morphine and fentanyl, in distribution in the CSF after intrathecal injection...
  13. pmc Role of spinal cyclooxygenase in human postoperative and chronic pain
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 112:1225-33. 2010
    ..Animal studies suggest that these drugs act, in part, by blocking prostaglandin production in the spinal cord. The authors tested intrathecal ketorolac in patients with chronic or postoperative pain...
  14. pmc Severity of acute pain after childbirth, but not type of delivery, predicts persistent pain and postpartum depression
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 140:87-94. 2008
    ..In contrast, the severity of the acute pain response to childbirth predicts persistent morbidity, suggesting the need to more carefully address pain treatment in the days following childbirth...
  15. ncbi request reprint Cystatin C in cerebrospinal fluid is not a diagnostic test for pain in humans
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 107:207-12. 2004
    ..These data suggest that cystatin C concentration in cerebrospinal fluid is an unreliable diagnostic marker for pain in humans...
  16. ncbi request reprint Interaction between intrathecal neostigmine and epidural clonidine in human volunteers
    D D Hood
    Department of Anesthesia, Wake Forest University Medical Center, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 85:315-25. 1996
    ..The purpose of the current study was to examine the interaction between intrathecal neostigmine and epidural clonidine for analgesia and side effects in humans...
  17. ncbi request reprint Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, North Carolina 27157 1009, USA
    Anesthesiology 106:557-62. 2007
    ..Here, the authors tested the role of spinal noradrenergic inhibition in gabapentin's analgesia for postoperative pain...
  18. ncbi request reprint Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats
    Thomas J Martin
    Department of Physiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 113:376-85. 2005
    ..Differences in drug potency could reflect fundamental differences in outcome measures or in the surgical procedures themselves. These data support combination study of intrathecal morphine and ketorolac for postoperative pain...
  19. ncbi request reprint Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Anesthesiology 106:1213-9. 2007
    ....
  20. ncbi request reprint P75-expressing elements are necessary for anti-allodynic effects of spinal clonidine and neostigmine
    X Paqueron
    Pain Mechanisms Laboratory of the Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1009, USA
    Neuroscience 102:681-6. 2001
    ....
  21. ncbi request reprint Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury
    Alfonso Romero-Sandoval
    Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Anesthesiology 104:351-5. 2006
    ..The current study tested whether clonidine would have a similar effect in established nerve injury...
  22. ncbi request reprint Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats
    H L Pan
    Department of Anesthesiology, Physiology, and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    J Pharmacol Exp Ther 288:1026-30. 1999
    ..This action may contribute, at least in part, to the antiallodynic effect of gabapentin on neuropathic pain...
  23. ncbi request reprint Morphine-induced spinal cholinergic activation: in vivo imaging with positron emission tomography
    H D Gage
    Division of Radiologic Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1061, USA
    Pain 91:139-45. 2001
    ..Following preclinical screening, PET scanning with [(18)F]FBT may be useful to investigate mechanisms of analgesic action in normal humans and in those with pain...
  24. ncbi request reprint Role of spinal NO in antiallodynic effect of intrathecal clonidine in neuropathic rats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 89:1518-23. 1998
    ..The objectives of this study were to assess the role of spinal NO in maintenance of allodynia and to determine the role of spinal NO in the antiallodynic effect of intrathecal clonidine...
  25. pmc Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation
    Weiya Ma
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 1127:52-8. 2007
    ....
  26. ncbi request reprint Morphine-induced spinal release of adenosine is reduced in neuropathic rats
    A Sandner-Kiesling
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA
    Anesthesiology 95:1455-9. 2001
    ....
  27. ncbi request reprint Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain
    J K Cheng
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 92:1126-31. 2000
    ....
  28. ncbi request reprint Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors
    Yoo Jin Kang
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesth Analg 96:1403-8, table of contents. 2003
    ....
  29. ncbi request reprint Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats
    Hideaki Obata
    Department of Anesthesiology and Center for the Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Pain 113:271-6. 2005
    ..Finally, these data suggest that intrathecal administration of Xen2174 at the time of spinal anesthesia might produce postoperative analgesia in humans...
  30. pmc Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis
    Alfonso Romero-Sandoval
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Behav Immun 21:569-80. 2007
    ..This early effect likely underlies the delayed anti-inflammatory and anti-hypersensitivity effects of perineural clonidine in this setting...
  31. ncbi request reprint Intrathecal neostigmine and sufentanil for early labor analgesia
    K E Nelson
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27103, USA
    Anesthesiology 91:1293-8. 1999
    ..In this study, the authors used intrathecal neostigmine in combination with intrathecal sufentanil to investigate the usefulness of neostigmine for reducing side effects and prolonging the duration of sufentanil...
  32. ncbi request reprint Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans
    J C Eisenach
    Department of Anesthesia, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina, USA
    Anesthesiology 86:1279-87. 1997
    ....
  33. ncbi request reprint An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury
    X Paqueron
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
    Anesthesiology 94:1074-81. 2001
    ....
  34. ncbi request reprint Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation
    W Ma
    Pain Mechanism Laboratory, Department of Anesthesiology and Center for the Study of Pharmacological Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuroscience 121:681-90. 2003
    ....
  35. ncbi request reprint Effects of intrathecal neostigmine, bupivacaine, and their combination on sympathetic nerve activity in rats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 88:481-6. 1998
    ..The current study examined directly the interaction of intrathecal injection of bupivacaine and neostigmine on splanchnic sympathetic efferent nerve activity...
  36. ncbi request reprint Perineural clonidine reduces p38 mitogen-activated protein kinase activation in sensory neurons
    Baogang Liu
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Neuroreport 17:1313-7. 2006
    ..These data suggest that activation of alpha2-adrenoceptors at the site of nerve injury, probably by immune modulation, reduces intracellular signaling in primary afferents that leads to hypersensitivity...
  37. pmc Assessment of behavior during labor in rats and effect of intrathecal morphine
    Chuanyao Tong
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 108:1081-6. 2008
    ..To address this, the authors classified and quantified spontaneous behaviors during labor and delivery in rats and examined the effects of a known analgesic, intrathecal morphine...
  38. ncbi request reprint Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine
    Weiya Ma
    Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 113:386-94. 2005
    ....
  39. ncbi request reprint Intrathecal morphine reduces the visceromotor response to acute uterine cervical distension in an estrogen-independent manner
    Sang Wook Shin
    Department of Anesthesiology and Center for the Study of Pharmacological Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 98:1467-71; discussion 6A. 2003
    ..The purpose of the present study was to determine whether this estrogen blockade of the action of morphine reflects a spinal mechanism...
  40. ncbi request reprint Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury
    W Ma
    Pain Mechanism Laboratory, Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Neuroscience 121:691-704. 2003
    ..Our data strongly suggest that during the initial several months after nerve injury, peripherally over-produced prostaglandins play an important role in the maintenance of neuropathic pain...
  41. ncbi request reprint The vascular mechanism of ephedrine's beneficial effect on uterine perfusion during pregnancy
    C Tong
    Department of Anesthesia, Wake Forest University Medical Center, Winston Salem, North Carolina 27157 1009
    Anesthesiology 76:792-8. 1992
    ....
  42. ncbi request reprint Allosteric adenosine modulation to reduce allodynia
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA
    Anesthesiology 95:416-20. 2001
    ..Although obvious adverse effects were not observed in this investigation, further study is required to determine the feasibility of the use of such modulators in the treatment of chronic pain associated with hyperalgesia and allodynia...
  43. ncbi request reprint Epidural fentanyl produces labor analgesia by a spinal mechanism
    R D'ANGELO
    Department of Anesthesiology, The Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina, USA
    Anesthesiology 88:1519-23. 1998
    ..The purpose of this study was to determine if epidural fentanyl produces analgesia in laboring patients by a primary spinal or supraspinal action...
  44. ncbi request reprint Intrathecal clonidine alleviates allodynia in neuropathic rats: interaction with spinal muscarinic and nicotinic receptors
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 90:509-14. 1999
    ..The current study determined the role of spinal muscarinic and nicotinic receptors in the antiallodynic effect of intrathecally administered clonidine in spinal nerve-ligated rats...
  45. ncbi request reprint Chronic intrathecal morphine administration produces homologous mu receptor/G-protein desensitization specifically in spinal cord
    C E Maher
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
    Brain Res 895:1-8. 2001
    ..t. morphine treatment were observed in brain sections. These data show that homologous desensitization of mu receptor/G-protein coupling occurs specifically in spinal cord following chronic morphine administration...
  46. ncbi request reprint The monoamine reuptake inhibitor milnacipran does not affect nociception to acute visceral distension in rats
    Sang Wook Shin
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesth Analg 98:1365-9, table of contents. 2004
    ..IMPLICATIONS: Neither intrathecal nor i.v. milnacipran, a monoamine reuptake inhibitor, inhibits an acute visceral pain response induced by colorectal or uterine cervical distension...
  47. ncbi request reprint Hyperexcitability of axotomized and neighboring unaxotomized sensory neurons is reduced days after perineural clonidine at the site of injury
    Baogang Liu
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Neurophysiol 94:3159-67. 2005
    ....
  48. ncbi request reprint Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain
    Carine Dalle
    Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Reg Anesth Pain Med 30:243-8. 2005
    ....
  49. ncbi request reprint Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran
    Sang Wook Shin
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 100:671-5. 2004
    ....
  50. ncbi request reprint Intrathecal ketorolac enhances antinociception from clonidine
    Dawn R Conklin
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesth Analg 96:191-4, table of contents. 2003
    ....
  51. ncbi request reprint Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding
    Carsten Bantel
    Department of Anesthesiology, Wake Forst University Schhol of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:103-8. 2002
    ..The purpose of the current study was to investigate whether this reflected an alteration in kinetics of adenosine in cerebrospinal fluid or in the number of spinal A1 adenosine receptors after nerve injury...
  52. ncbi request reprint Phase I human safety assessment of intrathecal neostigmine containing methyl- and propylparabens
    J C Eisenach
    Department of Anesthesia, Bowman Gray School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 85:842-6. 1997
    ..t. neostigmine in these volunteers. These data support the investigational application of i.t. neostigmine containing methyl- and propylparabens in the concentrations studied...
  53. ncbi request reprint alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes
    X Li
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA
    J Pharmacol Exp Ther 299:939-44. 2001
    ....
  54. ncbi request reprint Pregnancy and ephedrine increase the release of nitric oxide in ovine uterine arteries
    P Li
    Department of Anesthesia, Wake Forest University Medical Center, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 82:288-93. 1996
    ....
  55. ncbi request reprint Adenosine reduces glutamate release in rat spinal synaptosomes
    Xinhui Li
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Anesthesiology 103:1060-5. 2005
    ..Here, the authors test whether increased inhibition by adenosine of glutamate release from afferents after injury accounts for this difference...
  56. ncbi request reprint Analgesia induced by perineural clonidine is enhanced in persistent neuritis
    Alfonso Romero-Sandoval
    Department of Anesthesiology and Center for Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1009, USA
    Neuroreport 18:67-71. 2007
    ..These data support treatment strategies with alpha2-adrenoceptor agonists in persistent neuritis...
  57. ncbi request reprint Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats
    Sang Wook Shin
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 105:109-14. 2003
    ..Unlike morphine, which reduces response to UCD by spinal and supraspinal mechanisms and whose action is blocked by estrogen, the cyclooxygenase inhibitor, ketorolac acts at an estrogen-independent, non spinal site...
  58. ncbi request reprint Inhibitory M2 muscarinic receptors are upregulated in both axotomized and intact small diameter dorsal root ganglion cells after peripheral nerve injury
    K I Hayashida
    Department of Anesthesiology and Center for the Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuroscience 140:259-68. 2006
    ....
  59. ncbi request reprint Estrogen reduces efficacy of mu- but Not kappa-opioid agonist inhibition in response to uterine cervical distension
    Andreas Sandner-Kiesling
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:375-9. 2002
    ..With use of a novel model of uterine cervical distension nociception in rats, the estrogen dependency of opioid agonist-induced inhibition was investigated...
  60. ncbi request reprint The antinociceptive effects of spinal cyclooxygenase inhibitors on uterine cervical distension
    Dongping Du
    Pain Mechanism Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Brain Res 1024:130-6. 2004
    ..None of the inhibitors altered hemodynamic response to uterine cervical distension. The study suggests that targeting spinal COX-2 could be useful to treat transient and acute visceral pain from the uterine cervix...
  61. ncbi request reprint Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor
    Yong Zhang
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 102:416-20. 2005
    ..Therefore, using a controlled, blinded study design, the authors tested intrathecal morphine efficacy in rats with peripheral nerve injury and the role of spinal A1 adenosine receptors in the action of morphine...
  62. ncbi request reprint Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury
    Hideaki Obata
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 100:1258-62. 2004
    ..Here, the authors tested whether this same dependence was present in the acute setting of hypersensitivity after surgery...
  63. ncbi request reprint Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism
    Bridgette A Clayton
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 106:1019-25. 2007
    ..Here, the authors tested whether donepezil, a central nervous system penetrant cholinesterase inhibitor with a low incidence of gastrointestinal side effects, would relieve hypersensitivity in an animal model of neuropathic pain...
  64. pmc Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for the Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 136:348-55. 2008
    ....
  65. pmc Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
    Ken ichiro Hayashida
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 109:1077-84. 2008
    ..The authors hypothesized that gabapentin activates noradrenergic neurons in the locus coeruleus (LC) by a local action...
  66. pmc Neostigmine decreases bupivacaine use by patient-controlled epidural analgesia during labor: a randomized controlled study
    Vernon H Ross
    Departments of Anesthesiology, Wake Forest University School of Medicine, North Carolina 27157, USA
    Anesth Analg 109:524-31. 2009
    ..We therefore tested the hypothesis that epidural neostigmine in combination with bupivacaine by continuous infusion during labor would reduce the amount of bupivacaine required...
  67. ncbi request reprint Pharmacology of opioid and nonopioid analgesics in chronic pain states
    T J Martin
    Department of Physiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Pharmacol Exp Ther 299:811-7. 2001
    ..Additional models of chronic pain, particularly visceral pain, have been developed; however, the pharmacology of these models is not well established at this time...
  68. pmc Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats
    Ken ichiro Hayashida
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 1317:80-6. 2010
    ....
  69. ncbi request reprint Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain
    E Alfonso Romero-Sandoval
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    J Neurosci 25:8988-94. 2005
    ....
  70. ncbi request reprint Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain
    Weiya Ma
    Pain Mechanism Laboratory, Department of Anaesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Eur J Neurosci 15:1037-47. 2002
    ....
  71. ncbi request reprint Age-dependent responses to nerve injury-induced mechanical allodynia
    Douglas G Ririe
    Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Anesthesiology 104:344-50. 2006
    ....
  72. ncbi request reprint Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury
    Xiaoying Zhu
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Anesthesiology 99:1175-9. 2003
    ..The current study was undertaken to determine whether COX-1 was altered in this model...
  73. ncbi request reprint Multifactorial preoperative predictors for postcesarean section pain and analgesic requirement
    Peter H Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 104:417-25. 2006
    ..The study aimed to determine predictive factors for postcesarean pain and analgesia using an assessment of pain threshold and suprathreshold thermal stimuli as well as degree of somatization and anxiety...
  74. ncbi request reprint Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Anesthesiology 103:629-37. 2005
    ..The following studies were undertaken to determine how surgery influences food-reinforced behavior in rats and to determine the relevance of afferent input from the incision site on this behavior...
  75. ncbi request reprint Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain
    Steven R Childers
    Department of Physiology Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurochem 93:715-23. 2005
    ..These results suggest a mechanism of allosteric modulators to increase the number of activated G-proteins per receptor, and provide a neuroanatomical basis for understanding potential therapeutic effects of such drugs...
  76. ncbi request reprint Clonidine-induced neuronal activation in the spinal cord is altered after peripheral nerve injury
    Carlo Pancaro
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 98:748-53. 2003
    ....
  77. ncbi request reprint Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice
    Weiya Ma
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Brain Res 970:110-8. 2003
    ....
  78. ncbi request reprint Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac
    Weiya Ma
    Pain Mechanisms Laboratory, Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity, Wake Forest University School of Medicine, wisnton Salem, North Carolina 27157 1009, USA
    Anesthesiology 98:203-8. 2003
    ....
  79. ncbi request reprint Uterine cervical distension induces cFos expression in deep dorsal horn neurons of the rat spinal cord
    Chuanyao Tong
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 99:205-11. 2003
    ..The authors examined uterine cervical distension-evoked cFos immunoreactivity in rat spinal cords, and the inhibitory effect of spinal cyclo-oxygenase inhibition on cFos expression...
  80. ncbi request reprint Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Anesthesiology 101:191-203. 2004
    ..Analgesics display a number of limiting side effects, including sedation, cognitive impairment, and ileus. Although several postoperative rodent models have been developed, these models do not address these concerns...
  81. ncbi request reprint Immunocytochemical localization of the alpha3, alpha4, alpha5, alpha7, beta2, beta3 and beta4 nicotinic acetylcholine receptor subunits in the locus coeruleus of the rat
    Michelle A Vincler
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 974:25-36. 2003
    ..These data are consistent with the presence of multiple nAChRs within the LC and extend these findings to show the distribution pattern of each nAChR subunit throughout the LC nucleus...
  82. ncbi request reprint Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation
    Weiya Ma
    Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Exp Neurol 183:581-92. 2003
    ..Our data suggest that following PSNL, PGE2 is one of the possible PGs overproduced in injured nerve and PG overproduction is involved in the up-regulation of EP receptors in injured nerve...
  83. ncbi request reprint Knock down of the alpha 5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia
    Michelle A Vincler
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pharmacol Biochem Behav 80:135-43. 2005
    ..These results suggest that the increased expression of the alpha5 nAChR subunit following SNL contributes to spinal CREB phosphorylation and the maintenance of mechanical allodynia...
  84. ncbi request reprint Intrathecal ketorolac reverses hypersensitivity following acute fentanyl exposure
    Yoo Jin Kang
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Anesthesiology 97:1641-4. 2002
  85. ncbi request reprint Age-dependent responses to thermal hyperalgesia and mechanical allodynia in a rat model of acute postoperative pain
    Douglas G Ririe
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 99:443-8. 2003
    ..The purpose of the present study was to examine postoperative responses in rats of developmental ages paralleling the infant to young adult human...
  86. ncbi request reprint Treating and preventing chronic pain: a view from the spinal cord--Bonica Lecture, ASRA Annual Meeting, 2005
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Reg Anesth Pain Med 31:146-51. 2006
  87. ncbi request reprint Role of adenosine receptors in spinal G-protein activation after peripheral nerve injury
    Carsten Bantel
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:1443-9. 2002
    ..In this study the authors used [(35)S]guanosine-5'-O-(3-thiotriphosphate) ([(35)S]GTP gamma S) autoradiography in rat spinal cord sections to test this possibility...
  88. ncbi request reprint Plasticity of spinal nicotinic acetylcholine receptors following spinal nerve ligation
    Michelle Vincler
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neurosci Res 48:139-45. 2004
    ..We propose that the increased expression of the alpha3 and alpha5 nicotinic subunits may contribute to the mechanical hypersensitivity observed following spinal nerve ligation...
  89. pmc Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information
    K T Martucci
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Pain 153:1232-43. 2012
    ....
  90. ncbi request reprint 0.125% ropivacaine is similar to 0.125% bupivacaine for labor analgesia using patient-controlled epidural infusion
    M D Owen
    Department of Anesthesiology, The Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 86:527-31. 1998
    ..We conclude that 0.125% ropivacaine and bupivacaine are clinically indistinguishable and are both highly effective for labor analgesia using PCEA...
  91. ncbi request reprint Does dextrose affect analgesia or the side effects of intrathecal sufentanil?
    J C Gage
    Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 85:826-30. 1997
    ..In contrast, patient position had no effect on analgesia or side effects in patients receiving i.t. sufentanil in saline. I.t. dextrose alone had no effect...
  92. pmc Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Physiol 518:857-66. 1999
    ..4. Collectively, this study provides important in vivo evidence that protons contribute to activation/sensitization of cardiac sympathetic C-fibre afferents during myocardial ischaemia...
  93. pmc The puerperium alters spinal cord plasticity following peripheral nerve injury
    S Gutierrez
    Department of Anesthesiology, Wake Forest School of Medicine, Winston Salem, NC 27157 1009, USA
    Neuroscience 228:301-8. 2013
    ..These results suggest a change in the descending inhibitory/facilitating balance on spinal nociception neurotransmission during the puerperium, as mechanisms for its protective effect against injury-induced hypersensitivity...
  94. ncbi request reprint Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord
    Carsten Bantel
    Department of Anesthesiology, University of Munster, Germany
    Brain Res 1038:76-82. 2005
    ..These data suggest that the increased potency of clonidine in neuropathic pain could reflect increased efficiency of G-protein coupling from spinal alpha2-adrenergic receptors...
  95. ncbi request reprint Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury
    Patricia M Lavand'homme
    Department of Anesthesiology and Pain Clinic, Hôpital St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Anesthesiology 97:972-80. 2002
    ..In contrast to this notion, peripheral alpha(2)-adrenoceptor stimulation fails to induce pain in patients with chronic pain. We hypothesized that alpha(2) adrenoceptors at the site of nerve injury play an inhibitory, not excitatory role...
  96. ncbi request reprint Preventing chronic pain after surgery: who, how, and when?
    James C Eisenach
    Reg Anesth Pain Med 31:1-3. 2006
  97. ncbi request reprint Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury
    Xavier Paqueron
    Department of Anesthesiology, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Anesthesiology 99:199-204. 2003
    ..The authors examined cholinergic receptor involvement in thermal and mechanical sensitivity in normal and neuropathic animals and its interaction with intrathecal clonidine...
  98. ncbi request reprint Intraspinal adenosine induces spinal cord norepinephrine release in spinal nerve-ligated rats but not in normal or sham controls
    Carsten Bantel
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Munster, Munster, Germany
    Anesthesiology 98:1461-6. 2003
    ..The purpose of this study was to test whether spinal adenosine induces norepinephrine release selectively in settings of hypersensitivity...
  99. ncbi request reprint Intrathecal clonidine for postoperative analgesia in elderly patients: the influence of baricity on hemodynamic and analgesic effects
    Amir Baker
    Department of Anesthesiology and General Intensive Care, University of Vienna, Vienna, Austria
    Anesth Analg 99:128-34. 2004
    ..05). Sedation scores did not differ between groups. We conclude that increasing the baricity of IT clonidine solution in the conditions of our experiment reduces hemodynamic side effects but also analgesia from IT administered clonidine...
  100. ncbi request reprint Pharmacology of opioid inhibition to noxious uterine cervical distension
    Andreas Sandner-Kiesling
    Department of Anesthesiology and Intensive Care Medicine, Karl Franzens University, Graz, Austria
    Anesthesiology 97:966-71. 2002
    ..The authors examined the pharmacology of opioid agonist inhibition in visceral pain related to the uterine cervix, the source of labor pain...
  101. ncbi request reprint Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Pain 7:816-22. 2006
    ..Spinal cord glial activation contributes to the mechanical hypersensitivity that develops after hind paw incision...