J C Eisenach

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:29-34. 2002
  2. ncbi Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:24-8. 2002
  3. ncbi Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia
    J C Eisenach
    Department of Anesthesiology, Wake Forest University Medical Center, Winston Salem, NC 27157 1009, USA
    Pain 84:57-64. 2000
  4. ncbi Antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, MPV-2426, in sheep
    J C Eisenach
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 91:1425-36. 1999
  5. ncbi Severity of acute pain after childbirth, but not type of delivery, predicts persistent pain and postpartum depression
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 140:87-94. 2008
  6. ncbi Dose response of intrathecal adenosine in experimental pain and allodynia
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salen, North Carolina 27157, USA
    Anesthesiology 97:938-42. 2002
  7. ncbi Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Pain 101:89-95. 2003
  8. ncbi alpha2-adrenoceptors inhibit the intracellular Ca2+ response to electrical stimulation in normal and injured sensory neurons, with increased inhibition of calcitonin gene-related peptide expressing neurons after injury
    J C Eisenach
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuroscience 131:189-97. 2005
  9. ncbi Phase I safety assessment of intrathecal ketorolac
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 99:599-604. 2002
  10. ncbi Role of spinal cyclooxygenase in human postoperative and chronic pain
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 112:1225-33. 2010

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. ncbi Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:29-34. 2002
    ..The purpose of this study was to screen for efficacy of a different formulation of adenosine marketed in the US, using both acute noxious stimulation and capsaicin-evoked mechanical hypersensitivity...
  2. ncbi Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 96:24-8. 2002
    ..We performed a phase I safety trial of intrathecal injection of the American formulation of adenosine, which lacks mannitol...
  3. ncbi Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia
    J C Eisenach
    Department of Anesthesiology, Wake Forest University Medical Center, Winston Salem, NC 27157 1009, USA
    Pain 84:57-64. 2000
    ....
  4. ncbi Antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, MPV-2426, in sheep
    J C Eisenach
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 91:1425-36. 1999
    ..This study determined the antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, MPV-2426, in sheep...
  5. ncbi Severity of acute pain after childbirth, but not type of delivery, predicts persistent pain and postpartum depression
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 140:87-94. 2008
    ..In contrast, the severity of the acute pain response to childbirth predicts persistent morbidity, suggesting the need to more carefully address pain treatment in the days following childbirth...
  6. ncbi Dose response of intrathecal adenosine in experimental pain and allodynia
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salen, North Carolina 27157, USA
    Anesthesiology 97:938-42. 2002
    ..We studied two doses of intrathecal adenosine in humans with experimental hypersensitivity and the ability of the adenosine receptor antagonist, aminophylline, to reverse adenosine's effects...
  7. ncbi Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Pain 101:89-95. 2003
    ..These limited data support the hypothesis that human visceral afferents express KOR and that peripherally restricted KOR agonists produce analgesia in patients with chronic visceral pain...
  8. ncbi alpha2-adrenoceptors inhibit the intracellular Ca2+ response to electrical stimulation in normal and injured sensory neurons, with increased inhibition of calcitonin gene-related peptide expressing neurons after injury
    J C Eisenach
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuroscience 131:189-97. 2005
    ..There is a shift in phenotype of sensory neurons which are inhibited by clonidine after nerve injury, which may explain clonidine's increased potency in the treatment of neuropathic compared with acute pain...
  9. ncbi Phase I safety assessment of intrathecal ketorolac
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 99:599-604. 2002
    ..There were no long-term side effects 6 months after study. These data suggest that intrathecal ketorolac does not produce a high incidence of serious adverse events, and they support further investigation for analgesia...
  10. ncbi Role of spinal cyclooxygenase in human postoperative and chronic pain
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 112:1225-33. 2010
    ..Animal studies suggest that these drugs act, in part, by blocking prostaglandin production in the spinal cord. The authors tested intrathecal ketorolac in patients with chronic or postoperative pain...
  11. ncbi Cephalad movement of morphine and fentanyl in humans after intrathecal injection
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 99:166-73. 2003
    ..The purpose of this study was to examine differences between two often used opioids, morphine and fentanyl, in distribution in the CSF after intrathecal injection...
  12. ncbi Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 105:65-70. 2003
    ..Given the modest effect and common side effects, the role for intrathecal adenosine as a sole agent for the treatment of neuropathic pain may be limited...
  13. ncbi Effects of intrathecal ketorolac on human experimental pain
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 112:1216-24. 2010
    ..We used a spinal injection of small doses of the cyclooxygenase inhibitor ketorolac to survey the role of spinal cyclooxygenase in human experimental pain and hypersensitivity states...
  14. ncbi Cystatin C in cerebrospinal fluid is not a diagnostic test for pain in humans
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 107:207-12. 2004
    ..These data suggest that cystatin C concentration in cerebrospinal fluid is an unreliable diagnostic marker for pain in humans...
  15. ncbi Intrathecal but not intravenous opioids release adenosine from the spinal cord
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    J Pain 5:64-8. 2004
    ..Whether adenosine participates in analgesia from spinal opioids in humans is not known, but spinal adenosine itself is analgesic in humans, consistent with an opioid-adenosine role in analgesia...
  16. ncbi Interaction between intrathecal neostigmine and epidural clonidine in human volunteers
    D D Hood
    Department of Anesthesia, Wake Forest University Medical Center, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 85:315-25. 1996
    ..The purpose of the current study was to examine the interaction between intrathecal neostigmine and epidural clonidine for analgesia and side effects in humans...
  17. ncbi Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, North Carolina 27157 1009, USA
    Anesthesiology 106:557-62. 2007
    ..Here, the authors tested the role of spinal noradrenergic inhibition in gabapentin's analgesia for postoperative pain...
  18. ncbi Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats
    Thomas J Martin
    Department of Physiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1009, USA
    Pain 113:376-85. 2005
    ..Differences in drug potency could reflect fundamental differences in outcome measures or in the surgical procedures themselves. These data support combination study of intrathecal morphine and ketorolac for postoperative pain...
  19. ncbi Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Anesthesiology 106:1213-9. 2007
    ....
  20. ncbi P75-expressing elements are necessary for anti-allodynic effects of spinal clonidine and neostigmine
    X Paqueron
    Pain Mechanisms Laboratory of the Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1009, USA
    Neuroscience 102:681-6. 2001
    ....
  21. ncbi Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury
    Alfonso Romero-Sandoval
    Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
    Anesthesiology 104:351-5. 2006
    ....
  22. ncbi Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats
    H L Pan
    Department of Anesthesiology, Physiology, and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    J Pharmacol Exp Ther 288:1026-30. 1999
    ..This action may contribute, at least in part, to the antiallodynic effect of gabapentin on neuropathic pain...
  23. ncbi Morphine-induced spinal cholinergic activation: in vivo imaging with positron emission tomography
    H D Gage
    Division of Radiologic Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1061, USA
    Pain 91:139-45. 2001
    ..Following preclinical screening, PET scanning with [(18)F]FBT may be useful to investigate mechanisms of analgesic action in normal humans and in those with pain...
  24. ncbi Role of spinal NO in antiallodynic effect of intrathecal clonidine in neuropathic rats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 89:1518-23. 1998
    ..The objectives of this study were to assess the role of spinal NO in maintenance of allodynia and to determine the role of spinal NO in the antiallodynic effect of intrathecal clonidine...
  25. ncbi Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation
    Weiya Ma
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 1127:52-8. 2007
    ....
  26. ncbi Morphine-induced spinal release of adenosine is reduced in neuropathic rats
    A Sandner-Kiesling
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA
    Anesthesiology 95:1455-9. 2001
    ....
  27. ncbi Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain
    J K Cheng
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 92:1126-31. 2000
    ....
  28. ncbi Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors
    Yoo-Jin Kang
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Anesth Analg 96:1403-8, table of contents. 2003
    ..These data in animals suggest that spinal m4 type muscarinic receptors are important to the effect of clonidine in treating hypersensitivity to touch after nerve injury...
  29. ncbi Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats
    Hideaki Obata
    Department of Anesthesiology and Center for the Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
    Pain 113:271-6. 2005
    ..Finally, these data suggest that intrathecal administration of Xen2174 at the time of spinal anesthesia might produce postoperative analgesia in humans...
  30. ncbi Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis
    Alfonso Romero-Sandoval
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Behav Immun 21:569-80. 2007
    ..This early effect likely underlies the delayed anti-inflammatory and anti-hypersensitivity effects of perineural clonidine in this setting...
  31. ncbi Intrathecal neostigmine and sufentanil for early labor analgesia
    K E Nelson
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27103, USA
    Anesthesiology 91:1293-8. 1999
    ..In this study, the authors used intrathecal neostigmine in combination with intrathecal sufentanil to investigate the usefulness of neostigmine for reducing side effects and prolonging the duration of sufentanil...
  32. ncbi Effects of intrathecal neostigmine, bupivacaine, and their combination on sympathetic nerve activity in rats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 88:481-6. 1998
    ..The current study examined directly the interaction of intrathecal injection of bupivacaine and neostigmine on splanchnic sympathetic efferent nerve activity...
  33. ncbi Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans
    J C Eisenach
    Department of Anesthesia, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina, USA
    Anesthesiology 86:1279-87. 1997
    ....
  34. ncbi Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation
    W Ma
    Pain Mechanism Laboratory, Department of Anesthesiology and Center for the Study of Pharmacological Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuroscience 121:681-90. 2003
    ....
  35. ncbi An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury
    X Paqueron
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
    Anesthesiology 94:1074-81. 2001
    ....
  36. ncbi Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine
    Weiya Ma
    Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1009, USA
    Pain 113:386-94. 2005
    ....
  37. ncbi Intrathecal morphine reduces the visceromotor response to acute uterine cervical distension in an estrogen-independent manner
    Sang-Wook Shin
    Department of Anesthesiology and Center for the Study of Pharmacological Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA
    Anesthesiology 98:1467-71; discussion 6A. 2003
    ....
  38. ncbi Perineural clonidine reduces p38 mitogen-activated protein kinase activation in sensory neurons
    Baogang Liu
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Neuroreport 17:1313-7. 2006
    ..These data suggest that activation of alpha2-adrenoceptors at the site of nerve injury, probably by immune modulation, reduces intracellular signaling in primary afferents that leads to hypersensitivity...
  39. ncbi Assessment of behavior during labor in rats and effect of intrathecal morphine
    Chuanyao Tong
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 108:1081-6. 2008
    ..To address this, the authors classified and quantified spontaneous behaviors during labor and delivery in rats and examined the effects of a known analgesic, intrathecal morphine...
  40. ncbi Epidural fentanyl produces labor analgesia by a spinal mechanism
    R D'ANGELO
    Department of Anesthesiology, The Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina, USA
    Anesthesiology 88:1519-23. 1998
    ..The purpose of this study was to determine if epidural fentanyl produces analgesia in laboring patients by a primary spinal or supraspinal action...
  41. ncbi The vascular mechanism of ephedrine's beneficial effect on uterine perfusion during pregnancy
    C Tong
    Department of Anesthesia, Wake Forest University Medical Center, Winston Salem, North Carolina 27157 1009
    Anesthesiology 76:792-8. 1992
    ....
  42. ncbi Chronic intrathecal morphine administration produces homologous mu receptor/G-protein desensitization specifically in spinal cord
    C E Maher
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
    Brain Res 895:1-8. 2001
    ..t. morphine treatment were observed in brain sections. These data show that homologous desensitization of mu receptor/G-protein coupling occurs specifically in spinal cord following chronic morphine administration...
  43. ncbi Allosteric adenosine modulation to reduce allodynia
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA
    Anesthesiology 95:416-20. 2001
    ..Although obvious adverse effects were not observed in this investigation, further study is required to determine the feasibility of the use of such modulators in the treatment of chronic pain associated with hyperalgesia and allodynia...
  44. ncbi Intrathecal clonidine alleviates allodynia in neuropathic rats: interaction with spinal muscarinic and nicotinic receptors
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 90:509-14. 1999
    ..The current study determined the role of spinal muscarinic and nicotinic receptors in the antiallodynic effect of intrathecally administered clonidine in spinal nerve-ligated rats...
  45. ncbi Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury
    W Ma
    Pain Mechanism Laboratory, Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Neuroscience 121:691-704. 2003
    ..Our data strongly suggest that during the initial several months after nerve injury, peripherally over-produced prostaglandins play an important role in the maintenance of neuropathic pain...
  46. ncbi The monoamine reuptake inhibitor milnacipran does not affect nociception to acute visceral distension in rats
    Sang-Wook Shin
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Anesth Analg 98:1365-9, table of contents. 2004
    ..IMPLICATIONS: Neither intrathecal nor i.v. milnacipran, a monoamine reuptake inhibitor, inhibits an acute visceral pain response induced by colorectal or uterine cervical distension...
  47. ncbi Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran
    Sang-Wook Shin
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Anesthesiology 100:671-5. 2004
    ..Lack of efficacy of the antidepressant milnacipran against visceral stimuli suggests that visceral hypersensitivity may not share the same pharmacology of inhibition as somatic hypersensitivity after nerve injury...
  48. ncbi Intrathecal ketorolac enhances antinociception from clonidine
    Dawn R Conklin
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Anesth Analg 96:191-4, table of contents. 2003
    ....
  49. ncbi Hyperexcitability of axotomized and neighboring unaxotomized sensory neurons is reduced days after perineural clonidine at the site of injury
    Baogang Liu
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    J Neurophysiol 94:3159-67. 2005
    ....
  50. ncbi Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding
    Carsten Bantel
    Department of Anesthesiology, Wake Forst University Schhol of Medicine, Winston-Salem, North Carolina 27157, USA
    Anesthesiology 96:103-8. 2002
    ....
  51. ncbi Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain
    Carine Dalle
    Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1009, USA
    Reg Anesth Pain Med 30:243-8. 2005
    ..CONCLUSIONS: The current study shows that peripheral block of I h produces an antiallodynic effect, which suggests that I h channels represent a novel target for nerve block treatment of postoperative and neuropathic pain...
  52. ncbi Phase I human safety assessment of intrathecal neostigmine containing methyl- and propylparabens
    J C Eisenach
    Department of Anesthesia, Bowman Gray School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 85:842-6. 1997
    ..These data are important to the clinical use of this new therapy...
  53. ncbi Pregnancy and ephedrine increase the release of nitric oxide in ovine uterine arteries
    P Li
    Department of Anesthesia, Wake Forest University Medical Center, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 82:288-93. 1996
    ....
  54. ncbi alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes
    X Li
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA
    J Pharmacol Exp Ther 299:939-44. 2001
    ....
  55. ncbi Analgesia induced by perineural clonidine is enhanced in persistent neuritis
    Alfonso Romero Sandoval
    Department of Anesthesiology and Center for Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1009, USA
    Neuroreport 18:67-71. 2007
    ..These data support treatment strategies with alpha2-adrenoceptor agonists in persistent neuritis...
  56. ncbi Adenosine reduces glutamate release in rat spinal synaptosomes
    Xinhui Li
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Anesthesiology 103:1060-5. 2005
    ..This effect is unaltered after peripheral nerve injury and thereby is unlikely to account for the enhanced analgesic efficacy of intrathecal adenosine in this setting...
  57. ncbi Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats
    Sang-Wook Shin
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
    Pain 105:109-14. 2003
    ..Unlike morphine, which reduces response to UCD by spinal and supraspinal mechanisms and whose action is blocked by estrogen, the cyclooxygenase inhibitor, ketorolac acts at an estrogen-independent, non spinal site...
  58. ncbi Inhibitory M2 muscarinic receptors are upregulated in both axotomized and intact small diameter dorsal root ganglion cells after peripheral nerve injury
    K-I Hayashida
    Department of Anesthesiology and Center for the Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
    Neuroscience 140:259-68. 2006
    ....
  59. ncbi Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor
    Yong Zhang
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Anesthesiology 102:416-20. 2005
    ....
  60. ncbi Estrogen reduces efficacy of mu- but Not kappa-opioid agonist inhibition in response to uterine cervical distension
    Andreas Sandner-Kiesling
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Anesthesiology 96:375-9. 2002
    ..In addition, these data suggest that kappa-opioid agonists may be effective in the treatment of pain originating from the uterine cervix, regardless of estrogen status...
  61. ncbi Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for the Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 136:348-55. 2008
    ....
  62. ncbi Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
    Ken ichiro Hayashida
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 109:1077-84. 2008
    ..The authors hypothesized that gabapentin activates noradrenergic neurons in the locus coeruleus (LC) by a local action...
  63. ncbi Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism
    Bridgette A Clayton
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 106:1019-25. 2007
    ..Here, the authors tested whether donepezil, a central nervous system penetrant cholinesterase inhibitor with a low incidence of gastrointestinal side effects, would relieve hypersensitivity in an animal model of neuropathic pain...
  64. ncbi The antinociceptive effects of spinal cyclooxygenase inhibitors on uterine cervical distension
    Dongping Du
    Pain Mechanism Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
    Brain Res 1024:130-6. 2004
    ..None of the inhibitors altered hemodynamic response to uterine cervical distension. The study suggests that targeting spinal COX-2 could be useful to treat transient and acute visceral pain from the uterine cervix...
  65. ncbi Neostigmine decreases bupivacaine use by patient-controlled epidural analgesia during labor: a randomized controlled study
    Vernon H Ross
    Departments of Anesthesiology, Wake Forest University School of Medicine, North Carolina 27157, USA
    Anesth Analg 109:524-31. 2009
    ..We therefore tested the hypothesis that epidural neostigmine in combination with bupivacaine by continuous infusion during labor would reduce the amount of bupivacaine required...
  66. ncbi Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury
    Hideaki Obata
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
    Anesthesiology 100:1258-62. 2004
    ..These results indicate that, after surgery, T62 acts via a mechanism different from that of spinal nerve ligation, a model of chronic neuropathic pain...
  67. ncbi Pharmacology of opioid and nonopioid analgesics in chronic pain states
    T J Martin
    Department of Physiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Pharmacol Exp Ther 299:811-7. 2001
    ..Additional models of chronic pain, particularly visceral pain, have been developed; however, the pharmacology of these models is not well established at this time...
  68. ncbi Age-dependent responses to nerve injury-induced mechanical allodynia
    Douglas G Ririe
    Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Anesthesiology 104:344-50. 2006
    ....
  69. ncbi Clonidine-induced neuronal activation in the spinal cord is altered after peripheral nerve injury
    Carlo Pancaro
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Anesthesiology 98:748-53. 2003
    ....
  70. ncbi Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain
    E Alfonso Romero-Sandoval
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA
    J Neurosci 25:8988-94. 2005
    ....
  71. ncbi Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac
    Weiya Ma
    Pain Mechanisms Laboratory, Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity, Wake Forest University School of Medicine, wisnton Salem, North Carolina 27157 1009, USA
    Anesthesiology 98:203-8. 2003
    ....
  72. ncbi Treating and preventing chronic pain: a view from the spinal cord--Bonica Lecture, ASRA Annual Meeting, 2005
    James C Eisenach
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Reg Anesth Pain Med 31:146-51. 2006
  73. ncbi Intrathecal ketorolac reverses hypersensitivity following acute fentanyl exposure
    Yoo-Jin Kang
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
    Anesthesiology 97:1641-4. 2002
  74. ncbi Multifactorial preoperative predictors for postcesarean section pain and analgesic requirement
    Peter H Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 104:417-25. 2006
    ..The study aimed to determine predictive factors for postcesarean pain and analgesia using an assessment of pain threshold and suprathreshold thermal stimuli as well as degree of somatization and anxiety...
  75. ncbi Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain
    Weiya Ma
    Pain Mechanism Laboratory, Department of Anaesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Eur J Neurosci 15:1037-47. 2002
    ....
  76. ncbi Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Anesthesiology 103:629-37. 2005
    ..The following studies were undertaken to determine how surgery influences food-reinforced behavior in rats and to determine the relevance of afferent input from the incision site on this behavior...
  77. ncbi Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice
    Weiya Ma
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Brain Res 970:110-8. 2003
    ....
  78. ncbi Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation
    Weiya Ma
    Department of Anesthesiology, and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Exp Neurol 183:581-92. 2003
    ..Our data suggest that following PSNL, PGE2 is one of the possible PGs overproduced in injured nerve and PG overproduction is involved in the up-regulation of EP receptors in injured nerve...
  79. ncbi Plasticity of spinal nicotinic acetylcholine receptors following spinal nerve ligation
    Michelle Vincler
    Department of Anesthesiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neurosci Res 48:139-45. 2004
    ..We propose that the increased expression of the alpha3 and alpha5 nicotinic subunits may contribute to the mechanical hypersensitivity observed following spinal nerve ligation...
  80. ncbi Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats
    Ken ichiro Hayashida
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 1317:80-6. 2010
    ....
  81. ncbi Age-dependent responses to thermal hyperalgesia and mechanical allodynia in a rat model of acute postoperative pain
    Douglas G Ririe
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 99:443-8. 2003
    ..The purpose of the present study was to examine postoperative responses in rats of developmental ages paralleling the infant to young adult human...
  82. ncbi Uterine cervical distension induces cFos expression in deep dorsal horn neurons of the rat spinal cord
    Chuanyao Tong
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesthesiology 99:205-11. 2003
    ..The authors examined uterine cervical distension-evoked cFos immunoreactivity in rat spinal cords, and the inhibitory effect of spinal cyclo-oxygenase inhibition on cFos expression...
  83. ncbi Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Anesthesiology 101:191-203. 2004
    ..Analgesics display a number of limiting side effects, including sedation, cognitive impairment, and ileus. Although several postoperative rodent models have been developed, these models do not address these concerns...
  84. ncbi Knock down of the alpha 5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia
    Michelle A Vincler
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pharmacol Biochem Behav 80:135-43. 2005
    ..These results suggest that the increased expression of the alpha5 nAChR subunit following SNL contributes to spinal CREB phosphorylation and the maintenance of mechanical allodynia...
  85. ncbi Immunocytochemical localization of the alpha3, alpha4, alpha5, alpha7, beta2, beta3 and beta4 nicotinic acetylcholine receptor subunits in the locus coeruleus of the rat
    Michelle A Vincler
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 974:25-36. 2003
    ..These data are consistent with the presence of multiple nAChRs within the LC and extend these findings to show the distribution pattern of each nAChR subunit throughout the LC nucleus...
  86. ncbi Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury
    Xiaoying Zhu
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Anesthesiology 99:1175-9. 2003
    ..The current study was undertaken to determine whether COX-1 was altered in this model...
  87. ncbi Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain
    Steven R Childers
    Department of Physiology Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurochem 93:715-23. 2005
    ..These results suggest a mechanism of allosteric modulators to increase the number of activated G-proteins per receptor, and provide a neuroanatomical basis for understanding potential therapeutic effects of such drugs...
  88. ncbi Role of adenosine receptors in spinal G-protein activation after peripheral nerve injury
    Carsten Bantel
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Anesthesiology 96:1443-9. 2002
    ..The data suggest that increased adenosine release during conditions of SNL results in an increased basal activity of G proteins in the spinal cord during neuropathic pain...
  89. ncbi Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information
    K T Martucci
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Pain 153:1232-43. 2012
    ....
  90. ncbi 0.125% ropivacaine is similar to 0.125% bupivacaine for labor analgesia using patient-controlled epidural infusion
    M D Owen
    Department of Anesthesiology, The Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 86:527-31. 1998
    ..125% ropivacaine and 0.125% bupivacaine. We conclude that these two drugs are clinically indistinguishable at this concentration...
  91. ncbi Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Physiol 518:857-66. 1999
    ..4. Collectively, this study provides important in vivo evidence that protons contribute to activation/sensitization of cardiac sympathetic C-fibre afferents during myocardial ischaemia...
  92. ncbi Does dextrose affect analgesia or the side effects of intrathecal sufentanil?
    J C Gage
    Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 85:826-30. 1997
    ....
  93. ncbi Did experimenter bias conceal the efficacy of spinal opioids in previous studies with the spinal nerve ligation model of neuropathic pain?
    James C Eisenach
    Anesthesiology 100:765-7. 2004
  94. ncbi Intrathecal clonidine for postoperative analgesia in elderly patients: the influence of baricity on hemodynamic and analgesic effects
    Amir Baker
    Department of Anesthesiology and General Intensive Care, University of Vienna, Vienna, Austria
    Anesth Analg 99:128-34. 2004
    ..05). Sedation scores did not differ between groups. We conclude that increasing the baricity of IT clonidine solution in the conditions of our experiment reduces hemodynamic side effects but also analgesia from IT administered clonidine...
  95. ncbi Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury
    Xavier Paqueron
    Department of Anesthesiology, , Paris, France
    Anesthesiology 99:199-204. 2003
    ..These results do not favor a regulation of nociceptive transmission by a tonic release of acetylcholine in nerve-injured rats...
  96. ncbi Preventing chronic pain after surgery: who, how, and when?
    James C Eisenach
    Reg Anesth Pain Med 31:1-3. 2006
  97. ncbi Intraspinal adenosine induces spinal cord norepinephrine release in spinal nerve-ligated rats but not in normal or sham controls
    Carsten Bantel
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Munster, Munster, Germany
    Anesthesiology 98:1461-6. 2003
    ....
  98. ncbi ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors
    Laura S Stone
    Faculty of Dentistry, McGill Centre for Research on Pain, 3640 University Street, Montreal, Quebec H3A 2B2, Canada
    J Pharmacol Exp Ther 323:899-906. 2007
    ..The unique profile of ST91 may be advantageous in pain management...
  99. ncbi Spinal adrenergic and cholinergic receptor interactions activated by clonidine in postincisional pain
    Frederic Duflo
    Department of Anesthesiology and Intensive Care Medicine, hôpital de l Hôtel dieu, Lyon, 69288 cedex 02, France
    Anesthesiology 98:1237-42. 2003
    ..The current study sought to determine the subtype of alpha(2) adrenoceptors activated by clonidine in a rodent model for human postoperative pain, and to examine its interaction with spinal cholinergic receptors...
  100. ncbi Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord
    Carsten Bantel
    Department of Anesthesiology, University of Munster, Germany
    Brain Res 1038:76-82. 2005
    ..These data suggest that the increased potency of clonidine in neuropathic pain could reflect increased efficiency of G-protein coupling from spinal alpha2-adrenergic receptors...
  101. ncbi Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury
    Weiya Ma
    Department of Anesthesiology and Pain Clinic, Hopital St. Luc, Universite Catholique de Louvain, Brussels, Belgium
    Anesthesiology 97:972-80. 2002
    ....