Jasmin Divers

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Correcting for measurement error in individual ancestry estimates in structured association tests
    Jasmin Divers
    Center for Public Health Genomics, Department of Biostatistical Sciences, Division of Public Health Services, Wake Forest University Health Sciences, Winston Salem, North Carolina 27101, USA
    Genetics 176:1823-33. 2007
  2. pmc Comparing self-reported ethnicity to genetic background measures in the context of the Multi-Ethnic Study of Atherosclerosis (MESA)
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest University School of Medicine Winston Salem, North Carolina 27157, USA
    BMC Genet 12:28. 2011
  3. pmc The genetic architecture of lipoprotein subclasses in Gullah-speaking African American families enriched for type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR)
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 51:586-97. 2010
  4. pmc Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 27:1505-11. 2012
  5. pmc Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 82:805-11. 2012
  6. pmc Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD
    Barry I Freedman
    1Internal Medicine Nephrology, 2Biochemistry, 3Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 24:3366-71. 2009
  7. pmc Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study
    Thomas C Register
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 98:1916-22. 2013
  8. pmc Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR)
    Michele M Sale
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
    Diabetes 58:260-7. 2009
  9. pmc Genome-wide association of BMI in African Americans
    Maggie C Y Ng
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 20:622-7. 2012
  10. pmc A genome-wide association search for type 2 diabetes genes in African Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 7:e29202. 2012

Detail Information

Publications43

  1. pmc Correcting for measurement error in individual ancestry estimates in structured association tests
    Jasmin Divers
    Center for Public Health Genomics, Department of Biostatistical Sciences, Division of Public Health Services, Wake Forest University Health Sciences, Winston Salem, North Carolina 27101, USA
    Genetics 176:1823-33. 2007
    ..Our results show that the quadratic measurement error correction (QMEC) method performs better than the other methods and maintains the type I error to its nominal level...
  2. pmc Comparing self-reported ethnicity to genetic background measures in the context of the Multi-Ethnic Study of Atherosclerosis (MESA)
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest University School of Medicine Winston Salem, North Carolina 27157, USA
    BMC Genet 12:28. 2011
    ..We compare the agreement between SRE and genetic based measures of ancestry (GBMA), and conduct simulation studies based on observed MESA data to evaluate the performance of each measure under various conditions...
  3. pmc The genetic architecture of lipoprotein subclasses in Gullah-speaking African American families enriched for type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR)
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 51:586-97. 2010
    ....
  4. pmc Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 27:1505-11. 2012
    ..We tested for association of single nucleotide polymorphisms (SNPs) in MYH9 with T2DM-ESRD in European Americans; additionally, three APOL1 gene variants were evaluated...
  5. pmc Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 82:805-11. 2012
    ..After adjustment, two APOL1 risk variants weakly predict mild forms of kidney disease. Second hits appear necessary for the initiation of APOL1-associated nephropathy...
  6. pmc Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD
    Barry I Freedman
    1Internal Medicine Nephrology, 2Biochemistry, 3Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 24:3366-71. 2009
    ....
  7. pmc Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study
    Thomas C Register
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 98:1916-22. 2013
    ..Adipokines vary in relation to changes in body composition and may play roles in regulation of BMD and risk of cardiovascular disease...
  8. pmc Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR)
    Michele M Sale
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
    Diabetes 58:260-7. 2009
    ..Affected relative pairs with type 2 diabetes were recruited through the Sea Islands Genetic African American Registry (Project SuGAR)...
  9. pmc Genome-wide association of BMI in African Americans
    Maggie C Y Ng
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 20:622-7. 2012
    ..Further replication and meta-analysis in African Americans and other populations will shed light on the role of these loci in different ethnic populations...
  10. pmc A genome-wide association search for type 2 diabetes genes in African Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 7:e29202. 2012
    ..These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations...
  11. pmc Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans
    Barry I Freedman
    Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    PLoS Genet 7:e1002150. 2011
    ..These analyses reveal a role for FRMD3 in AA T2DN susceptibility and accounting for c22 nephropathy risk variants can assist in detecting DN susceptibility genes...
  12. pmc Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study
    Mariana Murea
    Department of Internal Medicine Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1053, USA
    BMC Nephrol 13:148. 2012
    ..Relationships between serum MCP-1 concentration and early nephropathy and subclinical cardiovascular disease (CVD) were assessed in African Americans (AAs) with type 2 diabetes (T2D)...
  13. pmc Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 29:626-32. 2009
    ....
  14. pmc Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 26:3805-10. 2011
    ..Plasma HDL particle subclass concentrations were compared in 73 African Americans based on APOL1 genotypes to detect differences potentially contributing to renal disease...
  15. pmc Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping
    Caitrin W McDonough
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Genet 126:805-17. 2009
    ..0017; OR (95% CI) = 0.65 (0.50-0.85)]. Collectively, these results suggest that multiple genes in this region may influence diabetic nephropathy susceptibility in AAs...
  16. pmc Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes
    Thomas C Register
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 98:E60-5. 2013
    ..Plasma DKK1, BMD in the spine, and CP in three arterial beds were assessed in African-Americans (AAs) to determine relationships of serum DKK1 with atherosclerotic vascular calcification...
  17. doi request reprint Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes
    Jasmin Divers
    Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    J Bone Miner Res 26:1554-60. 2011
    ..This relationship was independent of conventional CVD risk factors and supports the hypothesis that bone metabolism and atherosclerotic plaque mineralization are related processes...
  18. pmc Regional adipose tissue associations with calcified atherosclerotic plaque: African American-diabetes heart study
    Jasmin Divers
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 18:2004-9. 2010
    ..004). As in European Americans, PAT is associated with CP in African Americans with type 2 diabetes. Ethnic differences in the relationships between organ-specific adipose tissue depots and atherosclerosis require further study...
  19. pmc Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study
    Jasmin Divers
    Department of Public Health Sciences, Center for Diabetes Research, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
    J Clin Endocrinol Metab 95:5382-9. 2010
    ..Because pericardial adipose tissue (PAT) is associated with CP in the neighboring coronary arteries, we explored ethnic-specific relationships between PAT and CP...
  20. pmc The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 32:66-72. 2010
    ..Since MYH9 underlies approximately 40% of end-stage renal disease (ESRD) in AA, we tested for genetic association with LN...
  21. pmc Population ancestry and genetic risk for diabetes and kidney, cardiovascular, and bone disease: modifiable environmental factors may produce the cures
    Barry I Freedman
    Department of Internal Medicine Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC Center for Human Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC Electronic address
    Am J Kidney Dis 62:1165-75. 2013
    ..The present era of precision medicine will couple one's genetic makeup with specific therapies to reduce rates of disease based on the presence of disease-specific alleles. ..
  22. pmc Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus
    Jasmin Divers
    Departments of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
    Circ Cardiovasc Genet 6:97-105. 2013
    ....
  23. pmc Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 124:147-54. 2008
    ..This study presents exploratory analyses of the impact of admixture on studies of AA with T2DM-ESRD and supports the use of ancestral proportions as a means of reducing confounding effects due to admixture...
  24. pmc Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans
    Joshua P Lewis
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Genomics 96:211-9. 2010
    ..0018-0.041). Mediation testing revealed that 30-40% of the effects of these SNPs on T2D were significantly mediated by BMI. SNPs near PREX1 may contribute to T2D susceptibility mediated through effects of adiposity in European Americans...
  25. pmc Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: the African American-diabetes heart study
    Jasmin Divers
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes Care 33:131-8. 2010
    ..We explored ethnicity-specific relationships between albuminuria and calcified plaque involving the infrarenal aorta, coronary artery, and carotid artery in 835 European American and 393 African American subjects with type 2 diabetes...
  26. pmc Gene-gene interactions in APOL1-associated nephropathy
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 29:587-94. 2014
    ..Forty-two potentially interactive single nucleotide polymorphisms (SNPs) from a genome-wide association study in non-diabetic ESKD were tested for interaction with APOL1 to identify genes modifying risk for non-diabetic nephropathy...
  27. pmc Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants
    Isai Gopalakrishnan
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Hum Pathol 42:291-4. 2011
    ....
  28. pmc Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans
    Barry I Freedman
    Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 75:736-45. 2009
    ..Our study shows that gene-environment and/or gene-gene interactions may initiate kidney disease in genetically susceptible individuals, because African Americans homozygous for MYH9 risk alleles do not universally develop kidney disease...
  29. pmc JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Kidney Int 84:1207-13. 2013
    ....
  30. pmc Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes
    Mariana Murea
    Department of Internal Medicine, Section on Nephrology, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 33:502-9. 2011
    ..African-Americans (AAs) with diabetes have high incidence rates of end-stage renal disease (ESRD) with associated high mortality. Genetic factors modulating the risk of mortality on dialysis are poorly understood...
  31. pmc Susceptibility genes in common complex kidney disease
    Jasmin Divers
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Curr Opin Nephrol Hypertens 19:79-84. 2010
    ..A brief overview of methods for identifying gene variants is provided, along with genetic associations and new avenues under exploration...
  32. pmc Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Sidharth A Shah
    Section on Cardiology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Ann Noninvasive Electrocardiol 18:29-40. 2013
    ..We used the Multi-Ethnic Study of Atherosclerosis to examine association of QT with NOS1AP variants in an ethnically diverse cohort...
  33. pmc Correlates of coronary artery calcified plaque in blacks and whites with type 2 diabetes
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Ann Epidemiol 21:34-41. 2011
    ..To examine whether the relationship between cardiovascular disease risk factors and coronary artery calcification (CAC) is modified by race among those with diabetes...
  34. pmc Sickle cell trait is not independently associated with susceptibility to end-stage renal disease in African Americans
    Pamela J Hicks
    Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina, USA 27157 1053
    Kidney Int 80:1339-43. 2011
    ..05) in dominant models. In addition, no evidence of APOL1 or MYH9 interactions with sickle cell trait was detected. Hence, sickle cell trait is not associated with diabetic or non-diabetic ESRD in a large sample of African Americans...
  35. pmc Vitamin d, adiposity, and calcified atherosclerotic plaque in african-americans
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
    J Clin Endocrinol Metab 95:1076-83. 2010
    ..Prospective trials are needed to determine the cardiovascular effects of supplemental vitamin D in this ethnic group...
  36. pmc A genome-wide association study for diabetic nephropathy genes in African Americans
    Caitrin W McDonough
    Program in Molecular Medicine and Translational Science, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Kidney Int 79:563-72. 2011
    ..Thus, our results suggest that multiple loci underlie susceptibility to kidney disease in African Americans with type 2 diabetes and some may also contribute to all-cause ESRD...
  37. ncbi request reprint Genetic admixture: a tool to identify diabetic nephropathy genes in African Americans
    Jasmin Divers
    Division of Public Health Sciences, Department of Biostatistical Sciences, Section on Statistical Genetics and Bioinformatics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Ethn Dis 18:384-8. 2008
    ....
  38. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  39. pmc Relationships between electrochemical skin conductance and kidney disease in Type 2 diabetes
    Barry I Freedman
    Department of Internal Medicine Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC, USA Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA Center for Diabetes Research, Wake Forest School of Medicine, Winston Salem, NC, USA Electronic address
    J Diabetes Complications 28:56-60. 2014
    ..Since neuropathy and nephropathy are microvascular Type 2 diabetes (T2D) complications, relationships between skin conductance, estimated glomerular filtration rate (eGFR), and urine albumin:creatinine ratio (UACR) were assessed...
  40. pmc Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies
    Joshua P Lewis
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 57:2220-5. 2008
    ..Our objective was to examine the influence of type 2 diabetes genes identified in whole-genome association studies in a large African American case-control population...
  41. pmc Genetics in kidney disease in 2013: Susceptibility genes for renal and urological disorders
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Nat Rev Nephrol 10:69-70. 2014
    ..The new findings will lead to an increased understanding of the pathophysiology of these diseases, improved risk prediction and the development of novel therapies...
  42. pmc Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model
    David T Redden
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Genet 2:e137. 2006
    ....
  43. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
    ....