Research Topics
Species | Jingzhong DingSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Publications
The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)Jingzhong Ding
Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
Am J Clin Nutr 90:499-504. 2009..Cross-sectional studies suggest that pericardial fat is positively associated with coronary artery disease independent of total body fat...
The association of pericardial fat with calcified coronary plaqueJingzhong Ding
Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Obesity (Silver Spring) 16:1914-9. 2008..Pericardial fat has a higher secretion of inflammatory cytokines than subcutaneous fat. Cytokines released from pericardial fat around coronary arteries may act locally on the adjacent cells...- Association between non-subcutaneous adiposity and calcified coronary plaque: a substudy of the Multi-Ethnic Study of AtherosclerosisJingzhong Ding
Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Clin Nutr 88:645-50. 2008..Excessive non-subcutaneous fat deposition may impair the functions of surrounding tissues and organs through the release of inflammatory cytokines and free fatty acids... 
Effects of birth cohort and age on body composition in a sample of community-based elderlyJingzhong Ding
Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Clin Nutr 85:405-10. 2007..The effect of the recent obesity epidemic on body composition remains unknown. Furthermore, age-related changes in body composition are still unclear...- Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or strokeJingzhong Ding
Department of Internal Medicine Geriatrics, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
Am Heart J 152:1109-15. 2006..We investigated the association of polymorphisms and common haplotypes of the PAI-1 gene with plasma PAI-1 levels, as well as the risk of myocardial infarction and stroke... - The association of regional fat depots with hypertension in older persons of white and African American ethnicityJingzhong Ding
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
Am J Hypertens 17:971-6. 2004..Fat distribution has been shown to be a strong correlate of hypertension, independent of general obesity. However, population-based studies are lacking on the association of regional fat depots with hypertension... - Overweight and obesity over the adult life course and incident mobility limitation in older adults: the health, aging and body composition studyDenise K Houston
Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1207, USA
Am J Epidemiol 169:927-36. 2009..0001) on risk of mobility limitation for the cumulative effect of obesity in men and overweight and/or obesity in women. Onset of overweight and obesity in earlier life contributes to an increased risk of mobility limitation in old age... - Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) StudyDenise K Houston
Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157 1207, USA
Am J Clin Nutr 87:150-5. 2008..Dietary surveys suggest that many older, community-dwelling adults consume insufficient dietary protein, which may contribute to the age-related loss of lean mass (LM)... - Liver attenuation, pericardial adipose tissue, obesity, and insulin resistance: the Multi-Ethnic Study of Atherosclerosis (MESA)Paul A McAuley
Department of Human Performance and Sport Sciences, Winston Salem State University, Winston Salem, North Carolina, USA
Obesity (Silver Spring) 19:1855-60. 2011..10 ± 0.01 for whites, 0.11 ± 0.02 for Chinese, 0.08 ± 0.2 for blacks, and 0.14 ± 0.01 for Hispanics. Liver attenuation and pericardial adipose tissue were associated with insulin resistance, independent of BMI and waist circumference... - Does the amount of fat mass predict age-related loss of lean mass, muscle strength, and muscle quality in older adults?Annemarie Koster
National Institute on Aging, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
J Gerontol A Biol Sci Med Sci 66:888-95. 2011..We therefore examined the association of baseline total body fat with changes in leg lean mass, muscle strength, and muscle quality over 7 years of follow-up and whether this link was explained by adipocytokines and insulin resistance... - Abdominal obesity is an independent risk factor for chronic heart failure in older peopleBarbara J Nicklas
Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Am Geriatr Soc 54:413-20. 2006..To examine whether total and abdominal adiposity are risk factors for the development of chronic heart failure (CHF) in older men and women... - Association between carotid intima-media thickness and pericardial fat in the Multi-Ethnic Study of Atherosclerosis (MESA)Elsayed Z Soliman
Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, North Carolina 27104, USA
J Stroke Cerebrovasc Dis 19:58-65. 2010..We sought to examine the association between carotid IMT and PF, and to examine whether such an association is independent from common atherosclerosis risk factors including measures of overall adiposity... - Pericardial fat and atrial conduction abnormalities in the Multiethnic Study of Atherosclerosis (MESA)Michael J Babcock
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Obesity (Silver Spring) 19:179-84. 2011..Among Pfat, BMI and WC, BMI had the most robust association with P-wave indexes. These findings raise doubts about potential local effects of Pfat on atrial electrophysiology and morphology... - Diabetes, hyperglycemia, and inflammation in older individuals: the health, aging and body composition studyNathalie de Rekeneire
Laboratory of Epidemiology, National Institute on Aging, Bethesda, MD 20892 9205, USA
Diabetes Care 29:1902-8. 2006..The objective of this study was to assess the association of inflammation with hyperglycemia (impaired fasting glucose [IFG]/impaired glucose tolerance [IGT]) and diabetes in older individuals... - Intraperitoneal fat is associated with thickening of the thoracic aorta in individuals at high risk for cardiovascular eventsHaroon L Chughtai
Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
Obesity (Silver Spring) 19:1784-90. 2011..03). Elevated IP fat volume is associated with an increase in ascending AOWT, a condition that promotes CV events in middle aged and elderly adults... - Pericardial fat loss in postmenopausal women under conditions of equal energy deficitTina E Brinkley
Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Med Sci Sports Exerc 43:808-14. 2011..Weight loss induced by caloric restriction (CR) or aerobic exercise can reduce pericardial fat, and these reductions may help improve cardiovascular health... - Inflammatory markers and onset of cardiovascular events: results from the Health ABC studyMatteo Cesari
Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Circulation 108:2317-22. 2003..CONCLUSIONS: Findings suggest that inflammatory markers are independent predictors of cardiovascular events in older persons... - Regional adipose tissue associations with calcified atherosclerotic plaque: African American-diabetes heart studyJasmin Divers
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Obesity (Silver Spring) 18:2004-9. 2010..004). As in European Americans, PAT is associated with CP in African Americans with type 2 diabetes. Ethnic differences in the relationships between organ-specific adipose tissue depots and atherosclerosis require further study... - Renal sinus fat and poor blood pressure control in middle-aged and elderly individuals at risk for cardiovascular eventsHaroon L Chughtai
Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, NC, USA
Hypertension 56:901-6. 2010..These results indicate that further studies are warranted to determine whether fat accumulation in the RS promotes hypertension... - Weight change and cognitive function: findings from the Women's Health Initiative Study of Cognitive AgingIra Driscoll
Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
Obesity (Silver Spring) 19:1595-600. 2011..Relationships were largely independent of initial BMI, self-reported caloric intake or dieting. The lack of associations between weight gain and cognition in women is consistent with the existing literature... - Comparison of methods to measure heart size using noncontrast-enhanced computed tomography: correlation with left ventricular massKurt R Daniel
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Comput Assist Tomogr 32:934-41. 2008..Left ventricular (LV) mass is a useful independent predictor of cardiovascular events. We sought to develop a new correlate of LV mass using noncontrast-enhanced cardiac computed tomography (NCE-CCT)... - Individual pathogens, pathogen burden and markers of subclinical atherosclerosis: the Multi-Ethnic Study of AtherosclerosisMoyses Szklo
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
J Cardiovasc Med (Hagerstown) 10:747-51. 2009..A random sample of 1056 individuals chosen from 5030 Multi-Ethnic Study of Atherosclerosis cohort participants were included... - Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudyLenore J Launer
Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Lancet Neurol 10:969-77. 2011..People with type 2 diabetes are at risk of cognitive impairment and brain atrophy. We aimed to compare the effects on cognitive function and brain volume of intensive versus standard glycaemic control... - The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposityTongjian You
Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY 14214, USA
J Gerontol A Biol Sci Med Sci 63:414-9. 2008..The purpose of this study was to examine the relationship of metabolic syndrome to several adipokines and the role of total and visceral adiposity in influencing this relationship in older adults... - Kidney function as a predictor of loss of lean mass in older adults: health, aging and body composition studyLinda F Fried
Renal Section, Veterans Affairs Pittsburgh Healthcare System Pittsburgh, Pennsylvania 15240, USA
J Am Geriatr Soc 55:1578-84. 2007..To assess the association between kidney function and change in body composition in older individuals... - 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumoniaSachin Yende
CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 176:1129-37. 2007..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown... - Racial disparity in long-term mortality rate after hospitalization for myocardial infarction: the Atherosclerosis Risk in Communities studyJingzhong Ding
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Am Heart J 146:459-64. 2003..This study examined the racial disparity in mortality rates after MI and possible explanatory factors... - Alcohol intake and cerebral abnormalities on magnetic resonance imaging in a community-based population of middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) studyJingzhong Ding
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room 6009, Baltimore, MD 21205, USA
Stroke 35:16-21. 2004..We examined the associations of alcohol intake with MRI-defined cerebral abnormalities in a middle-aged, population-based cohort... - Serum leptin concentrations and body adipose measures in older black and white adultsConstance E Ruhl
Social and Scientific Systems, Inc, 8758 Georgia Avenue, Silver Spring, MD 20910, USA
Am J Clin Nutr 80:576-83. 2004..Among US adults, serum leptin concentrations are higher in women than in men and are higher in blacks than in whites independent of anthropometric measures of body fatness... - Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women: the atherosclerosis risk in communities studySherita Hill Golden
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Epidemiol 160:540-8. 2004..001). Higher FAI was associated with the hyperinsulinemia and hyperglycemia components of the metabolic syndrome. The role of androgens in glucose homeostasis in postmenopausal women requires further study... - Left ventricular mass indexed to height and prevalent MRI cerebrovascular disease in an African American cohort: the Atherosclerotic Risk in Communities studyErvin R Fox
NHLBI Jackson Heart Study, Mississippi, USA
Stroke 36:546-50. 2005..Despite the greater burden of stroke, the echocardiographic predictors of stroke in African Americans remain poorly understood... - Skin tissue cholesterol assay correlates with presence of coronary calciumDhananjay Vaidya
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
Atherosclerosis 181:167-73. 2005..CONCLUSIONS: SkTC was associated with the presence of CAC independently of serum lipids/lipoproteins in Caucasians but not African-Americans. SkTC may provide a useful indicator of subclinical atherosclerosis in Caucasians... - Metabolic syndrome and the risk of cardiovascular disease in older adultsJaved Butler
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
J Am Coll Cardiol 47:1595-602. 2006..The purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults... - Chronic kidney disease and functional limitation in older people: health, aging and body composition studyLinda F Fried
Department of Veterans Affairs Pittsburgh Healthcare System, University Drive, Pittsburgh, PA 15240, USA
J Am Geriatr Soc 54:750-6. 2006..To assess whether chronic kidney disease (CKD) is independently associated with incident physical-function limitation... - Body mass index and serum leptin concentration independently estimate percentage body fat in older adultsConstance E Ruhl
Social and Scientific Systems Inc, Silver Spring, MD, USA
Am J Clin Nutr 85:1121-6. 2007.... - Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition studyChristina L Wassel Fyr
Department of Epidemiology, University of Minnesota, Minneapolis, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454 1015, USA
Hum Genet 121:615-24. 2007..The association with adiponectin became stronger after adjustment for adiposity. These novel findings suggest that admixture mapping may identify genetic factors influencing the levels of IL-6 SR, CRP, IL-2 SR, and adiponectin... - Aspirin use for the primary prevention of coronary heart disease in older adultsNicolas Rodondi
Department of Epidemiology and Biostatistics, University of California, San Francisco, Calif, USA
Am J Med 118:1288. 2005..We determined the prevalence of aspirin use in relation to coronary heart disease risk and changes over time... - A prospective analysis of risk factors for white matter disease in the brain stem: the Cardiovascular Health StudyJingzhong Ding
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Room W6009, Baltimore, MD 21205, USA
Neuroepidemiology 22:275-82. 2003..However, no epidemiologic study has examined the associations between cardiovascular risk factors and WMD in the brain stem... - Associations of sleep-disordered breathing and cerebral changes on MRIJohn Robbins
Department of Medicine, University of California Davis, Sacramento, CA 95817, USA
J Clin Sleep Med 1:159-65. 2005..This study tested the significance of associations of SDB with evidence of brain injury or ischemia determined by cerebral magnetic resonance imaging (MRI) studies... - Sleep-disordered breathing and white matter disease in the brainstem in older adultsJingzhong Ding
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Sleep 27:474-9. 2004..To examine whether sleep-disordered breathing is associated with white matter disease in the brainstem... - Associations between two common polymorphisms in the ABCA1 gene and subclinical atherosclerosis: Multi-Ethnic Study of Atherosclerosis (MESA)Jeana L Benton
The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Atherosclerosis 193:352-60. 2007..We examined these associations in a sample of Multi-Ethnic Study of Atherosclerosis (MESA) participants... - Smoking, diabetes, and blood cholesterol differ in their associations with subclinical atherosclerosis: the Multiethnic Study of Atherosclerosis (MESA)A Richey Sharrett
The Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, 615N Wolfe St, Room E6518, Baltimore, MD 21205, USA
Atherosclerosis 186:441-7. 2006..Diabetes contributes uniquely to arterial stiffness... - Endogenous postmenopausal hormones and carotid atherosclerosis: a case-control study of the atherosclerosis risk in communities cohortSherita Hill Golden
Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, MD 21205, USA
Am J Epidemiol 155:437-45. 2002..20, 0.74). The authors found higher total testosterone and SHBG to be inversely related to carotid atherosclerosis, suggesting their potential importance in reducing atherosclerotic risk in postmenopausal women not using HRT...
Research Grants
- Pericardial fat and subclinical and clinical measures of coronary heart diseaseJingzhong Ding; Fiscal Year: 2009..Given the health impact of coronary heart disease, there is a pressing need to examine the relationship between pericardial fat and coronary heart disease. ..
- Pericardial fat and subclinical and clinical measures of coronary heart diseaseJingzhong Ding; Fiscal Year: 2009..Given the health impact of coronary heart disease, there is a pressing need to examine the relationship between pericardial fat and coronary heart disease. ..