Zheng Cui

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi The effect of aging on cellular immunity against cancer in SR/CR mice
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Immunol Immunother 53:473-8. 2004
  2. ncbi Novel innate cancer killing activity in humans
    Michael J Blanks
    Molecular Genetics and Genomics Program, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina, 27157, USA
    Cancer Cell Int 11:26. 2011
  3. ncbi Phosphatidylcholine and cell death
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1016, USA
    Biochim Biophys Acta 1585:87-96. 2002
  4. ncbi Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 100:6682-7. 2003
  5. ncbi The winding road to the discovery of the SR/CR mice
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Cancer Immun 3:14. 2003
  6. ncbi The spectrum of resistance in SR/CR mice: the critical role of chemoattraction in the cancer/leukocyte interaction
    Gregory Riedlinger
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina, 27157, USA
    BMC Cancer 10:179. 2010
  7. ncbi Cancer resistance of SR/CR mice in the genetic knockout backgrounds of leukocyte effector mechanisms: determinations for functional requirements
    Anne M Sanders
    Department of Pathology, Wake Forest University School of Medicine Winston Salem, North Carolina, USA
    BMC Cancer 10:121. 2010
  8. ncbi Impact of sex, MHC, and age of recipients on the therapeutic effect of transferred leukocytes from cancer-resistant SR/CR mice
    John R Stehle
    Department of Pathology, Wake Forest University School of Medicine Winston Salem, North Carolina 27157, USA
    BMC Cancer 9:328. 2009
  9. ncbi Transferable anticancer innate immunity in spontaneous regression/complete resistance mice
    Amy M Hicks
    Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 103:7753-8. 2006
  10. ncbi Effector mechanisms of the anti-cancer immune responses of macrophages in SR/CR mice
    Amy M Hicks
    Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Cancer Immun 6:11. 2006

Research Grants

  1. REGULATION OF POLYPLOIDY BY CYTIDYLYLTRANSFERASE (CT)
    Zheng Cui; Fiscal Year: 2002
  2. Spontaneous regression of late-stage tumors in mice
    Zheng Cui; Fiscal Year: 2003

Collaborators

Detail Information

Publications20

  1. ncbi The effect of aging on cellular immunity against cancer in SR/CR mice
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Immunol Immunother 53:473-8. 2004
    ..In this article, we summarize the lessons learned from these mice and discuss possible implications of these findings in our understanding of the effects of aging on the immunity against cancer...
  2. ncbi Novel innate cancer killing activity in humans
    Michael J Blanks
    Molecular Genetics and Genomics Program, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina, 27157, USA
    Cancer Cell Int 11:26. 2011
    ..abstract:..
  3. ncbi Phosphatidylcholine and cell death
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1016, USA
    Biochim Biophys Acta 1585:87-96. 2002
    ..This review summarizes recent progress in understanding the relationship between PC homeostasis and cell death...
  4. ncbi Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 100:6682-7. 2003
    ..The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer...
  5. ncbi The winding road to the discovery of the SR/CR mice
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Cancer Immun 3:14. 2003
  6. ncbi The spectrum of resistance in SR/CR mice: the critical role of chemoattraction in the cancer/leukocyte interaction
    Gregory Riedlinger
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina, 27157, USA
    BMC Cancer 10:179. 2010
    ..This resistance is effective against sarcoma 180 (S180) at exceptionally high doses and these mice remain healthy...
  7. ncbi Cancer resistance of SR/CR mice in the genetic knockout backgrounds of leukocyte effector mechanisms: determinations for functional requirements
    Anne M Sanders
    Department of Pathology, Wake Forest University School of Medicine Winston Salem, North Carolina, USA
    BMC Cancer 10:121. 2010
    ..This was tested by cross breeding SR/CR mice into the individual genetic knockout backgrounds of perforin (Prf-/-), superoxide (Cybb-/), or inducible nitric oxide (Nos2-/)...
  8. ncbi Impact of sex, MHC, and age of recipients on the therapeutic effect of transferred leukocytes from cancer-resistant SR/CR mice
    John R Stehle
    Department of Pathology, Wake Forest University School of Medicine Winston Salem, North Carolina 27157, USA
    BMC Cancer 9:328. 2009
    ..In the current studies, we investigated factors that may impact the efficacy and functionality of SR/CR donor leukocytes in recipients...
  9. ncbi Transferable anticancer innate immunity in spontaneous regression/complete resistance mice
    Amy M Hicks
    Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 103:7753-8. 2006
    ....
  10. ncbi Effector mechanisms of the anti-cancer immune responses of macrophages in SR/CR mice
    Amy M Hicks
    Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Cancer Immun 6:11. 2006
    ..In summary, purified SR/CR macrophages killed cancer cells in a non-ADCC manner via apoptosis induced by ROS and serine proteases...
  11. ncbi Mass spectrometry identification of circulating alpha-1-B glycoprotein, increased in aged female C57BL/6 mice
    John R Stehle
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Biochim Biophys Acta 1770:79-86. 2007
    ..These results suggest that alpha(1)B-glycoprotein changes in mice in a sex and age dependent manner...
  12. ncbi Disruption of choline methyl group donation for phosphatidylethanolamine methylation in hepatocarcinoma cells
    Cynthia J DeLong
    Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    J Biol Chem 277:17217-25. 2002
    ..The failure to use choline as a methyl source in hepatocarcinoma cells may contribute to methionine dependence, a widely observed aberration of one-carbon metabolism in malignancy...
  13. ncbi Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry
    Amy M Hicks
    Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Biochim Biophys Acta 1761:1022-9. 2006
    ..More importantly, these profiles may also set reference points for studying changes of GPL metabolism in different physiological and pathological conditions...
  14. ncbi Halo naevus: a visible case of immunosurveillance in humans?
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, NC, USA
    Lancet Oncol 5:397-8. 2004
  15. ncbi Polyploid formation via chromosome duplication induced by CTP:phosphocholine cytidylyltransferase deficiency and Bcl-2 overexpression: identification of two novel endogenous factors
    You-Jun Shen
    Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27599-7525, USA
    J Histochem Cytochem 53:725-33. 2005
    ..This conversion was irreversible even when both initiating factors were removed. In this study, we have identified Bcl-2 as a positive regulator and CTalpha as a negative regulator of polyploid formation...
  16. ncbi In situ immunocytochemical detection of altered membrane composition induced by cell-cell contact in cultured mammalian cells
    Wei Du
    Tumor Biology Section, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Microsc Res Tech 71:749-59. 2008
    ....
  17. ncbi Phospholipid profiling by tandem mass spectrometry
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2709-15. 2009
    ..This review discusses how to analyze glycerophospholipids from simple lipid extracts without preliminary chromatographic separation. The analytical method emphasized in the review is electrospray ionization with tandem mass spectrometry...
  18. ncbi Metabolipidomics: profiling metabolism of glycerophospholipid species by stable isotopic precursors and tandem mass spectrometry
    Onno B Bleijerveld
    Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, and Institute of Biomembranes, Utrecht University, P.O. Box 80176, 3508 TD, Utrecht, The Netherlands
    Anal Biochem 352:1-14. 2006
  19. ncbi Intracellular assembly of very low density lipoproteins containing apolipoprotein B100 in rat hepatoma McA-RH7777 cells
    Khai Tran
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    J Biol Chem 277:31187-200. 2002
    ..Taken together, these results suggest that VLDL assembly in McA-RH7777 cells takes place in compartments at the distal end of the secretory pathway...
  20. ncbi Human surfactant protein B promoter in transgenic mice: temporal, spatial, and stimulus-responsive regulation
    Marlene Strayer
    Division of Neonatology, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 282:L394-404. 2002
    ....

Research Grants8

  1. REGULATION OF POLYPLOIDY BY CYTIDYLYLTRANSFERASE (CT)
    Zheng Cui; Fiscal Year: 2002
    ..A better understanding of the mechanism that underlines the genome instability in cancer cells will be helpful for designing more efficient strategies of treating cancer. ..
  2. Spontaneous regression of late-stage tumors in mice
    Zheng Cui; Fiscal Year: 2003
    ..Necessary tools will be developed to extend these studies to search for similar genes in humans and to design better, more efficient strategies of cancer treatment and prevention. ..