Scott Cramer

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta
    Paul Cao
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Cancer 9:108. 2010
  2. ncbi request reprint The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II
    S D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Mol Genet 8:2063-9. 1999
  3. doi request reprint Association of prostate-specific antigen promoter genotype with clinical and histopathologic features of prostate cancer
    Scott D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 17:2451-7. 2008
  4. ncbi request reprint Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels
    Scott D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Natl Cancer Inst 95:1044-53. 2003
  5. ncbi request reprint Association studies of serum prostate-specific antigen levels and the genetic polymorphisms at the androgen receptor and prostate-specific antigen genes
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 11:664-9. 2002
  6. ncbi request reprint Analysis of G/A polymorphism in the androgen response element I of the PSA gene and its interactions with the androgen receptor polymorphisms
    Anuradha Rao
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Urology 61:864-9. 2003
  7. pmc Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Nephrol Dial Transplant 21:2292-5. 2006
  8. ncbi request reprint 5-Oxo-ETE analogs and the proliferation of cancer cells
    JOSEPH T O'FLAHERTY
    Department of Internal Medicine, Section on Infectious Diseases, Wake Forest University Medical Center, Medical Center Boulevard, Winston Salem, NC 27156, USA
    Biochim Biophys Acta 1736:228-36. 2005
  9. ncbi request reprint Sensitivity of prostate tumors to wild type and M protein mutant vesicular stomatitis viruses
    Maryam Ahmed
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Virology 330:34-49. 2004
  10. ncbi request reprint 5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism
    JOSEPH T O'FLAHERTY
    Department of Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27156, USA
    Cancer Res 62:6817-9. 2002

Research Grants

Collaborators

Detail Information

Publications25

  1. pmc MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta
    Paul Cao
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Cancer 9:108. 2010
    ..In addition, the expression of miR-101 alters upon androgen treatment and HIF-1alpha/HIF-1beta induction...
  2. ncbi request reprint The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II
    S D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Mol Genet 8:2063-9. 1999
    ..The data we present will facilitate future genetic testing to confirm the clinical diagnosis of PH2. These data will also facilitate heterozygote testing and prenatal testing in families affected with PH2 to aid in genetic counseling...
  3. doi request reprint Association of prostate-specific antigen promoter genotype with clinical and histopathologic features of prostate cancer
    Scott D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 17:2451-7. 2008
    ..15-36.49], presence of any Gleason grade 4/5 cancer (OR, 4.26; 95% CI, 1.30-14.00), presence of any intraductal cancer (OR, 1.03; 95% CI, 1.00-1.04), and serum PSA at diagnosis (OR, 2.04; 95% CI, 1.50-2.77)...
  4. ncbi request reprint Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels
    Scott D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Natl Cancer Inst 95:1044-53. 2003
    ..However, polymorphisms associated with variations in PSA levels have not been identified...
  5. ncbi request reprint Association studies of serum prostate-specific antigen levels and the genetic polymorphisms at the androgen receptor and prostate-specific antigen genes
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 11:664-9. 2002
    ..A systematic approach is required to identify sequence variants in these genes and other related genes, and to test for an association between these variants and PSA levels in large samples...
  6. ncbi request reprint Analysis of G/A polymorphism in the androgen response element I of the PSA gene and its interactions with the androgen receptor polymorphisms
    Anuradha Rao
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Urology 61:864-9. 2003
    ..Data are conflicting regarding the association of PSA promoter alleles with serum PSA in men...
  7. pmc Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2
    John Knight
    Department of Urology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Nephrol Dial Transplant 21:2292-5. 2006
    ..In this study, we have evaluated the potential of determining GR and d-glycerate dehydrogenase (DGDH) activity in blood mononuclear cells (BMC) as a diagnostic indicator of PH2...
  8. ncbi request reprint 5-Oxo-ETE analogs and the proliferation of cancer cells
    JOSEPH T O'FLAHERTY
    Department of Internal Medicine, Section on Infectious Diseases, Wake Forest University Medical Center, Medical Center Boulevard, Winston Salem, NC 27156, USA
    Biochim Biophys Acta 1736:228-36. 2005
    ..These results are the first to implicate the OXE receptor in malignant cell growth and to show that 5-oxo-ETEs activate cell death programs as well as PPARgamma independently of this receptor...
  9. ncbi request reprint Sensitivity of prostate tumors to wild type and M protein mutant vesicular stomatitis viruses
    Maryam Ahmed
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Virology 330:34-49. 2004
    ....
  10. ncbi request reprint 5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism
    JOSEPH T O'FLAHERTY
    Department of Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27156, USA
    Cancer Res 62:6817-9. 2002
    ..This novel receptor and the extracellular signal-regulated kinase and Akt pathways it recruits may contribute to the progression of prostate adenocarcinoma...
  11. ncbi request reprint Sequence variants in the human 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) gene are not associated with prostate cancer risk
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 53:175-8. 2002
    ..25-hydroxyvitamin D(3) 1-alpha-hydroxylase, the enzyme that catalyzes the final step of vitamin D synthesis, converting 25-hydroxyvitamin D(3) to 1,25-dihydroxyvitamin D(3), is expressed in the prostate...
  12. ncbi request reprint Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers
    Wennuan Liu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Clin Cancer Res 13:5028-33. 2007
    ..However, candidate prostate tumor suppressor genes in this region have not been identified, in part due to the large and broad nature of the deleted region implicated in previous studies...
  13. pmc A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2
    Tatsuya Takayama
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Nephrol Dial Transplant 22:2371-4. 2007
  14. pmc 1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells
    Linara S Axanova
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 70:1658-71. 2010
    ..We hypothesized that inhibition of the PI3K/AKT pathway synergizes with the antiproliferative signaling of 1,25(OH)(2)D(3)...
  15. ncbi request reprint The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function
    Kristin L Lockett
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Cancer Res 64:6344-8. 2004
    ..This study is the first to provide evidence that the ADPRT V762A-genetic variant contributes to CaP susceptibility and altered ADPRT/PARP-1 enzyme function in response to oxidative damage...
  16. pmc Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells
    Jacqueline Thorburn
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Biol Cell 16:1189-99. 2005
    ..These data identify a novel cell death pathway that combines apoptosis and autophagy and that is selectively inactivated at the earliest stages of epithelial cancer development...
  17. ncbi request reprint Genistein and vitamin D synergistically inhibit human prostatic epithelial cell growth
    Anuradha Rao
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 132:3191-4. 2002
    ..These are the first studies that demonstrate synergism between the prostatic cell growth inhibition elicited by genistein and that elicited by vitamin D compounds...
  18. pmc Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk
    Bao Li Chang
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Mol Genet 18:1368-75. 2009
    ....
  19. ncbi request reprint Glycolate and glyoxylate metabolism in HepG2 cells
    Paul R S Baker
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Physiol Cell Physiol 287:C1359-65. 2004
    ..Expression of AGT2 mRNA in HepG2 cells was confirmed by RT-PCR. These results indicate that HepG2 cells will be useful in clarifying the nonperoxisomal metabolism associated with oxalate synthesis in human hepatocytes...
  20. ncbi request reprint Vitamin D receptor and p21/WAF1 are targets of genistein and 1,25-dihydroxyvitamin D3 in human prostate cancer cells
    Anuradha Rao
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 64:2143-7. 2004
    ..We conclude that one mechanism of synergism between genistein and 1,25(OH)(2)D(3) is through genistein modulation of vitamin D signaling...
  21. pmc Characterization of adult prostatic progenitor/stem cells exhibiting self-renewal and multilineage differentiation
    Wendy W Barclay
    Department of Cancer Biology, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Stem Cells 26:600-10. 2008
    ..These studies are the first to report a reproducible system to assess adult prostatic progenitor/stem cells...
  22. ncbi request reprint Culture of mouse prostatic epithelial cells from genetically engineered mice
    Wendy W Barclay
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 63:291-8. 2005
    ..Progress has been made towards the development of better in vivo rodent genetic models for prostatic disease. However, an in vitro model is often preferred for the elucidation of cellular mechanisms involved in the disease...
  23. ncbi request reprint Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3
    Gary G Schwartz
    Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 25:1015-26. 2004
    ....
  24. ncbi request reprint Growth sensitivity of a recombinant simian virus 5 P/V mutant to type I interferon differs between tumor cell lines and normal primary cells
    Elizabeth K Wansley
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1064, USA
    Virology 335:131-44. 2005
    ..The implications of these results for the use of recombinant paramyxoviruses as vectors are discussed...
  25. pmc A system for studying epithelial-stromal interactions reveals distinct inductive abilities of stromal cells from benign prostatic hyperplasia and prostate cancer
    Wendy W Barclay
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Endocrinology 146:13-8. 2005
    ..Stromal cells derived by this method from areas of BPH and cancer induce epithelial cell growth in vivo, which mimics the natural history of these diseases...

Research Grants11

  1. Tak1, a novel prostate cancer tumor suppressor
    Scott D Cramer; Fiscal Year: 2010
    ..We have identified a potential prostate cancer tumor suppressor gene located on chromosome 6q15, the MAP3K7 gene. Our studies will test if this gene is a prostate cancer tumor suppressor and interrogate its downstream targets. ..
  2. GPHRP KNOCKOUT MOUSE AS A MODEL OF HYPEROXALURIA
    Scott Cramer; Fiscal Year: 2003
    ..A GRHPR knockout mouse that exhibits hyperoxaluria will be useful for the future development of novel therapeutic strategies for PH2 and for elucidating the tissue source(s) of oxalate in PH2 patients. ..
  3. Tak1, a novel prostate cancer tumor suppressor
    Scott Cramer; Fiscal Year: 2009
    ..We have identified a potential prostate cancer tumor suppressor gene located on chromosome 6q15, the MAP3K7 gene. Our studies will test if this gene is a prostate cancer tumor suppressor and interrogate its downstream targets. ..
  4. Vitamin D and Soy Isoflavone Inhibition of Prostate
    Scott Cramer; Fiscal Year: 2007
    ..Our long-term goals are to develop a mechanistic-based chemoprevention strategy that utilizes dietary supplementation with vitamin D and soy isoflavanoid. ..
  5. Mitochondrial GRHPR and Hyperoxaluria
    Scott Cramer; Fiscal Year: 2006
    ..The studies in this proposal could uncover the molecular basis of UncPH, develop new screening tools for PH, and elucidate basic mechanisms that dictate the intracellular targeting of GRHPR. ..
  6. Prostate Specific Antigen and Prostate Ca. Progression
    Scott Cramer; Fiscal Year: 2005
    ..In addition, the identification of PSA as a modulator of prostate cancer aggressiveness may change the way that the PSA test is used for prostate cancer screening. ..
  7. The prostate stem cell is a target of vitamin D chemoprevention
    Scott D Cramer; Fiscal Year: 2010
    ..This project will further our efforts to develop rationale chemoprevention strategies for prostate cancer. ..