Yong Q Chen

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Dietary fat-gene interactions in cancer
    Yong Q Chen
    Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Cancer Metastasis Rev 26:535-51. 2007
  2. pmc Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways
    Yunping Hu
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neoplasia 11:1042-53. 2009
  3. pmc In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids
    Iris J Edwards
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Biol Chem 283:18441-9. 2008
  4. pmc Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer
    Yunping Hu
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Neoplasia 12:826-36. 2010
  5. pmc Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway
    Haiguo Sun
    Department of Pathology, Wake ForestUniversity School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 32:1518-24. 2011
  6. pmc Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer
    Shihua Wang
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Carcinogenesis 33:404-12. 2012
  7. pmc Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Clin Invest 117:1866-75. 2007
  8. pmc APPL proteins FRET at the BAR: direct observation of APPL1 and APPL2 BAR domain-mediated interactions on cell membranes using FRET microscopy
    HEIDI J CHIAL
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 5:e12471. 2010
  9. pmc 1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells
    Linara S Axanova
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 70:1658-71. 2010
  10. pmc Multi-targeted therapy of cancer by omega-3 fatty acids
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States
    Cancer Lett 269:363-77. 2008

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Dietary fat-gene interactions in cancer
    Yong Q Chen
    Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Cancer Metastasis Rev 26:535-51. 2007
    ..The purpose of this review is to present a more cohesive view of dietary fat-gene interactions, and outline a working hypothesis of the intricate connection between fat, genes and cancer...
  2. pmc Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways
    Yunping Hu
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neoplasia 11:1042-53. 2009
    ..Those findings highlight the effectiveness of decorin in the presence of a powerful genetic cancer risk and implicate decorin as a potential new agent for prostate cancer therapy by targeting EGFR/AR-PI3K-Akt pathways...
  3. pmc In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids
    Iris J Edwards
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Biol Chem 283:18441-9. 2008
    ..These findings indicate that syndecan 1 is up-regulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma. This mechanism may contribute to the chemopreventive properties of n-3 fatty acids in prostate cancer...
  4. pmc Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer
    Yunping Hu
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Neoplasia 12:826-36. 2010
    ..The effect of DHA on PDK1/Akt/Bad signaling was abrogated by SDC-1 siRNA. These findings define a mechanism by which SDC-1-dependent suppression of phosphorylation of PDK1/Akt/Bad mediates n-3 PUFA-induced apoptosis in prostate cancer...
  5. pmc Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway
    Haiguo Sun
    Department of Pathology, Wake ForestUniversity School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 32:1518-24. 2011
    ..These data elucidate a pathway whereby SDC-1, upregulated by DHA, induces apoptosis in breast cancer cells through inhibition of MEK/Erk/Bad signaling...
  6. pmc Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer
    Shihua Wang
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Carcinogenesis 33:404-12. 2012
    ..Dietary omega-3 PUFA supplementation in conjunction with androgen ablation may significantly delay the development of castration-resistant prostate cancer in patients compared with androgen ablation alone...
  7. pmc Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Clin Invest 117:1866-75. 2007
    ..Our data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. This study highlights the importance of gene-diet interactions in prostate cancer...
  8. pmc APPL proteins FRET at the BAR: direct observation of APPL1 and APPL2 BAR domain-mediated interactions on cell membranes using FRET microscopy
    HEIDI J CHIAL
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 5:e12471. 2010
    ..Although previous studies have shown that APPL minimal BAR domains associate with curved cell membranes, direct interaction between APPL BAR domains on cell membranes in vivo has not been reported...
  9. pmc 1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells
    Linara S Axanova
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 70:1658-71. 2010
    ..We hypothesized that inhibition of the PI3K/AKT pathway synergizes with the antiproliferative signaling of 1,25(OH)(2)D(3)...
  10. pmc Multi-targeted therapy of cancer by omega-3 fatty acids
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States
    Cancer Lett 269:363-77. 2008
    ..In this review, we discuss the rationale for using long-chain n-3 PUFAs in cancer prevention and treatment and the challenges that such approaches pose in the design of clinical trials...
  11. ncbi request reprint Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation
    Konduru S R Sastry
    Department of Cancer Biology, Section on Comparative Medicine, and Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Biol Chem 282:14094-100. 2007
    ..Antiapoptotic signaling by epinephrine could be one of the mechanisms by which stress promotes tumorigenesis and decreases the efficacy of anti-cancer therapies...
  12. ncbi request reprint 5-Oxo-ETE analogs and the proliferation of cancer cells
    JOSEPH T O'FLAHERTY
    Department of Internal Medicine, Section on Infectious Diseases, Wake Forest University Medical Center, Medical Center Boulevard, Winston Salem, NC 27156, USA
    Biochim Biophys Acta 1736:228-36. 2005
    ..These results are the first to implicate the OXE receptor in malignant cell growth and to show that 5-oxo-ETEs activate cell death programs as well as PPARgamma independently of this receptor...
  13. ncbi request reprint Expression signature of the mouse prostate
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Biol Chem 280:36442-51. 2005
    ..In prostate tumors, interestingly, Cxcl12 was up-regulated in epithelial cells with a concomitant expression of Cxcr4. Expression of both the receptor and ligand may provide an autocrine mechanism for tumor cell migration and invasion...
  14. pmc Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides
    HEIDI J CHIAL
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Traffic 9:215-29. 2008
    ....
  15. pmc Polyunsaturated fatty acid metabolism in prostate cancer
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Cancer Metastasis Rev 30:295-309. 2011
    ....
  16. ncbi request reprint Phytanic acid, AMACR and prostate cancer risk
    Todd Thornburg
    Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Future Oncol 2:213-23. 2006
    ..A greater understanding of such relationships should provide better ways to establish overall risk, to screen for the disease and perhaps to offer specific opportunities for prevention and treatment...
  17. ncbi request reprint Malignant progenitors from patients with CD87+ acute myelogenous leukemia are sensitive to a diphtheria toxin-urokinase fusion protein
    Arthur E Frankel
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Exp Hematol 30:1316-23. 2002
    ..The work also suggests that blast proliferation assays yield similar responses to leukemia colony-forming cell colony assays...
  18. pmc Lipids and prostate cancer
    Janel Suburu
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Prostaglandins Other Lipid Mediat 98:1-10. 2012
    ..Here, we highlight the lipogenic nature of prostate cancer, especially the promotion of de novo lipid synthesis, and the significance of various dietary lipids in prostate cancer development and progression...
  19. ncbi request reprint Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells
    Isabelle M Berquin
    Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
    Oncogene 24:3177-86. 2005
    ..This could represent one of the mechanisms by which YB-1 contributes to breast tumor aggressiveness...
  20. pmc n-3 Polyunsaturated Fatty Acids and their Role in Cancer Chemoprevention
    Zhennan Gu
    State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P R China The Synergistic Innovation Center for Food Safety and Nutrition, Wuxi 214122, P R China Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Curr Pharmacol Rep 1:283-294. 2015
    ..In this review, we discuss inflammation-related cancer, anti-inflammatory effects of n-3 PUFA lipid mediators, antineoplastic activities of n-3 PUFA in vitro and in vivo, and present an update on recent human trials...
  21. ncbi request reprint Differential effects of delivery of omega-3 fatty acids to human cancer cells by low-density lipoproteins versus albumin
    Iris J Edwards
    Department of Pathology, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157, USA
    Clin Cancer Res 10:8275-83. 2004
    ..High FA concentration in LDL and up-regulation of LDL receptors in tumor cells suggest that the LDL receptor pathway may be the major route for FA delivery. We compared effects of n-3FA delivered to human cancer cells by LDL and albumin...
  22. ncbi request reprint Omega-3 fatty acids and cancer risk
    Yong Q Chen
    JAMA 296:282; author reply 282. 2006
  23. ncbi request reprint Mediation of the DCC apoptotic signal by DIP13 alpha
    Jiayou Liu
    Department of Pathology, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 277:26281-5. 2002
    ..Inhibition of endogenous DIP13 alpha expression by small interfering RNA blocks DCC-induced apoptosis. Our data suggest that DIP13 alpha is a mediator of the DCC apoptotic pathway...
  24. ncbi request reprint Analysis of a truncated form of cathepsin H in human prostate tumor cells
    Anuradha Waghray
    Department of Pathology, Barbara Ann Karmanos Cancer Institute and Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 277:11533-8. 2002
    ..Therefore, an increase in overall cathepsin H expression, particularly in the truncated form with a high secretion propensity, may affect cell biological behaviors such as those associated with tumor progression...

Research Grants3

  1. SYSTEMATIC ASSESS OF GENE EXPRESSION IN MOUSE PROSTATE
    Yong Chen; Fiscal Year: 2002
    ..The data should be a rich, valuable resource for devising future genetic targeting, animal modeling and other experiments related to developmental biology in general and prostate cancer in particular. ..
  2. SIGNALING MECHANISM IN DCC-INDUCED APOPTOSIS
    Yong Chen; Fiscal Year: 2003
    ....
  3. Effect of Dietary Omega-3 Fatty Acid Supplement on Prostate Cancer Metastasis
    Yong Chen; Fiscal Year: 2008
    ..Development of cancer in the[unreadable] prostate and metastasis in the lung, inguinal lymph nodes and tibia/femur will be monitored. Tumor burden[unreadable] will be quantified. ..