Douglas Case

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia
    Arthur E Frankel
    Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
    Clin Cancer Res 8:1004-13. 2002
  2. ncbi request reprint Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Lett 190:183-90. 2003
  3. ncbi request reprint Deficient nucleotide excision repair capacity enhances human prostate cancer risk
    Jennifer J Hu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 64:1197-201. 2004
  4. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
  5. pmc Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer--a phase II study
    Shannon K Tomlinson
    Dept of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    BMC Cancer 2:9. 2002
  6. pmc Design of Phase II cancer trials evaluating survival probabilities
    L Douglas Case
    Department of Public Health Sciences and the Comprehensive Cancer Center of Wake Forest University, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC, USA
    BMC Med Res Methodol 3:6. 2003
  7. ncbi request reprint Interpreting measures of treatment effect in cancer clinical trials
    L Douglas Case
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Oncologist 7:181-7. 2002
  8. doi request reprint Commentary on 'designing phase II studies in cancer with time-to-event endpoints'
    Doug Case
    Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University School of Medicine, North Carolina, USA
    Clin Trials 5:222-3; discussion 223-4. 2008
  9. ncbi request reprint Duration of accrual and follow-up for two-stage clinical trials
    L D Case
    Department of Public Health Sciences and the Comprehensive Cancer Center of Wake Forest University, Wake Forest University School of Medicine, USA
    Lifetime Data Anal 7:21-37. 2001
  10. ncbi request reprint Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity
    J J Hu
    Department of Cancer Biology and Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 22:917-22. 2001

Detail Information

Publications49

  1. ncbi request reprint Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia
    Arthur E Frankel
    Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
    Clin Cancer Res 8:1004-13. 2002
    ..We tested the safety and efficacy of a diphtheria fusion protein [diphtheria toxin (DT)388 granulocyte-macrophage colony-stimulating factor (GMCSF)] directed against the GMCSF receptor that is strongly expressed by leukemic blasts...
  2. ncbi request reprint Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Lett 190:183-90. 2003
    ..74; 95% CI=1.13-67.53). Although larger studies are needed to validate the study results, our data suggest that amino acid substitution variants of XRCC1 and XRCC3 genes may contribute to breast cancer susceptibility...
  3. ncbi request reprint Deficient nucleotide excision repair capacity enhances human prostate cancer risk
    Jennifer J Hu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 64:1197-201. 2004
    ..09 (95% CI, 0.46-2.59); 1.81 (95% CI, 0.77-4.27); and 2.63 (95% CI, 1.17-5.95), respectively. This pilot study is the first direct evidence associating deficient NERC with human CaP risk...
  4. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
    ....
  5. pmc Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer--a phase II study
    Shannon K Tomlinson
    Dept of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    BMC Cancer 2:9. 2002
    ..This phase II study was initiated to determine the activity and toxicity of sequential methotrexate--leucovorin and 5-fluorouracil chemotherapy in patients with advanced colorectal cancer...
  6. pmc Design of Phase II cancer trials evaluating survival probabilities
    L Douglas Case
    Department of Public Health Sciences and the Comprehensive Cancer Center of Wake Forest University, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC, USA
    BMC Med Res Methodol 3:6. 2003
    ....
  7. ncbi request reprint Interpreting measures of treatment effect in cancer clinical trials
    L Douglas Case
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Oncologist 7:181-7. 2002
    ..The most common mistake is to interpret both measures as relative risks, an interpretation that can lead to an incorrect impression of the impact of the treatment on response and survival...
  8. doi request reprint Commentary on 'designing phase II studies in cancer with time-to-event endpoints'
    Doug Case
    Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University School of Medicine, North Carolina, USA
    Clin Trials 5:222-3; discussion 223-4. 2008
  9. ncbi request reprint Duration of accrual and follow-up for two-stage clinical trials
    L D Case
    Department of Public Health Sciences and the Comprehensive Cancer Center of Wake Forest University, Wake Forest University School of Medicine, USA
    Lifetime Data Anal 7:21-37. 2001
    ..An example is given to illustrate the use of these techniques in designing a clinical trial to compare two chemotherapy regimens for lung cancer. Practical considerations of including an interim follow-up period are discussed...
  10. ncbi request reprint Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity
    J J Hu
    Department of Cancer Biology and Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 22:917-22. 2001
    ..9; P = 0.001). These results suggest that amino acid substitution variants of XRCC1 and APE1 may contribute to IR hypersensitivity...
  11. ncbi request reprint Intervention to increase screening mammography among women 65 and older
    R Michielutte
    Department of Family Community Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Health Educ Res 20:149-62. 2005
    ....
  12. ncbi request reprint Phase I trial of twice-weekly gemcitabine and concurrent radiation in patients with advanced pancreatic cancer
    A W Blackstock
    Department of Radiation Oncology, Wake Forest University Baptist Medical Center, Winston Salem, NC 27516, USA
    J Clin Oncol 17:2208-12. 1999
    ..To determine the maximum-tolerated dose, dose-limiting toxicities, and potential antitumor activity of twice-weekly gemcitabine and concurrent radiation in patients with locally advanced pancreatic cancer...
  13. pmc Adjuvant gemcitabine and concurrent radiation for patients with resected pancreatic cancer: a phase II study
    A W Blackstock
    Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Br J Cancer 95:260-5. 2006
    ..These results confirm the feasibility of delivering adjuvant concurrent gemcitabine and radiation to the upper abdomen. This strategy produced good local regional tumour control...
  14. ncbi request reprint Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response
    A W Blackstock
    Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27156, USA
    Clin Cancer Res 7:3263-8. 2001
    ..To test this hypothesis, we examined dFdCyd/dFdCTP uptake and clearance in HT-29 human colon carcinoma xenografts in nude mice by high-performance liquid chromatography (HPLC) and fluorine-19 magnetic resonance spectroscopy (F-19 MRS)...
  15. ncbi request reprint A preliminary analysis of health-related quality of life in the first year after permanent source interstitial brachytherapy (PIB) for clinically localized prostate cancer
    W R Lee
    Department of Radiation Oncology, Comprehensive Cancer Center of the Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Int J Radiat Oncol Biol Phys 46:77-81. 2000
    ..To prospectively assess the health-related quality of life (HRQOL) and changes in HRQOL during the first year after permanent source interstitial brachytherapy (PIB)...
  16. ncbi request reprint Phase I study of twice-weekly gemcitabine and concurrent thoracic radiation for patients with locally advanced non-small-cell lung cancer
    A W Blackstock
    Wake Forest University Baptist Medical Center, Winston Salem, NC, USA
    Int J Radiat Oncol Biol Phys 51:1281-9. 2001
    ..To determine the maximum tolerated dose (MTD) and dose-limiting toxicity of twice-weekly gemcitabine and concurrent thoracic radiation in patients with Stage IIIa/IIIb non-small-cell lung cancer (NSCLC)...
  17. ncbi request reprint A prospective quality-of-life study in men with clinically localized prostate carcinoma treated with radical prostatectomy, external beam radiotherapy, or interstitial brachytherapy
    W R Lee
    Comprehensive Cancer Center of Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Int J Radiat Oncol Biol Phys 51:614-23. 2001
    ..To prospectively assess the health-related quality of life (HRQOL) and changes in HRQOL during the first year after 3 different treatments for clinically localized prostate cancer...
  18. ncbi request reprint Subxiphoid pericardial window for pericardial effusive disease
    S A Mills
    Department of Surgery, Wake Forest University Medical Center, Winston Salem, North Carolina
    J Cardiovasc Surg (Torino) 30:768-73. 1989
    ..The establishment of a subxiphoid pericardial window allows rapid and safe drainage of pericardial effusions with sampling for cytology and pericardial biopsy. It has minimal morbidity and few recurrent effusions...
  19. ncbi request reprint Menogaril in the treatment of relapsed multiple myeloma. A phase II trial of the Cancer Center of Wake Forest University
    J M Cruz
    Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC
    Invest New Drugs 10:35-7. 1992
    ..The median progression-free interval was 3.0 months with a range of 0.7 to 22 months and median survival was 11.3 months with a range of 0.7 to 39+ months. Menogaril displays little activity in patients with previously treated MM...
  20. ncbi request reprint The effects of race and region on cardiovascular morbidity among elderly Americans with diabetes
    Alain G Bertoni
    Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Diabetes Care 28:2620-5. 2005
    ..Because geographic region is known to influence the risk of CVD in the U.S., we sought to determine the effects of race and region on cardiovascular morbidity among elderly Americans with diabetes...
  21. ncbi request reprint Incidence, time course, and determinants of menstrual bleeding after breast cancer treatment: a prospective study
    Jeanne A Petrek
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 24:1045-51. 2006
    ..To assess ovarian function using the surrogate of monthly bleeding after breast cancer treatment in premenopausal women...
  22. ncbi request reprint Smokeless tobacco use accelerates age-related loss of bone mineral density among older women in a multi-ethnic rural community
    Sara A Quandt
    Department of Public Health Sciences, Wake Forest University, School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1063, USA
    J Cross Cult Gerontol 20:109-25. 2005
    ..Women who formerly smoked and did not use supplements had a decreased BMD. ST should be considered as an additional risk factor for osteoporosis in populations where its use is prevalent...
  23. pmc Using a computer to teach patients about fecal occult blood screening. A randomized trial
    David P Miller
    Department of Internal Medicine, Section of General Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1051, USA
    J Gen Intern Med 20:984-8. 2005
    ..To determine whether a multimedia computer program could effectively teach patients about fecal occult blood testing (FOBT) and increase screening rates...
  24. ncbi request reprint The epidemiology of arm and hand swelling in premenopausal breast cancer survivors
    Electra D Paskett
    Ohio State University Comprehensive Cancer Center, A356 Starling Loving Hall, 320 West 10th Avenue, Columbus, OH 43210, USA
    Cancer Epidemiol Biomarkers Prev 16:775-82. 2007
    ..Breast cancer survivors suffer from lymphedema of the arm and/or hand. Accurate estimates of the incidence and prevalence of lymphedema are lacking, as are the effects of this condition on overall quality of life...
  25. pmc Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancer
    Beth O Van Emburgh
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Mol Carcinog 47:88-99. 2008
    ....
  26. pmc Sex differences in stroke severity, symptoms, and deficits after first-ever ischemic stroke
    Kevin M Barrett
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 16:34-9. 2007
    ..The purpose of the study was to assess whether there were sex differences in stroke severity, infarct characteristics, symptoms, or the symptoms-deficit relationship at the time of acute stroke presentation...
  27. pmc Sex differences in stroke evaluations in the Ischemic Stroke Genetics Study
    Thabele M Leslie-Mazwi
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 16:187-93. 2007
    ..Sex differences in stroke evaluation could lead to sex differences in the validity of diagnosing ischemic stroke subtypes. This study assessed sex differences in the Ischemic Stroke Genetics Study (ISGS)...
  28. ncbi request reprint A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapy
    Jerome M Butler
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Radiat Oncol Biol Phys 69:1496-501. 2007
    ..We assessed the effect of prophylactic d-threo-methylphenidate HCl (d-MPH), a central nervous system (CNS) stimulant on QOL and cognitive function in patients undergoing RT...
  29. doi request reprint BMI influences prognosis following surgery and adjuvant chemotherapy for lymph node positive breast cancer
    Mara Z Vitolins
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Breast J 14:357-65. 2008
    ....
  30. ncbi request reprint Phase Ia/Ib chemo-radiation trial of gemcitabine and dose-escalated thoracic radiation in patients with stage III A/B non-small cell lung cancer
    A William Blackstock
    Department of Radiation Oncology, Wake Forest University Comprehensive Cancer Center, Winston Salem, North Carolina 27516, USA
    J Thorac Oncol 1:434-40. 2006
    ..The safety of dose-escalated thoracic radiation concurrent with gemcitabine in patients with inoperable stage III non-small cell lung cancer has not been studied...
  31. pmc Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Ann Neurol 58:351-61. 2005
    ..There was no evidence of association between variants of ALOX5AP and ischemic stroke. These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations...
  32. ncbi request reprint Phase II trial of induction gemcitabine/CPT-11 followed by a twice-weekly infusion of gemcitabine and concurrent external beam radiation for the treatment of locally advanced pancreatic cancer
    Girish Mishra
    Division of Gastroenterology, Comprehensive Cancer Center, Wake Forest University, Winston Salem, North Carolina 27516, USA
    Am J Clin Oncol 28:345-50. 2005
    ..This phase II trial of induction irinotecan/gemcitabine followed by twice-weekly gemcitabine and upper abdominal radiation was initiated to determine the activity of this regimen in patients with unresectable pancreatic cancer...
  33. ncbi request reprint Genetic regulation of ionizing radiation sensitivity and breast cancer risk
    Jennifer J Hu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Environ Mol Mutagen 39:208-15. 2002
    ..001). Although larger studies are needed to validate the results, our data suggest that an inherited hypersensitivity to IR may contribute to human breast carcinogenesis...
  34. ncbi request reprint Supportive use of megestrol acetate (Megace) with head/neck and lung cancer patients receiving radiation therapy
    Richard P McQuellon
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1082, USA
    Int J Radiat Oncol Biol Phys 52:1180-5. 2002
    ..The purpose of this study was to measure the effect of megestrol acetate (MA) on weight loss and quality of life (QOL) in patients with cancer of the lung or head and neck undergoing curative radiation therapy...
  35. ncbi request reprint Quality of diets consumed by older rural adults
    Mara Z Vitolins
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1063, USA
    J Rural Health 18:49-56. 2002
    ....
  36. ncbi request reprint Long-term follow-up of a phase II trial studying a weekly doxorubicin-based multiple drug adjuvant therapy for stage II node-positive carcinoma of the breast
    Gretchen G Kimmick
    The Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC 27157 1082, USA
    Breast Cancer Res Treat 72:233-43. 2002
    ..This single-arm study aimed to evaluate the effectiveness of an intensive doxorubicin-based multidrug regimen as adjuvant therapy in women with stage II, node positive breast cancer...
  37. ncbi request reprint Dietary calcium intake and supplement use among older African American, white, and Native American women in a rural southeastern community
    Ronny A Bell
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Am Diet Assoc 102:844-7. 2002
  38. ncbi request reprint Nicotinic cholinergic receptor expression in the human nasal mucosa
    C Jane H Keiger
    University of North Carolina, Chapel Hill Craniofacial Center, School of Dentistry, USA
    Ann Otol Rhinol Laryngol 112:77-84. 2003
    ..These adverse respiratory effects may be due to activation of nAChRs in epithelial cells of the nose and trachea...
  39. ncbi request reprint DNA damage and breast cancer risk
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Carcinogenesis 24:883-9. 2003
    ....
  40. ncbi request reprint Tobacco use in a tri-ethnic population of older women in southeastern North Carolina
    John G Spangler
    Department of Family and Community Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Ethn Dis 13:226-32. 2003
    ..We examined the epidemiology of tobacco use among a tri-racial population of elderly women in southeastern North Carolina...
  41. ncbi request reprint Anatomical distribution of small cell lung cancer: effects of lobe and gender on brain metastasis and survival
    Abe E Sahmoun
    University of North Dakota School of Medicine, Fargo, ND 58102, USA
    Anticancer Res 25:1101-8. 2005
    ..The aim of this study was to examine the association between gender and pulmonary location and to examine the effects of these variables on the incidence of brain metastasis and the survival rate of patients with SCLC...
  42. ncbi request reprint DNA-repair genetic polymorphisms and breast cancer risk
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 12:1200-4. 2003
    ..We provide evidence that variants of XRCC1, XRCC3, and ERCC4/XPF genes, particularly in combination, contribute to breast cancer susceptibility...
  43. ncbi request reprint Hypertension and risk of brain metastasis from small cell lung cancer: a retrospective follow-up study
    Abe E Sahmoun
    Department of Medicine, University of North Dakota School of Medicine, Fargo, ND 58102, USA
    Anticancer Res 24:3115-20. 2004
    ..We examined the hypothesis that hypertension may increase the risk for brain metastasis (BM) in patients with primary small cell lung cancer (SCLC)...
  44. doi request reprint Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy
    Wendy Demark-Wahnefried
    Department of Behavioral Sciences, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Breast Cancer 8:70-9. 2008
    ..Exercise interventions can prevent these changes, but time and travel pose barriers to participation. The Survivor Training for Enhancing Total Health (STRENGTH) trial assessed the feasibility and impact of 2 home-based interventions...
  45. ncbi request reprint Power and sample size
    L Douglas Case
    Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Methods Mol Biol 404:377-408. 2007
    ..We will show how the power and required sample size can be calculated for several common types of studies, mention software that can be used for the necessary calculations, and discuss additional considerations...
  46. pmc Impact of restricting enrollment in stroke genetics research to adults able to provide informed consent
    Donna T Chen
    Department of Public Health Sciences, University of Virginia Center for Biomedical Ethics, University of Virginia, Charlottesville, VA, USA
    Stroke 39:831-7. 2008
    ..The purpose of this study was to assess differences in stroke cohort characteristics between those who provided informed consent and those whose enrollment was authorized by surrogate decision makers...
  47. ncbi request reprint Sexual problems in younger women after breast cancer surgery
    Stephanie R Burwell
    University of Georgia, Department of Child and Family Development, Athens, GA, USA
    J Clin Oncol 24:2815-21. 2006
    ..To examine sexual problems in younger women diagnosed with breast cancer during the first year after surgery and to identify sociodemographic, medical, and psychosocial predictors of sexual problems...
  48. pmc A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release
    Mar Matarin
    Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 6:414-20. 2007
    ..We aimed to identify any common genetic variability exerting a moderate to large effect on risk of ischaemic stroke, and to generate publicly available genome-wide genotype data to facilitate others doing the same...
  49. ncbi request reprint Cadmium and prostate cancer: a critical epidemiologic analysis
    Abe E Sahmoun
    Department of Internal Medicine, University of North Dakota School of Medicine, Fargo, North Dakota, USA
    Cancer Invest 23:256-63. 2005
    ..Future epidemiological studies that attempt to resolve the discrepancy between laboratory and epidemiological studies of cadmium carcinogenesis may benefit from incorporating biological measures of cadmium exposure...