Research Topics
Species | Douglas CaseSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Detail Information
Publications
Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemiaArthur E Frankel
Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
Clin Cancer Res 8:1004-13. 2002..We tested the safety and efficacy of a diphtheria fusion protein [diphtheria toxin (DT)388 granulocyte-macrophage colony-stimulating factor (GMCSF)] directed against the GMCSF receptor that is strongly expressed by leukemic blasts...- Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancerTasha R Smith
Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Cancer Lett 190:183-90. 2003..74; 95% CI=1.13-67.53). Although larger studies are needed to validate the study results, our data suggest that amino acid substitution variants of XRCC1 and XRCC3 genes may contribute to breast cancer susceptibility... - Deficient nucleotide excision repair capacity enhances human prostate cancer riskJennifer J Hu
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Cancer Res 64:1197-201. 2004..09 (95% CI, 0.46-2.59); 1.81 (95% CI, 0.77-4.27); and 2.63 (95% CI, 1.17-5.95), respectively. This pilot study is the first direct evidence associating deficient NERC with human CaP risk... 
The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African AmericansRasika A Mathias
Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
BMC Genet 12:50. 2011....- Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer--a phase II studyShannon K Tomlinson
Dept of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
BMC Cancer 2:9. 2002..This phase II study was initiated to determine the activity and toxicity of sequential methotrexate--leucovorin and 5-fluorouracil chemotherapy in patients with advanced colorectal cancer... - Design of Phase II cancer trials evaluating survival probabilitiesL Douglas Case
Department of Public Health Sciences and the Comprehensive Cancer Center of Wake Forest University, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC, USA
BMC Med Res Methodol 3:6. 2003.... - Interpreting measures of treatment effect in cancer clinical trialsL Douglas Case
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Oncologist 7:181-7. 2002..The most common mistake is to interpret both measures as relative risks, an interpretation that can lead to an incorrect impression of the impact of the treatment on response and survival... - Commentary on 'designing phase II studies in cancer with time-to-event endpoints'Doug Case
Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University School of Medicine, North Carolina, USA
Clin Trials 5:222-3; discussion 223-4. 2008 - Duration of accrual and follow-up for two-stage clinical trialsL D Case
Department of Public Health Sciences and the Comprehensive Cancer Center of Wake Forest University, Wake Forest University School of Medicine, USA
Lifetime Data Anal 7:21-37. 2001..An example is given to illustrate the use of these techniques in designing a clinical trial to compare two chemotherapy regimens for lung cancer. Practical considerations of including an interim follow-up period are discussed... - Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivityJ J Hu
Department of Cancer Biology and Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Carcinogenesis 22:917-22. 2001..9; P = 0.001). These results suggest that amino acid substitution variants of XRCC1 and APE1 may contribute to IR hypersensitivity... - Intervention to increase screening mammography among women 65 and olderR Michielutte
Department of Family Community Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Health Educ Res 20:149-62. 2005.... - Phase I trial of twice-weekly gemcitabine and concurrent radiation in patients with advanced pancreatic cancerA W Blackstock
Department of Radiation Oncology, Wake Forest University Baptist Medical Center, Winston Salem, NC 27516, USA
J Clin Oncol 17:2208-12. 1999..To determine the maximum-tolerated dose, dose-limiting toxicities, and potential antitumor activity of twice-weekly gemcitabine and concurrent radiation in patients with locally advanced pancreatic cancer... - Adjuvant gemcitabine and concurrent radiation for patients with resected pancreatic cancer: a phase II studyA W Blackstock
Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Br J Cancer 95:260-5. 2006..These results confirm the feasibility of delivering adjuvant concurrent gemcitabine and radiation to the upper abdomen. This strategy produced good local regional tumour control... - Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor responseA W Blackstock
Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27156, USA
Clin Cancer Res 7:3263-8. 2001..To test this hypothesis, we examined dFdCyd/dFdCTP uptake and clearance in HT-29 human colon carcinoma xenografts in nude mice by high-performance liquid chromatography (HPLC) and fluorine-19 magnetic resonance spectroscopy (F-19 MRS)... - A preliminary analysis of health-related quality of life in the first year after permanent source interstitial brachytherapy (PIB) for clinically localized prostate cancerW R Lee
Department of Radiation Oncology, Comprehensive Cancer Center of the Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
Int J Radiat Oncol Biol Phys 46:77-81. 2000..To prospectively assess the health-related quality of life (HRQOL) and changes in HRQOL during the first year after permanent source interstitial brachytherapy (PIB)... - Phase I study of twice-weekly gemcitabine and concurrent thoracic radiation for patients with locally advanced non-small-cell lung cancerA W Blackstock
Wake Forest University Baptist Medical Center, Winston Salem, NC, USA
Int J Radiat Oncol Biol Phys 51:1281-9. 2001..To determine the maximum tolerated dose (MTD) and dose-limiting toxicity of twice-weekly gemcitabine and concurrent thoracic radiation in patients with Stage IIIa/IIIb non-small-cell lung cancer (NSCLC)... - A prospective quality-of-life study in men with clinically localized prostate carcinoma treated with radical prostatectomy, external beam radiotherapy, or interstitial brachytherapyW R Lee
Comprehensive Cancer Center of Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
Int J Radiat Oncol Biol Phys 51:614-23. 2001..To prospectively assess the health-related quality of life (HRQOL) and changes in HRQOL during the first year after 3 different treatments for clinically localized prostate cancer... - Subxiphoid pericardial window for pericardial effusive diseaseS A Mills
Department of Surgery, Wake Forest University Medical Center, Winston Salem, North Carolina
J Cardiovasc Surg (Torino) 30:768-73. 1989..The establishment of a subxiphoid pericardial window allows rapid and safe drainage of pericardial effusions with sampling for cytology and pericardial biopsy. It has minimal morbidity and few recurrent effusions... - Menogaril in the treatment of relapsed multiple myeloma. A phase II trial of the Cancer Center of Wake Forest UniversityJ M Cruz
Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC
Invest New Drugs 10:35-7. 1992..The median progression-free interval was 3.0 months with a range of 0.7 to 22 months and median survival was 11.3 months with a range of 0.7 to 39+ months. Menogaril displays little activity in patients with previously treated MM... - The effects of race and region on cardiovascular morbidity among elderly Americans with diabetesAlain G Bertoni
Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Diabetes Care 28:2620-5. 2005..Because geographic region is known to influence the risk of CVD in the U.S., we sought to determine the effects of race and region on cardiovascular morbidity among elderly Americans with diabetes... - Incidence, time course, and determinants of menstrual bleeding after breast cancer treatment: a prospective studyJeanne A Petrek
Memorial Sloan-Kettering Cancer Center, New York, NY, USA
J Clin Oncol 24:1045-51. 2006..CONCLUSION: Using daily menstrual bleeding records, it is demonstrated that age, the specific chemotherapy regimen received, and tamoxifen use impact ovarian function... - Smokeless tobacco use accelerates age-related loss of bone mineral density among older women in a multi-ethnic rural communitySara A Quandt
Department of Public Health Sciences, Wake Forest University, School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1063, USA
J Cross Cult Gerontol 20:109-25. 2005..Women who formerly smoked and did not use supplements had a decreased BMD. ST should be considered as an additional risk factor for osteoporosis in populations where its use is prevalent... - Using a computer to teach patients about fecal occult blood screening. A randomized trialDavid P Miller
Department of Internal Medicine, Section of General Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1051, USA
J Gen Intern Med 20:984-8. 2005..To determine whether a multimedia computer program could effectively teach patients about fecal occult blood testing (FOBT) and increase screening rates... - The epidemiology of arm and hand swelling in premenopausal breast cancer survivorsElectra D Paskett
Ohio State University Comprehensive Cancer Center, A356 Starling Loving Hall, 320 West 10th Avenue, Columbus, OH 43210, USA
Cancer Epidemiol Biomarkers Prev 16:775-82. 2007..Breast cancer survivors suffer from lymphedema of the arm and/or hand. Accurate estimates of the incidence and prevalence of lymphedema are lacking, as are the effects of this condition on overall quality of life... - Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancerBeth O Van Emburgh
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Mol Carcinog 47:88-99. 2008.... - Sex differences in stroke severity, symptoms, and deficits after first-ever ischemic strokeKevin M Barrett
Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
J Stroke Cerebrovasc Dis 16:34-9. 2007..The purpose of the study was to assess whether there were sex differences in stroke severity, infarct characteristics, symptoms, or the symptoms-deficit relationship at the time of acute stroke presentation... - Sex differences in stroke evaluations in the Ischemic Stroke Genetics StudyThabele M Leslie Mazwi
Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
J Stroke Cerebrovasc Dis 16:187-93. 2007..Sex differences in stroke evaluation could lead to sex differences in the validity of diagnosing ischemic stroke subtypes. This study assessed sex differences in the Ischemic Stroke Genetics Study (ISGS)... - A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapyJerome M Butler
Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Int J Radiat Oncol Biol Phys 69:1496-501. 2007..We assessed the effect of prophylactic d-threo-methylphenidate HCl (d-MPH), a central nervous system (CNS) stimulant on QOL and cognitive function in patients undergoing RT... 
BMI influences prognosis following surgery and adjuvant chemotherapy for lymph node positive breast cancerMara Z Vitolins
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Breast J 14:357-65. 2008....- Phase Ia/Ib chemo-radiation trial of gemcitabine and dose-escalated thoracic radiation in patients with stage III A/B non-small cell lung cancerA William Blackstock
Department of Radiation Oncology, Wake Forest University Comprehensive Cancer Center, Winston Salem, North Carolina 27516, USA
J Thorac Oncol 1:434-40. 2006..The safety of dose-escalated thoracic radiation concurrent with gemcitabine in patients with inoperable stage III non-small cell lung cancer has not been studied... - Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic strokeJames F Meschia
Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
Ann Neurol 58:351-61. 2005..There was no evidence of association between variants of ALOX5AP and ischemic stroke. These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations... - Phase II trial of induction gemcitabine/CPT-11 followed by a twice-weekly infusion of gemcitabine and concurrent external beam radiation for the treatment of locally advanced pancreatic cancerGirish Mishra
Division of Gastroenterology, Comprehensive Cancer Center, Wake Forest University, Winston-Salem, North Carolina 27516, USA
Am J Clin Oncol 28:345-50. 2005..This regimen, however, has only modest activity and should not be explored further... - Genetic regulation of ionizing radiation sensitivity and breast cancer riskJennifer J Hu
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Environ Mol Mutagen 39:208-15. 2002..001). Although larger studies are needed to validate the results, our data suggest that an inherited hypersensitivity to IR may contribute to human breast carcinogenesis... - Supportive use of megestrol acetate (Megace) with head/neck and lung cancer patients receiving radiation therapyRichard P McQuellon
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1082, USA
Int J Radiat Oncol Biol Phys 52:1180-5. 2002..The purpose of this study was to measure the effect of megestrol acetate (MA) on weight loss and quality of life (QOL) in patients with cancer of the lung or head and neck undergoing curative radiation therapy... - Quality of diets consumed by older rural adultsMara Z Vitolins
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1063, USA
J Rural Health 18:49-56. 2002.... - Long-term follow-up of a phase II trial studying a weekly doxorubicin-based multiple drug adjuvant therapy for stage II node-positive carcinoma of the breastGretchen G Kimmick
The Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC 27157 1082, USA
Breast Cancer Res Treat 72:233-43. 2002..This single-arm study aimed to evaluate the effectiveness of an intensive doxorubicin-based multidrug regimen as adjuvant therapy in women with stage II, node positive breast cancer... - Dietary calcium intake and supplement use among older African American, white, and Native American women in a rural southeastern communityRonny A Bell
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
J Am Diet Assoc 102:844-7. 2002 - Nicotinic cholinergic receptor expression in the human nasal mucosaC Jane H Keiger
University of North Carolina, Chapel Hill Craniofacial Center, School of Dentistry, USA
Ann Otol Rhinol Laryngol 112:77-84. 2003..These adverse respiratory effects may be due to activation of nAChRs in epithelial cells of the nose and trachea... - DNA damage and breast cancer riskTasha R Smith
Department of Cancer Biology, Wake Forest University Health Sciences, Medical Center Blvd, Winston-Salem, NC 27157, USA
Carcinogenesis 24:883-9. 2003.... - Tobacco use in a tri-ethnic population of older women in southeastern North CarolinaJohn G Spangler
Department of Family and Community Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Ethn Dis 13:226-32. 2003..We examined the epidemiology of tobacco use among a tri-racial population of elderly women in southeastern North Carolina... - Anatomical distribution of small cell lung cancer: effects of lobe and gender on brain metastasis and survivalAbe E Sahmoun
University of North Dakota School of Medicine, Fargo, ND 58102, USA
Anticancer Res 25:1101-8. 2005..The aim of this study was to examine the association between gender and pulmonary location and to examine the effects of these variables on the incidence of brain metastasis and the survival rate of patients with SCLC... - DNA-repair genetic polymorphisms and breast cancer riskTasha R Smith
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Cancer Epidemiol Biomarkers Prev 12:1200-4. 2003..We provide evidence that variants of XRCC1, XRCC3, and ERCC4/XPF genes, particularly in combination, contribute to breast cancer susceptibility... - Hypertension and risk of brain metastasis from small cell lung cancer: a retrospective follow-up studyAbe E Sahmoun
Department of Medicine, University of North Dakota School of Medicine, Fargo, ND 58102, USA
Anticancer Res 24:3115-20. 2004..We examined the hypothesis that hypertension may increase the risk for brain metastasis (BM) in patients with primary small cell lung cancer (SCLC)... - Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapyWendy Demark-Wahnefried
Department of Behavioral Sciences, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Breast Cancer 8:70-9. 2008..Exercise interventions can prevent these changes, but time and travel pose barriers to participation. The Survivor Training for Enhancing Total Health (STRENGTH) trial assessed the feasibility and impact of 2 home-based interventions... - Power and sample sizeL Douglas Case
Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston Salem, NC, USA
Methods Mol Biol 404:377-408. 2007..We will show how the power and required sample size can be calculated for several common types of studies, mention software that can be used for the necessary calculations, and discuss additional considerations... - Impact of restricting enrollment in stroke genetics research to adults able to provide informed consentDonna T Chen
Department of Public Health Sciences, University of Virginia Center for Biomedical Ethics, University of Virginia, Charlottesville, VA, USA
Stroke 39:831-7. 2008..The purpose of this study was to assess differences in stroke cohort characteristics between those who provided informed consent and those whose enrollment was authorized by surrogate decision makers... - Sexual problems in younger women after breast cancer surgeryStephanie R Burwell
University of Georgia, Department of Child and Family Development, Athens, GA, USA
J Clin Oncol 24:2815-21. 2006..Increasing feelings of sexual attractiveness may also help sexual problems, especially among women for whom these feelings were altered by surgery or treatment... - A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data releaseMar Matarin
Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Lancet Neurol 6:414-20. 2007..We aimed to identify any common genetic variability exerting a moderate to large effect on risk of ischaemic stroke, and to generate publicly available genome-wide genotype data to facilitate others doing the same... - Cadmium and prostate cancer: a critical epidemiologic analysisAbe E Sahmoun
Department of Internal Medicine, University of North Dakota School of Medicine, Fargo, North Dakota, USA
Cancer Invest 23:256-63. 2005..Future epidemiological studies that attempt to resolve the discrepancy between laboratory and epidemiological studies of cadmium carcinogenesis may benefit from incorporating biological measures of cadmium exposure...