DONALD W contact BOWDEN

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University, Winston Salem, North Carolina, USA
    Diabetes 60:662-8. 2011
  2. pmc Association of SSTR2 polymorphisms and glucose homeostasis phenotypes: the Insulin Resistance Atherosclerosis Family Study
    Beth S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 58:1457-62. 2009
  3. pmc Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 27:1505-11. 2012
  4. pmc Buffy coat specimens remain viable as a DNA source for highly multiplexed genome-wide genetic tests after long term storage
    Josyf C Mychaleckyj
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    J Transl Med 9:91. 2011
  5. pmc Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    BMC Med Genet 11:22. 2010
  6. pmc Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes
    Jennifer L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    BMC Med Genet 6:42. 2005
  7. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
  8. ncbi request reprint Genetics of diabetes complications
    Donald W Bowden
    Biochemistry and Internal Medicine Endocrinology and Metabolism, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Diab Rep 2:191-200. 2002
  9. doi request reprint Genetic epidemiology of subclinical cardiovascular disease in the diabetes heart study
    D W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Ann Hum Genet 72:598-610. 2008
  10. ncbi request reprint Hormone replacement therapy is associated with increased C-reactive protein in women with Type 2 diabetes in the Diabetes Heart Study
    D W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 23:763-7. 2006

Collaborators

Detail Information

Publications100

  1. pmc Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University, Winston Salem, North Carolina, USA
    Diabetes 60:662-8. 2011
    ..The aim of this study was to elucidate which variant in TCF7L2 confers diabetes susceptibility in African Americans...
  2. pmc Association of SSTR2 polymorphisms and glucose homeostasis phenotypes: the Insulin Resistance Atherosclerosis Family Study
    Beth S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 58:1457-62. 2009
    ..CONCLUSIONS We observed evidence for association of SSTR2 polymorphisms with measures of glucose homeostasis. Thus, variants in SSTR2 may influence pathways of S(I)to modulate glucose homeostasis...
  3. pmc Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 27:1505-11. 2012
    ..We tested for association of single nucleotide polymorphisms (SNPs) in MYH9 with T2DM-ESRD in European Americans; additionally, three APOL1 gene variants were evaluated...
  4. pmc Buffy coat specimens remain viable as a DNA source for highly multiplexed genome-wide genetic tests after long term storage
    Josyf C Mychaleckyj
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    J Transl Med 9:91. 2011
    ..A common protocol is to store buffy coat specimens for future DNA isolation and these may remain in frozen storage for many years. It is uncertain if the DNA remains suitable for modern genome wide association (GWA) genotyping...
  5. pmc Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    BMC Med Genet 11:22. 2010
    ..Ordered subset linkage analysis (OSA) revealed a linkage peak on chromosome 7p in the subset of families with earlier age of T2D diagnosis...
  6. pmc Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes
    Jennifer L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    BMC Med Genet 6:42. 2005
    ..GLUT10 (gene symbol SLC2A10) is a facilitative glucose transporter within the type 2 diabetes (T2DM)-linked region on chromosome 20q12-13.1. Therefore, we evaluated GLUT10 as a positional candidate gene for T2DM in Caucasian Americans...
  7. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
    ....
  8. ncbi request reprint Genetics of diabetes complications
    Donald W Bowden
    Biochemistry and Internal Medicine Endocrinology and Metabolism, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Diab Rep 2:191-200. 2002
    ..In addition to their value in the study of diabetes complications, such families may be valuable resources for understanding cardiovascular disease and nephropathy in the nondiabetic population also...
  9. doi request reprint Genetic epidemiology of subclinical cardiovascular disease in the diabetes heart study
    D W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Ann Hum Genet 72:598-610. 2008
    ..Additional loci on chromosomes 1, 2, 7, 10, 13, and 21 had LODs > 2.0. The identification of trait-determining polymorphisms underlying these linkages will help delineate risk factors for CVD in T2DM and the general population...
  10. ncbi request reprint Hormone replacement therapy is associated with increased C-reactive protein in women with Type 2 diabetes in the Diabetes Heart Study
    D W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 23:763-7. 2006
    ..The aim of this study was to determine the influence of HRT on women with diabetes in a large cross-sectional study...
  11. pmc Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study
    Donald W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Mol Genet 19:4112-20. 2010
    ..This approach is applicable to a wide range of family studies and has potential to be a discovery tool for identification of novel genes influencing complex traits...
  12. ncbi request reprint Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the diabetes heart study
    Donald W Bowden
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 55:1985-94. 2006
    ....
  13. ncbi request reprint The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS)
    Donald W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 150:1032-8. 2005
    ..Epidemiological studies suggest that levels of C-reactive protein (CRP) predict cardiovascular disease (CVD). We have evaluated the relationship between CRP and subclinical CVD in a study cohort at high risk of CVD...
  14. pmc Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications
    Donald W Bowden
    Center for Diabetes Research, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina, USA
    Rev Diabet Stud 7:188-201. 2010
    ..The aim of this review is to provide a collective overview of the major results from the DHS family of studies, and relate them to the larger body of biomedical investigations of diabetes and its complications...
  15. pmc Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Diabetes Care 35:287-92. 2012
    ..These SNPs have not been extensively investigated for individual and cumulative effects on T2D risk in African Americans...
  16. ncbi request reprint A genome scan for diabetic nephropathy in African Americans
    Donald W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Kidney Int 66:1517-26. 2004
    ..There is substantial evidence for a genetic contribution to diabetic nephropathy susceptibility in the African American population, but little is known about location or identity of susceptibility genes...
  17. ncbi request reprint Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with Type 2 diabetes mellitus: the Diabetes Heart Study
    K P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 23:228-34. 2006
    ....
  18. pmc Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study
    N D Palmer
    Department of Biochemistry, Centers for Human Genomics and Diabetes Research, Wake Forest University School of Medicine, 1 Medical Center Blvd, Winston Salem, NC 27157, USA
    Diabetologia 53:281-9. 2010
    ....
  19. ncbi request reprint Association of adipose tissue deposition and beta-2 adrenergic receptor variants: the IRAS family study
    L A Lange
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Int J Obes (Lond) 29:449-57. 2005
    ..We examined whether two common polymorphisms in codons 16 (Arg16Gly) and 27 (Gln27Glu) are associated with measures of fat distribution in participants of the IRAS Family Study...
  20. ncbi request reprint Familial aggregation of coronary artery calcium in families with type 2 diabetes
    L E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Diabetes 50:861-6. 2001
    ..In these data, CAC seems heritable and may serve as an important feature in designing studies to map genes contributing to both atherosclerosis and type 2 diabetes...
  21. ncbi request reprint The impact of ethnicity and sex on subclinical cardiovascular disease: the Diabetes Heart Study
    B I Freedman
    Wake Forest University School of Medicine, Department of Internal Medicine Section on Nephrology, Medical Center Boulevard, 27157 1053, Winston Salem, NC 27157 1053, USA
    Diabetologia 48:2511-8. 2005
    ..We evaluated whether ethnic differences in subclinical cardiovascular disease, coronary and carotid artery calcified plaque and carotid artery intima-medial thickness (IMT) were present in members of The Diabetes Heart Study families...
  22. ncbi request reprint Heritability of spinal trabecular volumetric bone mineral density measured by QCT in the Diabetes Heart Study
    L Lenchik
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Calcif Tissue Int 75:305-12. 2004
    ..31-0.33, all P < 0.05). These data suggest that, like areal BMD, volumetric BMD is highly heritable and may be used in designing linkage studies to locate genes governing bone metabolism...
  23. ncbi request reprint Type 2 diabetes is not independently associated with spinal trabecular volumetric bone mineral density measured by QCT in the Diabetes Heart Study
    T C Register
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Bone 39:628-33. 2006
    ..05), although the differences disappeared after additional adjustment for BMI. These data suggest that areal BMD measured by DXA and trabecular volumetric BMD measured by QCT are not associated with type 2 diabetes independently from BMI...
  24. ncbi request reprint Loci contributing to adult height and body mass index in African American families ascertained for type 2 diabetes
    M M Sale
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem NC 27157, USA
    Ann Hum Genet 69:517-27. 2005
    ....
  25. ncbi request reprint Ethnic variation in the correlation between random serum glucose concentration and glycated haemoglobin
    A J Bleyer
    Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 26:128-33. 2009
    ..To determine if the relationship between serum glucose concentration and glycated haemoglobin is different between African-Americans and whites...
  26. ncbi request reprint Genome-wide linkage scans for renal function and albuminuria in Type 2 diabetes mellitus: the Diabetes Heart Study
    B I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Diabet Med 25:268-76. 2008
    ..We performed a genome-wide linkage scan in 416 Diabetes Heart Study (DHS) families to detect loci that contributed to renal function and albuminuria...
  27. pmc Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation
    B I Freedman
    Departments of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Transplant 9:2435-40. 2009
    ..The impact of transplanting kidneys from donors with multiple MYH9 risk alleles into recipients with similar genetic background at high risk for recurrent kidney disease needs to be determined...
  28. pmc Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1
    J L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Genomics 92:226-34. 2008
    ..We found substantial heterogeneity between study results...
  29. ncbi request reprint Adiponectin as a novel determinant of bone mineral density and visceral fat
    L Lenchik
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Bone 33:646-51. 2003
    ..1). These data suggest that adiponectin may play a role in the protective effects of visceral fat on BMD...
  30. ncbi request reprint Identification and characterization of PRKCBP1, a candidate RACK-like protein
    S C Fossey
    Molecular Genetics Program, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Mamm Genome 11:919-25. 2000
    ..The results of this analysis suggest that PRKCBP1 coding variations are uncommon and do not contribute to Type II diabetes in the general population...
  31. ncbi request reprint Genetic linkage of the tricho-dento-osseous syndrome to chromosome 17q21
    T C Hart
    Department of Pediatrics, Bowman Gray School of Medicine, Winston Salem, NC 27157, USA
    Hum Mol Genet 6:2279-84. 1997
    ..This finding represents the first step towards isolation and cloning of the TDO gene. Identification of this gene has important implications for understanding normal and abnormal craniofacial development of hair, teeth and bone...
  32. ncbi request reprint Genetic mapping of a 17q chromosomal region linked to obesity phenotypes in the IRAS family study
    B S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Obes (Lond) 30:1433-41. 2006
    ..In the IRAS Family Study a genomewide scan was performed on 1425 individuals of Hispanic descent (90 extended pedigree families) to identify regions of the genome linked to obesity phenotypes...
  33. ncbi request reprint A microsatellite polymorphism associated with the PLC1 (phospholipase C) locus: identification, mapping, and linkage to the MODY locus on chromosome 20
    C B Rothschild
    Department of Biochemistry, Bowman Gray School of Medicine, Winston Salem, North Carolina 27157
    Genomics 13:560-4. 1992
    ..2 and 6.6 cM, respectively, from these loci (sex-averaged distances). In addition, the PLC1 gene shows linkage to the maturity-onset diabetes of the young (MODY) locus on chromosome 20 with a lod score of 4.57 at theta = 0.089...
  34. pmc Variants in intron 13 of the ELMO1 gene are associated with diabetic nephropathy in African Americans
    T S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Ann Hum Genet 73:152-9. 2009
    ..5 x 10(-5)- P = 0.05). No associations were seen with these SNPs in those with T2DM lacking nephropathy or with ESRD due to non-diabetic causes. Variants in intron 13 of the ELMO1 gene appear to confer risk for diabetic nephropathy in AA...
  35. ncbi request reprint Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease
    H Yu
    Department of Biochemistry, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157 1053, USA
    Hypertension 31:906-11. 1998
    ..00014 and .0087, respectively). The association of KLK3b alleles with ESRD raises the possibility that polymorphisms in KLK3 may play a role in ESRD susceptibility. The lack of linkage might reflect our relatively small family set...
  36. ncbi request reprint Sublocalization of the Papillon-Lefevre syndrome locus on 11q14-q21
    T C Hart
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1093, USA
    Am J Med Genet 79:134-9. 1998
    ..This refinement of the candidate region for a PLS gene is in agreement with other recent reports of linkage for PLS to chromosome 11q14-q21 and should help in identification of the gene for PLS...
  37. ncbi request reprint Physical and genetic mapping of the muscle phosphofructokinase gene (PFKM): reassignment to human chromosome 12q
    T D Howard
    Department of Biochemistry, Bowman Gray School of Medicine of Wake Forest University, Medical Center Boulevard, Winston Salem, North Carolina, 27157, USA
    Genomics 34:122-7. 1996
    ..The PFKM-associated microsatellite will be a valuable tool in the evaluation of PFKM in diabetic populations as well as in linkage analysis in families with Tarui disease...
  38. ncbi request reprint A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20
    S C Fossey
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Genomics 76:45-57. 2001
    ..The combination of the BAC transcript map, YAC-to-BAC scaffold, and reference Human Genome Project sequence provides a powerful integrated resource for future genomic analysis of this region...
  39. ncbi request reprint Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome
    J A Price
    Department of Biochemistry, Wake Forest University School of Medicine, Bowman Gray Campus, Winston Salem, NC 27157, USA
    Hum Mol Genet 7:563-9. 1998
    ..This first report of a human mutation in the DLX genes is consistent with murine studies indicating their important role in the development of hair, teeth and bone...
  40. ncbi request reprint Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1
    P A Dawson
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Mol Genet Metab 74:186-99. 2001
    ..3 mM. D-Glucose and D-galactose competed with 2-deoxy-D-glucose and transport was inhibited by phloretin. The gene localization and functional properties suggest a role for GLUT10 in glucose metabolism and Type 2 diabetes...
  41. pmc Genetic linkage of hereditary gingival fibromatosis to chromosome 2p21
    T C Hart
    Department of Pediatrics, Section on Medical Genetics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Hum Genet 62:876-83. 1998
    ..This is the first report of linkage for isolated HGF, and the findings have implications for identification of the underlying genetic basis of gingival fibromatosis...
  42. pmc Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome
    T C Hart
    Department of Pediatrics, Section of Medical Genetics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Med Genet 36:881-7. 1999
    ..A more complete understanding of the functional physiology of cathepsin C carries significant implications for understanding normal and abnormal skin development and periodontal disease susceptibility...
  43. ncbi request reprint Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease
    H Yu
    Department of Biochemistry, Department of Internal Medicine, Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Genomics 69:225-34. 2000
    ..This observation suggests that other sequences within or near KLKB1, or another gene nearby, may contribute to ESRD susceptibility...
  44. ncbi request reprint Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14
    J T Bensen
    Program in Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Interferon Cytokine Res 21:899-904. 2001
    ..The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response...
  45. pmc Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 123:333-41. 2008
    ..We have identified a novel region of the ESR1 gene that may contain important functional polymorphisms in relation to susceptibility to T2DM and/or diabetic nephropathy...
  46. pmc Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies
    Joshua P Lewis
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 57:2220-5. 2008
    ..Our objective was to examine the influence of type 2 diabetes genes identified in whole-genome association studies in a large African American case-control population...
  47. ncbi request reprint A genome-wide scan for type 2 diabetes in African-American families reveals evidence for a locus on chromosome 6q
    Michele M Sale
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 53:830-7. 2004
    ..009 for interaction, DeltaP = 0.070 for OSA). These results provide evidence that genes predisposing African-American individuals to type 2 diabetes are located in the 6q and 7p regions of the genome...
  48. doi request reprint Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diab Vasc Dis Res 5:128-34. 2008
    ..057 and 0.080, respectively). These results provide additional evidence that EPHX2 contributes to the risk of subclinical CVD, although the true trait defining polymorphisms may not be identified and the effect size could be small...
  49. pmc Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 124:63-71. 2008
    ..This study confirms known diabetic nephropathy loci and identifies potentially novel susceptibility variants located within 6q24-27 in AA...
  50. ncbi request reprint Associations between electrocardiographic interval durations and coronary artery calcium scores: the Diabetes Heart Study
    Matthew R Nelson
    Department of Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Pacing Clin Electrophysiol 31:314-21. 2008
    ..We examined the relationship between coronary artery disease, measured by coronary artery calcified plaque (CAC), and the duration of QRS, JT, and QT intervals, among predominantly type two diabetic participants...
  51. ncbi request reprint Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families: the Insulin Resistance Atherosclerosis Study Family Study
    Carl D Langefeld
    Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1063, USA
    Diabetes 53:1170-4. 2004
    ..These results contribute to the growing evidence that chromosome 1q harbors at least one locus related to the metabolic precursors of diabetes...
  52. ncbi request reprint Heritability of GFR and albuminuria in Caucasians with type 2 diabetes mellitus
    Carl D Langefeld
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Kidney Dis 43:796-800. 2004
    ..Elevated urinary albumin excretion and decreased glomerular filtration rate (GFR) are risk factors for cardiovascular death and end-stage renal disease in individuals with type 2 diabetes mellitus (DM)...
  53. doi request reprint Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 57:1093-100. 2008
    ....
  54. pmc Chromogranin A polymorphisms are associated with hypertensive renal disease
    Rany M Salem
    Department of Medicine and Center for Molecular Genetics, University of California at San Diego and Veterans Administration San Diego Healthcare System 0838, 9500 Gilman Drive, La Jolla, CA 92093 0838, USA
    J Am Soc Nephrol 19:600-14. 2008
    ..In summary, common variants in chromogranin A associate with the risk of hypertensive ESRD in blacks...
  55. doi request reprint Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 57:1108-14. 2008
    ..We sought to replicate the finding that genetic variants in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene are associated with QT interval duration in a type 2 diabetes-enriched sample of European ancestry...
  56. ncbi request reprint Comparative genomic analysis of the HNF-4alpha transcription factor gene
    Allison M Bagwell
    Department of Biochemistry, Wake Forest University, School of Medicine, Winston Salem, NC 27157, USA
    Mol Genet Metab 81:112-21. 2004
    ..These results suggest that comparative sequence analysis can efficiently identify regulatory elements and that sequence variants in regulatory elements of HNF-4alpha can contribute to altered HNF-4alpha gene expression...
  57. pmc Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 124:147-54. 2008
    ..This study presents exploratory analyses of the impact of admixture on studies of AA with T2DM-ESRD and supports the use of ancestral proportions as a means of reducing confounding effects due to admixture...
  58. pmc Heritability of the severity of diabetic retinopathy: the FIND-Eye study
    Nedal H Arar
    Family Investigation of Nephropathy and Diabetes FIND Genetic Analysis and Data Coordinating Center, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 49:3839-45. 2008
    ....
  59. ncbi request reprint Prevalence of nephropathy in black patients with type 2 diabetes mellitus
    James Gitter
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 22:35-41. 2002
    ..Approximately 70% of black patients with type 2 diabetes cared for in indigent care clinics have abnormal proteinuria and are at heightened risk for ESRD and death...
  60. ncbi request reprint Heritability of carotid artery intima-medial thickness in type 2 diabetes
    Leslie A Lange
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Stroke 33:1876-81. 2002
    ..We hypothesize that in families with multiple members having diabetes, carotid IMT is likely to be associated with both inherited and environmental factors...
  61. ncbi request reprint Nephropathy in siblings of African Americans with overt type 2 diabetic nephropathy
    Scott G Satko
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Kidney Dis 40:489-94. 2002
    ..The prevalence of abnormal proteinuria and elevated serum creatinine (sCr) concentrations in diabetic sibs of African Americans (AAs) with overt type 2 diabetic nephropathy (DN) or end-stage renal disease (ESRD) is unknown...
  62. ncbi request reprint Evidence for a novel type 1 diabetes susceptibility locus on chromosome 8
    Michele M Sale
    Menzies Centre for Population Health Research, University of Tasmania, Hobart, Australia
    Diabetes 51:S316-9. 2002
    ..Continued investigation of this region for a novel type 1 diabetes susceptibility gene appears justified...
  63. ncbi request reprint Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods
    Leora Henkin
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Epidemiol 13:211-7. 2003
    ..In this report, we describe the methods of the IRAS Family Study, which was designed to identify the genetic and environmental risk factors for insulin resistance and visceral adiposity...
  64. ncbi request reprint Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients
    Takashi Akamizu
    Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    J Hum Genet 48:236-42. 2003
    ..These findings suggest the presence of susceptible genes of AITD, especially distinct subgroups of GD, in or near 5q23-q33...
  65. ncbi request reprint Evaluation of genetic variation and association in the matrix metalloproteinase 9 (MMP9) gene in ESRD patients
    Shohei Hirakawa
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Kidney Dis 42:133-42. 2003
    ..Expression of the matrix metalloproteinase 9 (MMP9) gene is increased in a variety of renal diseases. Several genetic studies have associated MMP9 with end-stage renal disease (ESRD)...
  66. ncbi request reprint Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease
    Hitomi Hiratani
    Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto University School of Medicine, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    J Clin Endocrinol Metab 90:2898-903. 2005
    ..0058). These findings suggest that alleles of intron 7 of the TSHR gene contribute to GD susceptibility...
  67. ncbi request reprint Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene cluster
    Jeannette T Bensen
    The Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Genomics 82:194-217. 2003
    ..0015) and a 4-bp insertion/deletion within the 3'UTR, rs16347-2 (p=0.0024), among African Americans with non-T2DM-associated ESRD...
  68. pmc MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:1175-84. 2008
    ..2, 95% CI = 1.5-3.4; n = 433), but not type 2 diabetic ESKD (n = 476). Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans...
  69. doi request reprint Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 57:1057-62. 2008
    ..Our objective was to comprehensively evaluate variants in ENPP1 for association with type 2 diabetic end-stage renal disease (ESRD)...
  70. pmc Kidney volume associations with subclinical renal and cardiovascular disease: the Diabetes Heart Study
    Anita M Saran
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 28:366-71. 2008
    ..The prognostic significance of total kidney volume (TKV) in subjects with type 2 diabetes mellitus (T2DM) is unknown...
  71. ncbi request reprint Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND)
    Jeffrey R Schelling
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, Rm 1300, 10900 Euclid Ave, Cleveland, OH 44106 7281, USA
    Diabetes 57:235-43. 2008
    ..Glomerular filtration rate (GFR), which characterizes diabetic nephropathy, was employed as a quantitative trait in a preliminary whole-genome scan...
  72. ncbi request reprint Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS family study
    Xiuqing Guo
    Medical Genetics Institutes, Cedars Sinai Medical Center, 8700 Beverly Blvd, 665W, Los Angeles, CA 90048, USA
    Diabetes 55:1723-30. 2006
    ..Therefore, a quantitative trait locus at 3q27, likely distinct from the APM1 gene, contributes to the variation of plasma adiponectin levels in the Hispanic-American population...
  73. ncbi request reprint Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes
    Jennifer L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 53:3007-12. 2004
    ..These results suggest that PTPN1 is a significant contributor to type 2 diabetes susceptibility in the Caucasian population. This risk is likely due to noncoding polymorphisms...
  74. ncbi request reprint Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 55:911-8. 2006
    ..These detailed genetic analyses provide strong evidence of a DI locus on 11q in African-American pedigrees, with additional suggestive evidence of independent AIR loci in the same region...
  75. ncbi request reprint Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 53:3013-9. 2004
    ..001) fasting glucose, respectively, in the IRASFS. This comprehensive genetic analysis of PTPN1 reveals significant association with metabolic traits consistent with the proposed in vivo role for the PTP-1B protein...
  76. ncbi request reprint Association of protein tyrosine phosphatase-N1 polymorphisms with coronary calcified plaque in the Diabetes Heart Study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 55:651-8. 2006
    ..53 +/- 0.1 to 0.57 +/- 0.1 (P = 8.1 x 10(-10)), suggesting a modest but detectable effect of this gene on the phenotype of CorCP in type 2 diabetic patients...
  77. ncbi request reprint Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS)
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 151:706-11. 2006
    ..These processes are implicated in the development and progression of atherosclerosis. Animal models demonstrate that interruption of CD40/CD40L signaling produces a more fibrous and stable atherosclerotic lesion...
  78. ncbi request reprint A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor MRI Center, Winston Salem, NC 27157, USA
    Diabetes 54:290-5. 2005
    ..Identifying genes in these regions should provide insight into the nature of genetic factors regulating plasma glucose and insulin concentrations...
  79. ncbi request reprint Pericardial and visceral adipose tissues measured volumetrically with computed tomography are highly associated in type 2 diabetic families
    Guy L Wheeler
    Department of Radiology, University of Missouri Health Care, Columbia, Missouri, USA
    Invest Radiol 40:97-101. 2005
    ..We describe a new method for quantifying pericardial adipose tissue volumes with computed tomography (CT), and present its precision and relation to established measures of adiposity...
  80. ncbi request reprint A genome scan for all-cause end-stage renal disease in African Americans
    Barry I Freedman
    Department of Internal Medicine Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Nephrol Dial Transplant 20:712-8. 2005
    ....
  81. ncbi request reprint Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetes
    Allison M Bagwell
    Molecular Genetics Program, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes 54:1185-90. 2005
    ..0% of chromosomes) accounting for the evidence of association. Our results suggest that type 2 diabetes linked to 20q12-13 is a heterogeneous disease in which different populations may have different type 2 diabetes susceptibility loci...
  82. ncbi request reprint Association of proopiomelanocortin gene polymorphisms with obesity in the IRAS family study
    Beth S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Obes Res 13:1491-8. 2005
    ..These results support the hypothesis that POMC contributes genetically to the development of obesity...
  83. ncbi request reprint Association of the mu-opioid receptor gene with type 2 diabetes mellitus in an African American population
    Carla J Gallagher
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Genet Metab 87:54-60. 2006
    ..046). Significant, but rare, risk and protective haplotypes were identified as driving these associations with T2DM (P=0.034-0.047). These associations suggest that the OPRM1 gene plays a role in T2DM susceptibility in African Americans...
  84. ncbi request reprint Association analysis of the plasminogen activator inhibitor-1 4G/5G polymorphism in Hispanics and African Americans: the IRAS family study
    Jeannette T Bensen
    Center for Human Genomics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Hered 57:128-37. 2004
    ..In addition, we explore whether transforming growth factor (TGF-beta1), a key regulator of PAI-1 expression, modifies the influence of the PAI-1 4G/5G polymorphism on these traits...
  85. ncbi request reprint Identification of quantitative trait loci for glucose homeostasis: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor, MRI Center, Winston Salem, NC 27157, USA
    Diabetes 53:1866-75. 2004
    ....
  86. ncbi request reprint A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study
    Yongmei Liu
    Departments of Public Health Sciences bInternal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Eur J Cardiovasc Prev Rehabil 13:655-7. 2006
    ..We tested for an association between a functional polymorphism, LTA 252A/G, and common carotid artery intima-media thickness in 1088 siblings from 435 Diabetes Heart Study families...
  87. pmc Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 93:304-9. 2008
    ..Genetic variation at the transcription factor 7-like 2 locus has been linked to type 2 diabetes in predominantly European-derived populations. The biological basis of these associations remains to be determined...
  88. pmc Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study
    J Jeffrey Carr
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Bone 42:43-52. 2008
    ..QCT determined vBMD was more strongly related to CP than aBMD by DXA. The relation between CP and BMD in diabetes is influenced by age, sex, and ethnicity, with further effect modification by hormone replacement therapy...
  89. ncbi request reprint Genetic factors in diabetic nephropathy
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Clin J Am Soc Nephrol 2:1306-16. 2007
    ..It seems likely that the risk for diabetes-associated kidney disease is magnified by inheriting risk alleles at several susceptibility loci, in the presence of hyperglycemia...
  90. pmc Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Mol Genet Metab 92:145-50. 2007
    ..028), rs4814597 (Pa=0.039) and rs2269023 (Pa=0.043). None of the PCSK2 SNPs were associated with age at T2DM diagnosis. A variant in the PCKS2 gene, rs2021785, appears to play a role in susceptibility to T2DM in this AA population...
  91. ncbi request reprint Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy
    Michele M Sale
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 56:2638-42. 2007
    ..Our objective was to investigate the importance of TCF7L2 in a larger African-American case-control population...
  92. ncbi request reprint Association of the estrogen receptor-alpha gene with the metabolic syndrome and its component traits in African-American families: the Insulin Resistance Atherosclerosis Family Study
    Carla J Gallagher
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 56:2135-41. 2007
    ....
  93. ncbi request reprint A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the diabetes heart study
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Epidemiol 166:340-7. 2007
    ..0001). In summary, CAPs of the coronary, carotid, and abdominal aortic arteries generally share common risk factors, even though several of these factors have a greater impact on CAP in one vascular bed than another...
  94. pmc Low plasma levels of FGF-2 and PDGF-BB are associated with cardiovascular events in type II diabetes mellitus (diabetes heart study)
    Joseph Yeboah
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Dis Markers 23:173-8. 2007
    ..We tested associations of the growth factors VEGF, FGF-2, HGF and PDGF-BB with coronary artery calcium scores and cardiovascular events (CVD) in type 2 diabetes mellitus (T2DM)...
  95. ncbi request reprint Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND)
    Sudha K Iyengar
    FIND Genetic Analysis and Data Coordinating Center, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106 7281, USA
    Diabetes 56:1577-85. 2007
    ..Large family collections consisting of multiple members with diabetes and advanced nephropathy are likely to accelerate the identification of genes causing diabetic nephropathy, a life-threatening complication of diabetes...
  96. ncbi request reprint Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations
    Carla J Gallagher
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Diabetes 56:675-84. 2007
    ..033) were associated with type 2 diabetes and/or ESRD. Results suggest that intron 1 and intron 2 of the ESR1 gene may contain functionally important regions related to type 2 diabetes or ESRD risk...
  97. ncbi request reprint Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 92:345-52. 2007
    ....
  98. ncbi request reprint Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study
    Leslie A Lange
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Hum Genet 70:717-25. 2006
    ..While the APOE locus shows evidence of contributing to CRP levels, no evidence of CRP gene polymorphism association with CRP levels was observed...
  99. ncbi request reprint Identification of podocin (NPHS2) gene mutations in African Americans with nondiabetic end-stage renal disease
    Judith A Engeler Dusel
    Department of Internal Medicine, Center for Human Genomics, Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 68:256-62. 2005
    ..Evidence for linkage of end-stage renal disease (ESRD) to chromosome 1q25-31 in the region of NPHS2 has been identified in a genome-wide scan in African American (AA) siblings...

Research Grants43

  1. Intergration of Functional and Molecular Genetics to Identify Diabetes Genes
    DONALD W contact BOWDEN; Fiscal Year: 2010
    ....
  2. MAPPING GENES FOR NIDDM NEPHROPATHY IN AFRICAN AMERICANS
    Donald Bowden; Fiscal Year: 2005
    ..Detailed sequencing and analysis will be used to identify the T2DM-ESRD gene. ..
  3. Identification of diabetes genes on human chromosome 20
    Donald Bowden; Fiscal Year: 2005
    ..g. insulin resistance, (3-cell function, etc.). Confirmation of association in multiple populations will justify a more detailed molecular genetic analysis similar to that being proposed for PTPN1. ..
  4. Molecular genetics of glucose homeostasis and fat
    Donald Bowden; Fiscal Year: 2006
    ..g. create an "ultra high density" SNP map of the associated chromosomal region. These new SNPs will be genotyped on the IRASFS DNAs to identify the trait defining alleles. ..
  5. Whole Genome Association Analysis of the Diabetes Heart Study
    Donald W Bowden; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: In this research study, genes which contribute to heart disease in people with diabetes will be identified. ..
  6. MAPPING GENES FOR NIDDM NEPHROPATHY IN AFRICAN AMERICANS
    Donald Bowden; Fiscal Year: 2006
    ..Detailed sequencing and analysis will be used to identify the T2DM-ESRD gene. ..
  7. Molecular genetics of glucose homeostasis and fat
    Donald Bowden; Fiscal Year: 2005
    ....
  8. Molecular genetics of glucose homeostasis and fat
    Donald Bowden; Fiscal Year: 2009
    ..g. create an "ultra high density" SNP map of the associated chromosomal region. These new SNPs will be genotyped on the IRASFS DNAs to identify the trait defining alleles. ..
  9. Identification of diabetes genes on human chromosome 20
    Donald Bowden; Fiscal Year: 2007
    ..g. insulin resistance, (3-cell function, etc.). Confirmation of association in multiple populations will justify a more detailed molecular genetic analysis similar to that being proposed for PTPN1. ..
  10. Epidemiology of cardiovascular disease in diabetes
    Donald Bowden; Fiscal Year: 2001
    ..Evidence for linkage to QTLs influencing CAC and IMT will be pursued in those chromosomal regions showing suggestive evidence for linkage and then performing further analyses to detect associations with these "saturation" markers. ..
  11. MAPPING GENES FOR NIDDM NEPHROPATHY IN AFRICAN AMERICANS
    Donald Bowden; Fiscal Year: 2001
    ..s. ..
  12. IRAS FAMILY STUDY--MOLECULAR GENETICS
    Donald Bowden; Fiscal Year: 2001
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin sensitivity, and consequently to risk of atherosclerosis. ..
  13. ID OF DIABETES GENES ON HUMAN CHROMOSOME 20Q12-Q13.1
    Donald Bowden; Fiscal Year: 2001
    ..Based on SNP disequilibrium studies, coding and non-coding polymorphisms strongly associated with diabetes will be functionally evaluated. ..
  14. MAPPING GENES FOR NIDDM NEPHROPATHY IN AFRICAN AMERICANS
    Donald Bowden; Fiscal Year: 2000
    ..s. ..
  15. ID OF DIABETES GENES ON HUMAN CHROMOSOME 20Q12-Q13.1
    Donald Bowden; Fiscal Year: 2002
    ..Based on SNP disequilibrium studies, coding and non-coding polymorphisms strongly associated with diabetes will be functionally evaluated. ..
  16. MAPPING GENES FOR NIDDM NEPHROPATHY IN AFRICAN AMERICANS
    Donald Bowden; Fiscal Year: 1999
    ..s. ..
  17. Genetic Epidemiology of Cerebrovascular Disease and Cognition in Diabetes
    Donald Bowden; Fiscal Year: 2009
    ..Successful completion of the study will create a unique database of information and provide insights into the genetic and lifestyle contributors to these disorders. ..
  18. MAPPING GENES FOR NIDDM NEPHROPATHY IN AFRICAN AMERICANS
    Donald Bowden; Fiscal Year: 2009
    ..Detailed sequencing and analysis will be used to identify the T2DM-ESRD gene. ..
  19. Genetics of African American type 2 diabetes
    Donald Bowden; Fiscal Year: 2006
    ..We will embark upon construction of a dense SNP map to facilitate the identification of minimal haplotypes associated with African American T2DM, followed by a focused search for genes contributing to diabetes. ..
  20. Genetics of African American type 2 diabetes
    Donald W Bowden; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This study is focused on identifying the gene which contributes to type 2 diabetes susceptibility in the African American population. ..
  21. Genetic Epidemiology of Cerebrovascular Disease and Cognition in Diabetes
    Donald W Bowden; Fiscal Year: 2010
    ..Successful completion of the study will create a unique database of information and provide insights into the genetic and lifestyle contributors to these disorders. ..
  22. IRAS FAMILY STUDY--MOLECULAR GENETICS
    Donald Bowden; Fiscal Year: 2003
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin sensitivity, and consequently to risk of atherosclerosis. ..
  23. ID OF DIABETES GENES ON HUMAN CHROMOSOME 20Q12-Q13.1
    Donald Bowden; Fiscal Year: 2001
    ..Based on SNP disequilibrium studies, coding and non-coding polymorphisms strongly associated with diabetes will be functionally evaluated. ..
  24. Identification of diabetes genes on human chromosome 20
    Donald Bowden; Fiscal Year: 2006
    ..g. insulin resistance, (3-cell function, etc.). Confirmation of association in multiple populations will justify a more detailed molecular genetic analysis similar to that being proposed for PTPN1. ..
  25. ID OF DIABETES GENES ON HUMAN CHROMOSOME 20Q12-Q13.1
    Donald Bowden; Fiscal Year: 2001
    ..Based on SNP disequilibrium studies, coding and non-coding polymorphisms strongly associated with diabetes will be functionally evaluated. ..
  26. ID OF DIABETES GENES ON HUMAN CHROMOSOME 20Q12-Q13.1
    Donald Bowden; Fiscal Year: 2004
    ..Based on SNP disequilibrium studies, coding and non-coding polymorphisms strongly associated with diabetes will be functionally evaluated. ..
  27. Epidemiology of cardiovascular disease in diabetes
    Donald Bowden; Fiscal Year: 2004
    ..Evidence for linkage to QTLs influencing CAC and IMT will be pursued in those chromosomal regions showing suggestive evidence for linkage and then performing further analyses to detect associations with these "saturation" markers. ..
  28. Epidemiology of cardiovascular disease in diabetes
    Donald Bowden; Fiscal Year: 2002
    ..Evidence for linkage to QTLs influencing CAC and IMT will be pursued in those chromosomal regions showing suggestive evidence for linkage and then performing further analyses to detect associations with these "saturation" markers. ..
  29. Epidemiology of cardiovascular disease in diabetes
    Donald Bowden; Fiscal Year: 2003
    ..Evidence for linkage to QTLs influencing CAC and IMT will be pursued in those chromosomal regions showing suggestive evidence for linkage and then performing further analyses to detect associations with these "saturation" markers. ..
  30. ID OF DIABETES GENES ON HUMAN CHROMOSOME 20Q12-Q13.1
    Donald Bowden; Fiscal Year: 2003
    ..Based on SNP disequilibrium studies, coding and non-coding polymorphisms strongly associated with diabetes will be functionally evaluated. ..
  31. Genetic Epidemiology of Cerebrovascular Disease and Cognition in Diabetes
    Donald Bowden; Fiscal Year: 2009
    ..Successful completion of the study will create a unique database of information and provide insights into the genetic and lifestyle contributors to these disorders. ..
  32. Intergration of Functional and Molecular Genetics to Identify Diabetes Genes
    Donald Bowden; Fiscal Year: 2009
    ....
  33. IRAS FAMILY STUDY--MOLECULAR GENETICS
    Donald Bowden; Fiscal Year: 2002
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin sensitivity, and consequently to risk of atherosclerosis. ..
  34. ID OF DIABETES GENES ON HUMAN CHROMOSOME 20Q12-Q13.1
    Donald Bowden; Fiscal Year: 2005
    ..Based on SNP disequilibrium studies, coding and non-coding polymorphisms strongly associated with diabetes will be functionally evaluated. ..
  35. IRAS FAMILY STUDY--MOLECULAR GENETICS
    Donald Bowden; Fiscal Year: 2000
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin sensitivity, and consequently to risk of atherosclerosis. ..
  36. MAPPING GENES FOR NIDDM NEPHROPATHY IN AFRICAN AMERICANS
    Donald Bowden; Fiscal Year: 2007
    ..Detailed sequencing and analysis will be used to identify the T2DM-ESRD gene. ..
  37. Genetics of African American type 2 diabetes
    Donald W Bowden; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: This study is focused on identifying the gene which contributes to type 2 diabetes susceptibility in the African American population. ..
  38. Identification of diabetes genes on human chromosome 20
    Donald Bowden; Fiscal Year: 2009
    ..g. insulin resistance, (3-cell function, etc.). Confirmation of association in multiple populations will justify a more detailed molecular genetic analysis similar to that being proposed for PTPN1. ..