ISABELLE BERQUIN

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2
    Joyce Wu
    Laboratory for Oncogenomic Research, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Res 66:4872-9. 2006
  2. pmc Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells
    Anna L Stratford
    Laboratory for Oncogenomic Research, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    Breast Cancer Res 10:R99. 2008
  3. ncbi request reprint Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells
    Isabelle M Berquin
    Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
    Oncogene 24:3177-86. 2005
  4. ncbi request reprint Expression signature of the mouse prostate
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Biol Chem 280:36442-51. 2005
  5. pmc Peroxisome proliferator-activated receptor gamma-mediated up-regulation of syndecan-1 by n-3 fatty acids promotes apoptosis of human breast cancer cells
    Haiguo Sun
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Res 68:2912-9. 2008
  6. pmc Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways
    Yunping Hu
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neoplasia 11:1042-53. 2009
  7. ncbi request reprint Omega-3 polyunsaturated fatty acids regulate syndecan-1 expression in human breast cancer cells
    Haiguo Sun
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Res 65:4442-7. 2005
  8. pmc In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids
    Iris J Edwards
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Biol Chem 283:18441-9. 2008
  9. ncbi request reprint Dietary fat-gene interactions in cancer
    Yong Q Chen
    Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Cancer Metastasis Rev 26:535-51. 2007
  10. ncbi request reprint Differential effects of delivery of omega-3 fatty acids to human cancer cells by low-density lipoproteins versus albumin
    Iris J Edwards
    Department of Pathology, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157, USA
    Clin Cancer Res 10:8275-83. 2004

Research Grants

  1. Role of YB-1 in EGFR regulation and breast cancer
    ISABELLE BERQUIN; Fiscal Year: 2007
  2. Role of YB-1 in EGFR regulation and breast cancer
    ISABELLE BERQUIN; Fiscal Year: 2009
  3. Role of YB-1 in EGFR regulation and breast cancer
    Isabelle M Berquin; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2
    Joyce Wu
    Laboratory for Oncogenomic Research, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Res 66:4872-9. 2006
    ..Targeting YB-1 or more specifically YB-1(Ser(102)) are novel approaches to inhibiting the expression of these receptors to ultimately suppress tumor cell growth...
  2. pmc Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells
    Anna L Stratford
    Laboratory for Oncogenomic Research, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    Breast Cancer Res 10:R99. 2008
    ..Using Motifscan we identified p90 ribosomal S6 kinase (RSK) as a potential candidate for activating YB-1...
  3. ncbi request reprint Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells
    Isabelle M Berquin
    Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
    Oncogene 24:3177-86. 2005
    ..This could represent one of the mechanisms by which YB-1 contributes to breast tumor aggressiveness...
  4. ncbi request reprint Expression signature of the mouse prostate
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Biol Chem 280:36442-51. 2005
    ..In prostate tumors, interestingly, Cxcl12 was up-regulated in epithelial cells with a concomitant expression of Cxcr4. Expression of both the receptor and ligand may provide an autocrine mechanism for tumor cell migration and invasion...
  5. pmc Peroxisome proliferator-activated receptor gamma-mediated up-regulation of syndecan-1 by n-3 fatty acids promotes apoptosis of human breast cancer cells
    Haiguo Sun
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Res 68:2912-9. 2008
    ..This provides a novel mechanism for the chemopreventive effects of n-3 PUFA in breast cancer...
  6. pmc Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways
    Yunping Hu
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neoplasia 11:1042-53. 2009
    ..Those findings highlight the effectiveness of decorin in the presence of a powerful genetic cancer risk and implicate decorin as a potential new agent for prostate cancer therapy by targeting EGFR/AR-PI3K-Akt pathways...
  7. ncbi request reprint Omega-3 polyunsaturated fatty acids regulate syndecan-1 expression in human breast cancer cells
    Haiguo Sun
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Res 65:4442-7. 2005
    ..Our studies show that n-3 LDL modifies the production of syndecan-1 in human breast cancer cells and suggest that biological processes regulated by syndecan-1 may be modified through LDL delivery of n-3 PUFA...
  8. pmc In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids
    Iris J Edwards
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Biol Chem 283:18441-9. 2008
    ..These findings indicate that syndecan 1 is up-regulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma. This mechanism may contribute to the chemopreventive properties of n-3 fatty acids in prostate cancer...
  9. ncbi request reprint Dietary fat-gene interactions in cancer
    Yong Q Chen
    Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Cancer Metastasis Rev 26:535-51. 2007
    ..The purpose of this review is to present a more cohesive view of dietary fat-gene interactions, and outline a working hypothesis of the intricate connection between fat, genes and cancer...
  10. ncbi request reprint Differential effects of delivery of omega-3 fatty acids to human cancer cells by low-density lipoproteins versus albumin
    Iris J Edwards
    Department of Pathology, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157, USA
    Clin Cancer Res 10:8275-83. 2004
    ..High FA concentration in LDL and up-regulation of LDL receptors in tumor cells suggest that the LDL receptor pathway may be the major route for FA delivery. We compared effects of n-3FA delivered to human cancer cells by LDL and albumin...
  11. pmc Multi-targeted therapy of cancer by omega-3 fatty acids
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States
    Cancer Lett 269:363-77. 2008
    ..In this review, we discuss the rationale for using long-chain n-3 PUFAs in cancer prevention and treatment and the challenges that such approaches pose in the design of clinical trials...
  12. pmc Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Clin Invest 117:1866-75. 2007
    ..Our data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. This study highlights the importance of gene-diet interactions in prostate cancer...
  13. ncbi request reprint Omega-3 fatty acids and cancer risk
    Yong Q Chen
    JAMA 296:282; author reply 282. 2006

Research Grants5

  1. Role of YB-1 in EGFR regulation and breast cancer
    ISABELLE BERQUIN; Fiscal Year: 2007
    ..Most importantly, this work will examine whether targeting YB-1 and EGFR in tumors represents a viable strategy for therapy in a subset of breast cancer where treatment options are currently limited. ..
  2. Role of YB-1 in EGFR regulation and breast cancer
    ISABELLE BERQUIN; Fiscal Year: 2009
    ..Most importantly, this work will examine whether targeting YB-1 and EGFR in tumors represents a viable strategy for therapy in a subset of breast cancer where treatment options are currently limited. ..
  3. Role of YB-1 in EGFR regulation and breast cancer
    Isabelle M Berquin; Fiscal Year: 2010
    ..Most importantly, this work will examine whether targeting YB-1 and EGFR in tumors represents a viable strategy for therapy in a subset of breast cancer where treatment options are currently limited. ..