Susan E Appt

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Soy-tibolone combination - effect on lipids in postmenopausal monkeys and women
    Susan E Appt
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Maturitas 60:216-22. 2008
  2. pmc Serum antimüllerian hormone predicts ovarian reserve in a monkey model
    Susan E Appt
    Wake Forest University Primate Center, Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 16:597-601. 2009
  3. ncbi request reprint Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition
    Susan E Appt
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Fertil Steril 86:1210-6. 2006
  4. pmc Reproductive aging and risk for chronic disease: Insights from studies of nonhuman primates
    Susan E Appt
    Wake Forest University School of Medicine, Department of Pathology Comparative Medicine, Wake Forest University Primate Center, Winston Salem, NC 27157 1040, USA
    Maturitas 67:7-14. 2010
  5. pmc Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis)
    Susan E Appt
    Department of Pathology Comparative Medicine, Wake Forest University Primate Center, Winston Salem, North Carolina, USA
    Comp Med 60:380-8. 2010
  6. pmc The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis)
    Susan E Appt
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Menopause 17:741-8. 2010
  7. ncbi request reprint Low dose estrogens inhibit coronary artery atherosclerosis in postmenopausal monkeys
    Susan E Appt
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC, United States
    Maturitas 55:187-94. 2006
  8. ncbi request reprint Effects of soybean glyceollins and estradiol in postmenopausal female monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nutr Cancer 56:74-81. 2006
  9. doi request reprint Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model
    Kelly F Ethun
    Wake Forest University Primate Center, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Menopause 20:777-84. 2013
  10. pmc Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys
    Kelly F Ethun
    Wake Forest University Primate Center and the Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 19:1242-52. 2012

Collaborators

Detail Information

Publications30

  1. pmc Soy-tibolone combination - effect on lipids in postmenopausal monkeys and women
    Susan E Appt
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Maturitas 60:216-22. 2008
    ..To determine whether co-administration of soy during tibolone treatment would prevent tibolone-induced dyslipoproteinemia in postmenopausal monkeys and women...
  2. pmc Serum antimüllerian hormone predicts ovarian reserve in a monkey model
    Susan E Appt
    Wake Forest University Primate Center, Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 16:597-601. 2009
    ..Here, we describe the relationship between AMH and ovarian reserve in cynomolgus monkeys (Macaca fascicularis) estimated to be 12 to 15 years of age (approximately 36-45 y in women)...
  3. ncbi request reprint Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition
    Susan E Appt
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Fertil Steril 86:1210-6. 2006
    ....
  4. pmc Reproductive aging and risk for chronic disease: Insights from studies of nonhuman primates
    Susan E Appt
    Wake Forest University School of Medicine, Department of Pathology Comparative Medicine, Wake Forest University Primate Center, Winston Salem, NC 27157 1040, USA
    Maturitas 67:7-14. 2010
    ....
  5. pmc Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis)
    Susan E Appt
    Department of Pathology Comparative Medicine, Wake Forest University Primate Center, Winston Salem, North Carolina, USA
    Comp Med 60:380-8. 2010
    ..These data indicate that VCD treatment markedly reduced primordial follicles while preserving larger estradiol- and testosterone-producing follicles and ovarian stroma, a condition that mimics ROR in women...
  6. pmc The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis)
    Susan E Appt
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Menopause 17:741-8. 2010
    ..The aim of this study was to determine the relationships among dietary protein source, cardiovascular risk, reproductive hormones, and ovarian aging...
  7. ncbi request reprint Low dose estrogens inhibit coronary artery atherosclerosis in postmenopausal monkeys
    Susan E Appt
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC, United States
    Maturitas 55:187-94. 2006
    ..To determine if low dose conjugated equine estrogens (CEE) result in a reduction of coronary artery atherosclerosis progression, and to relate these findings to previous studies using the traditional dose...
  8. ncbi request reprint Effects of soybean glyceollins and estradiol in postmenopausal female monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nutr Cancer 56:74-81. 2006
    ..05 for both) but not in the GLY group. These preliminary findings suggest that soybean glyceollins are natural compounds with potential estrogen-modulating properties in the breast...
  9. doi request reprint Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model
    Kelly F Ethun
    Wake Forest University Primate Center, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Menopause 20:777-84. 2013
    ..The primary aim of this study was to evaluate the endometrial profile of bazedoxifene acetate (BZA), a third-generation SERM, alone and in combination with conjugated equine estrogens (CEE) in a postmenopausal primate model...
  10. pmc Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys
    Kelly F Ethun
    Wake Forest University Primate Center and the Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 19:1242-52. 2012
    ....
  11. pmc Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes
    F Salih Muhammad
    Animal Resources Program, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Comp Med 59:46-59. 2009
    ..However, because adult rats were more sensitive to the irritant properties of VCD, the use of a lower dose should be considered...
  12. pmc Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden
    Sara E Walker
    Wake Forest University Primate Center, Section on Comparative, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 15:950-7. 2008
    ..The objective of this study was to determine the effects of dietary soy protein isolate (SPI) and social status on atherogenesis and arterial gene expression in a premenopausal monkey model...
  13. pmc Effects of bazedoxifene alone and with conjugated equine estrogens on coronary and peripheral artery atherosclerosis in postmenopausal monkeys
    Thomas B Clarkson
    Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 20:274-81. 2013
    ....
  14. pmc Premenopausal antimüllerian hormone concentration is associated with subsequent atherosclerosis
    Susan E Appt
    Wake Forest Primate Center and Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 19:1353-9. 2012
    ..The aim of this study was to determine if premenopausal ovarian reserve is associated with susceptibility for atherosclerosis...
  15. ncbi request reprint Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Biol Reprod 75:477-86. 2006
    ..1 for all). These findings indicate that high doses of dietary soy isoflavonoids have minimal uterotrophic or mammotrophic effects in an established primate model...
  16. doi request reprint Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause
    Areepan Sophonsritsuk
    Section on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 20:540-7. 2013
    ..The aim of this study was to determine the effects of estrogen therapy (ET) on carotid artery inflammation when initiated early and late relative to surgical menopause...
  17. pmc Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland
    Charles E Wood
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Lab Invest 88:938-48. 2008
    ....
  18. ncbi request reprint Usefulness of the monkey model to investigate the role soy in postmenopausal women's health
    Susan E Appt
    Department of Comparative Medicine, Comparative Medicine Clinical Research Center, Wake Forest University, School of Medicine, Winston Salem, NC, USA
    ILAR J 45:200-11. 2004
    ..Nevertheless, important attributes of soy have been identified, and it may have potential as a complementary component to hormone therapy...
  19. pmc Endocrine profile of an ovariectomized cynomolgus monkey (Macaca fascicularis) with a supernumerary ovary
    Kelly F Ethun
    Wake Forest University Primate Center and the Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Comp Med 61:462-6. 2011
    ....
  20. ncbi request reprint Controversies about HRT--lessons from monkey models
    Thomas B Clarkson
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Maturitas 51:64-74. 2005
    ..The results of monkey studies suggest little or no effects of estrogen only treatment; whereas, estrogen+progestin clearly increases breast cancer risk...
  21. ncbi request reprint Treatment with antibiotics reduces plasma equol concentration in cynomolgus monkeys (Macaca fascicularis)
    Robert M Blair
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Nutr 133:2262-7. 2003
    ..In conclusion, treatment with antibiotics resulted in a marked reduction in plasma equol concentrations and altered plasma isoflavonoid patterns in cynomolgus monkeys...
  22. ncbi request reprint MPA and postmenopausal coronary artery atherosclerosis revisited
    Thomas B Clarkson
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Steroids 68:941-51. 2003
    ..In conclusion, it is evident that the current experimental, clinical, and observational data do not provide evidence that progestins attenuate estrogen's cardiovascular benefits...
  23. pmc Effects of bazedoxifene, conjugated equine estrogens, and a tissue-selective estrogen complex containing both bazedoxifene and conjugated equine estrogens on cerebral artery atherosclerosis in postmenopausal monkeys
    Thomas B Clarkson
    From the Departments of 1Pathology Comparative Medicine and 2Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC
    Menopause 21:8-14. 2014
    ....
  24. doi request reprint Timing hypothesis for postmenopausal hormone therapy: its origin, current status, and future
    Thomas B Clarkson
    Center for Comparative Medicine and Research, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Menopause 20:342-53. 2013
    ....
  25. ncbi request reprint Dietary soy and soy isoflavones have gender-specific effects on plasma lipids and isoflavones in golden Syrian f(1)b hybrid hamsters
    Robert M Blair
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 132:3585-91. 2002
    ....
  26. ncbi request reprint Concentrations of isoflavones in macaques consuming standard laboratory monkey diet
    Fawn C Stroud
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    J Am Assoc Lab Anim Sci 45:20-3. 2006
    ..These data argue for the use of soy-free diets in studies investigating estrogenic effects on physiologic or behavioral endpoints...
  27. doi request reprint Peer review and reflection continues forever
    Susan E Appt
    Fertil Steril 89:1034-5. 2008
  28. ncbi request reprint Practical measurement of total and bioavailable estradiol in female macaques
    Karen Pazol
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Clin Chim Acta 340:117-26. 2004
    ..However, while these techniques are useful for humans, they have yet to be evaluated systematically for macaques-species which are frequently used to model estrogen effects on women's health...
  29. ncbi request reprint Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4'7-O-dioleate in monkeys
    Maija Badeau
    Department of Medicine, University of Helsinki, Helsinki 00014, Finland
    Biochim Biophys Acta 1738:115-20. 2005
    ..The results suggest that it may be possible to introduce intact genistein ester molecules into plasma by parenteral but not oral administration...
  30. ncbi request reprint Multidetector computed tomographic morphology of ovaries in cynomolgus macaques (Macaca fascicularis)
    Jeryl C Jones
    Department of Small Animal Clinical Sciences, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic and State University, Blacksburg, VA, USA
    J Am Assoc Lab Anim Sci 46:54-63. 2007
    ..41 to 0.67 ml compared with 0.40 to 0.65 ml by water displacement. MDCT is a promising technique for measuring longitudinal changes in macaque ovarian morphology reliably and noninvasively...

Research Grants1

  1. Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic Diseases
    Susan E Appt; Fiscal Year: 2010
    ..In addition, the outcomes observed in this study might well extend beyond the vascular and musculoskeletal systems to include other tissues that are sensitive to the effects of ovarian hormones, such as the brain. ..