Research Topics
| Susan E ApptSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis)Susan E Appt
Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
Menopause 17:741-8. 2010..The aim of this study was to determine the relationships among dietary protein source, cardiovascular risk, reproductive hormones, and ovarian aging...- Reproductive aging and risk for chronic disease: Insights from studies of nonhuman primatesSusan E Appt
Wake Forest University School of Medicine, Department of Pathology Comparative Medicine, Wake Forest University Primate Center, Winston Salem, NC 27157 1040, USA
Maturitas 67:7-14. 2010.... - Serum antimüllerian hormone predicts ovarian reserve in a monkey modelSusan E Appt
Wake Forest University Primate Center, Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Menopause 16:597-601. 2009..Here, we describe the relationship between AMH and ovarian reserve in cynomolgus monkeys (Macaca fascicularis) estimated to be 12 to 15 years of age (approximately 36-45 y in women)... - Soy-tibolone combination - effect on lipids in postmenopausal monkeys and womenSusan E Appt
Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Maturitas 60:216-22. 2008..To determine whether co-administration of soy during tibolone treatment would prevent tibolone-induced dyslipoproteinemia in postmenopausal monkeys and women... - Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis)Susan E Appt
Department of Pathology Comparative Medicine, Wake Forest University Primate Center, Winston Salem, North Carolina, USA
Comp Med 60:380-8. 2010..These data indicate that VCD treatment markedly reduced primordial follicles while preserving larger estradiol- and testosterone-producing follicles and ovarian stroma, a condition that mimics ROR in women... 
Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transitionSusan E Appt
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
Fertil Steril 86:1210-6. 2006....- Low dose estrogens inhibit coronary artery atherosclerosis in postmenopausal monkeysSusan E Appt
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC, United States
Maturitas 55:187-94. 2006..To determine if low dose conjugated equine estrogens (CEE) result in a reduction of coronary artery atherosclerosis progression, and to relate these findings to previous studies using the traditional dose... - Effects of soybean glyceollins and estradiol in postmenopausal female monkeysCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Nutr Cancer 56:74-81. 2006..05 for both) but not in the GLY group. These preliminary findings suggest that soybean glyceollins are natural compounds with potential estrogen-modulating properties in the breast... 
Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeysKelly F Ethun
Wake Forest University Primate Center and the Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
Menopause 19:1242-52. 2012....- Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomesF Salih Muhammad
Animal Resources Program, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
Comp Med 59:46-59. 2009..However, because adult rats were more sensitive to the irritant properties of VCD, the use of a lower dose should be considered... - Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burdenSara E Walker
Wake Forest University Primate Center, Section on Comparative, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Menopause 15:950-7. 2008..The objective of this study was to determine the effects of dietary soy protein isolate (SPI) and social status on atherogenesis and arterial gene expression in a premenopausal monkey model... - Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeysCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
Biol Reprod 75:477-86. 2006..1 for all). These findings indicate that high doses of dietary soy isoflavonoids have minimal uterotrophic or mammotrophic effects in an established primate model... - Usefulness of the monkey model to investigate the role soy in postmenopausal women's healthSusan E Appt
Department of Comparative Medicine, Comparative Medicine Clinical Research Center, Wake Forest University, School of Medicine, Winston-Salem, NC, USA
ILAR J 45:200-11. 2004..Nevertheless, important attributes of soy have been identified, and it may have potential as a complementary component to hormone therapy... - Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary glandCharles E Wood
Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
Lab Invest 88:938-48. 2008.... - Endocrine profile of an ovariectomized cynomolgus monkey (Macaca fascicularis) with a supernumerary ovaryKelly F Ethun
Wake Forest University Primate Center and the Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Comp Med 61:462-6. 2011.... - Controversies about HRT--lessons from monkey modelsThomas B Clarkson
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
Maturitas 51:64-74. 2005..The results of monkey studies suggest little or no effects of estrogen only treatment; whereas, estrogen+progestin clearly increases breast cancer risk... - Treatment with antibiotics reduces plasma equol concentration in cynomolgus monkeys (Macaca fascicularis)Robert M Blair
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Nutr 133:2262-7. 2003..In conclusion, treatment with antibiotics resulted in a marked reduction in plasma equol concentrations and altered plasma isoflavonoid patterns in cynomolgus monkeys... - MPA and postmenopausal coronary artery atherosclerosis revisitedThomas B Clarkson
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
Steroids 68:941-51. 2003..In conclusion, it is evident that the current experimental, clinical, and observational data do not provide evidence that progestins attenuate estrogen's cardiovascular benefits... - Effects of bazedoxifene alone and with conjugated equine estrogens on coronary and peripheral artery atherosclerosis in postmenopausal monkeysThomas B Clarkson
Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
Menopause 20:274-81. 2013.... - Premenopausal antimüllerian hormone concentration is associated with subsequent atherosclerosisSusan E Appt
Wake Forest Primate Center and Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
Menopause 19:1353-9. 2012..The aim of this study was to determine if premenopausal ovarian reserve is associated with susceptibility for atherosclerosis... - Dietary soy and soy isoflavones have gender-specific effects on plasma lipids and isoflavones in golden Syrian f(1)b hybrid hamstersRobert M Blair
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Nutr 132:3585-91. 2002.... - Timing hypothesis for postmenopausal hormone therapy: its origin, current status, and futureThomas B Clarkson
Center for Comparative Medicine and Research, Wake Forest University School of Medicine, Winston Salem, NC, USA
Menopause 20:342-53. 2013.... - Concentrations of isoflavones in macaques consuming standard laboratory monkey dietFawn C Stroud
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
J Am Assoc Lab Anim Sci 45:20-3. 2006..These data argue for the use of soy-free diets in studies investigating estrogenic effects on physiologic or behavioral endpoints... - Peer review and reflection continues foreverSusan E Appt
Fertil Steril 89:1034-5. 2008 - Multidetector computed tomographic morphology of ovaries in cynomolgus macaques (Macaca fascicularis)Jeryl C Jones
Department of Small Animal Clinical Sciences, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic and State University, Blacksburg, VA, USA
J Am Assoc Lab Anim Sci 46:54-63. 2007..41 to 0.67 ml compared with 0.40 to 0.65 ml by water displacement. MDCT is a promising technique for measuring longitudinal changes in macaque ovarian morphology reliably and noninvasively... - Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4'7-O-dioleate in monkeysMaija Badeau
Department of Medicine, University of Helsinki, Helsinki 00014, Finland
Biochim Biophys Acta 1738:115-20. 2005..The results suggest that it may be possible to introduce intact genistein ester molecules into plasma by parenteral but not oral administration... - Practical measurement of total and bioavailable estradiol in female macaquesKaren Pazol
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
Clin Chim Acta 340:117-26. 2004..However, while these techniques are useful for humans, they have yet to be evaluated systematically for macaques-species which are frequently used to model estrogen effects on women's health...
Research Grants
- Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic DiseasesSusan E Appt; Fiscal Year: 2010..In addition, the outcomes observed in this study might well extend beyond the vascular and musculoskeletal systems to include other tissues that are sensitive to the effects of ovarian hormones, such as the brain. ..