Atala Anthony

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Experimental and clinical experience with tissue engineering techniques for urethral reconstruction
    Anthony Atala
    Department of Urology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Urol Clin North Am 29:485-92, ix. 2002
  2. doi request reprint Engineering organs
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine, Winston Salem, NC 27157, USA
    Curr Opin Biotechnol 20:575-92. 2009
  3. doi request reprint Regenerative medicine strategies
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine, Winston Salem, NC 27157, USA
    J Pediatr Surg 47:17-28. 2012
  4. doi request reprint Tissue engineering of reproductive tissues and organs
    Anthony Atala
    Department of Urology, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Fertil Steril 98:21-9. 2012
  5. pmc Basic science research in urology training
    D Eberli
    Wake Forest Institute for Regenerative Medicine, Medical Center Boulevard, Winston Salem, NC, USA
    Indian J Urol 25:217-20. 2009
  6. pmc Tissue engineering of the penis
    Manish N Patel
    Wake Forest Institute for Regenerative Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    ScientificWorldJournal 11:2567-78. 2011
  7. pmc Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model
    Bum Soo Kim
    Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea
    BMC Med 10:94. 2012
  8. pmc GeneChip analysis of human embryonic stem cell differentiation into hemangioblasts: an in silico dissection of mixed phenotypes
    Shi Jiang Lu
    Advanced Cell Technology, Worcester, MA 01605, USA
    Genome Biol 8:R240. 2007
  9. ncbi request reprint Recent developments in tissue engineering and regenerative medicine
    Anthony Atala
    Wake Forest University School of Medicine, Department of Urology and Institute for Regenerative Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Pediatr 18:167-71. 2006
  10. ncbi request reprint Tissue-engineered autologous bladders for patients needing cystoplasty
    Anthony Atala
    Department of Urology and Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Lancet 367:1241-6. 2006

Research Grants

  1. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
  2. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2002
  3. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2003
  4. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2007
  5. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 1999
  6. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
  7. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2001
  8. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2000
  9. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2003

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Experimental and clinical experience with tissue engineering techniques for urethral reconstruction
    Anthony Atala
    Department of Urology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Urol Clin North Am 29:485-92, ix. 2002
    ..If a tubularized urethral repair is needed, the use of cells on the collagen matrix is essential for adequate tissue formation. Tissue engineering techniques are useful for urethral reconstruction...
  2. doi request reprint Engineering organs
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine, Winston Salem, NC 27157, USA
    Curr Opin Biotechnol 20:575-92. 2009
    ..Although stem cells are still in the research phase, some therapies arising from tissue engineering endeavors have already entered the clinical setting successfully, indicating the promise regenerative medicine holds for the future...
  3. doi request reprint Regenerative medicine strategies
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine, Winston Salem, NC 27157, USA
    J Pediatr Surg 47:17-28. 2012
    ..While stem cells are still in the research phase, some therapies arising from tissue engineering endeavors have already entered the clinical setting successfully, indicating the promise regenerative medicine holds for the future...
  4. doi request reprint Tissue engineering of reproductive tissues and organs
    Anthony Atala
    Department of Urology, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Fertil Steril 98:21-9. 2012
    ..This article discusses these tissue engineering strategies for various organs in the male and female reproductive tract...
  5. pmc Basic science research in urology training
    D Eberli
    Wake Forest Institute for Regenerative Medicine, Medical Center Boulevard, Winston Salem, NC, USA
    Indian J Urol 25:217-20. 2009
    ..Further, we will highlight different opportunities for trainees to obtain significant research exposure in urology...
  6. pmc Tissue engineering of the penis
    Manish N Patel
    Wake Forest Institute for Regenerative Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    ScientificWorldJournal 11:2567-78. 2011
    ..Recent progress suggests that engineered urologic tissues and cell therapy may soon have clinical applicability...
  7. pmc Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model
    Bum Soo Kim
    Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea
    BMC Med 10:94. 2012
    ..Recently, human amniotic fluid stem cells (hAFSCs) have been proposed as an ideal cell therapy source. In this study, we investigated whether periurethral injection of hAFSCs can restore urethral sphincter competency in a mouse model...
  8. pmc GeneChip analysis of human embryonic stem cell differentiation into hemangioblasts: an in silico dissection of mixed phenotypes
    Shi Jiang Lu
    Advanced Cell Technology, Worcester, MA 01605, USA
    Genome Biol 8:R240. 2007
    ..Blast cells are multipotent and can differentiate into multiple lineages of hematopoeitic cells (erythroid, granulocyte and macrophage), endothelial and smooth muscle cells...
  9. ncbi request reprint Recent developments in tissue engineering and regenerative medicine
    Anthony Atala
    Wake Forest University School of Medicine, Department of Urology and Institute for Regenerative Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Pediatr 18:167-71. 2006
    ..This paper reviews recent advances that have occurred in regenerative medicine and describes applications of new technologies to treat diseased or damaged organs and tissues...
  10. ncbi request reprint Tissue-engineered autologous bladders for patients needing cystoplasty
    Anthony Atala
    Department of Urology and Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Lancet 367:1241-6. 2006
    ..The presence of such segments in the urinary tract has been associated with many complications. We explored an alternative approach using autologous engineered bladder tissues for reconstruction...
  11. ncbi request reprint Recent applications of regenerative medicine to urologic structures and related tissues
    Anthony Atala
    Department of Urology, Wake Forest University School of Medicine, Institute for Regenerative Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Urol 16:305-9. 2006
    ..This paper reviews recent advances that have occurred in regenerative medicine and describes application of new technologies to treat diseased or damaged organs and tissues...
  12. ncbi request reprint Engineering tissues, organs and cells
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Tissue Eng Regen Med 1:83-96. 2007
    ..This review covers recent advances that have occurred in regenerative medicine and describes applications of these technologies using chemical compounds that may offer novel therapies for patients with end-stage organ failure...
  13. ncbi request reprint Advances in tissue and organ replacement
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Stem Cell Res Ther 3:21-31. 2008
    ..While stem cells are still in the research phase, some therapies arising from tissue engineering endeavors have already entered the clinical setting, indicating that regenerative medicine holds promise for the future...
  14. ncbi request reprint Tissue engineering for the replacement of organ function in the genitourinary system
    Anthony Atala
    Wake Forest Institute of Regenerative Medicine, Department of Urology, Winston Salem, NC, USA
    Am J Transplant 4:58-73. 2004
    ..Recent progress suggests that engineered genitourinary tissues may have clinical applicability in the future...
  15. ncbi request reprint Technology insight: Applications of tissue engineering and biological substitutes in urology
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine, and Department of Urology, Wake Forest University, School of Medicine, Winston Salem, NC 27157, USA
    Nat Clin Pract Urol 2:143-9. 2005
    ..This article reviews recent advances in regenerative medicine and describes applications of biological substitutes that may offer novel therapies for patients with end-stage organ failure...
  16. ncbi request reprint Applications of tissue engineering in the genitourinary tract
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Expert Rev Med Devices 2:119-26. 2005
    ..This article reviews some of the principles of tissue engineering and some of the applications of these principles to the genitourinary tract...
  17. ncbi request reprint Tissue engineering, stem cells and cloning: current concepts and changing trends
    Anthony Atala
    Department of Urology, Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Expert Opin Biol Ther 5:879-92. 2005
    ..This paper reviews recent advances in stem cell research and regenerative medicine, and describes the clinical applications of these technologies as novel therapies for tissue or organ loss...
  18. ncbi request reprint Regeneration of urologic tissues and organs
    Anthony Atala
    Department of Urology, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Adv Biochem Eng Biotechnol 94:181-210. 2005
    ..This chapter reviews recent advances that have occurred in the regeneration of urologic organs and describes how these applications may offer novel therapies for patients with urologic disease...
  19. ncbi request reprint Tissue engineering applications of therapeutic cloning
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Annu Rev Biomed Eng 6:27-40. 2004
    ..The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure...
  20. ncbi request reprint Tissue engineering and regenerative medicine: concepts for clinical application
    Anthony Atala
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Rejuvenation Res 7:15-31. 2004
    ..This paper reviews recent advances that have occurred in regenerative medicine and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure...
  21. doi request reprint Bioengineered tissues for urogenital repair in children
    Anthony Atala
    Institute for Regenerative Medicine and Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Pediatr Res 63:569-75. 2008
    ..This goal may soon be attainable with the use of tissue engineering techniques...
  22. ncbi request reprint Tissue engineering for urinary incontinence applications
    C J Koh
    Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Minerva Ginecol 56:371-8. 2004
    ..The principles of tissue engineering will be discussed as well as some current strategies for applying these principles in developing novel therapies for urinary incontinence...
  23. doi request reprint AFIRM: moving regenerative medicine onto the battlefield
    Atala Anthony
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Regen Med 3:463-4. 2008
  24. ncbi request reprint Extending life using tissue and organ replacement
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine, Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Curr Aging Sci 1:73-83. 2008
    ..There is a growing optimism that the successes in this field will achieve the goal of significantly extending the life of the patient...
  25. doi request reprint Tissue engineering of human bladder
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br Med Bull 97:81-104. 2011
    ..Further research to develop novel biomaterials and cell sources, as well as information gained from developmental biology, signal transduction studies and studies of the wound healing response would be beneficial...
  26. doi request reprint Regenerative medicine and tissue engineering in urology
    Anthony Atala
    Department of Urology, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Urol Clin North Am 36:199-209, viii-ix. 2009
    ..Recent progress suggests that engineered urologic tissues and cell therapy may have clinical applicability...
  27. doi request reprint Bilayered scaffold for engineering cellularized blood vessels
    Young Min Ju
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 31:4313-21. 2010
    ..We show that the bilayered scaffolds permit EC adhesion on the lumen and SMC infiltration into the outer layer. This study suggests that the use of bilayered scaffolds may lead to improved vessel formation...
  28. ncbi request reprint Engineering tissues and organs
    A Atala
    Department of Urology, Children s Hospital, Boston, Massachusetts, USA
    Curr Opin Urol 9:517-26. 1999
    ..As the science of tissue engineering evolves, one can expect a wider application of this technology to the armamentarium of urologic surgery...
  29. ncbi request reprint Therapeutic cloning and tissue engineering
    Chester J Koh
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Top Dev Biol 60:1-15. 2004
    ..The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure...
  30. doi request reprint Assessments of injectable alginate particle-embedded fibrin hydrogels for soft tissue reconstruction
    C M Hwang
    Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA
    Biomed Mater 8:014105. 2013
    ..This injectable hybrid system composed of degradable and non-degradable hydrogels may be a preferable approach to the repair of soft tissue defects...
  31. pmc Myogenic differentiation of human bone marrow mesenchymal stem cells on a 3D nano fibrous scaffold for bladder tissue engineering
    Hong Tian
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Biomaterials 31:870-7. 2010
    ..Our results demonstrate that myogenic-differentiated BMSC seeded on a nano fibrous PLLA scaffold can be potentially used for cell-based tissue engineering for bladder cancer patients requiring cystoplasty...
  32. ncbi request reprint Tissue engineering approaches for genital reconstruction
    Anthony Atala
    Laboratory for Tissue Engineering and Cellular Therapeutics, Department of Urology, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Adv Exp Med Biol 511:289-303. 2002
  33. ncbi request reprint Tissue engineering, stem cells, and cloning for the regeneration of urologic organs
    Anthony Atala
    Department of Urology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Clin Plast Surg 30:649-67. 2003
    ..Recent progress suggests that engineered urologic tissues may have an expanded clinical applicability in the future...
  34. doi request reprint Tissue engineering a complete vaginal replacement from a small biopsy of autologous tissue
    Roger E De Filippo
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Transplantation 86:208-14. 2008
    ..BJU Int 2000; 85: 715; Lai and Chang, Changgeng Yi Xue Za Zhi 1999; 22: 253; Parsons et al., J Pediatr Surg 2002; 37: 629; Seccia et al., Ann Plast Surg 2002; 49: 379; Filipas, Curr Opin Urol 2001; 11: 267)...
  35. ncbi request reprint Reconstitution of human corpus cavernosum smooth muscle in vitro and in vivo
    Richard T Kershen
    Laboratory for Tissue Engineering and Cellular Therapeutics, Department of Urology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Tissue Eng 8:515-24. 2002
    ..This study provides evidence that cultured human corporal smooth muscle cells may be used in conjunction with biodegradable polymer scaffolds to create corpus cavernosum smooth muscle tissue in vitro and in vivo...
  36. ncbi request reprint Urethral replacement using cell seeded tubularized collagen matrices
    Roger E De Filippo
    Department of Urology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Urol 168:1789-92; discussion 1792-3. 2002
    ..We investigated whether collagen matrices, either alone or with autologous cells, could be used for tubularized urethral replacement...
  37. doi request reprint A method to improve cellular content for corporal tissue engineering
    Daniel Eberli
    Wake Forest Institute for Regenerative Medicine and Department of Urology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27154, USA
    Tissue Eng Part A 14:1581-9. 2008
    ..This study demonstrates that dynamic cell attachment, using a bioreactor system, leads to the formation of morphologically and biochemically improved corporal tissue, which may be useful for penile reconstruction...
  38. doi request reprint Decellularization for whole organ bioengineering
    J E Arenas-Herrera
    Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomed Mater 8:014106. 2013
    ..This paper reviews recently described techniques used to decellularize whole organs such as the heart, lung, liver and kidney and describes possible methods for using these matrices for whole organ engineering...
  39. ncbi request reprint Ketorolac suppresses postoperative bladder spasms after pediatric ureteral reimplantation
    J M Park
    Department of Urology, The Children s Hospital and Harvard Medical School, Boston, MA, USA
    Anesth Analg 91:11-5. 2000
    ..2 (mild = 1.0, severe = 3.0), compared with 2.6 for the placebo group (P = 0.003). We conclude that IV ketorolac reduces the frequency and severity of postoperative bladder spasms after intravesical ureteroneocystostomy...
  40. doi request reprint Sources of stem cells for regenerative medicine
    JENNIFER HIPP
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157, USA
    Stem Cell Rev 4:3-11. 2008
    ..We also discuss the use of amniotic-fluid derived stem cells (AFS) for potential patient-specific therapies...
  41. ncbi request reprint Future perspectives in reconstructive surgery using tissue engineering
    A Atala
    Department of Urology, Children s Hospital, Boston, Massachusetts, USA
    Urol Clin North Am 26:157-65, ix-x. 1999
    ..Trials involving bladder replacement using tissue engineering techniques currently are being arranged. Recent progress suggests that engineered urologic tissues may have clinical applicability...
  42. doi request reprint Composite scaffolds for the engineering of hollow organs and tissues
    Daniel Eberli
    Wake Forest Institute for Regenerative Medicine, Medical Center Boulevard, Winston Salem, NC 27154 1094, USA
    Methods 47:109-15. 2009
    ..This scaffold system may be useful in patients requiring hollow organ replacement...
  43. doi request reprint Stem cells in urology
    Tamer AbouShwareb
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nat Clin Pract Urol 5:621-31. 2008
    ..Physicians should be optimistic that regenerative medicine and tissue engineering will one day provide mainstream treatment options for urologic disorders...
  44. doi request reprint Urine derived cells are a potential source for urological tissue reconstruction
    Yuanyuan Zhang
    Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Urol 180:2226-33. 2008
    ..We determined whether the cells present in urine have characteristics of normal bladder cells and investigated their potential uses for urological reconstructive procedures...
  45. ncbi request reprint Host cell mobilization for in situ tissue regeneration
    Sang Jin Lee
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Rejuvenation Res 11:747-56. 2008
    ..Therefore, it may be possible to enrich the infiltrate with such cell types and control their fate, provided the proper substrate-mediated signaling can be imparted into the scaffold for in situ tissue regeneration...
  46. doi request reprint The influence of electrospun aligned poly(epsilon-caprolactone)/collagen nanofiber meshes on the formation of self-aligned skeletal muscle myotubes
    Jin San Choi
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 29:2899-906. 2008
    ..The aligned composite nanofiber scaffolds seeded with skeletal muscle cells may provide implantable functional muscle tissues for patients with large muscle defects...
  47. doi request reprint Oxygen generating scaffolds for enhancing engineered tissue survival
    Se Heang Oh
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 30:757-62. 2009
    ..Such scaffolds may play an important role in tissue engineering where currently oxygen diffusion limits the engineering of large tissue implants...
  48. doi request reprint The in vivo stability of electrospun polycaprolactone-collagen scaffolds in vascular reconstruction
    Bryan W Tillman
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Biomaterials 30:583-8. 2009
    ..This study suggests that electrospun scaffolds combined with vascular cells may become an alternative to prosthetic vascular grafts for vascular reconstruction...
  49. ncbi request reprint Phenotypic and functional characterization of in vivo tissue engineered smooth muscle from normal and pathological bladders
    Jin Yao Lai
    Department of Urology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Urol 168:1853-7; discussion 1858. 2002
    ..We investigated the phenotypic and functional characteristics of tissue engineered bladder smooth muscle derived from patients with functionally normal bladders and functionally abnormal exstrophic and neuropathic bladders...
  50. ncbi request reprint Engineering of human cartilage rods: potential application for penile prostheses
    Byung Soo Kim
    Department of Urology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Urol 168:1794-7. 2002
    ..In the present study we investigated the possibility of engineering human cartilage rods for potential use as penile prostheses...
  51. pmc Regenerative medicine as applied to solid organ transplantation: current status and future challenges
    Giuseppe Orlando
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
    Transpl Int 24:223-32. 2011
    ..This review describes recent advances in the engineering of several key tissues and organs...
  52. doi request reprint Megaureter
    Steve J Hodges
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    ScientificWorldJournal 10:603-12. 2010
    ..Therefore, research efforts in this field have recently focused on improving our ability to diagnose clinically relevant obstructive uropathy and examining the developmental causes of megaureter, and how this disorder may be prevented...
  53. pmc The effect of epigenetic therapy on congenital neurogenic bladders--a pilot study
    Steve J Hodges
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Urology 75:868-72. 2010
    ....
  54. doi request reprint In vivo evaluation of acellular human dermis for abdominal wall repair
    Daniel Eberli
    Wake Forest Institute for Regenerative Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Biomed Mater Res A 93:1527-38. 2010
    ..This study shows that acellular biomaterials derived from human dermis are suitable for abdominal hernia repair...
  55. doi request reprint Efficient recovery of endothelial progenitors for clinical translation
    Bryan W Tillman
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Tissue Eng Part C Methods 15:213-21. 2009
    ..To address this problem, we have developed an extracorporeal cellular affinity (ECA) column that can recover CD133 expressing progenitor cells with high efficiency...
  56. pmc Bioengineered corporal tissue for structural and functional restoration of the penis
    Kuo Liang Chen
    Department of Urology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 107:3346-50. 2010
    ..This study demonstrates that neocorpora can be engineered for total pendular penile corporal body replacement. This technology has considerable potential for patients requiring penile reconstruction...
  57. ncbi request reprint Posterior urethral valves
    Steve J Hodges
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    ScientificWorldJournal 9:1119-26. 2009
    ....
  58. doi request reprint Optimization of a natural collagen scaffold to aid cell-matrix penetration for urologic tissue engineering
    Yan Liu
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 30:3865-73. 2009
    ..Scaffolds with such characteristics have potential applications in cell-based urological tissue engineering...
  59. doi request reprint Tissue-specific extracellular matrix coatings for the promotion of cell proliferation and maintenance of cell phenotype
    Yuanyuan Zhang
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, United States
    Biomaterials 30:4021-8. 2009
    ....
  60. ncbi request reprint The use of thermal treatments to enhance the mechanical properties of electrospun poly(epsilon-caprolactone) scaffolds
    Sang Jin Lee
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 29:1422-30. 2008
    ..This study suggests that the introduction of thermal fiber bonding to electrospun PCL scaffolds improved the biomechanical properties of these scaffolds, making them more suitable for tissue engineering applications...
  61. ncbi request reprint Smart biomaterials design for tissue engineering and regenerative medicine
    Mark E Furth
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 28:5068-73. 2007
    ..Clinical translation of these new classes of biomaterials will be supported by many of the same evaluation tools as those developed and described by Professor David F. Williams and colleagues over the past 30 years...
  62. ncbi request reprint Carbon nanotube applications for tissue engineering
    Benjamin S Harrison
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 28:344-53. 2007
    ..Overall, carbon nanotubes may play an integral role as unique biomaterial for creating and monitoring engineered tissue...
  63. ncbi request reprint Engineering of blood vessels from acellular collagen matrices coated with human endothelial cells
    Gilad E Amiel
    Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Tissue Eng 12:2355-65. 2006
    ..Tissue-engineered vessels may potentially be useful clinically as vascular grafts...
  64. ncbi request reprint Isolation of amniotic stem cell lines with potential for therapy
    Paolo De Coppi
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1094, USA
    Nat Biotechnol 25:100-6. 2007
    ....
  65. ncbi request reprint Controlled fabrication of a biological vascular substitute
    Joel Stitzel
    Virginia Tech Wake Forest University, School of Biomedical Engineering and Sciences, Wake Forest University, USA
    Biomaterials 27:1088-94. 2006
    ..This study demonstrates the promise of electrospinning as a fabrication process for a functional vascular graft for clinical use...
  66. ncbi request reprint Therapeutic cloning applications for organ transplantation
    Chester J Koh
    Wake Forest Institute for Regenerative Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Transpl Immunol 12:193-201. 2004
    ..The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure...
  67. ncbi request reprint In vitro evaluation of a poly(lactide-co-glycolide)-collagen composite scaffold for bone regeneration
    Sang Jin Lee
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 27:3466-72. 2006
    ..Use of the composite scaffolding system with cells may enhance the formation of bone tissue for therapeutic regeneration...
  68. ncbi request reprint The future of bladder research: molecular profiling, new drug targets, gene therapy, and tissue engineering
    George Christ
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, BRF1 Building, Room 442, Medical Center Blvd, Winston Salem, NC, 27157, USA
    Curr Urol Rep 8:95-9. 2007
  69. ncbi request reprint What's new in urology
    Anthony Atala
    Wake Forest Institute for Regenerative Medicine and Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Am Coll Surg 199:446-61. 2004
  70. ncbi request reprint Oxygen producing biomaterials for tissue regeneration
    Benjamin S Harrison
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 28:4628-34. 2007
    ..This indicates that improved tissue viability could be maintained for several days using oxygen producing biomaterials...
  71. ncbi request reprint Future perspectives in bladder reconstruction
    Anthony Atala
    Department of Urology, Children s Hospital Boston, Harvard Medical School, USA
    Adv Exp Med Biol 539:921-40. 2003
  72. doi request reprint Controlled heparin conjugation on electrospun poly(ε-caprolactone)/gelatin fibers for morphology-dependent protein delivery and enhanced cellular affinity
    J Lee
    Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Acta Biomater 8:2549-58. 2012
    ....
  73. ncbi request reprint Tissue engineered stents created from chondrocytes
    G E Amiel
    Laboratory for Tissue Engineering and Cellular Therapeutics, Department of Urology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Urol 165:2091-5. 2001
    ..This technology may be useful clinically for stricture disease in the genitourinary tract...
  74. ncbi request reprint Tissue engineering of artificial organs
    A Atala
    Department of Urology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Endourol 14:49-57. 2000
    ..Recent progress suggests that engineered urologic tissues may have clinical applicability in the future...
  75. ncbi request reprint Tissue engineering in urology
    A Atala
    Department of Urology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Curr Urol Rep 2:83-92. 2001
    ..Recent progress suggests that engineered urologic tissues may have clinical applicability in the future...
  76. ncbi request reprint Regenerative medicine and urology
    A Atala
    Department of Urology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    BJU Int 92:58-67. 2003
  77. ncbi request reprint Failure of differentiation into mature myotubes by muscle precursor cells with the side-population phenotype after injection into irreversibly damaged striated urethral sphincter
    Rene Yiou
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Transplantation 80:131-3. 2005
    ..In the setting of sphincter insufficiency, injection of MPCs at different stages of maturation may be a better option than purified muscle stem cells...
  78. doi request reprint Whole organ decellularization - a tool for bioscaffold fabrication and organ bioengineering
    Pedro M Baptista
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6526-9. 2009
    ..These bioscaffolds can further provide a tool to study cells in their natural three-dimensional environment, which is superior for drug discovery platform compared with cells cultured in two-dimensional petri dishes...
  79. pmc Differentiation of human bone marrow mesenchymal stem cells into bladder cells: potential for urological tissue engineering
    Hong Tian
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Tissue Eng Part A 16:1769-79. 2010
    ..In conclusion, smooth muscle- and urothelium-like cells derived from human BMSCs provide an alternative cell source for potential use in bladder tissue engineering...
  80. ncbi request reprint Urethral stricture repair with an off-the-shelf collagen matrix
    Abdel W El-Kassaby
    Center for Genitourinary Tissue Reconstruction, Department of Urology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Urol 169:170-3; discussion 173. 2003
    ..We explored the feasibility of using a bladder submucosa collagen based inert matrix as a free graft substitute for urethral stricture repair...
  81. ncbi request reprint Stem cell sources to treat diabetes
    Mark E Furth
    Department of Urology and Wake Forest, Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Cell Biochem 106:507-11. 2009
    ..Banking strategies to identify small numbers of stem cell lines homozygous for major histocompatibility loci have been proposed to enable beneficial genetic matching that would decrease the need for immunosuppression...
  82. ncbi request reprint Tubularized urethral replacement with unseeded matrices: what is the maximum distance for normal tissue regeneration?
    Ryan P Dorin
    Department of Urology, LAC USC Medical Center, 1200 N State St Suite 5900, Los Angeles, CA 90033, USA
    World J Urol 26:323-6. 2008
    ..We investigated the maximum potential distance of normal native tissue regeneration over a range of distances using acellular matrices for tubular grafts as an experimental model...
  83. ncbi request reprint Tubularized incised plate urethroplasty: expanded use in primary and repeat surgery for hypospadias
    J G Borer
    Department of Urology, Children's Hospital and Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
    J Urol 165:581-5. 2001
    ..The technique has few complications as well as proved success and versatility that continues to expand its applicability and popularity...
  84. ncbi request reprint Sibling vesicoureteral reflux in multiple gestation births
    M Kaefer
    Department of Urology, Children s Hospital and Harvard Medical School, Boston, MA, USA
    Pediatrics 105:800-4. 2000
    ..We report the incidence of VUR in siblings of multiple gestation births and for the first time compare the relative incidence of reflux between identical and fraternal twins...
  85. pmc Complete duplication of collecting system in a horseshoe kidney presenting with recurrent urinary tract infections: report of an exceedingly rare congenital anomaly and review of literature
    Majid Mirzazadeh
    Department of Urology, Wake Forest University Baptist Medical Centre, Winston Salem, North Carolina, USA
    ScientificWorldJournal 11:1591-6. 2011
    ..Further, our patient was managed conservatively, whereas the previous four patients were managed with surgery...
  86. ncbi request reprint Systems for therapeutic angiogenesis in tissue engineering
    S Soker
    Department of Urology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    World J Urol 18:10-8. 2000
    ..This article reviews the process of blood-vessel growth and tissue vascularization, placing emphasis on strategies that can be employed for efficient vascularization of engineered tissues in vitro and in vivo...
  87. ncbi request reprint Tunica repair with acellular bladder matrix maintains corporal tissue function
    D Eberli
    Department of Urology and Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Int J Impot Res 19:602-9. 2007
    ..These results show that ABM is biocompatible, durable and effective when used as a tunica substitute. The matrix may be useful as an off-the-shelf biomaterial for patients requiring tunica albuginea repair...
  88. ncbi request reprint Controlled release of therapeutic agents: slow delivery and cell encapsulation
    M Machluf
    Department of Urology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    World J Urol 18:80-3. 2000
    ..Similar studies are also being conducted in our laboratory on encapsulation of ovarian cells for the secretion of progesterone and estrogen in culture and in vivo using microencapsulation techniques...
  89. doi request reprint Development of a composite vascular scaffolding system that withstands physiological vascular conditions
    Sang Jin Lee
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 29:2891-8. 2008
    ..The PCL/collagen composite scaffolds are biocompatible, possess biomechanical properties that resist high degrees of pressurized flow over long term, and provide a favorable environment that supports the growth of vascular cells...
  90. ncbi request reprint Antiangiogenic properties of gold nanoparticles
    Priyabrata Mukherjee
    Department of Biochemistry, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Clin Cancer Res 11:3530-4. 2005
    ..These results report for the first time a novel property of gold nanoparticles to bind heparin-binding proteins and thereby inhibit their subsequent signaling events...
  91. pmc Stem cells: cross-talk and developmental programs
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Boston, MA4 02115, USA
    Philos Trans R Soc Lond B Biol Sci 359:823-37. 2004
    ..Understanding the relevant molecular pathways of stem cell repair phenotype should be a priority, in our view, for the entire stem cell field...
  92. doi request reprint Cyclic mechanical preconditioning improves engineered muscle contraction
    Du Geon Moon
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Tissue Eng Part A 14:473-82. 2008
    ..This finding has important implications to the application of tissue engineering and regenerative medicine to skeletal muscle replacement and reconstruction...
  93. ncbi request reprint Prospects for engineering the urinary tract
    Chester J Koh
    Wake Forest Institute for Regenerative Medicine, Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nephron Exp Nephrol 98:e65-70. 2004
    ....
  94. ncbi request reprint Endoscopic treatment of vesicoureteral reflux with autologous chondrocytes: postoperative sonographic features
    Harriet J Paltiel
    Department of Radiology, Children s Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Radiology 232:390-7. 2004
    ....
  95. ncbi request reprint Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat
    Angela Chiavegato
    Deparment of Biomedical Sciences, University of Padua, Viale G Colombo, 3 35121 Padova, Italy
    J Mol Cell Cardiol 42:746-59. 2007
    ....
  96. ncbi request reprint The regeneration process of the striated urethral sphincter involves activation of intrinsic satellite cells
    Rene Yiou
    Laboratory of Tissue Engineering and Cellular Therapeutics, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Anat Embryol (Berl) 206:429-35. 2003
    ..The therapeutic implications of this knowledge and the possible origin of the sphincteric satellite cells are discussed...
  97. ncbi request reprint Principals of neovascularization for tissue engineering
    Masashi Nomi
    Department of Urology, Laboratory for Cellular Therapeutics and Tissue Engineering, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Mol Aspects Med 23:463-83. 2002
    ..This paper reviews the process of blood vessel growth and tissue vascularization, and discuss strategies for efficient vascularization of engineered tissues...
  98. doi request reprint This month in investigative urology
    Anthony Atala
    J Urol 180:1214-5. 2008
  99. ncbi request reprint Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices
    German Falke
    Laboratory for Tissue Engineering and Cellular Therapeutics, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Tissue Eng 9:871-9. 2003
    ..This study demonstrates that human cavernosal smooth muscle and endothelial cells seeded on three-dimensional acellular collagen matrices derived from donor corpora are able to form well-vascularized corporal tissues in vivo...
  100. ncbi request reprint Tumor cell-associated neuropilin-1 and vascular endothelial growth factor expression as determinants of tumor growth in neuroblastoma
    Karen Marcus
    Department of Radiation Oncology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Neuropathology 25:178-87. 2005
    ..Our studies indicate that VEGF and VEGF receptor expression in NBL tumor cells are associated with tumor growth and that angiogenic factors may serve as a biological marker together with already established MYCN amplification...
  101. ncbi request reprint A novel use of centrifugal force for cell seeding into porous scaffolds
    W T Godbey
    Children s Hospital Harvard Medical School, Boston, MA 02115, USA
    Biomaterials 25:2799-805. 2004
    ..33 x 10(5) cells/ml). This system is useful for the seeding of biomaterials having cylindrical or planar geometries, and may be used under conditions that require low cell numbers and/or short seeding time periods...

Research Grants11

  1. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
    ..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
  2. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2002
    ..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..
  3. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2003
    ..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..
  4. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2007
    ..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
  5. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 1999
    ..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..
  6. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
    ..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
  7. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2001
    ..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..
  8. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2000
    ..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..
  9. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2003
    ..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..