Karl Erik Andersson

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. doi request reprint β3-receptor agonists for overactive bladder--new frontier or more of the same?
    Karl Erik Andersson
    Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Curr Urol Rep 14:435-41. 2013
  2. doi request reprint Selective β₃-adrenoceptor agonists for the treatment of overactive bladder
    Karl Erik Andersson
    Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina Electronic address
    J Urol 190:1173-80. 2013
  3. doi request reprint Treatment of lower urinary tract symptoms: agents for intraprostatic injection
    Karl Erik Andersson
    Institute of Regenerative Medicine, Wake Forest University School of Medicine, Wake Forest Baptist Medical Center, Winston Salem, NC 27157, USA
    Scand J Urol 47:83-90. 2013
  4. doi request reprint Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction
    K E Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pharmacol Rev 63:811-59. 2011
  5. doi request reprint Therapeutic targets for premature ejaculation
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    Maturitas 70:26-33. 2011
  6. ncbi request reprint Urothelial effects of oral agents for overactive bladder
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Curr Urol Rep 9:459-64. 2008
  7. doi request reprint Urodynamic evaluation of fesoterodine metabolite, doxazosin and their combination in a rat model of partial urethral obstruction
    Claudius Fullhase
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC, USA
    BJU Int 106:287-93. 2010
  8. doi request reprint Alterations in bladder function associated with urothelial defects in uroplakin II and IIIa knockout mice
    Tamer AbouShwareb
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Neurourol Urodyn 28:1028-33. 2009
  9. doi request reprint Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering
    Shantaram Bharadwaj
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27101, USA
    Tissue Eng Part A 17:2123-32. 2011
  10. doi request reprint Impact of partial urethral obstruction on bladder function: time-dependent changes and functional correlates of altered expression of Ca²⁺ signaling regulators
    David Burmeister
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Physiol Renal Physiol 302:F1517-28. 2012

Collaborators

Detail Information

Publications58

  1. doi request reprint β3-receptor agonists for overactive bladder--new frontier or more of the same?
    Karl Erik Andersson
    Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Curr Urol Rep 14:435-41. 2013
    ..In this short review, the mechanisms of action, clinical efficacy, and adverse effect profiles of the two groups of drugs are compared and discussed. ..
  2. doi request reprint Selective β₃-adrenoceptor agonists for the treatment of overactive bladder
    Karl Erik Andersson
    Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina Electronic address
    J Urol 190:1173-80. 2013
    ..Discovery of the β₃-adrenoceptor with high expression in the bladder suggested that this receptor, which mediates detrusor relaxation, could be a target for overactive bladder symptoms...
  3. doi request reprint Treatment of lower urinary tract symptoms: agents for intraprostatic injection
    Karl Erik Andersson
    Institute of Regenerative Medicine, Wake Forest University School of Medicine, Wake Forest Baptist Medical Center, Winston Salem, NC 27157, USA
    Scand J Urol 47:83-90. 2013
    ....
  4. doi request reprint Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction
    K E Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pharmacol Rev 63:811-59. 2011
    ..This requires identification of new therapeutic targets and design of new approaches. Research in the field is expanding, and several promising new targets for future drugs have been identified...
  5. doi request reprint Therapeutic targets for premature ejaculation
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    Maturitas 70:26-33. 2011
    ..It is clear that exploiting the full therapeutic potential of these targets will require additional basic and clinical research...
  6. ncbi request reprint Urothelial effects of oral agents for overactive bladder
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Curr Urol Rep 9:459-64. 2008
    ..This has not yet been demonstrated to imply superior clinical efficacy. Nevertheless, mucosal afferent signaling pathways are therapeutically interesting targets that should be further explored...
  7. doi request reprint Urodynamic evaluation of fesoterodine metabolite, doxazosin and their combination in a rat model of partial urethral obstruction
    Claudius Fullhase
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC, USA
    BJU Int 106:287-93. 2010
    ....
  8. doi request reprint Alterations in bladder function associated with urothelial defects in uroplakin II and IIIa knockout mice
    Tamer AbouShwareb
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Neurourol Urodyn 28:1028-33. 2009
    ..The effects of deleting genes encoding uroplakins II (UPII) and III (UPIIIa) on mouse bladder physiology/dysfunction were studied in male and female wild type and knockout (KO) mice...
  9. doi request reprint Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering
    Shantaram Bharadwaj
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27101, USA
    Tissue Eng Part A 17:2123-32. 2011
    ....
  10. doi request reprint Impact of partial urethral obstruction on bladder function: time-dependent changes and functional correlates of altered expression of Ca²⁺ signaling regulators
    David Burmeister
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Physiol Renal Physiol 302:F1517-28. 2012
    ..These data extend prior work to suggest that molecular profiling of key regulatory molecules during the progression of PUO-mediated bladder dysfunction may shed new light on potential biomarkers and/or therapeutic targets...
  11. doi request reprint Beta3-adrenoceptors in the rat sacral spinal cord and their functional relevance in micturition under normal conditions and in a model of partial urethral obstruction
    Claudius Fullhase
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC, USA
    Neurourol Urodyn 30:1382-7. 2011
    ....
  12. pmc Impaired bladder function in aging male rats
    Weixin Zhao
    Wake Forest Institute for Regenerative Medicine, Winston Salem, North Carolina, USA
    J Urol 184:378-85. 2010
    ..Some confounding variables can be avoided by studying age related changes in an animal model. We evaluated the impact of age on bladder function in vivo and in vitro, and characterized the corresponding morphological changes...
  13. doi request reprint Smooth-muscle-specific gene transfer with the human maxi-k channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys
    George J Christ
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Primate Center, Department of Comparative Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Eur Urol 56:1055-66. 2009
    ..Despite the advent of effective oral therapies for erectile dysfunction (ED), many patients are not successfully treated, and side effects have been documented...
  14. pmc The pharmacology of regenerative medicine
    George J Christ
    Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27101, USA
    Pharmacol Rev 65:1091-133. 2013
    ..Hopefully, the broad foundational knowledge provided herein will spark sustained conversations among experts in diverse fields of scientific research to the benefit of all. ..
  15. doi request reprint Long-term structural and functional effects of autologous muscle precursor cell therapy in a nonhuman primate model of urinary sphincter deficiency
    Sherif Badra
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina
    J Urol 190:1938-45. 2013
    ..We measured the long-term efficacy of autologous muscle precursor cell therapy in premenopausal female nonhuman primates with sustained urinary sphincter deficiency...
  16. pmc Bladder dysfunction in a new mutant mouse model with increased superoxide--lack of nitric oxide?
    Roberto Soler
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina, USA
    J Urol 183:780-5. 2010
    ..Mice with mutation in the Immp2l gene have high superoxide ion levels and a consequent decrease in the bioavailable amount of nitric oxide. We studied bladder function in this mouse model...
  17. ncbi request reprint Pharmacology of alpha1-adrenoceptor antagonists in the lower urinary tract and central nervous system
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nat Clin Pract Urol 4:368-78. 2007
    ....
  18. doi request reprint Stem cell therapy ameliorates bladder dysfunction in an animal model of Parkinson disease
    Roberto Soler
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina, USA
    J Urol 187:1491-7. 2012
    ..We evaluated the effect of human amniotic fluid stem cells and bone marrow derived mesenchymal stem cells (ALLCELLS, Emeryville, California) on bladder dysfunction in a rat model of Parkinson disease...
  19. doi request reprint Rodent models for urodynamic investigation
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC, USA
    Neurourol Urodyn 30:636-46. 2011
    ..The present review discusses the principles of urodynamics in rodents, techniques, and terminology, as well as some commonly used disease models, and their translational value...
  20. doi request reprint Spinal effects of the fesoterodine metabolite 5-hydroxymethyl tolterodine and/or doxazosin in rats with or without partial urethral obstruction
    Claudius Fullhase
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Urol 184:783-9. 2010
    ....
  21. doi request reprint Transient receptor potential A1 and cannabinoid receptor activity in human normal and hyperplastic prostate: relation to nerves and interstitial cells
    Christian Gratzke
    Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA
    Eur Urol 57:902-10. 2010
    ..Ion channel transient receptor potential A1 (TRPA1) and cannabinoid (CB) receptors are involved in mechanoafferent signaling from the bladder and the urethra...
  22. doi request reprint Bladder dysfunction and parkinsonism: current pathophysiological understanding and management strategies
    Lysanne Campeau
    Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Urol Rep 12:396-403. 2011
    ..This review presents the most recent studies and evidence on the pathophysiological mechanisms of PD-related voiding dysfunction and its available therapies...
  23. ncbi request reprint The future of bladder research: molecular profiling, new drug targets, gene therapy, and tissue engineering
    George Christ
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, BRF1 Building, Room 442, Medical Center Blvd, Winston Salem, NC, 27157, USA
    Curr Urol Rep 8:95-9. 2007
  24. ncbi request reprint Phosphodiesterases (PDEs) and PDE inhibitors for treatment of LUTS
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Neurourol Urodyn 26:928-33. 2007
    ..Information for the review was obtained from searches of the PubMed database, and from the authors' files...
  25. doi request reprint Angiogenic gene modification of skeletal muscle cells to compensate for ageing-induced decline in bioengineered functional muscle tissue
    Dawn M Delo
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    BJU Int 102:878-84. 2008
    ....
  26. pmc Common theme for drugs effective in overactive bladder treatment: inhibition of afferent signaling from the bladder
    Brandy Hood
    Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Int J Urol 20:21-7. 2013
    ..In the present review, the different mechanisms forming the pharmacological basis for the use of these drugs are discussed...
  27. doi request reprint The effect of in vitro formation of acetylcholine receptor (AChR) clusters in engineered muscle fibers on subsequent innervation of constructs in vivo
    In Kap Ko
    Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 34:3246-55. 2013
    ..This technique has considerable potential for enhancing muscle tissue function...
  28. pmc Characterization of the early proliferative response of the rodent bladder to subtotal cystectomy: a unique model of mammalian organ regeneration
    Charles C Peyton
    Department of Urology, Wake Forest Baptist Medical Center, Winston Salem, North Carolina, United States of America
    PLoS ONE 7:e47414. 2012
    ..This report extends previous observations and further establishes the rodent bladder as an excellent model for studying novel aspects of mammalian organ regeneration...
  29. doi request reprint Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2): consequences for mouse bladder development and function
    Amy N Hicks
    Wake Forest Institute for Regenerative Medicine, Winston Salem, North Carolina
    Neurourol Urodyn 32:1130-6. 2013
    ..To describe the morphological and functional consequences for bladder development and function when nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) is lacking or reduced...
  30. doi request reprint Development of bladder dysfunction in a rat model of dopaminergic brain lesion
    Roberto Soler
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    Neurourol Urodyn 30:188-93. 2011
    ..We evaluated the temporal development of bladder dysfunction in rat PD model where urodynamic changes were induced by unilateral injection of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB)...
  31. ncbi request reprint Effects of Allogeneic Bone Marrow Derived Mesenchymal Stromal Cell Therapy on Voiding Function in a Rat Model of Parkinson Disease
    Lysanne Campeau
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina Department of Urology, New York University, New York, New York Electronic address
    J Urol . 2013
    ..We sought to prolong the effect by injecting allogeneic rat bone marrow mesenchymal stromal cells before and after microencapsulation into the substantia nigra pars compacta...
  32. doi request reprint A nonhuman primate model of stable urinary sphincter deficiency
    Sherif Badra
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27101, USA
    J Urol 189:1967-74. 2013
    ..We developed and characterized a nonhuman primate model of defined injury to the urethral sphincter complex...
  33. pmc Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo
    Amy N Hicks
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina, USA
    PLoS ONE 7:e47869. 2012
    ..Whilst there have been recent suggestions that Nmnat2 may be an endogenous modulator of axon integrity, this work represents the first in vivo study demonstrating that Nmnat2 is involved in axon development or survival in a mammal...
  34. doi request reprint Tadalafil for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: pathophysiology and mechanism(s) of action
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Neurourol Urodyn 30:292-301. 2011
    ..This manuscript reviews the published literature describing the pathophysiology of male LUTS, with an emphasis on mechanisms that may be modulated or improved by phosphodiesterase type 5 (PDE5) inhibition...
  35. pmc Cardiac effects of muscarinic receptor antagonists used for voiding dysfunction
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Br J Clin Pharmacol 72:186-96. 2011
    ..Differences between drugs cannot be excluded, but risk assessments based on available evidence are not possible...
  36. doi request reprint Detrusor myocyte activity and afferent signaling
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Neurourol Urodyn 29:97-106. 2010
    ....
  37. doi request reprint Cardiovascular morbidity, heart rates and use of antimuscarinics in patients with overactive bladder
    Karl Erik Andersson
    Wake Forest University, Winston Salem, NC, USA
    BJU Int 106:268-74. 2010
    ....
  38. doi request reprint The role of the transient receptor potential (TRP) superfamily of cation-selective channels in the management of the overactive bladder
    Karl Erik Andersson
    Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    BJU Int 106:1114-27. 2010
    ..There seem to be several links between activation of different members of the TRP superfamily and LUTS/DO/OAB, and further exploration of the involvement of these channels in LUT function, normally and in dysfunction, may be rewarding...
  39. doi request reprint Metrics for evaluation of age-related changes in erectile capacity in a rodent model
    Weixin Zhao
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Sex Med 6:1885-92. 2009
    ..The observed penile erection can be characterized by the change in ICP and the ratio of ICP over blood pressure (BP; systemic blood pressure)...
  40. doi request reprint Effects on bladder function of combining elocalcitol and tolterodine in rats with outflow obstruction
    Tomi Streng
    Department of Pharmacology, Turku University, Turku, Finland
    BJU Int 110:E125-31. 2012
    ..If confirmed also in a clinical setting, this could allow for individual dose adjustments to improve efficacy in obstruction-related LUTS, and possibly reduce unwanted adverse activities by antimuscarinic therapy...
  41. ncbi request reprint Microarray analysis of exstrophic human bladder smooth muscle
    Jason Hipp
    Department of Urology, Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    BJU Int 101:100-5. 2008
    ....
  42. doi request reprint Urine derived cells are a potential source for urological tissue reconstruction
    Yuanyuan Zhang
    Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Urol 180:2226-33. 2008
    ..We determined whether the cells present in urine have characteristics of normal bladder cells and investigated their potential uses for urological reconstructive procedures...
  43. ncbi request reprint Regenerative pharmacology: the future is now
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Mol Interv 7:79-86. 2007
    ....
  44. ncbi request reprint Pharmacotherapy of the overactive bladder
    Karl Erik Andersson
    Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, United States
    Discov Med 8:118-24. 2009
    ..Which of these therapeutic principles will be developed to become clinically useful treatments remain to be established...
  45. pmc Early stages of in situ bladder regeneration in a rodent model
    David Burmeister
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27101, USA
    Tissue Eng Part A 16:2541-51. 2010
    ..These initial studies establish the utility of the present model system for studying de novo tissue regeneration in vivo and may provide guidance with respect to optimization of intrinsic regenerative capacity for clinical applications...
  46. ncbi request reprint Rho-kinase and effects of Rho-kinase inhibition on the lower urinary tract
    George J Christ
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Neurourol Urodyn 26:948-54. 2007
    ..Rho-kinase inhibitors thus appear to represent a potentially attractive therapeutic possibility for the treatment of LUTS...
  47. ncbi request reprint Treating patients with overactive bladder syndrome with antimuscarinics: heart rate considerations
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    BJU Int 100:1007-14. 2007
    ..This is without doubt the most detailed and the most reader-friendly paper on this subject, and I am sure that it will help urologists to assist in further educating their patients when prescribing these compounds...
  48. ncbi request reprint A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice
    Baisong Lu
    Institute for Regenerative Medicine, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Biol Reprod 78:601-10. 2008
    ..The results provide a novel link between mitochondrial dysfunction and infertility and suggest that superoxide ion targeting agents may prove useful for treating infertility in a subpopulation of infertile patients...
  49. doi request reprint Protective effect of a β3-adrenoceptor agonist on bladder function in a rat model of chronic bladder ischemia
    Norifumi Sawada
    Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo City, Yamanashi, Japan
    Eur Urol 64:664-71. 2013
    ..The β3-adrenoceptor (AR) agonist mirabegron has been introduced as a treatment for the overactive bladder. Its effects on the function of the ischemic bladder are not known...
  50. doi request reprint Prophylactic effect of tadalafil on bladder function in a rat model of chronic bladder ischemia
    Masanori Nomiya
    Department of Urology, Fukushima Medical University School of Medicine, Fukushima City, Japan
    J Urol 189:754-61. 2013
    ..We investigated the effect of tadalafil on chronic ischemia related bladder dysfunction...
  51. doi request reprint Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Curr Opin Urol 19:380-94. 2009
    ..Individual drugs are not discussed in detail; particular consideration is given to therapeutic aspects of the management of the elderly patient...
  52. doi request reprint Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder
    Christian Gratzke
    Wake Forest Institute for Regenerative Medicine, Winston Salem, North Carolina, USA
    J Urol 181:1939-48. 2009
    ..We investigated the distribution of cannabinoid receptor subtypes 1 and 2 in the detrusor of different species and studied the effects of cannabinoid receptor 1 and 2 agonists on bladder function...
  53. doi request reprint Voiding pattern analysis as a surrogate for cystometric evaluation in uroplakin II knockout mice
    Steve J Hodges
    Wake Forest Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Urol 179:2046-51. 2008
    ..We developed a simple surrogate measure of bladder function using ultraviolet visualization of urinary voiding patterns in a uroplakin II knockout mouse animal model...
  54. doi request reprint Effects of long-term dietary soy treatment on female urethral morphology and function in ovariectomized nonhuman primates
    Christian Gratzke
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Urol 180:2247-53. 2008
    ..Whether such effects can be achieved by soy based phytoestrogen diets is unclear. We studied the effects of chronic phytoestrogen treatment on the structural and functional properties of the urethra in ovariectomized monkeys...
  55. doi request reprint Presence of central nervous system, cardiovascular and overall co-morbidity burden in patients with overactive bladder disorder in a real-world setting
    Carl V Asche
    University of Utah College of Pharmacy, Salt Lake City, UT, USA
    BJU Int 109:572-80. 2012
    ..To determine the proportion of patients with overactive bladder (OAB) potentially at risk for adverse events by assessing their pre-existing central nervous system (CNS), cardiovascular (CV) and other co-morbidities...
  56. doi request reprint Antimuscarinic mechanisms and the overactive detrusor: an update
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Medical School, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Eur Urol 59:377-86. 2011
    ..Antimuscarinics are the drugs of choice for the treatment of detrusor overactivity (DO) and overactive bladder (OAB) syndrome. However, the mechanisms for their beneficial effects have not yet been definitely established...
  57. doi request reprint Pelvic floor disorders: linking genetic risk factors to biochemical changes
    Lysanne Campeau
    Institute for Regenerative Medicine, Wake Forest University, Department of Urology, Wake Forest University Baptist Medical Center, Winston Salem, NC, USA
    BJU Int 108:1240-7. 2011
    ..Genotyping of candidate genes participating in ECM formation will elucidate the missing link between the manifestation of the disease and the biochemical changes observed systematically, in addition to those in the pelvic floor...
  58. doi request reprint Microarray analysis of bladder smooth muscle from patients with myelomeningocele
    Jennifer A Hipp
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    BJU Int 102:741-6. 2008
    ....