Martha A Alexander-Miller

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint High-avidity CD8+ T cells: optimal soldiers in the war against viruses and tumors
    Martha A Alexander-Miller
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Immunol Res 31:13-24. 2005
  2. pmc CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation
    Nicole M Beauchamp
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Virol 86:10640-50. 2012
  3. pmc Abortive versus productive viral infection of dendritic cells with a paramyxovirus results in differential upregulation of select costimulatory molecules
    Sharmila S Pejawar
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Virol 79:7544-57. 2005
  4. pmc Functional divergence among CD103+ dendritic cell subpopulations following pulmonary poxvirus infection
    Nicole M Beauchamp
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Virol 84:10191-9. 2010
  5. ncbi request reprint Modulation of CD8+ T cell avidity by increasing the turnover of viral antigen during infection
    Peter M Gray
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cell Immunol 231:14-9. 2004
  6. pmc Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract
    Peter M Gray
    Department of Microbiology and Immunology, Room 5108, Gray Building, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Virol 79:3339-49. 2005
  7. ncbi request reprint Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity
    Andrew G Cawthon
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 169:3492-8. 2002
  8. pmc Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1
    Subhashini Arimilli
    1 Room 5140 Gray Building, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Leukoc Biol 87:977-88. 2010
  9. pmc Vaccinia virus infection of mature dendritic cells results in activation of virus-specific naïve CD8+ T cells: a potential mechanism for direct presentation
    Nicole L Yates
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Virology 359:349-61. 2007
  10. pmc Paramyxovirus activation and inhibition of innate immune responses
    Griffith D Parks
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston Salem, NC 27157 1064, USA Electronic address
    J Mol Biol 425:4872-92. 2013

Research Grants

  1. CONTROL OF CYTOTOXIC T CELL DIFFERENTIATION/ACTIVITY
    MARTHA ALEXANDER MILLER; Fiscal Year: 1999
  2. Control of cytotoxic T cell differentiation and activity
    MARTHA ALEXANDER MILLER; Fiscal Year: 2007
  3. Cellular Immune Responses to Respiratory Infection
    MARTHA ALEXANDER MILLER; Fiscal Year: 2007
  4. Control of cytotoxic T cell differentiation and activity
    MARTHA ALEXANDER MILLER; Fiscal Year: 2009
  5. Cellular Immune Response to Respiratory Infection
    MARTHA ALEXANDER MILLER; Fiscal Year: 2009
  6. Cellular Immune Responses to Respiratory Infection
    MARTHA ALEXANDER MILLER; Fiscal Year: 2006
  7. Control of cytotoxic T cell differentiation and activity
    MARTHA ALEXANDER MILLER; Fiscal Year: 2006
  8. CONTROL OF CYTOTOXIC T CELL DIFFERENTIATION/ACTIVITY
    MARTHA ALEXANDER MILLER; Fiscal Year: 2000
  9. CONTROL OF CYTOTOXIC T CELL DIFFERENTIATION/ACTIVITY
    MARTHA ALEXANDER MILLER; Fiscal Year: 2001
  10. CONTROL OF CYTOTOXIC T CELL DIFFERENTIATION/ACTIVITY
    MARTHA ALEXANDER MILLER; Fiscal Year: 2002

Collaborators

  • Griffith D Parks
  • Subhashini Arimilli
  • Wei Du
  • Douglas S Lyles
  • John S Parks
  • Mark S Miller
  • Zheng Cui
  • Gregory A Hawkins
  • Lloyd J Old
  • Igor M Belyakov
  • STEVEN MIZEL
  • MARTHA ALEXANDER MILLER
  • Rama D Yammani
  • MARTHA ANN ALEXANDER MILLER
  • Samuel Amoah
  • Peter M Gray
  • Nicole M Beauchamp
  • Sharmila Pejawar-Gaddy
  • Charles J Kroger
  • Beth C Holbrook
  • Rhea Y Busick
  • Andrew G Cawthon
  • Amanda L Brown
  • John B Johnson
  • Sharad K Sharma
  • Nicole L Yates
  • Amy M Hicks
  • Sharmila S Pejawar
  • James T Snyder
  • Lance K Blevins
  • Shunxing Rong
  • Swapnil Shewale
  • Jeongmin Seo
  • Jason M Grayson
  • Xuewei Zhu
  • Abraham K Gebre
  • Elena Boudyguina
  • Thaddeus C Gurley
  • Eric T Weimer
  • Elizabeth M Hiltbold
  • Negin Gitiban-Vaghefi
  • Joseph Kim
  • Gregory Riedlinger
  • Andrew J G Simpson
  • C von Kap-herr
  • Mark J Pettenati
  • Anne M Sanders
  • Mark C Willingham
  • Holly M Weir
  • Ellen M Palmer
  • Jay A Berzofskyl

Detail Information

Publications30

  1. ncbi request reprint High-avidity CD8+ T cells: optimal soldiers in the war against viruses and tumors
    Martha A Alexander-Miller
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Immunol Res 31:13-24. 2005
    ..This review summarizes the current knowledge regarding CD8+ T-cell avidity and explores some of the important issues that are, as of yet, unresolved...
  2. pmc CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation
    Nicole M Beauchamp
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Virol 86:10640-50. 2012
    ..These findings show that CD8 marks a population of lung airway-derived DC with distinct migratory and maturation responses that likely contribute differentially to the immune response depending on the infecting pathogen...
  3. pmc Abortive versus productive viral infection of dendritic cells with a paramyxovirus results in differential upregulation of select costimulatory molecules
    Sharmila S Pejawar
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Virol 79:7544-57. 2005
    ..Further, they suggest that the amount of virus encountered and/or the permissivity of a dendritic cell to infection can alter the resulting maturation phenotype and functional capacity of the infected dendritic cell...
  4. pmc Functional divergence among CD103+ dendritic cell subpopulations following pulmonary poxvirus infection
    Nicole M Beauchamp
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Virol 84:10191-9. 2010
    ..However, the functional capabilities of cells within this population differ with the expression of CD8, suggesting that CD103(+) cells may be divided further into distinct subsets...
  5. ncbi request reprint Modulation of CD8+ T cell avidity by increasing the turnover of viral antigen during infection
    Peter M Gray
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cell Immunol 231:14-9. 2004
    ..Our results are the first demonstration of the control of avidity during the antiviral response through an engineered change to a viral antigen. The implications of our findings for vaccine development are discussed...
  6. pmc Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract
    Peter M Gray
    Department of Microbiology and Immunology, Room 5108, Gray Building, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Virol 79:3339-49. 2005
    ..These studies add to the growing evidence for immune dysregulation following viral infection of the respiratory tract...
  7. ncbi request reprint Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity
    Andrew G Cawthon
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 169:3492-8. 2002
    ..These novel findings provide insights into the control of functional avidity in response to viral infection...
  8. pmc Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1
    Subhashini Arimilli
    1 Room 5140 Gray Building, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Leukoc Biol 87:977-88. 2010
    ..The reduced ability to mobilize calcium was associated with reduced expression of ORAI1, the CRAC channel subunit. These findings reveal a previously unknown mechanism for the negative regulation of function in effector T cells...
  9. pmc Vaccinia virus infection of mature dendritic cells results in activation of virus-specific naïve CD8+ T cells: a potential mechanism for direct presentation
    Nicole L Yates
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Virology 359:349-61. 2007
    ....
  10. pmc Paramyxovirus activation and inhibition of innate immune responses
    Griffith D Parks
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston Salem, NC 27157 1064, USA Electronic address
    J Mol Biol 425:4872-92. 2013
    ..We discuss the importance of innate responses in DC following paramyxovirus infection and their consequences for the ability to mount and maintain antiviral T cells. ..
  11. ncbi request reprint Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells
    Charles J Kroger
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 179:748-51. 2007
    ....
  12. pmc High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion
    Samuel Amoah
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 190:5020-9. 2013
    ..These findings support a novel model wherein modulation of the Treg response as a result of high viral burden regulates late-stage SLEC number...
  13. ncbi request reprint High avidity CD8+ T cells generated from CD28-deficient or wildtype mice exhibit a differential dependence on lipid raft integrity for activation
    Andrew G Cawthon
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cell Immunol 227:148-55. 2004
    ..These data suggest that the lines generated from the CD28-deficient mice have developed alternative strategies to promote high sensitivity to peptide antigen...
  14. pmc Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection
    Samuel Amoah
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 189:638-45. 2012
    ..These results highlight the potential contribution of avidity in the differentiation and evolution of the T cell effector response after viral infection...
  15. ncbi request reprint Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5
    Sharmila Pejawar-Gaddy
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Viral Immunol 20:76-87. 2007
    ..These findings provide evidence that different professional antigen-presenting cells can detect and respond to virus via distinct mechanisms...
  16. pmc Differentiation-dependent differences in murine T cell susceptibility to negative regulation by the lung
    Rhea Y Busick
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Respir Cell Mol Biol 44:597-605. 2011
    ..The selective resistance of CD8(+) memory cells may allow the host to limit damage during the effector phase while retaining a protective response that can effectively limit subsequent infection...
  17. pmc In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection
    Beth C Holbrook
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina
    Viral Immunol 26:302-13. 2013
    ..The possibility of tuning within select individual effectors is a previously unappreciated mechanism for the control of avidity in vivo...
  18. pmc Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions
    Amanda L Brown
    Department of Pathology, Section on Lipid Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 32:2122-30. 2012
    ..Fish oil, containing omega-3 fatty acids, attenuates atherosclerosis. We hypothesized that omega-3 fatty acid-enriched oils are atheroprotective through alteration of monocyte subsets and their trafficking into atherosclerotic lesions...
  19. pmc Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization
    John B Johnson
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    J Virol 86:9929-40. 2012
    ..They also define pathways of virus complement-mediated neutralization and suggest the design of more effective viral vectors...
  20. pmc Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction
    Sharad K Sharma
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunology 133:307-17. 2011
    ..These results suggest that regulated control of the initiation of TCR signalling in high versus low avidity cells determines the amount of peptide required for T-cell activation...
  21. pmc Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice
    Zheng Cui
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 100:6682-7. 2003
    ..The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer...
  22. pmc Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter
    Charles J Kroger
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Immunology 122:167-78. 2007
    ..We propose that CD8 cell surface expression is not a static property, but can be modulated to 'fine tune' the sensitivity of responding CTL to a defined concentration of antigen...
  23. ncbi request reprint Loss of function in virus-specific lung effector T cells is independent of infection
    Subhashini Arimilli
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Leukoc Biol 83:564-74. 2008
    ..These findings suggest an additional paradigm for the immunoregulation of effector cells that enter the lung as a result of virus infection...
  24. pmc TLR-4 and -6 agonists reverse apoptosis and promote maturation of simian virus 5-infected human dendritic cells through NFkB-dependent pathways
    Subhashini Arimilli
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    Virology 365:144-56. 2007
    ....
  25. pmc Transferable anticancer innate immunity in spontaneous regression/complete resistance mice
    Amy M Hicks
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 103:7753-8. 2006
    ....
  26. ncbi request reprint Molecular mechanisms and biological significance of CTL avidity
    James T Snyder
    Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Curr HIV Res 1:287-94. 2003
    ....
  27. pmc Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function
    Subhashini Arimilli
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    J Virol 82:10975-85. 2008
    ....
  28. pmc Regulation of maturation and activating potential in CD8+ versus CD8- dendritic cells following in vivo infection with vaccinia virus
    Rama D Yammani
    Department of Microbiology and Immunology, Room 5053, Hanes Building, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Virology 378:142-50. 2008
    ..These findings provide new insights into the control of DC maturation in vivo and demonstrate that the regulation of maturation in vivo following virus infection can be differentially controlled in distinct types of DC...
  29. ncbi request reprint High avidity CD8+ T cells are the initial population elicited following viral infection of the respiratory tract
    Peter M Gray
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Immunol 170:174-81. 2003
    ..However, as the response progresses, low avidity cells are activated/expanded to a greater extent compared with high avidity cells...
  30. ncbi request reprint Ligation of CD80 is critical for high-level CD25 expression on CD8+ T lymphocytes
    Sharmila Pejawar-Gaddy
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Immunol 177:4495-502. 2006
    ..These findings provide new insights into the role of CD80 vs CD86 and have important implications for the design of vaccines and immunotherapeutics aimed at the generation of a robust CD8+ T cell response in vivo...

Research Grants20

  1. CONTROL OF CYTOTOXIC T CELL DIFFERENTIATION/ACTIVITY
    MARTHA ALEXANDER MILLER; Fiscal Year: 1999
    ..These findings may contribute to the development of improved immunotherapeutic and vaccination strategies in which the selective activation or deletion of CTL possessing a defined avidity would be beneficial. ..
  2. Control of cytotoxic T cell differentiation and activity
    MARTHA ALEXANDER MILLER; Fiscal Year: 2007
    ..abstract_text> ..
  3. Cellular Immune Responses to Respiratory Infection
    MARTHA ALEXANDER MILLER; Fiscal Year: 2007
    ..Results from these studies should provide information that will promote development of new vaccines that will provide optimal protection against respiratory pathogens. ..
  4. Control of cytotoxic T cell differentiation and activity
    MARTHA ALEXANDER MILLER; Fiscal Year: 2009
    ..abstract_text> ..
  5. Cellular Immune Response to Respiratory Infection
    MARTHA ALEXANDER MILLER; Fiscal Year: 2009
    ..This information is of critical importance for designing optimally effective therapeutics and vaccines. ..
  6. Cellular Immune Responses to Respiratory Infection
    MARTHA ALEXANDER MILLER; Fiscal Year: 2006
    ..Results from these studies should provide information that will promote development of new vaccines that will provide optimal protection against respiratory pathogens. ..
  7. Control of cytotoxic T cell differentiation and activity
    MARTHA ALEXANDER MILLER; Fiscal Year: 2006
    ..abstract_text> ..
  8. CONTROL OF CYTOTOXIC T CELL DIFFERENTIATION/ACTIVITY
    MARTHA ALEXANDER MILLER; Fiscal Year: 2000
    ..These findings may contribute to the development of improved immunotherapeutic and vaccination strategies in which the selective activation or deletion of CTL possessing a defined avidity would be beneficial. ..
  9. CONTROL OF CYTOTOXIC T CELL DIFFERENTIATION/ACTIVITY
    MARTHA ALEXANDER MILLER; Fiscal Year: 2001
    ..These findings may contribute to the development of improved immunotherapeutic and vaccination strategies in which the selective activation or deletion of CTL possessing a defined avidity would be beneficial. ..
  10. CONTROL OF CYTOTOXIC T CELL DIFFERENTIATION/ACTIVITY
    MARTHA ALEXANDER MILLER; Fiscal Year: 2002
    ..These findings may contribute to the development of improved immunotherapeutic and vaccination strategies in which the selective activation or deletion of CTL possessing a defined avidity would be beneficial. ..
  11. CONTROL OF CYTOTOXIC T CELL DIFFERENTIATION/ACTIVITY
    MARTHA ALEXANDER MILLER; Fiscal Year: 2003
    ..These findings may contribute to the development of improved immunotherapeutic and vaccination strategies in which the selective activation or deletion of CTL possessing a defined avidity would be beneficial. ..
  12. Control of T cell response during respiratory infection
    MARTHA ALEXANDER MILLER; Fiscal Year: 2003
    ....
  13. Cellular Immune Responses to Respiratory Infection
    MARTHA ALEXANDER MILLER; Fiscal Year: 2004
    ..Results from these studies should provide information that will promote development of new vaccines that will provide optimal protection against respiratory pathogens. ..
  14. Cellular Immune Responses to Respiratory Infection
    MARTHA ALEXANDER MILLER; Fiscal Year: 2005
    ..Results from these studies should provide information that will promote development of new vaccines that will provide optimal protection against respiratory pathogens. ..
  15. Control of cytotoxic T cell differentiation and activity
    MARTHA ALEXANDER MILLER; Fiscal Year: 2005
    ..abstract_text> ..
  16. Cellular Immune Response to Respiratory Infection
    MARTHA ANN ALEXANDER MILLER; Fiscal Year: 2010
    ..This information is of critical importance for designing optimally effective therapeutics and vaccines. ..