Research Topics
| ROBERT TURESKYSummaryAffiliation: Wadsworth Center Country: USA Publications
Research Grants
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Detail Information
Publications
Interspecies metabolism of heterocyclic aromatic amines and the uncertainties in extrapolation of animal toxicity data for human risk assessmentRobert J Turesky
National Center for Toxicological Research, Division of Chemistry, Jefferson, AR, USA
Mol Nutr Food Res 49:101-17. 2005..The impact of these parameters on the metabolism and toxicological properties of HAAS and uncertainties in extrapolation of animal toxicity data for human risk assessment are presented in this article...- Quantitation of carcinogenic heterocyclic aromatic amines and detection of novel heterocyclic aromatic amines in cooked meats and grill scrapings by HPLC/ESI-MSRobert J Turesky
Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
J Agric Food Chem 53:3248-58. 2005..A number of known HAAs and novel HAAs of unknown genotoxic potential are formed at appreciable levels in cooked meats... - Formation and biochemistry of carcinogenic heterocyclic aromatic amines in cooked meatsRobert J Turesky
Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
Toxicol Lett 168:219-27. 2007..The incorporation of HAA biomarkers in epidemologic studies will help to clarify the role of these dietary genotoxicants in the etiology of human cancer... 
Biomonitoring the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Hair: Impact of Exposure, Hair Pigmentation, and Cytochrome P450 1A2 PhenotypeRobert J Turesky
Corresponding Authors Robert J Turesky, Division of Environmental Health Sciences, Wadsworth Center, Albany, NY 12201
Cancer Epidemiol Biomarkers Prev 22:356-64. 2013....- Cytochrome P450-mediated metabolism and DNA binding of 2-amino-1,7-dimethylimidazo[4,5-g]quinoxaline and its carcinogenic isomer 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in miceRobert J Turesky
Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, New York 12201, United States
Chem Res Toxicol 25:410-21. 2012..Given the high amounts of MeIgQx formed in cooked meats, further investigations are warranted to assess the carcinogenic potential of this HAA... - Tobacco smoking and urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, ChinaRobert J Turesky
Wadsworth Center, New York State Department of Health, Albany, New York, Empire State Plaza, P O Box 509, Albany, NY 12201 0509, USA
Cancer Epidemiol Biomarkers Prev 16:1554-60. 2007..Our data indicate that AalphaC represents a major HAA exposure in adult men of Shanghai, China, and that tobacco smoke is an important point source of their AalphaC exposure... - Identification of 2-amino-1,7-dimethylimidazo[4,5-g]quinoxaline: an abundant mutagenic heterocyclic aromatic amine formed in cooked beefRobert J Turesky
Division of Environmental Disease Prevention, Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA
Chem Res Toxicol 20:520-30. 2007..This newly discovered 7-MeIgQx molecule is one of the most abundant HAAs formed in cooked ground beef patties and pan-fried scrapings. The human health risk of 7-MeIgQx requires investigation... - The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indoleRobert J Turesky
Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA
Chem Res Toxicol 22:726-33. 2009..These findings clearly demonstrate that NAT2 genetic polymorphism plays a major role in the genotoxic potency of AalphaC... - Perspective: ochratoxin A is not a genotoxic carcinogenRobert J Turesky
Division of Environmental Disease Prevention, Wadsworth Center, NYS Department of Health, Albany, New York 12201, USA
Chem Res Toxicol 18:1082-90. 2005 - Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic aminesRobert J Turesky
Division of Environmental Health Sciences, Wadsworth Center, Albany, New York 12201, United States
Chem Res Toxicol 24:1169-214. 2011..Lastly, the analytical approaches that have been successfully employed to biomonitor aromatic amines and HAAs, and emerging biomarkers of HAAs that may be implemented in molecular epidemiology studies are discussed... - Quantitation of 13 heterocyclic aromatic amines in cooked beef, pork, and chicken by liquid chromatography-electrospray ionization/tandem mass spectrometryWeijuan Ni
Division of Environmental Disease Prevention and Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201 0509, USA
J Agric Food Chem 56:68-78. 2008..The toxicological properties of these recently discovered I gQx derivatives warrant further investigation and assessment... - Biomonitoring of carcinogenic heterocyclic aromatic amines in hair: a validation studyErin E Bessette
Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, New York 12201, USA
Chem Res Toxicol 22:1454-63. 2009..Thus, hair appears to be a promising tissue with by which we can noninvasively biomonitor the chronic exposure to PhIP, a potential human carcinogen... - Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cellsBarbara C Spink
Laboratory of Molecular Toxicology, Wadsworth Center, New York State Department of Health, Albany, NY 12201 0509, USA
Toxicol Appl Pharmacol 240:355-66. 2009..These studies indicate that LTEE causes adaptive responses in MCF-7 cells, which may reflect processes that contribute to the overall carcinogenic effect of E(2)... - A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urineDan Gu
Division of Environmental Health Sciences, New York State Department of Health, Albany, New York 12201, USA
Chem Res Toxicol 23:788-801. 2010..P450 1A2 primarily catalyzes the detoxification of MeIQx by oxidation of the 8-methyl group, whereas it catalyzes the bioactivation of PhIP by oxidation of the exocyclic amine group... - Biomonitoring of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its carcinogenic metabolites in urineJean Marie Fede
Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA
Chem Res Toxicol 22:1096-105. 2009..The extraction scheme is versatile and has been employed to isolate other ring-hydroxylated and glucuronidated metabolites of PhIP, for characterization by LC-ESI/MS/MS... - Novel LC-ESI/MS/MS(n) method for the characterization and quantification of 2'-deoxyguanosine adducts of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by 2-D linear quadrupole ion trap mass spectrometryAngela K Goodenough
Division of Environmental Disease Prevention, Wadsworth Center, NYS Department of Health, Albany, New York 12201 0509, USA
Chem Res Toxicol 20:263-76. 2007..In addition, an isomeric dG-PhIP adduct was detected in vivo. This LC-ESI/MS/MS(n) method is the first reported application on the use of the MS(3) scan mode for the analysis of DNA adducts in vivo... - Identification of carcinogen DNA adducts in human saliva by linear quadrupole ion trap/multistage tandem mass spectrometryErin E Bessette
Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
Chem Res Toxicol 23:1234-44. 2010..These findings demonstrate that PhIP is a significant DNA-damaging agent in humans. Saliva appears to be a promising biological fluid in which to assay DNA adducts of tobacco and dietary carcinogens by selective LIT MS techniques... - Screening for DNA adducts by data-dependent constant neutral loss-triple stage mass spectrometry with a linear quadrupole ion trap mass spectrometerErin E Bessette
Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA
Anal Chem 81:809-19. 2009.... - Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null miceYan Weng
Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York 12201 0509, USA
Cancer Res 67:7825-32. 2007.... - Hplc/electrospray ionization mass spectrometric analysis of the heterocyclic aromatic amine carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in human milkKara A Scott
Guelph Waterloo Centre for Graduate Work in Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Chem Res Toxicol 20:88-94. 2007..68 pg/mL) for all subjects except one, for whom a concentration of 1.0 pg PhIP/mL was measured. Our results indicate that the levels of PhIP in human milk are substantially lower than what was previously reported... - Analysis and quantification of DNA adducts of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in liver of rats by liquid chromatography/electrospray tandem mass spectrometryAxel Paehler
, Nestec Ltd, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland
Chem Res Toxicol 15:551-61. 2002..The dG-N(2)-MeIQx adduct, previously thought to be a minor adduct, is likely to be an important contributor to the genotoxic damage of MeIQx... - Heterocyclic aromatic amine metabolism, DNA adduct formation, mutagenesis, and carcinogenesisRobert J Turesky
Division of Chemistry, National Center for Toxicological Research, Jefferson, AR 72079, USA
Drug Metab Rev 34:625-50. 2002..These biochemical data combined may help to better assess the role that HAAs may have in the development of some common forms of human cancers... - Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2Robert J Turesky
National Center for Toxicological Research, 3900 NCTR Dr, HFT 100 Jefferson, AR 72079 9502, USA
Mutat Res 506:187-95. 2002..These pronounced interspecies differences in metabolism of MeIQx and PhIP may affect the biological activity of these mutagens and must be considered when assessing human health risk... - The effects of coffee on enzymes involved in metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in ratsRobert J Turesky
Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
Chem Biol Interact 145:251-65. 2003..These data suggest that the effect of coffee on inhibition of PhIP N-oxidation and ensuing DNA damage is more important in vivo than its effect on induction of PhIP N-hydroxylation... - Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytesSophie Langouet
INSERM U456, Faculte de Pharmacie, Universite de Rennes I, 35043 Rennes, France
Carcinogenesis 23:115-22. 2002..Some human hepatocyte populations are more active at transforming PhIP to a genotoxic species than rat hepatocytes pretreated with the potent CYP1A2 inducer 3-MC... - Formation and analysis of heterocyclic aromatic amine-DNA adducts in vitro and in vivoRobert J Turesky
Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
J Chromatogr B Analyt Technol Biomed Life Sci 802:155-66. 2004..In this review, the principal methods to synthesize and characterize DNA adducts, and the methods applied to measure HAA-DNA adduct in vitro and vivo are discussed... - Rapid biomonitoring of heterocyclic aromatic amines in human urine by tandem solvent solid phase extraction liquid chromatography electrospray ionization mass spectrometryRicky D Holland
Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
Chem Res Toxicol 17:1121-36. 2004..This tandem solvent solid phase extraction LC/ESI/MS/MS procedure may be used to rapidly assess the daily exposure to a variety of HAAs in urine... - Formation of a mutagenic heterocyclic aromatic amine from creatinine in urine of meat eaters and vegetariansRicky D Holland
Division of Chemistry, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Chem Res Toxicol 18:579-90. 2005.... - Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to ratsHennicke G Kamp
Department of Chemistry, Division of Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Erwin Schroedinger Strasse 52, D 67663 Kaiserslautern, Germany
Mol Nutr Food Res 49:1160-7. 2005..For the selective induction of tumors in the kidney, increased oxidative stress in connection with severe cytotoxicity and increased cell proliferation might represent driving factors... - Simultaneous determination of 3-nitrotyrosine and tyrosine in plasma proteins of rats and assessment of artifactual tyrosine nitrationThierry Delatour
Nestle Research Center, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
J Chromatogr B Analyt Technol Biomed Life Sci 779:189-99. 2002..Tyrosine and 3-nitrotyrosine fractions are mixed in an appropriate ratio prior to the analysis. The method was applied to animals exposed to ferric nitrilotriacetate to induce oxidative stress... - Aristolochic acid and the etiology of endemic (Balkan) nephropathyArthur P Grollman
Laboratory of Chemical Biology, Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA
Proc Natl Acad Sci U S A 104:12129-34. 2007.... - Determination of apurinic/apyrimidinic lesions in DNA with high-performance liquid chromatography and tandem mass spectrometryKenneth P Roberts
Department of Chemistry and Biochemistry, The University of Tulsa, Tulsa, Oklahoma 74104, USA
Chem Res Toxicol 19:300-9. 2006..Initial results show a quantification limit with 100 mug of DNA to be 100 fmol (three abasic sites per 10(7) bases)... - 3-Nitrotyrosine butyl ester: a novel derivative to assess tyrosine nitration in rat plasma by liquid chromatography-tandem mass spectrometry detectionThierry Delatour
, Nestec Ltd, Vers-chez-les-Blanc, Lausanne 26, 1000, Switzerland
Anal Biochem 302:10-8. 2002..In this context, analysis of eight rat plasma samples showed quantifiable levels in only four of the samples of the order of 1.4-1.5 nM... - Identification of aminobiphenyl derivatives in commercial hair dyesRobert J Turesky
Division of Chemistry, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Chem Res Toxicol 16:1162-73. 2003..Studies on dermal absorption and bioavailability of 4-ABP from hair dyes are required to determine if this aromatic amine contributes to the increased risk of bladder cancer reported in frequent users of hair dyes...
Research Grants
- Chemical markers of heterocyclic aromatic amines for human biomonitoringROBERT TURESKY; Fiscal Year: 2007..e. through exposures, or genetic polymorphisms, and then intervening in this group using disease prevention and early detection strategies. ..
- Novel approach to measure DNA adducts in humansROBERT TURESKY; Fiscal Year: 2007....
- 2-Amino-9H-pyrido[2,3-b]indole: a potential colorectal carcinogen formed in tobacRobert J Turesky; Fiscal Year: 2010....
- Chemical markers of heterocyclic aromatic amines for human biomonitoringRobert J Turesky; Fiscal Year: 2010..e. through exposures, or genetic polymorphisms, and then intervening in this group using disease prevention and early detection strategies. ..