Stewart Sell

Summary

Affiliation: Wadsworth Center
Country: USA

Publications

  1. pmc Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines
    Katherine S Koch
    Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0636, USA
    Immunology 119:98-115. 2006
  2. ncbi request reprint Cancer and stem cell signaling: a guide to preventive and therapeutic strategies for cancer stem cells
    S Sell
    Wadsworth Center and Ordway Research Institute, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA
    Stem Cell Rev 3:1-6. 2007
  3. ncbi request reprint Potential gene therapy strategies for cancer stem cells
    Stewart Sell
    Wadsworth Center and Ordway Research Institute, New York State Dept of Health, Empire State Plaza, Albany, NY 12201, USA
    Curr Gene Ther 6:579-91. 2006
  4. ncbi request reprint Stem cell origin of cancer and differentiation therapy
    Stewart Sell
    Center and Ordway Research Institute, New York State Health Department, Wadsworth Center, P O Box 509, Room C 400, Empire State Plaza, Albany, NY 12201, USA
    Crit Rev Oncol Hematol 51:1-28. 2004
  5. ncbi request reprint Leukemia: stem cells, maturation arrest, and differentiation therapy
    Stewart Sell
    Wadsworth Center and Ordway Research Institute, New York State Department of Health, Albany, NY 12201, USA
    Stem Cell Rev 1:197-205. 2005
  6. ncbi request reprint Mouse models to study the interaction of risk factors for human liver cancer
    Stewart Sell
    Ordway Research Institute and Wadsworth Center, Rpoom C 400, Empire State Plaza, Albany, NY 12201, USA
    Cancer Res 63:7553-62. 2003
  7. pmc Liver cancer stem cells
    Stewart Sell
    Wadsworth Center, Ordway Research Institute, University at Albany, Albany, NY 12201, USA
    J Clin Oncol 26:2800-5. 2008
  8. pmc Alpha-fetoprotein, stem cells and cancer: how study of the production of alpha-fetoprotein during chemical hepatocarcinogenesis led to reaffirmation of the stem cell theory of cancer
    Stewart Sell
    Wadsworth Center and Ordway Research Institute, Albany, NY, USA
    Tumour Biol 29:161-80. 2008
  9. pmc On the stem cell origin of cancer
    Stewart Sell
    Wadsworth Center and Ordway Research Institute, Empire State Plaza, Albany, NY 12201, USA
    Am J Pathol 176:2584-494. 2010
  10. pmc Infection, stem cells and cancer signals
    S Sell
    Wadsworth Center and Ordway Research Institute, Empire State Plaza, Albany, NY 12201, USA
    Curr Pharm Biotechnol 12:182-8. 2011

Research Grants

  1. DIFFERENTIATION OF BLOOD STEM CELLS INTO LIVER CELLS
    Stewart Sell; Fiscal Year: 2005
  2. STEM CELLS AND AGING
    Stewart Sell; Fiscal Year: 2007
  3. HEPTOCYTE PROLIFERATION AND AFLATOXIN METABOLISM
    Stewart Sell; Fiscal Year: 2004
  4. AFB1 AND P53 CARCINOGENESIS IN HBSAG TRANSGENIC MICE
    Stewart Sell; Fiscal Year: 2002
  5. STEM CELLS AND HEPATOCARCINOGENESIS
    Stewart Sell; Fiscal Year: 2009

Collaborators

Detail Information

Publications29

  1. pmc Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines
    Katherine S Koch
    Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0636, USA
    Immunology 119:98-115. 2006
    ..Whether these patterns reflect associations with mechanisms that are regulatory of immune privilege or functional tissue-specific plasticity is unknown...
  2. ncbi request reprint Cancer and stem cell signaling: a guide to preventive and therapeutic strategies for cancer stem cells
    S Sell
    Wadsworth Center and Ordway Research Institute, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA
    Stem Cell Rev 3:1-6. 2007
  3. ncbi request reprint Potential gene therapy strategies for cancer stem cells
    Stewart Sell
    Wadsworth Center and Ordway Research Institute, New York State Dept of Health, Empire State Plaza, Albany, NY 12201, USA
    Curr Gene Ther 6:579-91. 2006
    ..With advances in approaches using specific inhibitory RNA, such combination therapy may now be possible, but critical problems in delivering the inhibitory effect specifically to the cancer stem cells have yet to be worked out...
  4. ncbi request reprint Stem cell origin of cancer and differentiation therapy
    Stewart Sell
    Center and Ordway Research Institute, New York State Health Department, Wadsworth Center, P O Box 509, Room C 400, Empire State Plaza, Albany, NY 12201, USA
    Crit Rev Oncol Hematol 51:1-28. 2004
    ..Retinoid acid (RA) induced differentiation therapy has acquired a therapeutic niche in treatment of acute promyelocytic leukemia and the ability of RA to prevent cancer is currently under examination...
  5. ncbi request reprint Leukemia: stem cells, maturation arrest, and differentiation therapy
    Stewart Sell
    Wadsworth Center and Ordway Research Institute, New York State Department of Health, Albany, NY 12201, USA
    Stem Cell Rev 1:197-205. 2005
    ..Because acute myeloid leukemias usually have mutation of more than one gene, combinations of specific inhibitors that act on the effects of different specific genetic lesions promises to result in more effective and permanent treatment...
  6. ncbi request reprint Mouse models to study the interaction of risk factors for human liver cancer
    Stewart Sell
    Ordway Research Institute and Wadsworth Center, Rpoom C 400, Empire State Plaza, Albany, NY 12201, USA
    Cancer Res 63:7553-62. 2003
    ..Future studies will explore the effects of modifying factors on the development of HCC...
  7. pmc Liver cancer stem cells
    Stewart Sell
    Wadsworth Center, Ordway Research Institute, University at Albany, Albany, NY 12201, USA
    J Clin Oncol 26:2800-5. 2008
    ..However, definitive markers for these putative cancer stem cells have not yet been found and a liver cancer stem cell has not been isolated...
  8. pmc Alpha-fetoprotein, stem cells and cancer: how study of the production of alpha-fetoprotein during chemical hepatocarcinogenesis led to reaffirmation of the stem cell theory of cancer
    Stewart Sell
    Wadsworth Center and Ordway Research Institute, Albany, NY, USA
    Tumour Biol 29:161-80. 2008
    ..Therapy directed toward interruption of the cell signaling pathways that maintain cancer stem cells could lead to new modalities to the prevention of regrowth of the cancer...
  9. pmc On the stem cell origin of cancer
    Stewart Sell
    Wadsworth Center and Ordway Research Institute, Empire State Plaza, Albany, NY 12201, USA
    Am J Pathol 176:2584-494. 2010
    ....
  10. pmc Infection, stem cells and cancer signals
    S Sell
    Wadsworth Center and Ordway Research Institute, Empire State Plaza, Albany, NY 12201, USA
    Curr Pharm Biotechnol 12:182-8. 2011
    ..The common thread among these diverse pathways is that the infections act to alter tissue stem cell signaling with continued proliferation of tumor transit amplifying cells...
  11. ncbi request reprint Cancer stem cells and differentiation therapy
    Stewart Sell
    New York State Health Department, Wadsworth Center and Ordway Research Institute, Albany, NY 12201, USA
    Tumour Biol 27:59-70. 2006
    ....
  12. doi request reprint Characterization of mammary cancer stem cells in the MMTV-PyMT mouse model
    Jun Ma
    Translational and Functional Genomics Laboratory, Ordway Research Institute, Albany, NY 12208, USA
    Tumour Biol 33:1983-96. 2012
    ..In conclusion, our data show that primary mammary cancers from MMTV-PyMT mice contain putative cancer stem cells that survive in culture and can be used to create a model for study of mammary cancer stem cells...
  13. pmc Direct and indirect contribution of bone marrow-derived cells to cancer
    Ian Guest
    Department of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    Int J Cancer 126:2308-18. 2010
    ....
  14. pmc Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1
    Zoran Ilic
    Ordway Research Institute, Albany, NY 12208, USA
    Toxicol Appl Pharmacol 242:241-6. 2010
    ..We propose the mGSTA3 KO mouse as a useful model with which to study the interplay of risk factors leading to HCC development in humans, as well as for testing of additional possible functions of mGSTA3...
  15. pmc Age dependence of oval cell responses and bile duct carcinomas in male fischer 344 rats fed a cyclic choline-deficient, ethionine-supplemented diet
    Ian Guest
    Department of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY, USA
    Hepatology 52:1750-7. 2010
    ..In contrast to most published studies using uninterrupted choline deficiency plus a carcinogen, hepatocellular carcinoma (HCC) was not observed under the conditions of this study...
  16. doi request reprint Tumor-derived mesenchymal stem cells and orthotopic site increase the tumor initiation potential of putative mouse mammary cancer stem cells derived from MMTV-PyMT mice
    Denise Grant Lanza
    Translational and Functional Genomics Laboratory, Ordway Research Institute, Albany, NY 12208, USA
    Tumour Biol 33:1997-2005. 2012
    ..Tumor initiation was also significantly increased in the orthotopic injection site compared to heterotopic injections. We conclude that tumor stroma and orthotopic sites both enhance tumor initiation by mammary cancer stem cells...
  17. pmc Separate origins of hepatitis B virus surface antigen-negative foci and hepatocellular carcinomas in transgenic HBsAg (alb/psx) mice
    Dana R Crawford
    Center for Immunology and Microbial Disease, The Albany Medical College, Albany, New York, USA
    Am J Pathol 169:223-32. 2006
    ..Thus, HBsAg-negative progenitor cells with deletions in the transgene appear to be responsible for compensatory regeneration of the liver, whereas HCCs arise from clonal expansion of hepatocytes with intact alb/psx transgenes...
  18. ncbi request reprint Derivation, characterization, and phenotypic variation of hepatic progenitor cell lines isolated from adult rats
    Li Yin
    Division of Experimental Pathology, Albany Medical College, Albany, NY, USA
    Hepatology 35:315-24. 2002
    ....
  19. ncbi request reprint Cellular origin of hepatocellular carcinomas
    Stewart Sell
    Department of Pathology and Laboratory Medicine, Division of Experimental Pathology, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208 3479, USA
    Semin Cell Dev Biol 13:419-24. 2002
    ..Extrahepatic (bone marrow) origin of the periductular stem cells is supported by recent data showing that hepatocytes may express genetic markers of donor hematopoietic cells after bone marrow transplantation...
  20. ncbi request reprint The hepatocyte: heterogeneity and plasticity of liver cells
    Stewart Sell
    Department of Pathology and Laboratory Medicine, Division of Experimental Pathology, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208 3479, USA
    Int J Biochem Cell Biol 35:267-71. 2003
    ....
  21. ncbi request reprint Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders
    Anna B Glinskii
    Translational and Functional Genomics Laboratory, Department of Pathology and Laboratory Medicine, Division of Urology, Albany Medical College, Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Science, Albany, NY, USA
    Cell Cycle 8:3925-42. 2009
    ..According to this model, random genetic variations which generate transRNAs asserting antagonistic phenotype-altering effects compared to ancestral alleles will be selected and retained as SNP variants...
  22. ncbi request reprint Proliferation of hepatic lineage cells of normal C57BL and interleukin-6 knockout mice after cocaine-induced periportal injury
    D Rosenberg
    Division of Experimental Pathology, Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY 12208 3479, USA
    Hepatology 31:948-55. 2000
    ..Increased proliferation of oval cells in IL-6 knockout mice may compensate for the lower proliferation of other liver cell types...
  23. ncbi request reprint Reduced expression of p27kip1 and increased hepatocyte proliferation in p53-deficient mice
    Chuanwei Yang
    Center for Immunology and Microbial Disease, Albany Medical College, New York, USA
    Mol Carcinog 36:15-22. 2003
    ..We postulate that this increased proliferation leads to increased susceptibility to aflatoxin-induced hepatocarcinogenesis...
  24. pmc Hepatocyte nuclear factor-1 as marker of epithelial phenotype reveals marrow-derived hepatocytes, but not duct cells, after liver injury in mice
    E Scott Swenson
    Section of Digestive Diseases, Yale University School of Medicine, LMP 1080, New Haven, Connecticut 06520 8019, USA
    Stem Cells 26:1768-77. 2008
    ..The use of a nuclear marker of mature hepatocytes or cholangiocytes, such as HNF1, improves discrimination of marrow-derived epithelial cells in tissue sections...
  25. ncbi request reprint Hepatic progenitor cell lines from allyl alcohol-treated adult rats are derived from gamma-irradiated mouse STO cells
    Mingjun Zhang
    Department of Pharmacology, University of California, San Diego, La Jolla 92093, USA
    Stem Cells 21:449-58. 2003
    ....
  26. ncbi request reprint Unexpected artifacts raise new caution in stem cell culture research
    Hyam L Leffert
    Hepatology 39:258. 2004
  27. ncbi request reprint Adult stem cell plasticity: introduction to the first issue of stem cell reviews
    Stewart Sell
    Stem Cell Rev 1:1-7. 2005
  28. ncbi request reprint Low hepatic glutathione S-transferase and increased hepatic DNA adduction contribute to increased tumorigenicity of aflatoxin B1 in newborn and partially hepatectomized mice
    Thomas Shupe
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Medical Science Building, P O Box 100275, Gainesville, FL 32610 0275, USA
    Toxicol Lett 148:1-9. 2004
    ..These results indicate that increased susceptibility to AFB1 hepatocarcinogenesis in newborn mice, and in adult mice following partial hepatectomy, is due to decreased GST and increased adduct formation in proliferating liver...
  29. ncbi request reprint Embryonic mouse STO cell-derived xenografts express hepatocytic functions in the livers of nonimmunosuppressed adult rats
    Mingjun Zhang
    Department of Pharmacology, University of California, San Diego, La Jolla, California, 92093 0636, USA
    Stem Cells 23:186-99. 2005
    ....

Research Grants22

  1. DIFFERENTIATION OF BLOOD STEM CELLS INTO LIVER CELLS
    Stewart Sell; Fiscal Year: 2005
    ..If this project is successful, it would overcome a major hurdle in the possible use of hepatic stem cells for treatment of liver failure or ex vivo gene therapy. ..
  2. STEM CELLS AND AGING
    Stewart Sell; Fiscal Year: 2007
    ..The results of these experiments should provide critical proof for one of the most important hypothetical properties of adult stem cells. ..
  3. HEPTOCYTE PROLIFERATION AND AFLATOXIN METABOLISM
    Stewart Sell; Fiscal Year: 2004
    ..the effect Of HBV associated injury and AFB I hepatocarcinogensis in these mice. In Specific Aim 3, the effect of HBV associated injury and AFB1 hepatocarcinogenesis in these mice will be examined. ..
  4. AFB1 AND P53 CARCINOGENESIS IN HBSAG TRANSGENIC MICE
    Stewart Sell; Fiscal Year: 2002
    ..These studies should lead to an understanding of how each of these risk factors affect hepatocyte proliferation and how these effects contribute to AFB1 hepatocarcinogenesis. ..
  5. STEM CELLS AND HEPATOCARCINOGENESIS
    Stewart Sell; Fiscal Year: 2009
    ..Knowledge of the cellular origin of cancer is critical for understanding how cancer evolves and for developing prevention strategies. ..