Research Topics
Species | Stewart SellSummaryAffiliation: Wadsworth Center Country: USA Publications
Research Grants
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Publications
Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell linesKatherine S Koch
Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0636, USA
Immunology 119:98-115. 2006..Whether these patterns reflect associations with mechanisms that are regulatory of immune privilege or functional tissue-specific plasticity is unknown...
Cancer and stem cell signaling: a guide to preventive and therapeutic strategies for cancer stem cellsS Sell
Wadsworth Center and Ordway Research Institute, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA
Stem Cell Rev 3:1-6. 2007- Potential gene therapy strategies for cancer stem cellsStewart Sell
Wadsworth Center and Ordway Research Institute, New York State Dept of Health, Empire State Plaza, Albany, NY 12201, USA
Curr Gene Ther 6:579-91. 2006..With advances in approaches using specific inhibitory RNA, such combination therapy may now be possible, but critical problems in delivering the inhibitory effect specifically to the cancer stem cells have yet to be worked out... - Stem cell origin of cancer and differentiation therapyStewart Sell
Center and Ordway Research Institute, New York State Health Department, Wadsworth Center, P O Box 509, Room C 400, Empire State Plaza, Albany, NY 12201, USA
Crit Rev Oncol Hematol 51:1-28. 2004..Retinoid acid (RA) induced differentiation therapy has acquired a therapeutic niche in treatment of acute promyelocytic leukemia and the ability of RA to prevent cancer is currently under examination... - Leukemia: stem cells, maturation arrest, and differentiation therapyStewart Sell
Wadsworth Center and Ordway Research Institute, New York State Department of Health, Albany, NY 12201, USA
Stem Cell Rev 1:197-205. 2005..Because acute myeloid leukemias usually have mutation of more than one gene, combinations of specific inhibitors that act on the effects of different specific genetic lesions promises to result in more effective and permanent treatment... - Mouse models to study the interaction of risk factors for human liver cancerStewart Sell
Ordway Research Institute and Wadsworth Center, Rpoom C 400, Empire State Plaza, Albany, NY 12201, USA
Cancer Res 63:7553-62. 2003..Future studies will explore the effects of modifying factors on the development of HCC... - Liver cancer stem cellsStewart Sell
Wadsworth Center, Ordway Research Institute, University at Albany, Albany, NY 12201, USA
J Clin Oncol 26:2800-5. 2008..However, definitive markers for these putative cancer stem cells have not yet been found and a liver cancer stem cell has not been isolated... - Alpha-fetoprotein, stem cells and cancer: how study of the production of alpha-fetoprotein during chemical hepatocarcinogenesis led to reaffirmation of the stem cell theory of cancerStewart Sell
Wadsworth Center and Ordway Research Institute, Albany, NY, USA
Tumour Biol 29:161-80. 2008..Therapy directed toward interruption of the cell signaling pathways that maintain cancer stem cells could lead to new modalities to the prevention of regrowth of the cancer... - On the stem cell origin of cancerStewart Sell
Wadsworth Center and Ordway Research Institute, Empire State Plaza, Albany, NY 12201, USA
Am J Pathol 176:2584-494. 2010.... - Infection, stem cells and cancer signalsS Sell
Wadsworth Center and Ordway Research Institute, Empire State Plaza, Albany, NY 12201, USA
Curr Pharm Biotechnol 12:182-8. 2011..The common thread among these diverse pathways is that the infections act to alter tissue stem cell signaling with continued proliferation of tumor transit amplifying cells... - Cancer stem cells and differentiation therapyStewart Sell
New York State Health Department, Wadsworth Center and Ordway Research Institute, Albany, NY 12201, USA
Tumour Biol 27:59-70. 2006.... 
Characterization of mammary cancer stem cells in the MMTV-PyMT mouse modelJun Ma
Translational and Functional Genomics Laboratory, Ordway Research Institute, Albany, NY 12208, USA
Tumour Biol 33:1983-96. 2012..In conclusion, our data show that primary mammary cancers from MMTV-PyMT mice contain putative cancer stem cells that survive in culture and can be used to create a model for study of mammary cancer stem cells...- Direct and indirect contribution of bone marrow-derived cells to cancerIan Guest
Department of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
Int J Cancer 126:2308-18. 2010.... - Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1Zoran Ilic
Ordway Research Institute, Albany, NY 12208, USA
Toxicol Appl Pharmacol 242:241-6. 2010..We propose the mGSTA3 KO mouse as a useful model with which to study the interplay of risk factors leading to HCC development in humans, as well as for testing of additional possible functions of mGSTA3... - Age dependence of oval cell responses and bile duct carcinomas in male fischer 344 rats fed a cyclic choline-deficient, ethionine-supplemented dietIan Guest
Department of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY, USA
Hepatology 52:1750-7. 2010.... - Tumor-derived mesenchymal stem cells and orthotopic site increase the tumor initiation potential of putative mouse mammary cancer stem cells derived from MMTV-PyMT miceDenise Grant Lanza
Translational and Functional Genomics Laboratory, Ordway Research Institute, Albany, NY 12208, USA
Tumour Biol 33:1997-2005. 2012..Tumor initiation was also significantly increased in the orthotopic injection site compared to heterotopic injections. We conclude that tumor stroma and orthotopic sites both enhance tumor initiation by mammary cancer stem cells... - Separate origins of hepatitis B virus surface antigen-negative foci and hepatocellular carcinomas in transgenic HBsAg (alb/psx) miceDana R Crawford
Center for Immunology and Microbial Disease, The Albany Medical College, Albany, New York, USA
Am J Pathol 169:223-32. 2006..Thus, HBsAg-negative progenitor cells with deletions in the transgene appear to be responsible for compensatory regeneration of the liver, whereas HCCs arise from clonal expansion of hepatocytes with intact alb/psx transgenes... - Derivation, characterization, and phenotypic variation of hepatic progenitor cell lines isolated from adult ratsLi Yin
Division of Experimental Pathology, Albany Medical College, Albany, NY, USA
Hepatology 35:315-24. 2002.... - Cellular origin of hepatocellular carcinomasStewart Sell
Department of Pathology and Laboratory Medicine, Division of Experimental Pathology, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208 3479, USA
Semin Cell Dev Biol 13:419-24. 2002..Extrahepatic (bone marrow) origin of the periductular stem cells is supported by recent data showing that hepatocytes may express genetic markers of donor hematopoietic cells after bone marrow transplantation... - The hepatocyte: heterogeneity and plasticity of liver cellsStewart Sell
Department of Pathology and Laboratory Medicine, Division of Experimental Pathology, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208 3479, USA
Int J Biochem Cell Biol 35:267-71. 2003.... - Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disordersAnna B Glinskii
Translational and Functional Genomics Laboratory, Department of Pathology and Laboratory Medicine, Division of Urology, Albany Medical College, Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Science, Albany, NY, USA
Cell Cycle 8:3925-42. 2009..According to this model, random genetic variations which generate transRNAs asserting antagonistic phenotype-altering effects compared to ancestral alleles will be selected and retained as SNP variants... - Proliferation of hepatic lineage cells of normal C57BL and interleukin-6 knockout mice after cocaine-induced periportal injuryD Rosenberg
Division of Experimental Pathology, Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY 12208 3479, USA
Hepatology 31:948-55. 2000..Increased proliferation of oval cells in IL-6 knockout mice may compensate for the lower proliferation of other liver cell types... - Reduced expression of p27kip1 and increased hepatocyte proliferation in p53-deficient miceChuanwei Yang
Center for Immunology and Microbial Disease, Albany Medical College, New York, USA
Mol Carcinog 36:15-22. 2003..We postulate that this increased proliferation leads to increased susceptibility to aflatoxin-induced hepatocarcinogenesis... - Hepatocyte nuclear factor-1 as marker of epithelial phenotype reveals marrow-derived hepatocytes, but not duct cells, after liver injury in miceE Scott Swenson
Section of Digestive Diseases, Yale University School of Medicine, LMP 1080, New Haven, Connecticut 06520 8019, USA
Stem Cells 26:1768-77. 2008..The use of a nuclear marker of mature hepatocytes or cholangiocytes, such as HNF1, improves discrimination of marrow-derived epithelial cells in tissue sections... - Hepatic progenitor cell lines from allyl alcohol-treated adult rats are derived from gamma-irradiated mouse STO cellsMingjun Zhang
Department of Pharmacology, University of California, San Diego, La Jolla 92093, USA
Stem Cells 21:449-58. 2003.... - Unexpected artifacts raise new caution in stem cell culture researchHyam L Leffert
Hepatology 39:258. 2004 - Adult stem cell plasticity: introduction to the first issue of stem cell reviewsStewart Sell
Stem Cell Rev 1:1-7. 2005 - Low hepatic glutathione S-transferase and increased hepatic DNA adduction contribute to increased tumorigenicity of aflatoxin B1 in newborn and partially hepatectomized miceThomas Shupe
Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Medical Science Building, P O Box 100275, Gainesville, FL 32610 0275, USA
Toxicol Lett 148:1-9. 2004..These results indicate that increased susceptibility to AFB1 hepatocarcinogenesis in newborn mice, and in adult mice following partial hepatectomy, is due to decreased GST and increased adduct formation in proliferating liver... - Embryonic mouse STO cell-derived xenografts express hepatocytic functions in the livers of nonimmunosuppressed adult ratsMingjun Zhang
Department of Pharmacology, University of California, San Diego, La Jolla, California, 92093 0636, USA
Stem Cells 23:186-99. 2005....
Research Grants
- DIFFERENTIATION OF BLOOD STEM CELLS INTO LIVER CELLSStewart Sell; Fiscal Year: 2005..If this project is successful, it would overcome a major hurdle in the possible use of hepatic stem cells for treatment of liver failure or ex vivo gene therapy. ..
- STEM CELLS AND AGINGStewart Sell; Fiscal Year: 2007..The results of these experiments should provide critical proof for one of the most important hypothetical properties of adult stem cells. ..
- HEPTOCYTE PROLIFERATION AND AFLATOXIN METABOLISMStewart Sell; Fiscal Year: 2004..the effect Of HBV associated injury and AFB I hepatocarcinogensis in these mice. In Specific Aim 3, the effect of HBV associated injury and AFB1 hepatocarcinogenesis in these mice will be examined. ..
- AFB1 AND P53 CARCINOGENESIS IN HBSAG TRANSGENIC MICEStewart Sell; Fiscal Year: 2002..These studies should lead to an understanding of how each of these risk factors affect hepatocyte proliferation and how these effects contribute to AFB1 hepatocarcinogenesis. ..
- STEM CELLS AND HEPATOCARCINOGENESISStewart Sell; Fiscal Year: 2009..Knowledge of the cellular origin of cancer is critical for understanding how cancer evolves and for developing prevention strategies. ..